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AMR Drug RepurposingSmart Screeningresearch prototype

Prasugrel Hydrochloride

FDA-approved product (tablet, oral), marketed as Effient, Prasugrel, Prasugrel Hydrochloride.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Prasugrel Hydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Acute coronary syndrome
  • Hemorrhage
  • Intermediate coronary syndrome
  • Myocardial infarction

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Platelet aggregation inhibitors excl. heparin
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli, K. pneumoniae and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA64.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli54.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae44.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis64.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Prasugrel Hydrochloride in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-8.0 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.0 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.6 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-8.5 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Prasugrel Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • P3AMI Antiplatelet Trial

    NCT02376283 · start 2015-03-09

    Registered record
    Registry ID
    NCT02376283
    Conditions
    Heart Attack
    Interventions
    Prasugrel; Clopidogrel; ticagrelor
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-03-09
    Completion
    2016-11
    Enrolment
    87

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHeart Attack
    InterventionPrasugrel; Clopidogrel; ticagrelor
    PhasePhase 4
    Registry statusCompleted

  • A Pharmacodynamic Study of a Personalized Strategy for P2Y12 Inhibition Versus Ticagrelor in Reducing Ischemic and Bleeding Risk

    NCT02044146 · start 2014-09

    Registered record
    Registry ID
    NCT02044146
    Conditions
    Acute Coronary Syndrome; Percutaneous Coronary Intervention
    Interventions
    Ticagrelor, Prasugrel, Clopidogrel
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2014-09
    Completion
    2017-06
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Coronary Syndrome; Percutaneous Coronary Intervention
    InterventionTicagrelor, Prasugrel, Clopidogrel
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Prasugrel and Ticagrelor in ST-segment Elevation Myocardial Infarction

    NCT02075125 · start 2014-01

    Registered record
    Registry ID
    NCT02075125
    Conditions
    ST-Segment Elevation Myocardial Infarction
    Interventions
    Prasugrel 60 mg; Ticagrelor 180 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2014-01
    Completion
    2015-04
    Enrolment
    39

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionST-Segment Elevation Myocardial Infarction
    InterventionPrasugrel 60 mg; Ticagrelor 180 mg
    PhasePhase 3
    Registry statusTerminated

  • Prospective, Randomized Trial of Ticagrelor Versus Prasugrel in Patients With Acute Coronary Syndrome

    NCT01944800 · start 2013-09-15

    Registered record
    Registry ID
    NCT01944800
    Conditions
    Acute Coronary Syndrome (ACS)
    Interventions
    Ticagrelor; Prasugrel
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2013-09-15
    Completion
    2021-09
    Enrolment
    4,018

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Coronary Syndrome (ACS)
    InterventionTicagrelor; Prasugrel
    PhasePhase 4
    Registry statusCompleted

  • Effect of Prasugrel Versus Clopidogrel on Platelet Function After Bivalirudin Cessation

    NCT01789814 · start 2013-07

    Registered record
    Registry ID
    NCT01789814
    Conditions
    Coronary Artery Disease
    Interventions
    Prasugrel; Clopidogrel
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2013-07
    Completion
    2014-07
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCoronary Artery Disease
    InterventionPrasugrel; Clopidogrel
    PhasePhase 4
    Registry statusCompleted

  • PKPD Study of Ticagrelor and Prasugrel in Healthy Korean Males

    NCT01876797 · start 2013-07

    Registered record
    Registry ID
    NCT01876797
    Conditions
    Healthy
    Interventions
    ticagrelor/prasugrel
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2013-07
    Completion
    2013-08
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    Interventionticagrelor/prasugrel
    PhasePhase 1
    Registry statusCompleted

  • Sampling P2Y12 Receptor Inhibition With Prasugrel and Ticagrelor in Patients Submitted to Thrombolysis

    NCT02215993 · start 2013-07

    Registered record
    Registry ID
    NCT02215993
    Conditions
    Acute Coronary Syndrome; Platelet Function
    Interventions
    Prasugrel; Ticagrelor
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2013-07
    Completion
    2014-10
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Coronary Syndrome; Platelet Function
    InterventionPrasugrel; Ticagrelor
    PhasePhase 4
    Registry statusCompleted

  • PraSugrel vs TicagrElor in ST-Elevation Myocardial Infarction paTients With Diabetes Mellitus

    NCT01531114 · start 2013-05

    Registered record
    Registry ID
    NCT01531114
    Conditions
    ST-Elevation Myocardial Infarction
    Interventions
    ticagrelor; prasugrel
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2013-05
    Completion
    2015-07
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionST-Elevation Myocardial Infarction
    Interventionticagrelor; prasugrel
    PhasePhase 3
    Registry statusCompleted

  • A Study of Prasugrel in Pediatric Participants With Sickle Cell Disease (SCD)

    NCT01794000 · start 2013-04

    Registered record
    Registry ID
    NCT01794000
    Conditions
    Sickle Cell Disease
    Interventions
    Prasugrel; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2013-04
    Completion
    2015-12
    Enrolment
    341

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSickle Cell Disease
    InterventionPrasugrel; Placebo
    PhasePhase 3
    Registry statusTerminated

  • Comparison of Prasugrel and Ticagrelor in the Treatment of Acute Myocardial Infarction

    NCT02808767 · start 2013-01

    Registered record
    Registry ID
    NCT02808767
    Conditions
    Myocardial Infarction; Angioplasty, Balloon, Coronary; Platelet Aggregation Inhibitors
    Interventions
    Prasugrel; Ticagrelor
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2013-01
    Completion
    2017-05
    Enrolment
    1,226

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMyocardial Infarction; Angioplasty, Balloon, Coronary; Platelet Aggregation Inhibitors
    InterventionPrasugrel; Ticagrelor
    PhasePhase 4
    Registry statusCompleted

  • Rapid Activity of Platelet Inhibitor Drugs Study 2

    NCT01805570 · start 2012-11

    Registered record
    Registry ID
    NCT01805570
    Conditions
    Myocardial Infarction
    Interventions
    Prasugrel; Ticagrelor
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-11
    Completion
    2013-04
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMyocardial Infarction
    InterventionPrasugrel; Ticagrelor
    PhasePhase 4
    Registry statusCompleted

  • VERifynow in DIabetes Non-responsiveness: a Study on Switching From Clopidogrel to Prasugrel

    NCT01684813 · start 2012-10

    Registered record
    Registry ID
    NCT01684813
    Conditions
    Diabetes Mellitus Type II; Acute Coronary Syndrome
    Interventions
    Prasugrel.; Clopidogrel
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-10
    Completion
    2013-10
    Enrolment
    65

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetes Mellitus Type II; Acute Coronary Syndrome
    InterventionPrasugrel.; Clopidogrel
    PhasePhase 4
    Registry statusCompleted

  • Differential Effect of Ticagrelor Versus Prasugrel on the Adenosine-induced Coronary Vasodilatory Responses in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention

    NCT01642966 · start 2012-09

    Registered record
    Registry ID
    NCT01642966
    Conditions
    Acute Coronary Syndrome
    Interventions
    Prasugrel; Ticagrelor
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-09
    Completion
    2012-09
    Enrolment
    56

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Coronary Syndrome
    InterventionPrasugrel; Ticagrelor
    PhasePhase 4
    Registry statusCompleted

  • Therapeutic Control of Aspirin-Exacerbated Respiratory Disease (Aspirin)

    NCT01597375 · start 2012-08-31

    Registered record
    Registry ID
    NCT01597375
    Conditions
    Asthma, Aspirin-Induced; Aspirin Exacerbated Asthma
    Interventions
    Placebo Oral Tablet; Prasugrel Oral Tablet
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2012-08-31
    Completion
    2016-12-14
    Enrolment
    46

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma, Aspirin-Induced; Aspirin Exacerbated Asthma
    InterventionPlacebo Oral Tablet; Prasugrel Oral Tablet
    PhasePhase 2
    Registry statusCompleted

  • PROMUS Element Plus US Post-Approval Study

    NCT01589978 · start 2012-05

    Registered record
    Registry ID
    NCT01589978
    Conditions
    Coronary Artery Disease
    Interventions
    PROMUS Element Plus Coronary Stent System; Aspirin; P2Y12 antagonist
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-05
    Completion
    2018-06
    Enrolment
    2,681

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCoronary Artery Disease
    InterventionPROMUS Element Plus Coronary Stent System; Aspirin; P2Y12 antagonist
    PhasePhase 4
    Registry statusCompleted