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AMR Drug RepurposingSmart Screeningresearch prototype

Cycloserine

FDA-approved product (capsule, oral), marketed as Seromycin.

Registered studies
50+
Lab records
6
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Cycloserine
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Extrapulmonary tuberculosis
  • Tuberculosis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Antibiotics
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J04AB01

Repurposing investigation

Cycloserine is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA13.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli65.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae15.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis5.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • E. coli: measured active in 2 of 4 lab records
  • M. tuberculosis: measured active in 0 of 2 lab records
Open Cycloserine in ChEMBL Registered studies below
Show the 6 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-4.0 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-4.8 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-4.0 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-4.0 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Cycloserine with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Improving Therapeutic Learning in Depression: Proof of Concept

    NCT02376257 · start 2014-09-16

    Registered record
    Registry ID
    NCT02376257
    Conditions
    Major Depressive Disorder
    Interventions
    250 mg DCS; 100 mg Modafinil; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2014-09-16
    Completion
    2017-05
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMajor Depressive Disorder
    Intervention250 mg DCS; 100 mg Modafinil; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Understanding the Importance of Plasticity in the Brain Mechanisms of Dyspnoea Perception

    NCT01985750 · start 2013-11

    Registered record
    Registry ID
    NCT01985750
    Conditions
    Chronic Obstructive Pulmonary Disease
    Interventions
    d-cycloserine; placebo
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Unknown
    Start
    2013-11
    Completion
    2020-02
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Obstructive Pulmonary Disease
    Interventiond-cycloserine; placebo
    PhaseEarly phase 1
    Registry statusUnknown

  • Enhancing Panic and Smoking Reduction Treatment With D-Cycloserine

    NCT01944423 · start 2013-10

    Registered record
    Registry ID
    NCT01944423
    Conditions
    Nicotine Addiction; Panic Attack
    Interventions
    d-cycloserine; Pill Placebo; Nicotine replacement therapy; Panic and Smoking Reduction Treatment
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2013-10
    Completion
    2018-10
    Enrolment
    53

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNicotine Addiction; Panic Attack
    Interventiond-cycloserine; Pill Placebo; Nicotine replacement therapy; Panic and Smoking Reduction Treatment
    PhaseEarly phase 1
    Registry statusCompleted

  • A Randomized Controlled Trial of Cognitive Remediation and D-cycloserine for Individuals With Bipolar Disorder

    NCT01934972 · start 2013-03

    Registered record
    Registry ID
    NCT01934972
    Conditions
    Bipolar Disorder
    Interventions
    CR + DCS (D-cycloserine); CR + placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2013-03
    Completion
    2017-04
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBipolar Disorder
    InterventionCR + DCS (D-cycloserine); CR + placebo
    PhasePhase 3
    Registry statusCompleted

  • The Effects of D-cycloserine on Stimulus Generalization of Conditioned Fear Healthy Controls.

    NCT01733030 · start 2013-01

    Registered record
    Registry ID
    NCT01733030
    Conditions
    Post Traumatic Stress Syndrome
    Interventions
    Seromycin; Seromycin
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2013-01
    Completion
    2015-10-01
    Enrolment
    56

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost Traumatic Stress Syndrome
    InterventionSeromycin; Seromycin
    PhaseNot recorded
    Registry statusCompleted

  • D-cycloserine Augmented CBT for Panic Disorder

    NCT01680107 · start 2012-10

    Registered record
    Registry ID
    NCT01680107
    Conditions
    Panic Disorder
    Interventions
    d-cycloserine; placebo; cognitive-behaviour therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2012-10
    Completion
    2018-04-30
    Enrolment
    33

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPanic Disorder
    Interventiond-cycloserine; placebo; cognitive-behaviour therapy
    PhasePhase 3
    Registry statusTerminated

  • Augmentation of Psychotherapy With D-Cycloserine in Agoraphobia

    NCT01928823 · start 2011-11

    Registered record
    Registry ID
    NCT01928823
    Conditions
    Agoraphobia
    Interventions
    CBT; D-Cycloserine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2011-11
    Completion
    2014-05
    Enrolment
    73

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAgoraphobia
    InterventionCBT; D-Cycloserine
    PhasePhase 2
    Registry statusCompleted

  • D-cycloserine Augmentation of Cognitive Behavioral Therapy (CBT) for Pediatric Obsessive-compulsive Disorder (OCD)

    NCT01411774 · start 2011-06

    Registered record
    Registry ID
    NCT01411774
    Conditions
    Obsessive-compulsive Disorder
    Interventions
    Cognitive-behavioral therapy; d-cycloserine; Pill placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2011-06
    Completion
    2017-06
    Enrolment
    142

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObsessive-compulsive Disorder
    InterventionCognitive-behavioral therapy; d-cycloserine; Pill placebo
    PhasePhase 3
    Registry statusCompleted

  • Enhancing Exposure Therapy for Post Traumatic Stress Disorder (PTSD): Virtual Reality and Imaginal Exposure With a Cognitive Enhancer

    NCT01352637 · start 2011-05

    Registered record
    Registry ID
    NCT01352637
    Conditions
    Post Traumatic Stress Disorder
    Interventions
    DCS (D-Cycloserine ) + Prolonged Imaginal Exposure; DCS (D-Cycloserine ) + Virtual Reality Exposure; Placebo + Prolonged Imaginal Exposure; Placebo (sugar pill) + Virtual Reality Exposure
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2011-05
    Completion
    2018-09
    Enrolment
    192

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost Traumatic Stress Disorder
    InterventionDCS (D-Cycloserine ) + Prolonged Imaginal Exposure; DCS (D-Cycloserine ) + Virtual Reality Exposure; Placebo + Prolonged Imaginal Exposure; Placebo (sugar pill) + Virtual Reality Exposure
    PhasePhase 3
    Registry statusCompleted

  • D-Cycloserine and Social Skills Training in Autism Spectrum Disorders

    NCT01086475 · start 2010-03

    Registered record
    Registry ID
    NCT01086475
    Conditions
    Autistic Disorder; Asperger's Disorder; Pervasive Developmental Disorder NOS
    Interventions
    D-cycloserine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2010-03
    Completion
    2014-01
    Enrolment
    68

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAutistic Disorder; Asperger's Disorder; Pervasive Developmental Disorder NOS
    InterventionD-cycloserine; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Drug Discrimination in Methadone-Maintained Humans Study 3

    NCT01068847 · start 2010-02

    Registered record
    Registry ID
    NCT01068847
    Conditions
    Drug Dependence
    Interventions
    2-4 of the drugs listed below
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2010-02
    Completion
    2012-11
    Enrolment
    9

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDrug Dependence
    Intervention2-4 of the drugs listed below
    PhasePhase 1
    Registry statusCompleted

  • Neoadjuvant Combination Chemotherapy of DCS and DCF in Patients With Locally Advanced Gastric Adenocarcinoma

    NCT01286766 · start 2009-09

    Registered record
    Registry ID
    NCT01286766
    Conditions
    Gastric Cancer
    Interventions
    DCS (docetaxel with cisplatin with TS-1); DCF (docetaxel with cisplatin with 5-FU)
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2009-09
    Completion
    2012-06
    Enrolment
    6

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGastric Cancer
    InterventionDCS (docetaxel with cisplatin with TS-1); DCF (docetaxel with cisplatin with 5-FU)
    PhasePhase 2
    Registry statusCompleted

  • Investigation of Cycloserine as a Smoking Cessation Treatment

    NCT01062932 · start 2009-05

    Registered record
    Registry ID
    NCT01062932
    Conditions
    Nicotine Addiction
    Interventions
    Cycloserine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2009-05
    Completion
    2010-09
    Enrolment
    34

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNicotine Addiction
    InterventionCycloserine; Placebo
    PhasePhase 1
    Registry statusCompleted

  • Transcranial Direct Current Stimulation (tDCS) Augmentation by D-Cycloserine as a Treatment for Depression

    NCT00869765 · start 2009-04

    Registered record
    Registry ID
    NCT00869765
    Conditions
    Major Depressive Disorder; Bipolar Disorder
    Interventions
    D-Cycloserine; tDCS (Eldith DC-Stimulator (CE certified))
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2009-04
    Completion
    2010-09
    Enrolment
    5

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMajor Depressive Disorder; Bipolar Disorder
    InterventionD-Cycloserine; tDCS (Eldith DC-Stimulator (CE certified))
    PhasePhase 2
    Registry statusCompleted

  • Developing Memory Reconsolidation Blockers as Novel Posttraumatic Stress Disorder (PTSD) Treatments

    NCT01490697 · start 2009-03

    Registered record
    Registry ID
    NCT01490697
    Conditions
    Post-traumatic Stress Disorder
    Interventions
    Mifepristone; d-Cycloserine; Placebo-matching Mifepristone; Placebo-matching d-Cycloserine (DCS)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-03
    Completion
    2015-09
    Enrolment
    34

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost-traumatic Stress Disorder
    InterventionMifepristone; d-Cycloserine; Placebo-matching Mifepristone; Placebo-matching d-Cycloserine (DCS)
    PhasePhase 4
    Registry statusCompleted