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AMR Drug RepurposingSmart Screeningresearch prototype

Minocycline Hydrochloride

FDA-approved product (capsule, oral), marketed as Amzeeq, Arestin, Dynacin and 7 more.

Registered studies
50+
Lab records
26
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Minocycline Hydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Acne
  • Bacterial disease
  • Conjunctivitis
  • Infection
  • Ornithosis
  • Periodontitis
  • Respiratory tract infectious disorder
  • Rosacea
  • Spotted fever

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Antiinfectives and antiseptics for local oral treatment; Antiinfectives for treatment of acne; Tetracyclines
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC D10AF07; WHO ATC J01AA08

Repurposing investigation

Minocycline Hydrochloride is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA89.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli89.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae98.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis80.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 4 of 4 lab records
  • E. coli: measured active in 3 of 3 lab records
  • K. pneumoniae: measured active in 14 of 17 lab records
  • M. tuberculosis: measured active in 2 of 2 lab records
Open Minocycline Hydrochloride in ChEMBL Registered studies below
Show the 26 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.3 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-8.2 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.0 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.5 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Minocycline Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Open Study Assessing the Feasibility of Minocycline in Patients With Unipolar Depression

    NCT01574742 · start 2012-06

    Registered record
    Registry ID
    NCT01574742
    Conditions
    Unipolar Depression
    Interventions
    Minocycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Unknown
    Start
    2012-06
    Completion
    2014-06
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUnipolar Depression
    InterventionMinocycline
    PhasePhase 1
    Registry statusUnknown

  • Novel Medication Strategies Targeting Brain Mechanisms in Pediatric OCD

    NCT01695291 · start 2012-05

    Registered record
    Registry ID
    NCT01695291
    Conditions
    Obsessive Compulsive Disorder
    Interventions
    Minocycline; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2012-05
    Completion
    2018-05
    Enrolment
    31

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObsessive Compulsive Disorder
    InterventionMinocycline; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Minocycline Augmentation in Schizophrenia

    NCT01561742 · start 2012-02

    Registered record
    Registry ID
    NCT01561742
    Conditions
    Schizophrenia
    Interventions
    Minocycline; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2012-02
    Completion
    2015-01
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia
    InterventionMinocycline; Placebo
    PhaseNot applicable
    Registry statusUnknown

  • Effect of Minocycline on Pain Caused by Nerve Damage

    NCT01869907 · start 2011-09

    Registered record
    Registry ID
    NCT01869907
    Conditions
    Neuropathic Pain Caused by Lumbar Radicular Pain
    Interventions
    Minocycline; placebo; Amitriptyline
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-09
    Completion
    2014-08
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeuropathic Pain Caused by Lumbar Radicular Pain
    InterventionMinocycline; placebo; Amitriptyline
    PhasePhase 4
    Registry statusCompleted

  • Bioequivalence Minocycline Bioequivalence

    NCT01755611 · start 2011-06-17

    Registered record
    Registry ID
    NCT01755611
    Conditions
    Skin Infections (Acne)
    Interventions
    Minocycline 100mg; Minocycline 100mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2011-06-17
    Completion
    2011-06-25
    Enrolment
    25

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSkin Infections (Acne)
    InterventionMinocycline 100mg; Minocycline 100mg
    PhasePhase 1
    Registry statusCompleted

  • Efficacy of Oral Minocycline (Solodyn) and Oral Minocycline (Solodyn) Plus Azelaic Acid (Finacea) for Acne Rosacea

    NCT05014906 · start 2010-05

    Registered record
    Registry ID
    NCT05014906
    Conditions
    Rosacea
    Interventions
    Minocycline 45 MG; Azelaic acid
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-05
    Completion
    2011-09
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRosacea
    InterventionMinocycline 45 MG; Azelaic acid
    PhasePhase 4
    Registry statusCompleted

  • Trial of Minocycline to Treat Children With Fragile X Syndrome

    NCT01053156 · start 2010-01

    Registered record
    Registry ID
    NCT01053156
    Conditions
    Fragile X Syndrome
    Interventions
    minocycline hydrochloride; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-01
    Completion
    2011-12
    Enrolment
    66

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFragile X Syndrome
    Interventionminocycline hydrochloride; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • Minocycline as Neuroprotectant After Aneurysmal Subarachnoid Hemorrhage

    NCT02113176 · start 2010-01

    Registered record
    Registry ID
    NCT02113176
    Conditions
    Subarachnoid Aneurysm Hemorrhage
    Interventions
    Minocycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Withdrawn
    Start
    2010-01
    Completion
    2018-12
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSubarachnoid Aneurysm Hemorrhage
    InterventionMinocycline
    PhasePhase 1 / Phase 2
    Registry statusWithdrawn

  • Safety and Efficacy Comparison of Minocycline Microgranules Versus Lymecycline in the Treatment of Mild to Moderate Acne

    NCT00988026 · start 2009-06

    Registered record
    Registry ID
    NCT00988026
    Conditions
    Mild to Moderate Acne
    Interventions
    Minocycline vs Lymecycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2009-06
    Completion
    2010-04
    Enrolment
    168

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMild to Moderate Acne
    InterventionMinocycline vs Lymecycline
    PhasePhase 4
    Registry statusUnknown

  • Granuloma Annulare Treated With Rifampin, Ofloxacin, and Minocycline Combination Therapy

    NCT00720980 · start 2008-05

    Registered record
    Registry ID
    NCT00720980
    Conditions
    Granuloma Annulare
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2008-05
    Completion
    2008-07
    Enrolment
    6

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGranuloma Annulare
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Long-term Safety of Minocycline in Patients With Gum Disease

    NCT00668746 · start 2007-12

    Registered record
    Registry ID
    NCT00668746
    Conditions
    Periodontitis
    Interventions
    Minocycline HCl microspheres
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-12
    Completion
    2009-02
    Enrolment
    35

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeriodontitis
    InterventionMinocycline HCl microspheres
    PhasePhase 4
    Registry statusCompleted

  • Intrapleural Minocycline After Aspiration of Spontaneous Pneumothorax

    NCT00839553 · start 2007-04

    Registered record
    Registry ID
    NCT00839553
    Conditions
    Pneumothorax
    Interventions
    Intrapleural Minocycline application
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2007-04
    Completion
    2009-04
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumothorax
    InterventionIntrapleural Minocycline application
    PhaseNot applicable
    Registry statusUnknown

  • Minocycline for the Treatment of Decreased Mental Function in HIV-Infected Adults

    NCT00361257 · start 2007-03

    Registered record
    Registry ID
    NCT00361257
    Conditions
    HIV Infections
    Interventions
    Minocycline; Placebo (Tetracycline)
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2007-03
    Completion
    2010-01
    Enrolment
    107

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionMinocycline; Placebo (Tetracycline)
    PhasePhase 2
    Registry statusTerminated

  • A Prospective Trial of Nasal Mupirocin, Hexachlorophene Body Wash, and Systemic Antibiotics for Prevention of Recurrent Methicillin Resistant Staphylococcus Aureus Infections

    NCT01049438 · start 2006-08

    Registered record
    Registry ID
    NCT01049438
    Conditions
    Methicillin Resistant Staphylococcus Aureus Skin Infections
    Interventions
    nasal mupirocin; topical 3% hexachlorophene body wash; oral anti-MRSA antibiotic
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2006-08
    Completion
    2009-09
    Enrolment
    31

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin Resistant Staphylococcus Aureus Skin Infections
    Interventionnasal mupirocin; topical 3% hexachlorophene body wash; oral anti-MRSA antibiotic
    PhaseNot applicable
    Registry statusCompleted

  • Combination Therapy Selection Trial in Amyotrophic Lateral Sclerosis

    NCT00355576 · start 2006-07

    Registered record
    Registry ID
    NCT00355576
    Conditions
    Amyotrophic Lateral Sclerosis
    Interventions
    Celecoxib; Creatine; Minocycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2006-07
    Completion
    2007-05
    Enrolment
    86

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAmyotrophic Lateral Sclerosis
    InterventionCelecoxib; Creatine; Minocycline
    PhasePhase 2
    Registry statusCompleted