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AMR Drug RepurposingSmart Screeningresearch prototype

Fluorometholone

FDA-approved product (cream, topical), marketed as Fluor-Op, Fluorometholone, Fml and 2 more.

Registered studies
37
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Fluorometholone
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Acne
  • Eye inflammation
  • Hemorrhoid
  • Inflammation

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Corticosteroids; Corticosteroids, moderately potent (group ii); Corticosteroids, moderately potent, other combinations; Corticosteroids, combinations for treatment of acne; Corticosteroids, plain
FDA pharmacologic class
Corticosteroid FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA51.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli27.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae26.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis34.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

37registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Fluorometholone in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-8.0 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-8.9 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.5 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Fluorometholone with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Comparison of Two Steroid Regimens to Prevent Transplant Rejection After Corneal Transplant (DMEK)

    NCT01448213 · start 2011-10

    Registered record
    Registry ID
    NCT01448213
    Conditions
    Fuchs' Dystrophy; Bullous Keratopathy
    Interventions
    Prednisolone acetate; Fluorometholone
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2011-10
    Completion
    2014-01
    Enrolment
    264

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFuchs' Dystrophy; Bullous Keratopathy
    InterventionPrednisolone acetate; Fluorometholone
    PhasePhase 2
    Registry statusCompleted

  • Cross-linking of Corneal Collagen (CXL) With Ultraviolet-A in Asymmetric Corneas

    NCT01189864 · start 2010-02-01

    Registered record
    Registry ID
    NCT01189864
    Conditions
    Keratoconus; Ectasia; Degeneration
    Interventions
    Ciprofloxicin or Vigamox or other.; Nonsteroidal (Acular, Acuvail, Voltaren Xibrom, etc); Steroid (FML, Pred Forte, Flarex, etc.)
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Terminated
    Start
    2010-02-01
    Completion
    2017-02-03
    Enrolment
    3,493

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKeratoconus; Ectasia; Degeneration
    InterventionCiprofloxicin or Vigamox or other.; Nonsteroidal (Acular, Acuvail, Voltaren Xibrom, etc); Steroid (FML, Pred Forte, Flarex, etc.)
    PhaseNot recorded
    Registry statusTerminated

  • Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas (2)

    NCT01097447 · start 2009-12-01

    Registered record
    Registry ID
    NCT01097447
    Conditions
    Keratoconus; Ectasia; Degeneration
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Terminated
    Start
    2009-12-01
    Completion
    2017-04-30
    Enrolment
    2,619

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKeratoconus; Ectasia; Degeneration
    InterventionNot recorded
    PhaseNot recorded
    Registry statusTerminated

  • Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas

    NCT01024322 · start 2009-10-01

    Registered record
    Registry ID
    NCT01024322
    Conditions
    Keratoconus; Ectasia; Degeneration
    Interventions
    Ciprofloxicine or Vigamox or other.; Nonsteroidal (Acular, Voltaren Xibrom, etc); Steroid (FML, Pred Forte, Flarex, etc.)
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Terminated
    Start
    2009-10-01
    Completion
    2017-02-03
    Enrolment
    1,189

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKeratoconus; Ectasia; Degeneration
    InterventionCiprofloxicine or Vigamox or other.; Nonsteroidal (Acular, Voltaren Xibrom, etc); Steroid (FML, Pred Forte, Flarex, etc.)
    PhaseNot recorded
    Registry statusTerminated

  • Topical Cyclosporine vs. Placebo for Epiphora Associated With Docetaxel

    NCT00824811 · start 2009-06

    Registered record
    Registry ID
    NCT00824811
    Conditions
    Epiphora
    Interventions
    Cyclosporine Eye Drops (Restasis); Lubricant Eye Drops (Refresh Endura™); Fluorometholone Eye Drops (FML Forte®)
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Withdrawn
    Start
    2009-06
    Completion
    Not recorded
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEpiphora
    InterventionCyclosporine Eye Drops (Restasis); Lubricant Eye Drops (Refresh Endura™); Fluorometholone Eye Drops (FML Forte®)
    PhasePhase 2
    Registry statusWithdrawn

  • Randomized Controlled Trial of Subconjunctival Bevacizumab Injection in Impending Recurrent Pterygium

    NCT01288404 · start 2008-01

    Registered record
    Registry ID
    NCT01288404
    Conditions
    Pterygium of the Conjunctiva and Cornea
    Interventions
    Fluorometholone; Bevacizumab; Bevacizumab; Bevacizumab
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2008-01
    Completion
    2010-11
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPterygium of the Conjunctiva and Cornea
    InterventionFluorometholone; Bevacizumab; Bevacizumab; Bevacizumab
    PhaseNot applicable
    Registry statusCompleted

  • Usefulness of Topical Non-Steroidal Anti-Inflammatory Drugs or Steroids Before Trabeculectomy and Clinical Outcomes

    NCT00707421 · start 2005-07

    Registered record
    Registry ID
    NCT00707421
    Conditions
    Glaucoma; Trabeculectomy; Fibrosis; Intraocular Pressure
    Interventions
    ketorolac acetate; fluorometholone; artificial lacrimal tears
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-07
    Completion
    2009-05
    Enrolment
    62

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGlaucoma; Trabeculectomy; Fibrosis; Intraocular Pressure
    Interventionketorolac acetate; fluorometholone; artificial lacrimal tears
    PhasePhase 3
    Registry statusCompleted