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AMR Drug RepurposingSmart Screeningresearch prototype

Fluvastatin Sodium

FDA-approved product (capsule, oral), marketed as Fluvastatin Sodium, Lescol, Lescol Xl.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Fluvastatin Sodium
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cardiovascular disease
  • Familial hypercholesterolemia
  • Hypercholesterolemia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Hmg coa reductase inhibitors
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA47.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli27.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae18.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis59.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Fluvastatin Sodium in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Fluvastatin Sodium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Acetaminophen or Fluvastatin Compared to Placebo on the Transient Post-Dose Symptoms (PDS) Following an Intravenous (i.v.) Infusion of a Single Dose of Zoledronic Acid 5mg, in Post-menopausal Women With Low Bone Mass

    NCT00489424 · start 2007-06

    Registered record
    Registry ID
    NCT00489424
    Conditions
    Osteoporosis
    Interventions
    Placebo; Acetaminophen; Fluvastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-06
    Completion
    2007-12
    Enrolment
    793

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoporosis
    InterventionPlacebo; Acetaminophen; Fluvastatin
    PhasePhase 4
    Registry statusCompleted

  • Improvement of Erectile Dysfunction by Fluvastatin in Patients With Cardiovascular Risk Factors

    NCT00382161 · start 2006-10

    Registered record
    Registry ID
    NCT00382161
    Conditions
    Impotence
    Interventions
    Fluvastatin-sodium
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Withdrawn
    Start
    2006-10
    Completion
    2007-12
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionImpotence
    InterventionFluvastatin-sodium
    PhasePhase 3
    Registry statusWithdrawn

  • Intensive Medical Treatment for Nephropathy Caused by Type 2 Diabetes With Hypertension

    NCT00407680 · start 2006-10

    Registered record
    Registry ID
    NCT00407680
    Conditions
    Type 2 Diabetes Mellitus; Hypertension
    Interventions
    Intensive therapy Valsartan,Fluvastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2006-10
    Completion
    2009-03
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionType 2 Diabetes Mellitus; Hypertension
    InterventionIntensive therapy Valsartan,Fluvastatin
    PhasePhase 4
    Registry statusUnknown

  • Fluvastatin Versus Hepatitis C Virus

    NCT00441493 · start 2006-09

    Registered record
    Registry ID
    NCT00441493
    Conditions
    Hepatitis C
    Interventions
    fluvastatin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2006-09
    Completion
    2007-09
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHepatitis C
    Interventionfluvastatin
    PhaseNot applicable
    Registry statusCompleted

  • The Effect of Fluvastatin XL® Treatment in Patients With Metabolic Syndrome

    NCT00664742 · start 2006-09

    Registered record
    Registry ID
    NCT00664742
    Conditions
    Metabolic Syndrome
    Interventions
    Fluvastatin XL®
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-09
    Completion
    2007-10
    Enrolment
    614

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMetabolic Syndrome
    InterventionFluvastatin XL®
    PhasePhase 4
    Registry statusCompleted

  • Reducing the Overall Risk Level in Patients Suffering From Metabolic Syndrome

    NCT00821574 · start 2005-07

    Registered record
    Registry ID
    NCT00821574
    Conditions
    Hypertension, Dyslypidaemia
    Interventions
    Fluvastatin; Valsartan; Hydrochlorothiazide
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2005-07
    Completion
    2007-03
    Enrolment
    144

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension, Dyslypidaemia
    InterventionFluvastatin; Valsartan; Hydrochlorothiazide
    PhasePhase 4
    Registry statusCompleted

  • Efficacy and Safety of Fluvastatin in Different Doses in Adults With Mixed Dyslipidemia or Primary Hypercholesterolemia

    NCT00136799 · start 2005-06

    Registered record
    Registry ID
    NCT00136799
    Conditions
    Mixed Dyslipidemia; Hypercholesterolemia
    Interventions
    Fluvastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-06
    Completion
    2006-04
    Enrolment
    325

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMixed Dyslipidemia; Hypercholesterolemia
    InterventionFluvastatin
    PhasePhase 3
    Registry statusCompleted

  • Fluvastatin in Adults With Dislipidemia With History of Muscle Problems

    NCT00125125 · start 2005-05

    Registered record
    Registry ID
    NCT00125125
    Conditions
    Dyslipidemia
    Interventions
    Fluvastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2005-05
    Completion
    2005-12
    Enrolment
    218

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDyslipidemia
    InterventionFluvastatin
    PhasePhase 4
    Registry statusCompleted

  • Polymorphism of the Cytochrome P450-system in Renal Transplants

    NCT00223054 · start 2005-03

    Registered record
    Registry ID
    NCT00223054
    Conditions
    Function of Renal Transplant
    Interventions
    tacrolimus; sirolimus; everolimus; cyclosporin A
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2005-03
    Completion
    2006-10
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFunction of Renal Transplant
    Interventiontacrolimus; sirolimus; everolimus; cyclosporin A
    PhaseNot recorded
    Registry statusCompleted

  • A 12 Week Study of MK0653A in Patients Who Have Been Hospitalized for a Possible Heart Problem (0653A-808)

    NCT00132717 · start 2005-01-01

    Registered record
    Registry ID
    NCT00132717
    Conditions
    Hypercholesterolemia
    Interventions
    MK0653A (ezetimibe [+] simvastatin); Comparator: atorvastatin; Comparator: fluvastatin; Comparator: lovastatin; Comparator: pravastatin; Comparator: rosuvastatin; Comparator: simvastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-01-01
    Completion
    2007-06-01
    Enrolment
    450

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypercholesterolemia
    InterventionMK0653A (ezetimibe [+] simvastatin); Comparator: atorvastatin; Comparator: fluvastatin; Comparator: lovastatin +3 more
    PhasePhase 3
    Registry statusCompleted

  • Fluvastatin After Heart Transplantation

    NCT00421005 · start 2004-11

    Registered record
    Registry ID
    NCT00421005
    Conditions
    Heart Transplantation; Hypercholesterolemia
    Interventions
    fluvastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2004-11
    Completion
    2008-11
    Enrolment
    56

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHeart Transplantation; Hypercholesterolemia
    Interventionfluvastatin
    PhasePhase 4
    Registry statusUnknown

  • Other Effects of Fluvastatin Are Investigated in Patients With Metabolic Syndrome

    NCT00138528 · start 2004-10

    Registered record
    Registry ID
    NCT00138528
    Conditions
    Metabolic Syndrome
    Interventions
    Fluvastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-10
    Completion
    2006-02
    Enrolment
    55

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMetabolic Syndrome
    InterventionFluvastatin
    PhasePhase 4
    Registry statusCompleted

  • Trial to Evaluate the Efficacy of Fluvastatin on Certain Markers

    NCT00171262 · start 2004-08

    Registered record
    Registry ID
    NCT00171262
    Conditions
    Dyslipidemia
    Interventions
    Fluvastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-08
    Completion
    2007-06
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDyslipidemia
    InterventionFluvastatin
    PhasePhase 4
    Registry statusCompleted

  • Efficacy and Safety of Fluvastatin or Valsartan and Their Combination in Dyslipidemic Patients With Hypertension and Endothelial Dysfunction

    NCT00171327 · start 2004-07

    Registered record
    Registry ID
    NCT00171327
    Conditions
    Hypertension; Dyslipidemia
    Interventions
    valsartan, fluvastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-07
    Completion
    2005-09
    Enrolment
    213

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension; Dyslipidemia
    Interventionvalsartan, fluvastatin
    PhasePhase 4
    Registry statusCompleted

  • Investigation of the Steady State Pharmacokinetics of Tacrolimus, Mycophenolate Mofetil and Fluvastatin After Renal Transplantation

    NCT00223015 · start 2004-05

    Registered record
    Registry ID
    NCT00223015
    Conditions
    Renal Transplantation
    Interventions
    Fluvastatin, Tacrolimus, Mycophenolat Mofetil
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-05
    Completion
    2005-04
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRenal Transplantation
    InterventionFluvastatin, Tacrolimus, Mycophenolat Mofetil
    PhasePhase 4
    Registry statusCompleted