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AMR Drug RepurposingSmart Screeningresearch prototype

Hydrocortisone Probutate

FDA-approved product (cream, topical), marketed as Pandel.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Hydrocortisone Probutate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Adrenal gland disease
  • Adrenocortical insufficiency
  • Allergic conjunctivitis
  • Asthma
  • Atopic eczema
  • Bursitis
  • Cancer
  • Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
  • Congenital adrenal hyperplasia
  • Crohn's disease
  • Dermatitis
  • Endocrine system disease
  • Exanthem
  • Eye inflammation
  • Hemorrhoid
  • Herpes Labialis
  • and 19 more

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Corticosteroids for local oral treatment; Corticosteroids acting locally; Corticosteroids; Corticosteroids, weak (group i); Corticosteroids, moderately potent (group ii)
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA50.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli35.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae35.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis34.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Hydrocortisone Probutate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Hydrocortisone Probutate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Neural Correlates of Stress Hormones

    NCT02523664 · start 2014-01

    Registered record
    Registry ID
    NCT02523664
    Conditions
    Borderline Personality Disorder; PTSD
    Interventions
    Hydrocortisone; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-01
    Completion
    2018-12
    Enrolment
    78

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBorderline Personality Disorder; PTSD
    InterventionHydrocortisone; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • Mother-caregivers of Children With Duchenne Muscular Dystrophy

    NCT01921374 · start 2013-08

    Registered record
    Registry ID
    NCT01921374
    Conditions
    Other Diseases or Conditions
    Interventions
    sleep parameters; Hormonal profile; Inflammatory profile; Cardiovascular profile; Metabolic profile
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2013-08
    Completion
    2014-07
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOther Diseases or Conditions
    Interventionsleep parameters; Hormonal profile; Inflammatory profile; Cardiovascular profile +1 more
    PhaseNot applicable
    Registry statusCompleted

  • Cardiovascular Status in Adrenal Insufficiency

    NCT03426319 · start 2013-08

    Registered record
    Registry ID
    NCT03426319
    Conditions
    Adrenal Insufficiency
    Interventions
    Cardiovascular evaluation
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2013-08
    Completion
    2014-06
    Enrolment
    68

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdrenal Insufficiency
    InterventionCardiovascular evaluation
    PhaseNot recorded
    Registry statusCompleted

  • High Volume Injection or Autologous Conditioned Plasma (ACP) in Chronic Achilles Tendinopathy

    NCT02417987 · start 2012-05

    Registered record
    Registry ID
    NCT02417987
    Conditions
    Tendinopathy
    Interventions
    Placebo; High Volume injection; Autologous conditioned plasma (ACP)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-05
    Completion
    2014-11
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTendinopathy
    InterventionPlacebo; High Volume injection; Autologous conditioned plasma (ACP)
    PhaseNot applicable
    Registry statusCompleted

  • Efficacy of Hydrocortisone in Treatment of Severe Sepsis/Septic Shock Patients With Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)

    NCT01284452 · start 2010-12

    Registered record
    Registry ID
    NCT01284452
    Conditions
    Septic Shock; Severe Sepsis; Acute Lung Injury; Acute Respiratory Distress Syndrome
    Interventions
    Placebo; Hydrocortisone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-12
    Completion
    2015-03
    Enrolment
    197

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSeptic Shock; Severe Sepsis; Acute Lung Injury; Acute Respiratory Distress Syndrome
    InterventionPlacebo; Hydrocortisone
    PhaseNot applicable
    Registry statusCompleted

  • Hypoglycemia Associated Autonomic Failure in Type 1 Diabetes Mellitus

    NCT00608101 · start 2010-09

    Registered record
    Registry ID
    NCT00608101
    Conditions
    Type 1 Diabetes
    Interventions
    Fludrocortisone; Dexamethasone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2010-09
    Completion
    2010-09
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionType 1 Diabetes
    InterventionFludrocortisone; Dexamethasone
    PhaseNot applicable
    Registry statusWithdrawn

  • Anti-inflammatory Treatment at the Onset of Necrotizing Enterocolitis (NEC) in Preterm Infants

    NCT01156480 · start 2009-09

    Registered record
    Registry ID
    NCT01156480
    Conditions
    Necrotizing Enterocolitis
    Interventions
    hydrocortisone; placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2009-09
    Completion
    2012-11
    Enrolment
    2

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNecrotizing Enterocolitis
    Interventionhydrocortisone; placebo
    PhaseNot applicable
    Registry statusTerminated

  • Study of Sirolimus With PEG-Asparaginase in Acute Lymphoblastic Leukemia (ALL)

    NCT00957320 · start 2009-06

    Registered record
    Registry ID
    NCT00957320
    Conditions
    Acute Lymphoblastic Leukemia
    Interventions
    Sirolimus; PEG-asparaginase
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Withdrawn
    Start
    2009-06
    Completion
    2012-08
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Lymphoblastic Leukemia
    InterventionSirolimus; PEG-asparaginase
    PhasePhase 1
    Registry statusWithdrawn

  • The Use of Oral Budesonide and Rectal Hydrocortisone for the Treatment of Active Ulcerative Colitis

    NCT00805285 · start 2008-10

    Registered record
    Registry ID
    NCT00805285
    Conditions
    Inflammatory Bowel Disease; Ulcerative Colitis
    Interventions
    Combination Oral Budesonide and Rectal Hydrocortisone
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2008-10
    Completion
    2010-03
    Enrolment
    1

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInflammatory Bowel Disease; Ulcerative Colitis
    InterventionCombination Oral Budesonide and Rectal Hydrocortisone
    PhasePhase 2
    Registry statusTerminated

  • Adrenal Insufficiency in Cirrhotics With Ascites. Effects of Hydrocortisone on Renal and Haemodynamic Function

    NCT00657306 · start 2008-05

    Registered record
    Registry ID
    NCT00657306
    Conditions
    Cirrhosis With Ascites
    Interventions
    hydrocortisone; dextrose solution 5%
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2008-05
    Completion
    2009-05
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCirrhosis With Ascites
    Interventionhydrocortisone; dextrose solution 5%
    PhasePhase 2
    Registry statusUnknown

  • Effect of Calcipotriol Plus Hydrocortisone Ointment on the Adrenal Hormone Balance and Calcium Metabolism in Patients With Psoriasis Vulgaris on the Face and Skin Folds

    NCT00704262 · start 2008-05

    Registered record
    Registry ID
    NCT00704262
    Conditions
    Psoriasis Vulgaris
    Interventions
    Calcipotriol plus hydrocortisone (LEO 80190)
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2008-05
    Completion
    2009-12
    Enrolment
    33

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPsoriasis Vulgaris
    InterventionCalcipotriol plus hydrocortisone (LEO 80190)
    PhasePhase 2
    Registry statusCompleted

  • Rituximab and Combination Chemotherapy in Treating Patients With Newly Diagnosed, HIV-Associated Burkitt's Lymphoma

    NCT00392834 · start 2006-09

    Registered record
    Registry ID
    NCT00392834
    Conditions
    Lymphoma
    Interventions
    filgrastim; pegfilgrastim; rituximab; cyclophosphamide; cytarabine; doxorubicin hydrochloride; etoposide; ifosfamide; leucovorin calcium; liposomal cytarabine; methotrexate; therapeutic hydrocortisone; vincristine sulfate
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2006-09
    Completion
    2013-07
    Enrolment
    34

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLymphoma
    Interventionfilgrastim; pegfilgrastim; rituximab; cyclophosphamide +9 more
    PhasePhase 2
    Registry statusCompleted

  • Combination of Docetaxel + Estramustine + Hydrocortisone Versus Docetaxel + Prednisone in Patients With Advanced Prostate Cancer

    NCT00705822 · start 2006-08

    Registered record
    Registry ID
    NCT00705822
    Conditions
    Prostatic Neoplasms
    Interventions
    Docetaxel + Estramustine + Hydrocortisone; Docetaxel + Prednisone
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2006-08
    Completion
    2009-07
    Enrolment
    54

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstatic Neoplasms
    InterventionDocetaxel + Estramustine + Hydrocortisone; Docetaxel + Prednisone
    PhasePhase 3
    Registry statusTerminated

  • Transarterial Chemotherapy Compared With Oral Chemotherapy in the Treatment of Advanced Hepatocellular Carcinoma

    NCT02240771 · start 2006-01

    Registered record
    Registry ID
    NCT02240771
    Conditions
    Hepatocellular Carcinoma
    Interventions
    Transarterial chemotherapy; Oral chemotherapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Unknown
    Start
    2006-01
    Completion
    2015-03
    Enrolment
    124

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHepatocellular Carcinoma
    InterventionTransarterial chemotherapy; Oral chemotherapy
    PhasePhase 2 / Phase 3
    Registry statusUnknown

  • Imatinib Mesylate and Combination Chemotherapy With or Without a Donor Stem Cell Transplant in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia

    NCT00618501 · start 2005-10

    Registered record
    Registry ID
    NCT00618501
    Conditions
    Leukemia
    Interventions
    cytarabine; daunorubicin hydrochloride; etoposide; imatinib mesylate; leucovorin calcium; methotrexate; prednisolone; therapeutic hydrocortisone; vincristine sulfate; allogeneic hematopoietic stem cell transplantation
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2005-10
    Completion
    2009-01
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLeukemia
    Interventioncytarabine; daunorubicin hydrochloride; etoposide; imatinib mesylate +6 more
    PhasePhase 2
    Registry statusCompleted