Skip to content
AMR Drug RepurposingSmart Screeningresearch prototype

Vitamin A

FDA-approved product (capsule, oral), marketed as Aquasol A, Vitamin A.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Vitamin A
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Acne
  • Eye disease
  • Nasal congestion

Indications ChEMBL records as approved, from FDA and DailyMed labels.

WHO therapeutic group
Vitamin a, plain; Retinoids for topical use in acne; Other nasal preparations; Other ophthalmologicals
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

No supported pathogen reaches ≥40% AI-predicted activity for Vitamin A, so it is not among the repurposing candidates. Its predictions are shown below.

AI-predicted activity

AI prediction · nothing measured
  • MRSA20.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli32.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae13.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis36.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Vitamin A in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Vitamin A with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Randomized,International Multi-center Clinical Trial of RIF Plus RA for Non-high-risk APL

    NCT04175587 · start 2019-12-01

    Registered record
    Registry ID
    NCT04175587
    Conditions
    Acute Promyelocytic Leukaemia
    Interventions
    Compound Realgar-Indigo Naturalis Formula Plus Retinoic Acid
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2019-12-01
    Completion
    2023-08-31
    Enrolment
    109

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Promyelocytic Leukaemia
    InterventionCompound Realgar-Indigo Naturalis Formula Plus Retinoic Acid
    PhasePhase 3
    Registry statusUnknown

  • Synergy of Exercise and Nutrition in Preventing and Treating Frailty

    NCT06975540 · start 2019-10-14

    Registered record
    Registry ID
    NCT06975540
    Conditions
    Frail Elderly
    Interventions
    Multidomain physical exercise
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-10-14
    Completion
    2022-07-29
    Enrolment
    47

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFrail Elderly
    InterventionMultidomain physical exercise
    PhaseNot applicable
    Registry statusCompleted

  • "Intra-articular Hyaluronic Acid Injection for Accelerating Functional Recovery After Knee Arthroscopy"

    NCT07476508 · start 2019-10-10

    Registered record
    Registry ID
    NCT07476508
    Conditions
    Meniscus Lesion; Knee Injuries; Medial Meniscus Tear
    Interventions
    Standard Postoperative Rehabilitation Protocol; Oral Chondroitin Sulfate (Flextrum); ntra-articular Hyaluronic Acid Injection (Biolevox)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-10-10
    Completion
    2022-03-31
    Enrolment
    290

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMeniscus Lesion; Knee Injuries; Medial Meniscus Tear
    InterventionStandard Postoperative Rehabilitation Protocol; Oral Chondroitin Sulfate (Flextrum); ntra-articular Hyaluronic Acid Injection (Biolevox)
    PhaseNot applicable
    Registry statusCompleted

  • Vitamin D Oral Replacement in Asthma

    NCT03686150 · start 2019-01-30

    Registered record
    Registry ID
    NCT03686150
    Conditions
    Asthma; Vitamin D Deficiency; Pediatric Obesity
    Interventions
    Vitamin D3 oral regimen
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-01-30
    Completion
    2021-09-30
    Enrolment
    112

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma; Vitamin D Deficiency; Pediatric Obesity
    InterventionVitamin D3 oral regimen
    PhaseNot applicable
    Registry statusCompleted

  • Longitudinal Effect of Vitamin D3 Replacement on Cognitive Performance and MRI Markers in Multiple Sclerosis Patients

    NCT03610139 · start 2018-05-21

    Registered record
    Registry ID
    NCT03610139
    Conditions
    Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Clinically Isolated Syndrome; Clinically Isolated Syndrome, CNS Demyelinating; Vitamin D3 Deficiency
    Interventions
    Vitamin D3
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2018-05-21
    Completion
    2022-12-31
    Enrolment
    162

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMultiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Clinically Isolated Syndrome; Clinically Isolated Syndrome, CNS Demyelinating +1 more
    InterventionVitamin D3
    PhaseNot applicable
    Registry statusUnknown

  • Effect of Vitamin C on Collagen Production in Comparison to Hereditary Gingival Fibromatosis: Histopathological Study

    NCT07043985 · start 2018-01-03

    Registered record
    Registry ID
    NCT07043985
    Conditions
    Tissue Modification After Vit c Injection
    Interventions
    biopsy
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2018-01-03
    Completion
    2025-05-06
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTissue Modification After Vit c Injection
    Interventionbiopsy
    PhaseNot applicable
    Registry statusCompleted

  • The Effect of Vitamin D on Fertility

    NCT03890458 · start 2017-05-01

    Registered record
    Registry ID
    NCT03890458
    Conditions
    Infertility; Infertility, Female; Vitamin D Deficiency; Vitamin D3 Deficiency
    Interventions
    DEVIT-3
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2017-05-01
    Completion
    2017-11-30
    Enrolment
    118

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility; Infertility, Female; Vitamin D Deficiency; Vitamin D3 Deficiency
    InterventionDEVIT-3
    PhasePhase 4
    Registry statusCompleted

  • The Impact of Vitamin B12 Deficiency on Infant Gut Microbiota

    NCT03365583 · start 2017-03-03

    Registered record
    Registry ID
    NCT03365583
    Conditions
    Vitamin B 12 Deficiency
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2017-03-03
    Completion
    2017-11-03
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitamin B 12 Deficiency
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • 6 Years Study on Changes in Bone Quality, Bone Turnover and Curve Severity in AIS With and Without Calcium and Vit-D Supplementation

    NCT02904421 · start 2016-10

    Registered record
    Registry ID
    NCT02904421
    Conditions
    Scoliosis; Vitamin D; Bone
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2016-10
    Completion
    2019-11
    Enrolment
    330

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionScoliosis; Vitamin D; Bone
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Nicotinamide Riboside and Mitochondrial Metabolism

    NCT03951285 · start 2016-05-25

    Registered record
    Registry ID
    NCT03951285
    Conditions
    Obesity
    Interventions
    NR in BMI-discordant twins; NR in BMI-concordant twins
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2016-05-25
    Completion
    2019-05-31
    Enrolment
    56

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObesity
    InterventionNR in BMI-discordant twins; NR in BMI-concordant twins
    PhaseNot applicable
    Registry statusCompleted

  • Evaluation of Diagnostic Efficiency of PIVKA-II and Other Tumor Markers in HCC

    NCT03047603 · start 2016-05-01

    Registered record
    Registry ID
    NCT03047603
    Conditions
    Hepatocellular Carcinoma
    Interventions
    PIVKA-II
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2016-05-01
    Completion
    2019-03-20
    Enrolment
    4,005

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHepatocellular Carcinoma
    InterventionPIVKA-II
    PhaseNot recorded
    Registry statusCompleted

  • Atrial Fibrillation Patient Preference Study

    NCT02611635 · start 2016-02-02

    Registered record
    Registry ID
    NCT02611635
    Conditions
    Atrial Fibrillation
    Interventions
    VKA: Warfarin (Waran); NOAC: Rivaroxaban (Xarelto, BAY59-7939); NOAC: Dabigatran etexilate; NOAC: Apixaban; NOAC: Edoxaban; NOAC: Lixiana
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2016-02-02
    Completion
    2017-02-16
    Enrolment
    382

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation
    InterventionVKA: Warfarin (Waran); NOAC: Rivaroxaban (Xarelto, BAY59-7939); NOAC: Dabigatran etexilate; NOAC: Apixaban +2 more
    PhaseNot recorded
    Registry statusCompleted

  • Rapid Normalization of Vitamin D in Critically Ill Children: A Phase II Dose Evaluation Randomized Controlled Trial

    NCT02452762 · start 2016-01

    Registered record
    Registry ID
    NCT02452762
    Conditions
    Hypovitaminosis D
    Interventions
    Vitamin D3; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2016-01
    Completion
    2018-01
    Enrolment
    67

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypovitaminosis D
    InterventionVitamin D3; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Cholecalciferol in Newly Diagnosed Non-Hodgkin Lymphoma or Chronic Lymphocytic Leukemia With Vitamin D Deficiency

    NCT02553447 · start 2015-10-19

    Registered record
    Registry ID
    NCT02553447
    Conditions
    Chronic Lymphocytic Leukemia; Non-Hodgkin Lymphoma; Untreated Chronic Lymphocytic Leukemia; Vitamin D Deficiency
    Interventions
    Cholecalciferol; Laboratory Biomarker Analysis
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-10-19
    Completion
    2025-04-12
    Enrolment
    197

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Lymphocytic Leukemia; Non-Hodgkin Lymphoma; Untreated Chronic Lymphocytic Leukemia; Vitamin D Deficiency
    InterventionCholecalciferol; Laboratory Biomarker Analysis
    PhaseNot applicable
    Registry statusCompleted

  • Long Term Nitric Oxide Bioavailability on Vascular Health in Chronic Obstructive Pulmonary Disease

    NCT02774226 · start 2015-09

    Registered record
    Registry ID
    NCT02774226
    Conditions
    Chronic Obstructive Pulmonary Disease (COPD)
    Interventions
    Tetrahydrobiopterin (BH4); Antioxidant Cocktail
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2015-09
    Completion
    2018-07-30
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Obstructive Pulmonary Disease (COPD)
    InterventionTetrahydrobiopterin (BH4); Antioxidant Cocktail
    PhasePhase 2
    Registry statusCompleted