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AMR Drug RepurposingSmart Screeningresearch prototype

Vitamin A

FDA-approved product (capsule, oral), marketed as Aquasol A, Vitamin A.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Vitamin A
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Acne
  • Eye disease
  • Nasal congestion

Indications ChEMBL records as approved, from FDA and DailyMed labels.

WHO therapeutic group
Vitamin a, plain; Retinoids for topical use in acne; Other nasal preparations; Other ophthalmologicals
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

No supported pathogen reaches ≥40% AI-predicted activity for Vitamin A, so it is not among the repurposing candidates. Its predictions are shown below.

AI-predicted activity

AI prediction · nothing measured
  • MRSA20.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli32.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae13.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis36.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Vitamin A in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Vitamin A with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Serum Vitamin D Levels in Critically Ill Patients Undergoing Regional Citrate Anticoagulation CRRT

    NCT02414386 · start 2015-08

    Registered record
    Registry ID
    NCT02414386
    Conditions
    Multi Organ Failure; Acute Kidney Injury
    Interventions
    biospecimen retention
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2015-08
    Completion
    2018-12-04
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMulti Organ Failure; Acute Kidney Injury
    Interventionbiospecimen retention
    PhaseNot recorded
    Registry statusCompleted

  • Analyzing IBS to Identify Biomarkers and Microbiome Signatures

    NCT02419963 · start 2015-05

    Registered record
    Registry ID
    NCT02419963
    Conditions
    Diarrhoea Predominant Irritable Bowel Syndrome; IBS
    Interventions
    endoscopy for tissue biopsy; Blood Sample; Stool Sample
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-05
    Completion
    2016-12-12
    Enrolment
    26

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiarrhoea Predominant Irritable Bowel Syndrome; IBS
    Interventionendoscopy for tissue biopsy; Blood Sample; Stool Sample
    PhaseNot applicable
    Registry statusCompleted

  • A Study to Assess the Relative Bioavailability of Process Variants of Selumetinib in Healthy Male Volunteers

    NCT02322749 · start 2015-02

    Registered record
    Registry ID
    NCT02322749
    Conditions
    Healthy Volunteers Bioequivalence or Bioavailability Study
    Interventions
    selumetinib 75mg single dose; selumetinib 75mg single dose; selumetinib 75mg single dose
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2015-02
    Completion
    2015-04
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Volunteers Bioequivalence or Bioavailability Study
    Interventionselumetinib 75mg single dose; selumetinib 75mg single dose; selumetinib 75mg single dose
    PhasePhase 1
    Registry statusCompleted

  • Ketogenic Diet in Infants With Epilepsy (KIWE)

    NCT02205931 · start 2015-01

    Registered record
    Registry ID
    NCT02205931
    Conditions
    Epilepsy
    Interventions
    Ketogenic diet; Antiepileptic drug therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2015-01
    Completion
    2019-06
    Enrolment
    160

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEpilepsy
    InterventionKetogenic diet; Antiepileptic drug therapy
    PhasePhase 4
    Registry statusUnknown

  • A Phase I Study of High-dose L-methylfolate in Combination With Temozolomide and Bevacizumab in Recurrent High Grade Glioma

    NCT01891747 · start 2013-07

    Registered record
    Registry ID
    NCT01891747
    Conditions
    Malignant Glioma
    Interventions
    Bevacizumab; Temozolomide; Vitamin C
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2013-07
    Completion
    2022-01-31
    Enrolment
    14

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalignant Glioma
    InterventionBevacizumab; Temozolomide; Vitamin C
    PhasePhase 1
    Registry statusCompleted

  • Controlled, Randomized, Four-arm Comparative, Open Label, Multi-centric Clinical Trial to Compare the Efficacy and Safety Parameters of the Once-a-week or Once-a-month Administered 7000 IU, or 30000 IU Vitamin D (Cholecalciferol) to a 1000 IU Dosage Applied Daily in Vitamin D Deficient Patients

    NCT02069990 · start 2013-03

    Registered record
    Registry ID
    NCT02069990
    Conditions
    Vitamin D Deficiency
    Interventions
    Cholecalciferol
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2013-03
    Completion
    2013-09
    Enrolment
    89

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitamin D Deficiency
    InterventionCholecalciferol
    PhasePhase 3
    Registry statusCompleted

  • Vitamin D3 Supplementation for Low-Risk Prostate Cancer: A Randomized Trial

    NCT01759771 · start 2013-01-03

    Registered record
    Registry ID
    NCT01759771
    Conditions
    Prostate Cancer
    Interventions
    Vitamin D3; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2013-01-03
    Completion
    2020-05-11
    Enrolment
    130

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Cancer
    InterventionVitamin D3; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Anti-inflammatory Dietary Intervention in Overweight and Obese Adolescents

    NCT01665742 · start 2012-01

    Registered record
    Registry ID
    NCT01665742
    Conditions
    Overweight; Obesity
    Interventions
    Supplement containing fish oil, vitamin C, alpha-tocopherol, green tea extract and lycopene; Placebo supplement
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-01
    Completion
    2013-11
    Enrolment
    58

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOverweight; Obesity
    InterventionSupplement containing fish oil, vitamin C, alpha-tocopherol, green tea extract and lycopene; Placebo supplement
    PhaseNot applicable
    Registry statusCompleted

  • Effect of Calcium + Vitamin D Supplementation on Weight Management in Very-low Calcium Consumers

    NCT01447433 · start 2011-04

    Registered record
    Registry ID
    NCT01447433
    Conditions
    Obesity; Overweight
    Interventions
    Calcium Carbonate; Energy restriction
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-04
    Completion
    2012-02
    Enrolment
    53

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObesity; Overweight
    InterventionCalcium Carbonate; Energy restriction
    PhasePhase 4
    Registry statusCompleted

  • Investigating the Acute Effects of Flavonoids in Blueberries on Cognitive Function.

    NCT01289860 · start 2009-05

    Registered record
    Registry ID
    NCT01289860
    Conditions
    Healthy Adults.
    Interventions
    Flavonoids; Control
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-05
    Completion
    2013-01
    Enrolment
    47

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Adults.
    InterventionFlavonoids; Control
    PhaseNot applicable
    Registry statusCompleted

  • Pik Lenin High Altitude Research Expedition 2009

    NCT01571687 · start 2009-04

    Registered record
    Registry ID
    NCT01571687
    Conditions
    Oxidative Stress; Cell-derived Microparticles
    Interventions
    antioxidant supplements; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-04
    Completion
    2009-08
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOxidative Stress; Cell-derived Microparticles
    Interventionantioxidant supplements; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • Prevention of Osteoporosis in Bone Marrow Transplantation (BMT) Patients

    NCT00824993 · start 2008-12-09

    Registered record
    Registry ID
    NCT00824993
    Conditions
    Hematological Malignancies
    Interventions
    Ibandronate; Vitamin Supplements
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-12-09
    Completion
    2017-04-07
    Enrolment
    78

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHematological Malignancies
    InterventionIbandronate; Vitamin Supplements
    PhasePhase 3
    Registry statusCompleted

  • Calcitriol, Physical Activity, and Bone Health in Cancer Survivors

    NCT00904033 · start 2008-12-01

    Registered record
    Registry ID
    NCT00904033
    Conditions
    Breast Neoplasms; Bone and Bones
    Interventions
    Calcitriol; Exercise; Multivitamin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2008-12-01
    Completion
    2018-01-01
    Enrolment
    41

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBreast Neoplasms; Bone and Bones
    InterventionCalcitriol; Exercise; Multivitamin
    PhasePhase 2
    Registry statusCompleted

  • Intervention Study to Prevent Obesity in Sedentary 8 Year Old Swedish Children

    NCT01087411 · start 2008-10

    Registered record
    Registry ID
    NCT01087411
    Conditions
    Cardiovascular Risk Factors; Metabolic Risk Factors; Sedentary Lifestyle; Overweight
    Interventions
    Motivational Interviewing; Physical activity; Supplementation with fish liver oli capsules; Placebo oil capsules
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2008-10
    Completion
    2012-12
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCardiovascular Risk Factors; Metabolic Risk Factors; Sedentary Lifestyle; Overweight
    InterventionMotivational Interviewing; Physical activity; Supplementation with fish liver oli capsules; Placebo oil capsules
    PhaseNot applicable
    Registry statusWithdrawn

  • hCAP18 Levels and Vitamin D Deficiency in Healthy Subjects

    NCT00742235 · start 2007-07

    Registered record
    Registry ID
    NCT00742235
    Conditions
    Healthy Subjects; Vitamin D Deficiency
    Interventions
    ergocalciferol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2007-07
    Completion
    2012-01
    Enrolment
    99

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Subjects; Vitamin D Deficiency
    Interventionergocalciferol
    PhaseNot applicable
    Registry statusCompleted