Vitamin A
FDA-approved product (capsule, oral), marketed as Aquasol A, Vitamin A.
- Registered studies
- 50+
- Lab records
- 0
- Pathogens at ≥40%
- 0 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLApproved for
- Acne
- Eye disease
- Nasal congestion
Indications ChEMBL records as approved, from FDA and DailyMed labels.
- WHO therapeutic group
- Vitamin a, plain; Retinoids for topical use in acne; Other nasal preparations; Other ophthalmologicals
- Anti-infective classification
- Not classified as an anti-infective.
Repurposing investigation
No supported pathogen reaches ≥40% AI-predicted activity for Vitamin A, so it is not among the repurposing candidates. Its predictions are shown below.
AI-predicted activity
AI prediction · nothing measured- MRSA20.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- E. coli32.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- K. pneumoniae13.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- M. tuberculosis36.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredDihydrofolate reductase ↗ (E. coli)
Not yet docked: queued in the docking rundetails
KPC-2 carbapenemase ↗ (K. pneumoniae)
Not yet docked: queued in the docking rundetails
Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)
Not yet docked: queued in the docking rundetails
Dihydrofolate reductase ↗ (MRSA)
Not yet docked: queued in the docking rundetails
AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Vitamin A with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- DichlorphenamideExisting use: Glaucoma73.9% AI-predicted activityagainst M. tuberculosisLab records exist2 registered studies
- Tamsulosin HydrochlorideExisting use: Benign prostatic hyperplasia, Prostate carcinoma73.2% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Thiethylperazine MalateExisting use: Allergic disease71.8% AI-predicted activityagainst M. tuberculosisNo documented evidence found
- SaquinavirExisting use: HIV infection, HIV-1 infection, Viral disease71.5% AI-predicted activityagainst M. tuberculosis50+ registered studies
- AvacopanExisting use: Anti-neutrophil antibody associated vasculitis, Anti-neutrophil cytoplasmic antibody-associated vasculitis, Granulomatosis with Polyangiitis and 1 more71.3% AI-predicted activityagainst M. tuberculosis26 registered studies
- Lasmiditan SuccinateExisting use: Migraine disorder71.0% AI-predicted activityagainst M. tuberculosisNo documented evidence found
- SotorasibExisting use: Neoplasm, Non-small cell lung carcinoma71.0% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Vinblastine SulfateExisting use: Classic Hodgkin lymphoma, Fungal infectious disease, Hodgkins lymphoma and 3 more70.8% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Haloperidol DecanoateExisting use: Conduct disorder, Mental or behavioural disorder, Psychosis and 4 more70.1% AI-predicted activityagainst M. tuberculosis50+ registered studies
- HydrochlorothiazideExisting use: Angina pectoris, Cardiovascular disease, Chronic kidney disease and 9 more70.1% AI-predicted activityagainst M. tuberculosis50+ registered studies
- TolvaptanExisting use: Autosomal dominant polycystic kidney disease, Cardiovascular disease, Congestive heart failure and 4 more70.0% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Larotrectinib SulfateExisting use: Abdominal Neoplasms, Cancer, Metastasis and 1 more69.2% AI-predicted activityagainst M. tuberculosis5 registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
Pediatric Safety Follow-up Study of Prior Treatment With Romosozumab for Osteogenesis Imperfecta
NCT07366086 · start 2026-03-18
Registered record
- Registry ID
- NCT07366086
- Conditions
- Osteogenesis Imperfecta
- Interventions
- Vitamin D; Calcium
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Recruiting
- Start
- 2026-03-18
- Completion
- 2028-04-19
- Enrolment
- 71
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionOsteogenesis ImperfectaInterventionVitamin D; CalciumPhasePhase 3Registry statusRecruitingThe Impact of 12 Week Retention of Nutrients on Skin and the Perception of Physical Health Status
NCT07383974 · start 2025-11-03
Registered record
- Registry ID
- NCT07383974
- Conditions
- Healthy Volunteers; Dietary Supplementation; Skin Health; Health Status; Antioxidants
- Interventions
- Vitamin C & Green Tea Capsules + Multivitamin & Mineral Capsules Combination; Placebo Combination (Matching)
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Recruiting
- Start
- 2025-11-03
- Completion
- 2026-02-02
- Enrolment
- 120
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHealthy Volunteers; Dietary Supplementation; Skin Health; Health Status +1 moreInterventionVitamin C & Green Tea Capsules + Multivitamin & Mineral Capsules Combination; Placebo Combination (Matching)PhaseNot applicableRegistry statusRecruitingThe Effects of Vitamin C on Acute-Exercise in Postmenopausal Females
NCT07109115 · start 2025-09-01
Registered record
- Registry ID
- NCT07109115
- Conditions
- Females; Males; Menopause; Sedentary; Healthy Participants
- Interventions
- Vitamin C (Ascorbic Acid)
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Terminated
- Start
- 2025-09-01
- Completion
- 2026-07-01
- Enrolment
- 1
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionFemales; Males; Menopause; Sedentary +1 moreInterventionVitamin C (Ascorbic Acid)PhaseNot applicableRegistry statusTerminatedEfficacy of Vitamin C Supplementation on Serum TNF-α Levels and Disease Activity in SLE Patients
NCT07071233 · start 2024-09-01
Registered record
- Registry ID
- NCT07071233
- Conditions
- Systemic Lupus Erythematosus (SLE)
- Interventions
- Vitamin C; Placebo
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- 2024-09-01
- Completion
- 2024-11-30
- Enrolment
- 38
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionSystemic Lupus Erythematosus (SLE)InterventionVitamin C; PlaceboPhaseNot applicableRegistry statusCompletedEffect of Stellate Ganglion Block on Drooling in Parkinson's Syndrome
NCT06370195 · start 2024-04
Registered record
- Registry ID
- NCT06370195
- Conditions
- Parkinson's Syndrome
- Interventions
- Comprehensive rehabilitation; Stellate ganglion block; Lidocaine hydrochloride; Placebo injection
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Unknown
- Start
- 2024-04
- Completion
- 2024-12
- Enrolment
- 100
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionParkinson's SyndromeInterventionComprehensive rehabilitation; Stellate ganglion block; Lidocaine hydrochloride; Placebo injectionPhaseNot applicableRegistry statusUnknownEfficacy of Stellate Ganglion Block in Children With Cerebral Palsy and Dysphagia
NCT06211426 · start 2024-01-15
Registered record
- Registry ID
- NCT06211426
- Conditions
- Cerebral Palsy
- Interventions
- routine rehabilitation treatment; Stellate ganglion block
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Withdrawn
- Start
- 2024-01-15
- Completion
- 2024-04-30
- Enrolment
- 0
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionCerebral PalsyInterventionroutine rehabilitation treatment; Stellate ganglion blockPhaseNot applicableRegistry statusWithdrawnMultimodal Project
NCT05656716 · start 2023-01-15
Registered record
- Registry ID
- NCT05656716
- Conditions
- Breast Cancer
- Interventions
- Nutritional intervention; Physical exercise intervention
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Unknown
- Start
- 2023-01-15
- Completion
- 2024-09
- Enrolment
- 80
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionBreast CancerInterventionNutritional intervention; Physical exercise interventionPhaseNot applicableRegistry statusUnknownFrailty Rehabilitation
NCT03824106 · start 2022-09-02
Registered record
- Registry ID
- NCT03824106
- Conditions
- Frailty
- Interventions
- Control; Group Exercise; Nutrition and Medication review; Protein Supplement; Vitamin D
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Recruiting
- Start
- 2022-09-02
- Completion
- 2025-12-31
- Enrolment
- 324
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionFrailtyInterventionControl; Group Exercise; Nutrition and Medication review; Protein Supplement +1 morePhaseNot applicableRegistry statusRecruitingRegistry on Augmented Antithrombotic Treatment Regimens for Patients With Arterial Thrombotic APS
NCT05646394 · start 2022-07-01
Registered record
- Registry ID
- NCT05646394
- Conditions
- Antiphospholipid Syndrome; Arterial Thrombosis
- Interventions
- Dual antiplatelet therapy; Combined antithrombotic therapy; Vitamin K antagonist standard intensity; Vitamin K antagonist high intensity
- Study type
- OBSERVATIONAL
- Phase
- Not recorded
- Registry status
- Recruiting
- Start
- 2022-07-01
- Completion
- 2029-12-31
- Enrolment
- 150
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionAntiphospholipid Syndrome; Arterial ThrombosisInterventionDual antiplatelet therapy; Combined antithrombotic therapy; Vitamin K antagonist standard intensity; Vitamin K antagonist high intensityPhaseNot recordedRegistry statusRecruitingDifferent Regimens of Vitamin D in Treatment of Children With Chronic Liver Disease
NCT05717569 · start 2022-05-01
Registered record
- Registry ID
- NCT05717569
- Conditions
- Chronic Liver Disease and Cirrhosis
- Interventions
- Vitamin D
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- 2022-05-01
- Completion
- 2023-01-01
- Enrolment
- 24
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionChronic Liver Disease and CirrhosisInterventionVitamin DPhaseNot applicableRegistry statusCompletedEffect of Audistim® Day/Night on Hearing Comfort and Patient Quality of Life of Patients With Chronic Tinnitus.
NCT05300594 · start 2022-03-01
Registered record
- Registry ID
- NCT05300594
- Conditions
- Tinnitus
- Interventions
- Plant extracts, vitamins and mineral; Placebo
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- 2022-03-01
- Completion
- 2023-06-05
- Enrolment
- 110
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionTinnitusInterventionPlant extracts, vitamins and mineral; PlaceboPhaseNot applicableRegistry statusCompletedEvaluation of Safety and Dosing of a Vitamin C Bundle for Sepsis Treatment in Africa
NCT04999137 · start 2021-09-01
Registered record
- Registry ID
- NCT04999137
- Conditions
- Sepsis; Septic Shock; HIV
- Interventions
- Vitamin C; Vitamin B1
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Unknown
- Start
- 2021-09-01
- Completion
- 2021-12-29
- Enrolment
- 60
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionSepsis; Septic Shock; HIVInterventionVitamin C; Vitamin B1PhasePhase 2Registry statusUnknownA Study to Examine the Effect of a Thermogenic Energy Drink in Healthy Adults
NCT05061797 · start 2021-08-23
Registered record
- Registry ID
- NCT05061797
- Conditions
- Metabolism
- Interventions
- Thermogenic Energy Drink - Active Study Product Formula; Placebo
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- 2021-08-23
- Completion
- 2021-11-16
- Enrolment
- 30
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionMetabolismInterventionThermogenic Energy Drink - Active Study Product Formula; PlaceboPhaseNot applicableRegistry statusCompletedExamining the Impact of a Self-compassion Intervention on Physical Activity Behaviour Among People With Prediabetes
NCT04863235 · start 2021-03-01
Registered record
- Registry ID
- NCT04863235
- Conditions
- PreDiabetes
- Interventions
- Control Group; Intervention Group
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Unknown
- Start
- 2021-03-01
- Completion
- 2022-09
- Enrolment
- 80
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionPreDiabetesInterventionControl Group; Intervention GroupPhaseNot applicableRegistry statusUnknownThe Effects of Antioxidant Supplementation on Multiple Endurance Race Performance, Physiology, and Recovery.
NCT04314596 · start 2020-01-20
Registered record
- Registry ID
- NCT04314596
- Conditions
- Oxidative Stress; Muscle Strength; Resistance Training; Body Composition; Muscle Damage
- Interventions
- Cross Training Course; Oceanix
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- 2020-01-20
- Completion
- 2020-02-19
- Enrolment
- 18
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionOxidative Stress; Muscle Strength; Resistance Training; Body Composition +1 moreInterventionCross Training Course; OceanixPhaseNot applicableRegistry statusCompleted