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AMR Drug RepurposingSmart Screeningresearch prototype

Tigecycline

FDA-approved product (powder, intravenous), marketed as Tigecycline, Tygacil.

Registered studies
50+
Lab records
152
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Tigecycline
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Infection
  • Skin disease caused by bacterial infection
  • Skin disorder caused by infection
  • Soft Tissue Infections

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Tetracyclines
FDA pharmacologic class
Tetracycline-class Antibacterial FDA label ↗
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01AA12; FDA class Tetracycline-class Antibacterial

Repurposing investigation

Tigecycline is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA88.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli78.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae99.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis62.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • K. pneumoniae: measured active in 152 of 152 lab records
Open Tigecycline in ChEMBL Registered studies below
Show the latest 150 of 152 laboratory records, with sources

Loading records…

Every record is in ChEMBL, linked above. “Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Tigecycline with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • PK/PD of the Sedatives, Analgesics and Antibiotics in Patients Receiving ECMO

    NCT03787550 · start 2020-02-07

    Registered record
    Registry ID
    NCT03787550
    Conditions
    Drug Effect
    Interventions
    The Sedatives, analgesics and antibiotics
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2020-02-07
    Completion
    2022-03-31
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDrug Effect
    InterventionThe Sedatives, analgesics and antibiotics
    PhaseNot recorded
    Registry statusUnknown

  • A Randomized Controlled Trial Comparing Imipenem and Tigecycline Versus Imipenem and Tigecycline With GM-CSF for the Management of Spontaneous Bacterial Peritonitis Presenting With Septic Shock.

    NCT04208763 · start 2019-12-20

    Registered record
    Registry ID
    NCT04208763
    Conditions
    Spontaneous Bacterial Peritonitis
    Interventions
    Imipenem; Tigecycline; GMCSF; Colistin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2019-12-20
    Completion
    2021-12-31
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSpontaneous Bacterial Peritonitis
    InterventionImipenem; Tigecycline; GMCSF; Colistin
    PhaseNot applicable
    Registry statusUnknown

  • Efficacy Analysis of Tigecycline-based Therapy and Polymyxin B-based Therapy in ICU Infection

    NCT04970537 · start 2017-07-23

    Registered record
    Registry ID
    NCT04970537
    Conditions
    Tigecycline; Polymyxin B; Intensive Care Unit
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2017-07-23
    Completion
    2021-07-31
    Enrolment
    800

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTigecycline; Polymyxin B; Intensive Care Unit
    InterventionNot recorded
    PhaseNot recorded
    Registry statusUnknown

  • Vitro Study of Tigecycline to Treat Chronic Myeloid Leukemia

    NCT02883036 · start 2016-09

    Registered record
    Registry ID
    NCT02883036
    Conditions
    Chronic Myeloid Leukemia
    Interventions
    blood sampling; blood sampling
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2016-09
    Completion
    Not recorded
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Myeloid Leukemia
    Interventionblood sampling; blood sampling
    PhaseNot recorded
    Registry statusUnknown

  • Study of Tigecycline Pharmacokinetics in Patients Undergoing Continuous Renal Replacement Therapy(CRRT)

    NCT02931526 · start 2016-08

    Registered record
    Registry ID
    NCT02931526
    Conditions
    Bacterial Infection; Critically Ill
    Interventions
    Tigecycline
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2016-08
    Completion
    Not recorded
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacterial Infection; Critically Ill
    InterventionTigecycline
    PhaseNot recorded
    Registry statusUnknown

  • A Study of Plazomicin Compared With Colistin in Patients With Infection Due to Carbapenem-Resistant Enterobacteriaceae (CRE)

    NCT01970371 · start 2014-09-16

    Registered record
    Registry ID
    NCT01970371
    Conditions
    Bloodstream Infections (BSI) Due to CRE; Hospital-Acquired Bacterial Pneumonia (HABP) Due to CRE; Ventilator-Associated Bacterial Pneumonia (VABP) Due to CRE; Complicated Urinary Tract Infection (cUTI) Due to CRE; Acute Pyelonephritis (AP) Due to CRE
    Interventions
    plazomicin; colistin; meropenem; tigecycline; antibiotic of Investigator's choice
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2014-09-16
    Completion
    2016-09-15
    Enrolment
    69

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBloodstream Infections (BSI) Due to CRE; Hospital-Acquired Bacterial Pneumonia (HABP) Due to CRE; Ventilator-Associated Bacterial Pneumonia (VABP) Due to CRE; Complicated Urinary Tract Infection (cUTI) Due to CRE +1 more
    Interventionplazomicin; colistin; meropenem; tigecycline +1 more
    PhasePhase 3
    Registry statusCompleted

  • Treatment of Hemodialysis Catheter-Related Bacteremia

    NCT02040818 · start 2013-11

    Registered record
    Registry ID
    NCT02040818
    Conditions
    Hemodialysis Catheter-related Bacteremia
    Interventions
    tigecycline, N-acetylcysteine, heparin combination; guide-wire exchange
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Withdrawn
    Start
    2013-11
    Completion
    Not recorded
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHemodialysis Catheter-related Bacteremia
    Interventiontigecycline, N-acetylcysteine, heparin combination; guide-wire exchange
    PhasePhase 2 / Phase 3
    Registry statusWithdrawn

  • Retrospective Transverse Observational Study Of Previous Study (Initial Protocol, B1811030)

    NCT01840319 · start 2013-02

    Registered record
    Registry ID
    NCT01840319
    Conditions
    Survival Status at Day 30 After the Last Intake
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2013-02
    Completion
    2013-07
    Enrolment
    156

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurvival Status at Day 30 After the Last Intake
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • A Study To Determine The Efficacy And Safety Of Tigecycline Compared With Imipenem/Cliastatin to Treat Complicated Intra-Abdominal Infection

    NCT01721408 · start 2012-11

    Registered record
    Registry ID
    NCT01721408
    Conditions
    Intra-abdominal Infection
    Interventions
    Tigecycline; Imipenem/cilastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-11
    Completion
    2015-10
    Enrolment
    470

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIntra-abdominal Infection
    InterventionTigecycline; Imipenem/cilastatin
    PhasePhase 4
    Registry statusCompleted

  • Concentration of Antimicrobials in Catheter-lock Solutions

    NCT01592032 · start 2012-05

    Registered record
    Registry ID
    NCT01592032
    Conditions
    Catheter-Related Infections; Bacteremia.
    Interventions
    Vancomycin antimicrobial-lock solution; Teicoplanin antimicrobial-lock solution; Linezolid antimicrobial-lock solution; Daptomycin antimicrobial-lock solution; Tigecycline antimicrobial-lock solution
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2012-05
    Completion
    2015-12
    Enrolment
    125

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCatheter-Related Infections; Bacteremia.
    InterventionVancomycin antimicrobial-lock solution; Teicoplanin antimicrobial-lock solution; Linezolid antimicrobial-lock solution; Daptomycin antimicrobial-lock solution +1 more
    PhasePhase 4
    Registry statusUnknown

  • Use of a Novel Catheter Lock Solution For Treatment of Hemodialysis Catheter Infections

    NCT01483872 · start 2012-03

    Registered record
    Registry ID
    NCT01483872
    Conditions
    Infection; Dialysis Catheter
    Interventions
    NAC/Tigecycline/Heparin combination lock solution; Standard anticoagulant (Heparin or Citrate)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2012-03
    Completion
    2013-09
    Enrolment
    9

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfection; Dialysis Catheter
    InterventionNAC/Tigecycline/Heparin combination lock solution; Standard anticoagulant (Heparin or Citrate)
    PhasePhase 3
    Registry statusTerminated

  • Study Evaluating Tigecycline Versus Clindamycin Or Vancomycin On Complicated Skin And Skin Structure Infections Including Those Due To Methicillin-Resistant Staphylococcus Aureus (MRSA) In Pediatric Subjects

    NCT00911573 · start 2011-08

    Registered record
    Registry ID
    NCT00911573
    Conditions
    Skin Diseases; Infection
    Interventions
    Tigecycline; Clindamycin (or Vancomycin if needed)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Withdrawn
    Start
    2011-08
    Completion
    2014-05
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSkin Diseases; Infection
    InterventionTigecycline; Clindamycin (or Vancomycin if needed)
    PhasePhase 3
    Registry statusWithdrawn

  • Pharmacokinetics and Safety of Tigecycline in the Treatment of Clostridium Difficile Associated Diarrhea (CDAD)

    NCT01401023 · start 2011-07

    Registered record
    Registry ID
    NCT01401023
    Conditions
    Diarrhea; Clostridium Difficile
    Interventions
    Tigecycline
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-07
    Completion
    2013-07
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiarrhea; Clostridium Difficile
    InterventionTigecycline
    PhaseNot applicable
    Registry statusCompleted

  • Study To Evaluate The Effect Of Single Intravenous Doses Of Tigecycline On QTc Intervals In Healthy Subjects

    NCT01287793 · start 2011-01

    Registered record
    Registry ID
    NCT01287793
    Conditions
    Healthy
    Interventions
    tigecycline; tigecycline; moxifloxacin; 100 mL 0.9% Sodium Chloride intravenous; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2011-01
    Completion
    2011-05
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    Interventiontigecycline; tigecycline; moxifloxacin; 100 mL 0.9% Sodium Chloride intravenous +1 more
    PhasePhase 1
    Registry statusCompleted

  • A Prospective Observational Study of Patients With Drug Resistant Acinetobacter Baumannii Bacteremia

    NCT01511224 · start 2010-08

    Registered record
    Registry ID
    NCT01511224
    Conditions
    Acinetobacter Bacteraemia
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2010-08
    Completion
    2013-06
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcinetobacter Bacteraemia
    InterventionNot recorded
    PhaseNot recorded
    Registry statusUnknown