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AMR Drug RepurposingSmart Screeningresearch prototype

Tigecycline

FDA-approved product (powder, intravenous), marketed as Tigecycline, Tygacil.

Registered studies
50+
Lab records
152
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Tigecycline
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Infection
  • Skin disease caused by bacterial infection
  • Skin disorder caused by infection
  • Soft Tissue Infections

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Tetracyclines
FDA pharmacologic class
Tetracycline-class Antibacterial FDA label ↗
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01AA12; FDA class Tetracycline-class Antibacterial

Repurposing investigation

Tigecycline is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA88.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli78.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae99.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis62.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • K. pneumoniae: measured active in 152 of 152 lab records
Open Tigecycline in ChEMBL Registered studies below
Show the latest 150 of 152 laboratory records, with sources

Loading records…

Every record is in ChEMBL, linked above. “Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Tigecycline with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Study Evaluating The Safety And Effectiveness In Subjects With Tigecycline Treatment

    NCT01072539 · start 2010-05

    Registered record
    Registry ID
    NCT01072539
    Conditions
    Complicated Skin and Skin Structure Infections; Complicated Intra-abdominal Infections; Community-Acquired Bacterial Pneumonia
    Interventions
    tigecycline
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2010-05
    Completion
    2015-04
    Enrolment
    3,172

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionComplicated Skin and Skin Structure Infections; Complicated Intra-abdominal Infections; Community-Acquired Bacterial Pneumonia
    Interventiontigecycline
    PhaseNot recorded
    Registry statusCompleted

  • Safety and Efficacy Study of a Fluoroquinolone to Treat Complicated Skin Infections

    NCT00719810 · start 2008-06

    Registered record
    Registry ID
    NCT00719810
    Conditions
    Skin Structure Infections; Bacterial Skin Diseases; Staphylococcal Skin Infections
    Interventions
    delafloxacin; delafloxacin; tigecycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2008-06
    Completion
    2008-10
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSkin Structure Infections; Bacterial Skin Diseases; Staphylococcal Skin Infections
    Interventiondelafloxacin; delafloxacin; tigecycline
    PhasePhase 2
    Registry statusCompleted

  • Study Evaluating the Pharmacokinetics (PK), Safety, and Tolerability of Tigecycline in Patients 8 to 11 Years of Age

    NCT00488345 · start 2007-12

    Registered record
    Registry ID
    NCT00488345
    Conditions
    Bacterial Infections; Intra-Abdominal Infection; Pneumonia, Bacterial; Skin Diseases, Bacterial; Skin Diseases, Infectious
    Interventions
    Tygacil
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2007-12
    Completion
    2009-09
    Enrolment
    59

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacterial Infections; Intra-Abdominal Infection; Pneumonia, Bacterial; Skin Diseases, Bacterial +1 more
    InterventionTygacil
    PhasePhase 2
    Registry statusCompleted

  • Study Evaluating the Safety and Efficacy of Intravenous Tigecycline to Treat Hospitalized Japanese Subjects

    NCT00575094 · start 2007-11

    Registered record
    Registry ID
    NCT00575094
    Conditions
    Community-Acquired Infections
    Interventions
    tigecycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-11
    Completion
    2008-03
    Enrolment
    9

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCommunity-Acquired Infections
    Interventiontigecycline
    PhasePhase 3
    Registry statusCompleted

  • Post-Marketing Study Of The Safety Of Tygacil (Tigecycline)

    NCT00683332 · start 2007-04

    Registered record
    Registry ID
    NCT00683332
    Conditions
    Complicated Skin and Skin Structure Infections; Complicated Intra-abdominal Infections
    Interventions
    Tigecycline (Tygacil)
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2007-04
    Completion
    2010-05
    Enrolment
    621

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionComplicated Skin and Skin Structure Infections; Complicated Intra-abdominal Infections
    InterventionTigecycline (Tygacil)
    PhaseNot recorded
    Registry statusCompleted

  • Open Label Non-comparative Clinical Trial of Tigecycline in Patients With Catheter Infection

    NCT00419991 · start 2007-01

    Registered record
    Registry ID
    NCT00419991
    Conditions
    Staphylococcal Infections
    Interventions
    Tigecycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-01
    Completion
    2008-05
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcal Infections
    InterventionTigecycline
    PhasePhase 4
    Registry statusCompleted

  • Pharmacokinetic Study Of Tigecycline In Adult Subjects With Primary Biliary Cirrhosis

    NCT00406237 · start 2006-12

    Registered record
    Registry ID
    NCT00406237
    Conditions
    Liver Cirrhosis, Biliary
    Interventions
    tigecycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2006-12
    Completion
    2009-03
    Enrolment
    8

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLiver Cirrhosis, Biliary
    Interventiontigecycline
    PhasePhase 1
    Registry statusCompleted

  • A Pharmacovigilance Evaluation And Assessment Of The Prescribing Practice For Tygacil In Usual Health Care Setting

    NCT00488488 · start 2006-11

    Registered record
    Registry ID
    NCT00488488
    Conditions
    Infection
    Interventions
    tigecycline
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2006-11
    Completion
    2010-03
    Enrolment
    1,028

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfection
    Interventiontigecycline
    PhaseNot recorded
    Registry statusCompleted

  • A Novel Catheter Lock Solution for Treatment of Tunneled Hemodialysis Catheter-Associated Bacteremia

    NCT00614679 · start 2006-10

    Registered record
    Registry ID
    NCT00614679
    Conditions
    End-Stage Renal Disease; Hemodialysis Catheter-associated Infection
    Interventions
    catheter lock solution consisting of N-acetylcystein, tigecycline and heparin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2006-10
    Completion
    2009-12
    Enrolment
    18

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEnd-Stage Renal Disease; Hemodialysis Catheter-associated Infection
    Interventioncatheter lock solution consisting of N-acetylcystein, tigecycline and heparin
    PhasePhase 1
    Registry statusCompleted

  • Study Comparing the Safety and Efficacy of Tigecycline With Ampicillin-Sulbactam or Amoxicillin-Clavulanate to Treat Skin Infections

    NCT00368537 · start 2006-09

    Registered record
    Registry ID
    NCT00368537
    Conditions
    Skin Diseases, Bacterial
    Interventions
    Tigecycline; ampicillin-sulbactam
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-09
    Completion
    2008-09
    Enrolment
    550

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSkin Diseases, Bacterial
    InterventionTigecycline; ampicillin-sulbactam
    PhasePhase 4
    Registry statusCompleted

  • Study Evaluating the Safety and Efficacy of Tigecycline in Hospitalized Patients With cIAI

    NCT00488306 · start 2006-08

    Registered record
    Registry ID
    NCT00488306
    Conditions
    Abdominal Abscess
    Interventions
    tigecycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-08
    Completion
    2007-08
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbdominal Abscess
    Interventiontigecycline
    PhasePhase 4
    Registry statusCompleted

  • Tigecycline In-Vitro Surveillance Study In Taiwan

    NCT00488397 · start 2006-08

    Registered record
    Registry ID
    NCT00488397
    Conditions
    Community Acquired Infections
    Interventions
    In-vitro testing
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2006-08
    Completion
    2011-02
    Enrolment
    7,902

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCommunity Acquired Infections
    InterventionIn-vitro testing
    PhaseNot recorded
    Registry statusCompleted

  • Study Evaluating the Safety and Efficacy of Tigecycline in Hospitalized Patients With cSSSI

    NCT00488761 · start 2006-07

    Registered record
    Registry ID
    NCT00488761
    Conditions
    Skin Diseases, Infectious
    Interventions
    Tigecycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-07
    Completion
    2007-08
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSkin Diseases, Infectious
    InterventionTigecycline
    PhasePhase 4
    Registry statusCompleted

  • Study Comparing Tigecycline and Imipenem/Cilastatin in Chinese Subjects With Complicated Intra-Abdominal Infections

    NCT00136201 · start 2005-11

    Registered record
    Registry ID
    NCT00136201
    Conditions
    Abdominal Abscess
    Interventions
    tigecycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-11
    Completion
    2006-12
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbdominal Abscess
    Interventiontigecycline
    PhasePhase 3
    Registry statusCompleted

  • Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection (cIAI)

    NCT00230971 · start 2005-10

    Registered record
    Registry ID
    NCT00230971
    Conditions
    Appendicitis; Cholecystitis; Diverticulitis; Intra-Abdominal Abscess; Intra-Abdominal Infection; Peritonitis
    Interventions
    tigecycline; ceftriaxone plus metronidazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2005-10
    Completion
    2008-09
    Enrolment
    473

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAppendicitis; Cholecystitis; Diverticulitis; Intra-Abdominal Abscess +2 more
    Interventiontigecycline; ceftriaxone plus metronidazole
    PhasePhase 4
    Registry statusCompleted