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AMR Drug RepurposingSmart Screeningresearch prototype

Eszopiclone

FDA-approved product (tablet, oral), marketed as Eszopiclone, Lunesta.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Eszopiclone
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Insomnia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Benzodiazepine related drugs
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli, MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA50.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli40.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae32.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis49.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Eszopiclone in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.3 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.2 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.8 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-8.2 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Eszopiclone with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Eszopiclone for Improving Sleep in Multiple Sclerosis (MS)

    NCT00594087 · start 2006-12

    Registered record
    Registry ID
    NCT00594087
    Conditions
    Relapsing Remitting Multiple Sclerosis; Sleep Initiation and Maintenance Disorders; Fatigue
    Interventions
    eszopiclone; placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2006-12
    Completion
    2008-06
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRelapsing Remitting Multiple Sclerosis; Sleep Initiation and Maintenance Disorders; Fatigue
    Interventioneszopiclone; placebo
    PhaseNot applicable
    Registry statusCompleted

  • A Long-Term Safety and Efficacy Study of Eszopiclone in Elderly With Primary Chronic Insomnia

    NCT00386334 · start 2006-10

    Registered record
    Registry ID
    NCT00386334
    Conditions
    Insomnia
    Interventions
    Eszopiclone; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-10
    Completion
    2008-02
    Enrolment
    388

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInsomnia
    InterventionEszopiclone; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Effect of Eszopiclone on Sleep Disturbance and Pain in Cancer

    NCT00365261 · start 2006-09

    Registered record
    Registry ID
    NCT00365261
    Conditions
    Sleep Initiation and Maintenance Disorders
    Interventions
    Eszopiclone; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-09
    Completion
    2009-12
    Enrolment
    45

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSleep Initiation and Maintenance Disorders
    InterventionEszopiclone; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Eszopiclone Co-Administered With Escitalopram for Insomnia in Elderly Adults With Major Depressive Disorder

    NCT00813735 · start 2006-09

    Registered record
    Registry ID
    NCT00813735
    Conditions
    Insomnia
    Interventions
    Eszopiclone; Placebo; Escitalopram
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-09
    Completion
    2009-04
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInsomnia
    InterventionEszopiclone; Placebo; Escitalopram
    PhasePhase 4
    Registry statusCompleted

  • Study of the Insomnia in Patients With Low Back Pain

    NCT00365976 · start 2006-08

    Registered record
    Registry ID
    NCT00365976
    Conditions
    Primary Insomnia
    Interventions
    Eszopiclone; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-08
    Completion
    2010-09
    Enrolment
    58

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPrimary Insomnia
    InterventionEszopiclone; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Eszopiclone in the Treatment of Insomnia and Fibromyalgia

    NCT00392041 · start 2006-08

    Registered record
    Registry ID
    NCT00392041
    Conditions
    Fibromyalgia; Insomnia
    Interventions
    Eszopiclone; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-08
    Completion
    2009-03
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFibromyalgia; Insomnia
    InterventionEszopiclone; placebo
    PhasePhase 4
    Registry statusCompleted

  • Treatment of Insomnia in Patients With Parkinson's Disease: A Multi-site, Placebo-controlled Study of Eszopiclone

    NCT00324896 · start 2006-05

    Registered record
    Registry ID
    NCT00324896
    Conditions
    Parkinson's Disease; Insomnia
    Interventions
    eszopiclone; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-05
    Completion
    2009-06
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionParkinson's Disease; Insomnia
    Interventioneszopiclone; placebo
    PhasePhase 3
    Registry statusCompleted

  • Sleep Loss and Mechanisms of Impaired Glucose Metabolism

    NCT00555750 · start 2006-03

    Registered record
    Registry ID
    NCT00555750
    Conditions
    Primary Insomnia
    Interventions
    eszopiclone; placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2006-03
    Completion
    2008-08
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPrimary Insomnia
    Interventioneszopiclone; placebo
    PhaseNot applicable
    Registry statusCompleted

  • The Treatment of Insomnia in Symptomatic Peri- and Postmenopausal Women

    NCT00374192 · start 2006-02

    Registered record
    Registry ID
    NCT00374192
    Conditions
    Menopause; Insomnia
    Interventions
    Eszopiclone; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2006-02
    Completion
    2007-07
    Enrolment
    67

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMenopause; Insomnia
    InterventionEszopiclone; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • Residual Effects of Zolpidem Tartrate Extended Release and Eszopiclone Vs Placebo

    NCT00283790 · start 2006-01

    Registered record
    Registry ID
    NCT00283790
    Conditions
    Insomnia
    Interventions
    zolpidem tartrate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-01
    Completion
    2006-04
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInsomnia
    Interventionzolpidem tartrate
    PhasePhase 4
    Registry statusCompleted

  • Insomnia and Osteoarthritis Study

    NCT00374556 · start 2006-01

    Registered record
    Registry ID
    NCT00374556
    Conditions
    Osteoarthritis; Insomnia
    Interventions
    Placebo; Eszopiclone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2006-01
    Completion
    2013-12
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis; Insomnia
    InterventionPlacebo; Eszopiclone
    PhaseNot applicable
    Registry statusCompleted

  • Improving Sleep and Psychological Functioning in People With Depression and Insomnia

    NCT00247624 · start 2005-10

    Registered record
    Registry ID
    NCT00247624
    Conditions
    Sleep Initiation and Maintenance Disorders; Depression
    Interventions
    Eszopiclone; Fluoxetine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2005-10
    Completion
    2008-12
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSleep Initiation and Maintenance Disorders; Depression
    InterventionEszopiclone; Fluoxetine; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Eszopiclone for Sleep Disturbance and Nightmares in Post-Traumatic Stress Disorder

    NCT00120250 · start 2005-06

    Registered record
    Registry ID
    NCT00120250
    Conditions
    Post-Traumatic Stress Disorders
    Interventions
    Eszopiclone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2005-06
    Completion
    2008-06
    Enrolment
    27

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost-Traumatic Stress Disorders
    InterventionEszopiclone
    PhasePhase 4
    Registry statusCompleted

  • Safety and Efficacy of Eszopiclone in Patients With Generalized Anxiety Disorder

    NCT00235508 · start 2005-06

    Registered record
    Registry ID
    NCT00235508
    Conditions
    Insomnia; Generalized Anxiety Disorder
    Interventions
    Eszopiclone (Lunesta)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2005-06
    Completion
    2006-04
    Enrolment
    420

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInsomnia; Generalized Anxiety Disorder
    InterventionEszopiclone (Lunesta)
    PhasePhase 4
    Registry statusCompleted

  • Efficacy & Safety of Eszopiclone (Lunesta) in Nursing Home Patients

    NCT00460993 · start 2005-06

    Registered record
    Registry ID
    NCT00460993
    Conditions
    Poor Quality Sleep
    Interventions
    Lunesta
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2005-06
    Completion
    2010-12
    Enrolment
    71

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPoor Quality Sleep
    InterventionLunesta
    PhasePhase 4
    Registry statusCompleted