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AMR Drug RepurposingSmart Screeningresearch prototype

Enalapril Maleate

FDA-approved product (tablet, oral), marketed as Enalapril Maleate, Epaned, Epaned Kit and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Enalapril Maleate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cardiovascular disease
  • Congestive heart failure
  • Heart failure
  • Hypertension
  • Ventricular Dysfunction, Left

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Ace inhibitors, plain
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA33.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli22.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae14.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis69.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Enalapril Maleate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Enalapril Maleate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • This Study Will Evaluate the Efficacy and Safety of LCZ696 Compared to Enalapril on Morbidity and Mortality of Patients With Chronic Heart Failure

    NCT01035255 · start 2009-12

    Registered record
    Registry ID
    NCT01035255
    Conditions
    Heart Failure With Reduced Ejection Fraction
    Interventions
    LCZ696 200 mg BID; Enalapril 10 mg BID
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2009-12
    Completion
    2014-05
    Enrolment
    8,442

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHeart Failure With Reduced Ejection Fraction
    InterventionLCZ696 200 mg BID; Enalapril 10 mg BID
    PhasePhase 3
    Registry statusTerminated

  • Prognostic Value of the Circadian Pattern of Ambulatory Blood Pressure for Multiple Risk Assessment

    NCT00741585 · start 2008-09-01

    Registered record
    Registry ID
    NCT00741585
    Conditions
    Essential Hypertension; Cardiovascular Disease; Stroke; Chronic Kidney Disease
    Interventions
    Any antihypertensive medication alone or in combination; Any antihypertensive medication alone or in combination; Ambulatory blood pressure monitoring
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-09-01
    Completion
    2018-06-30
    Enrolment
    21,983

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEssential Hypertension; Cardiovascular Disease; Stroke; Chronic Kidney Disease
    InterventionAny antihypertensive medication alone or in combination; Any antihypertensive medication alone or in combination; Ambulatory blood pressure monitoring
    PhasePhase 4
    Registry statusCompleted

  • China Stroke Primary Prevention Trial

    NCT00794885 · start 2008-05

    Registered record
    Registry ID
    NCT00794885
    Conditions
    Primary Hypertension
    Interventions
    Enalapril/folic acid; Enalapril maleate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-05
    Completion
    2014-06
    Enrolment
    20,702

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPrimary Hypertension
    InterventionEnalapril/folic acid; Enalapril maleate
    PhasePhase 4
    Registry statusCompleted

  • CSPPT- Chronic Kidney Diseases Study

    NCT01871740 · start 2008-05

    Registered record
    Registry ID
    NCT01871740
    Conditions
    Hypertension; Hyperhomocysteinemia
    Interventions
    Enalapril maleate and folic acid tablets; Enalapril maleate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2008-05
    Completion
    2014-08
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension; Hyperhomocysteinemia
    InterventionEnalapril maleate and folic acid tablets; Enalapril maleate
    PhasePhase 4
    Registry statusWithdrawn

  • Effect of Sitagliptin and an ACE Inhibitor on Blood Pressure in Metabolic Syndrome

    NCT00666848 · start 2008-03

    Registered record
    Registry ID
    NCT00666848
    Conditions
    Metabolic Syndrome; Hypertension
    Interventions
    Placebo; Enalapril 5mg; Enalapril 10mg; Sitagliptin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-03
    Completion
    2010-01
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMetabolic Syndrome; Hypertension
    InterventionPlacebo; Enalapril 5mg; Enalapril 10mg; Sitagliptin
    PhasePhase 4
    Registry statusCompleted

  • Effect of Turmeric on Diabetic Nephropathy

    NCT01015937 · start 2008-03

    Registered record
    Registry ID
    NCT01015937
    Conditions
    Diabetic Nephropathy; Proteinuria
    Interventions
    Turmeric extract; Angiotensin-converting enzyme (ACE) inhibitor + Angiotensin-II type 1 receptor (ATI) blocker
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2008-03
    Completion
    2009-08
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetic Nephropathy; Proteinuria
    InterventionTurmeric extract; Angiotensin-converting enzyme (ACE) inhibitor + Angiotensin-II type 1 receptor (ATI) blocker
    PhaseNot applicable
    Registry statusCompleted

  • Prevention of Diabetes and Hypertension

    NCT00456963 · start 2007-09

    Registered record
    Registry ID
    NCT00456963
    Conditions
    Diabetes Mellitus; Hypertension
    Interventions
    Diet; Moderate exercise; enalapril tablets; placebo tablets; Losartan Tablets
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2007-09
    Completion
    2010-03
    Enrolment
    3,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetes Mellitus; Hypertension
    InterventionDiet; Moderate exercise; enalapril tablets; placebo tablets +1 more
    PhasePhase 4
    Registry statusTerminated

  • The Fabrazyme® and Arbs and ACE Inhibitor Treatment (FAACET) Study

    NCT00446862 · start 2007-03

    Registered record
    Registry ID
    NCT00446862
    Conditions
    Fabry Disease; Proteinuria
    Interventions
    enalapril and other angiotensin converting enzyme inhibitors; losartan and other angiotensin receptor blockers
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2007-03
    Completion
    2012-12
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFabry Disease; Proteinuria
    Interventionenalapril and other angiotensin converting enzyme inhibitors; losartan and other angiotensin receptor blockers
    PhaseNot recorded
    Registry statusCompleted

  • Intracerebral Hemorrhage Acutely Decreasing Arterial Pressure Trial

    NCT00963976 · start 2007-01

    Registered record
    Registry ID
    NCT00963976
    Conditions
    Intracerebral Hemorrhage
    Interventions
    labetalol/hydralazine/enalapril
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2007-01
    Completion
    2012-02
    Enrolment
    74

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIntracerebral Hemorrhage
    Interventionlabetalol/hydralazine/enalapril
    PhasePhase 2
    Registry statusCompleted

  • ARCHIPELAGO: Irbesartan in Patients With Acute Coronary Syndrome Without ST Segment Elevation

    NCT00296218 · start 2006-02

    Registered record
    Registry ID
    NCT00296218
    Conditions
    Myocardial Ischemia; Hypertension
    Interventions
    Irbesartan
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-02
    Completion
    Not recorded
    Enrolment
    440

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMyocardial Ischemia; Hypertension
    InterventionIrbesartan
    PhasePhase 3
    Registry statusCompleted

  • Sirolimus Therapy for Poor Prognosis Immunoglobulin A Nephropathy

    NCT00396721 · start 2006-01

    Registered record
    Registry ID
    NCT00396721
    Conditions
    Glomerulonephritis, IGA; Nephropathy, IGA; IGA Nephropathy
    Interventions
    ACE inhibitor + statin; Sirolimus (study drug)+ACE inhibitor + statin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2006-01
    Completion
    2010-02
    Enrolment
    23

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGlomerulonephritis, IGA; Nephropathy, IGA; IGA Nephropathy
    InterventionACE inhibitor + statin; Sirolimus (study drug)+ACE inhibitor + statin
    PhasePhase 2
    Registry statusCompleted

  • Effect of Enalapril and Losartan Association Therapy on Proteinuria and Inflammatory Biomarkers in Diabetic Nephropathy: a Clinical Trial on Type 2 Diabetes Mellitus

    NCT00419835 · start 2005-05

    Registered record
    Registry ID
    NCT00419835
    Conditions
    Macroalbuminuric Diabetic Nephropathy
    Interventions
    enalapril; losartan
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2005-05
    Completion
    2007-09
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMacroalbuminuric Diabetic Nephropathy
    Interventionenalapril; losartan
    PhasePhase 4
    Registry statusCompleted

  • Comparison of the Antihypertensive Efficacy of Valsartan and Enalapril After Missing One Dose

    NCT00302705 · start 2005-01

    Registered record
    Registry ID
    NCT00302705
    Conditions
    Hypertension
    Interventions
    Valsartan, Enalapril; Ambulatory blood pressure monitoring; Missing one dose
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2005-01
    Completion
    2007-03
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionValsartan, Enalapril; Ambulatory blood pressure monitoring; Missing one dose
    PhasePhase 4
    Registry statusCompleted

  • Mortality Control Program for Economically Productive Age Group in Tribal Area of Melghat.

    NCT07436104 · start 2004-01-01

    Registered record
    Registry ID
    NCT07436104
    Conditions
    Hypertension (HTN); Diarrhea; Pneumonia; Malaria Fever; COPD; Asthma (Diagnosis); Diarrhea Chronic
    Interventions
    Trained village health workers (VHWs) , provided treatment of HTN, diarrhoea, malaria, pneumonia, asthma and COPD by Amlodipine, ORS, Norfloxacin, Chloroquine, Azithromycin, salbutamol rotacaps; Appropriate referral
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-01-01
    Completion
    2023-08-31
    Enrolment
    72,564

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension (HTN); Diarrhea; Pneumonia; Malaria Fever +3 more
    InterventionTrained village health workers (VHWs) , provided treatment of HTN, diarrhoea, malaria, pneumonia, asthma and COPD by Amlodipine, ORS, Norfloxacin, Chloroquine, Azithromycin, salbutamol rotacaps; Appropriate referral
    PhasePhase 4
    Registry statusCompleted

  • Aspirin and Enalapril in Microalbuminuric Type 2 Diabetes Mellitus Patients

    NCT00427271 · start 2003-03

    Registered record
    Registry ID
    NCT00427271
    Conditions
    Diabetes Mellitus; Microalbuminuria
    Interventions
    aspirin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2003-03
    Completion
    2007-01
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetes Mellitus; Microalbuminuria
    Interventionaspirin
    PhasePhase 4
    Registry statusUnknown