Clomipramine Hydrochloride
FDA-approved product (capsule, oral), marketed as Anafranil, Clomipramine Hydrochloride.
- Registered studies
- 33
- Lab records
- 0
- Pathogens at ≥40%
- 2 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLApproved for
- Depressive disorder
- Major depressive disorder
- Obsessive-compulsive disorder
Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗
- WHO therapeutic group
- Non-selective monoamine reuptake inhibitors
- Anti-infective classification
- Not classified as an anti-infective.
Repurposing investigation
This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis and MRSA. It was surfaced computationally for further investigation; it is not an established treatment for these infections.
AI-predicted activity
AI prediction · nothing measured- MRSA43.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- E. coli37.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- K. pneumoniae18.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- M. tuberculosis67.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
33registered studies name this medicine, for any condition. See them below.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredAutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Clomipramine Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- Mefloquine HydrochlorideExisting use: Malaria, Plasmodium falciparum malaria, Plasmodium vivax malaria81.8% AI-predicted activityagainst M. tuberculosisLab records exist8 registered studies
- KetoconazoleExisting use: Adrenal gland disease, Blastomycosis, Cushing syndrome and 3 more81.2% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- LevoketoconazoleExisting use: Adrenal gland disease, Adrenal gland hyperfunction, Cushing syndrome81.2% AI-predicted activityagainst M. tuberculosis6 registered studies
- Fluphenazine DecanoateExisting use: Mental or behavioural disorder, Psychosis80.7% AI-predicted activityagainst M. tuberculosis4 registered studies
- Fluphenazine EnanthateExisting use: Mental or behavioural disorder, Psychosis80.7% AI-predicted activityagainst M. tuberculosisNo documented evidence found
- NifurtimoxExisting use: American trypanosomiasis, Chagas disease, Leishmaniasis and 1 more78.4% AI-predicted activityagainst M. tuberculosis19 registered studies
- Fluphenazine HydrochlorideExisting use: Mental or behavioural disorder, Psychosis77.8% AI-predicted activityagainst M. tuberculosis5 registered studies
- NitazoxanideExisting use: Amebiasis, Diarrhea77.8% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- TopiramateExisting use: Epilepsy, Lennox-Gastaut syndrome, Migraine disorder and 1 more77.4% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- TrabectedinExisting use: Cancer, Dedifferentiated liposarcoma, Leiomyosarcoma and 7 more76.8% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Chlorpromazine HydrochlorideExisting use: Conduct disorder, Mental or behavioural disorder, Nausea and vomiting and 3 more75.0% AI-predicted activityagainst M. tuberculosis33 registered studies
- ProchlorperazineExisting use: Anxiety disorder, Nausea and vomiting, Psychosis and 1 more74.1% AI-predicted activityagainst M. tuberculosis50+ registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
Citalopram vs Clomipramine vs Placebo in Recurrent Depression
NCT01575158 · start 1997-10
Registered record
- Registry ID
- NCT01575158
- Conditions
- Depression
- Interventions
- Citalopram; Clomipramine; placebo
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- 1997-10
- Completion
- 2007-09
- Enrolment
- 59
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionDepressionInterventionCitalopram; Clomipramine; placeboPhaseNot applicableRegistry statusCompletedTo Demonstrate the Relative Bioavailability of Geneva and Basel (Anafranil) 25 mg Clomipramine Hydrochloride Capsules Under Fed and Fasted Conditions
NCT00913952 · start 1994-04
Registered record
- Registry ID
- NCT00913952
- Conditions
- Depression
- Interventions
- Geneva 25 mg Clomipramine Hydrochloride Capsules Under Fasting Conditions; Geneva 25 mg Clomipramine Hydrochloride Capsules Under Fed Conditions; Basel (Anafranil) 25 mg Clomipramine Hydrochloride Capsules Under Fed Conditions
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- 1994-04
- Completion
- 1994-06
- Enrolment
- 18
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionDepressionInterventionGeneva 25 mg Clomipramine Hydrochloride Capsules Under Fasting Conditions; Geneva 25 mg Clomipramine Hydrochloride Capsules Under Fed Conditions; Basel (Anafranil) 25 mg Clomipramine Hydrochloride Capsules Under Fed ConditionsPhasePhase 1Registry statusCompletedTo Demonstrate the Relative Bioavailability of Geneva and Basel (Anafranil) 25 mg Clomipramine Hydrochloride Capsules Under Fasted Conditions
NCT00913783 · start 1992-11
Registered record
- Registry ID
- NCT00913783
- Conditions
- Depression
- Interventions
- Clomipramine Hydrochloride 25 mg Capsules (Geneva Pharmaceuticals); Anafranil Clomipramine Hydrochloride 25 mg Capsules (Basel)
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- 1992-11
- Completion
- 1992-12
- Enrolment
- 36
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionDepressionInterventionClomipramine Hydrochloride 25 mg Capsules (Geneva Pharmaceuticals); Anafranil Clomipramine Hydrochloride 25 mg Capsules (Basel)PhasePhase 1Registry statusCompleted