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AMR Drug RepurposingSmart Screeningresearch prototype

Clomipramine Hydrochloride

FDA-approved product (capsule, oral), marketed as Anafranil, Clomipramine Hydrochloride.

Registered studies
33
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Clomipramine Hydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Depressive disorder
  • Major depressive disorder
  • Obsessive-compulsive disorder

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Non-selective monoamine reuptake inhibitors
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis and MRSA. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA43.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli37.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae18.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis67.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

33registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Clomipramine Hydrochloride in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-5.9 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-5.0 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-5.1 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-5.9 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Clomipramine Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Effect of a Family-Based CBT Self-Help Intervention for Adolescents With OCD

    NCT06942494 · start 2025-04-30

    Registered record
    Registry ID
    NCT06942494
    Conditions
    Obsessive - Compulsive Disorder
    Interventions
    conventional medical treatment (TAU); Family-Based Self-help Book for Adolescents with Obsessive-Compulsive Disorder
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2025-04-30
    Completion
    2027-12-31
    Enrolment
    88

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObsessive - Compulsive Disorder
    Interventionconventional medical treatment (TAU); Family-Based Self-help Book for Adolescents with Obsessive-Compulsive Disorder
    PhaseNot applicable
    Registry statusRecruiting

  • Efficacy of Hydroxyzine for Patients With Panic Disorder

    NCT05737511 · start 2023-12-30

    Registered record
    Registry ID
    NCT05737511
    Conditions
    Panic Disorder
    Interventions
    Hydroxyzine; Escitalopram Oxalate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Not yet recruiting
    Start
    2023-12-30
    Completion
    2026-12-30
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPanic Disorder
    InterventionHydroxyzine; Escitalopram Oxalate
    PhasePhase 4
    Registry statusNot yet recruiting

  • Reducing Maximal Support in OCD: Efficacy of Stepped-Care Online CBT

    NCT06659094 · start 2023-08-21

    Registered record
    Registry ID
    NCT06659094
    Conditions
    Obsessive Compulsive Disorder (OCD)
    Interventions
    stepped-care Internet-based cognitive behavioral therapy(SC-ICBT); Cognitive Behavioral Group Therapy (CBGT); conventional medical treatment (TAU)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-08-21
    Completion
    2025-12-30
    Enrolment
    95

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObsessive Compulsive Disorder (OCD)
    Interventionstepped-care Internet-based cognitive behavioral therapy(SC-ICBT); Cognitive Behavioral Group Therapy (CBGT); conventional medical treatment (TAU)
    PhaseNot applicable
    Registry statusCompleted

  • MODELING OBSESSIVE COMPULSIVE DISORDER AND EXPLORING TREATMENT RESPONSE USING INNOVATIVE THERAPIES AND STEM CELLS

    NCT07488663 · start 2023-04-30

    Registered record
    Registry ID
    NCT07488663
    Conditions
    Obsessive - Compulsive Disorder
    Interventions
    deep transcranial magnetic stimulation (dTMS); Theta burst stimulation (TBS)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Enrolling by invitation
    Start
    2023-04-30
    Completion
    2027-04-29
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObsessive - Compulsive Disorder
    Interventiondeep transcranial magnetic stimulation (dTMS); Theta burst stimulation (TBS)
    PhaseNot applicable
    Registry statusEnrolling by invitation

  • Combination Therapy of Different Antidepressants With Dietary Supplements

    NCT05931965 · start 2022-10-05

    Registered record
    Registry ID
    NCT05931965
    Conditions
    Depression
    Interventions
    L-methylfolate; Vitamin B12; magnesium
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-10-05
    Completion
    2023-08-31
    Enrolment
    88

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDepression
    InterventionL-methylfolate; Vitamin B12; magnesium
    PhaseNot applicable
    Registry statusCompleted

  • Comparative Responses to 15 Different Antidepressants in Major Depressive Disorder

    NCT05952713 · start 2022-10-01

    Registered record
    Registry ID
    NCT05952713
    Conditions
    Major Depressive Disorder
    Interventions
    Antidepressant
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2022-10-01
    Completion
    2023-07-01
    Enrolment
    73,336

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMajor Depressive Disorder
    InterventionAntidepressant
    PhaseNot recorded
    Registry statusCompleted

  • Taste Supra-thresholds Among a Sample of Depressed Egyptian Adult Under Anti-depressants Therapy

    NCT04923321 · start 2021-02-22

    Registered record
    Registry ID
    NCT04923321
    Conditions
    Taste Disorders
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2021-02-22
    Completion
    2021-05-07
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTaste Disorders
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Gustatory Dysfunction Among a Sample of Depressed Egyptian Adults Under Anti-depressants Therapy

    NCT03599011 · start 2020-02-22

    Registered record
    Registry ID
    NCT03599011
    Conditions
    Taste Disorders
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2020-02-22
    Completion
    2020-10-07
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTaste Disorders
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Gustatory Modulators Among a Sample of Depressed Egyptian Adults Under Anti-depressants Therapy

    NCT04923425 · start 2020-02-22

    Registered record
    Registry ID
    NCT04923425
    Conditions
    Taste Disorders
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2020-02-22
    Completion
    2020-10-07
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTaste Disorders
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • rTMS in Treatment Refractory Obsessive-Compulsive Disorder

    NCT02450695 · start 2016-07

    Registered record
    Registry ID
    NCT02450695
    Conditions
    Obsessive-Compulsive Disorder
    Interventions
    rTMS
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2016-07
    Completion
    2019-04
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObsessive-Compulsive Disorder
    InterventionrTMS
    PhaseNot applicable
    Registry statusWithdrawn

  • A Phase 2 Study of On-demand Therapy With Clomipramine and Sildenafil Combination in Premature Ejaculation

    NCT02571101 · start 2015-11

    Registered record
    Registry ID
    NCT02571101
    Conditions
    Premature Ejaculation
    Interventions
    CDFR0812-15/25mg; CDFR0812-15/50mg; Condencia; CDFR0812-Placebo; Condencia-Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2015-11
    Completion
    2016-06
    Enrolment
    297

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPremature Ejaculation
    InterventionCDFR0812-15/25mg; CDFR0812-15/50mg; Condencia; CDFR0812-Placebo +1 more
    PhasePhase 2
    Registry statusUnknown

  • Pharmacovigilance in Gerontopsychiatric Patients

    NCT02374567 · start 2015-01

    Registered record
    Registry ID
    NCT02374567
    Conditions
    Dementia; Depression; Schizophrenia; Psychosomatic Disorders; Anxiety Disorders
    Interventions
    Phenobarbital; Phenytoin; Carbamazepine; Oxcarbazepine; Valproic Acid; Lamotrigine; Topiramate; Gabapentin; Levetiracetam; Pregabalin; Lacosamide; Clonazepam; Biperiden; Levomepromazine; Fluphenazine; Perphenazine; Perazine; Thioridazine; Haloperidol; Melperone; Pipamperone; Bromperidol; Benperidol; Sertindole; Ziprasidone; Flupentixol; Chlorprothixene; Zuclopenthixol; Fluspirilene; Pimozide; Clozapine; Olanzapine; Quetiapine; Sulpiride; Tiapride; Amisulpride; Prothipendyl; Risperidone; Aripiprazole; Paliperidone; Diazepam; Oxazepam; Lorazepam; Bromazepam; Clobazam; Alprazolam; Hydroxyzine; Buspirone; Chloral Hydrate; Flurazepam; Nitrazepam; Triazolam; Lormetazepam; Temazepam; Midazolam; Brotizolam; Zopiclone; Zolpidem; Zaleplon; Melatonin; Clomethiazole; Diphenhydramine; Promethazine; Imipramine; Clomipramine; Opipramol; Trimipramine; Amitriptyline; Nortriptyline; Doxepin; Maprotiline; Amitriptyline oxide; Fluoxetine; Citalopram; Paroxetine; Sertraline; Fluvoxamine; Escitalopram; Tran
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2015-01
    Completion
    2017-06-28
    Enrolment
    407

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDementia; Depression; Schizophrenia; Psychosomatic Disorders +1 more
    InterventionPhenobarbital; Phenytoin; Carbamazepine; Oxcarbazepine +75 more
    PhasePhase 3
    Registry statusTerminated

  • YouScript IMPACT Registry

    NCT02191358 · start 2014-10

    Registered record
    Registry ID
    NCT02191358
    Conditions
    Adverse Drug Events; Adverse Drug Reactions; Drug Interaction Potentiation; Drug Metabolism, Poor, CYP2D6-RELATED; Drug Metabolism, Poor, CYP2C19-RELATED; Cytochrome P450 Enzyme Deficiency; Cytochrome P450 CYP2D6 Enzyme Deficiency; Cytochrome P450 CYP2C9 Enzyme Deficiency; Cytochrome P450 CYP2C19 Enzyme Deficiency; Cytochrome P450 CYP3A Enzyme Deficiency; Poor Metabolizer Due to Cytochrome P450 CYP2C9 Variant; Poor Metabolizer Due to Cytochrome P450 CYP2C19 Variant; Poor Metabolizer Due to Cytochrome P450 CYP2D6 Variant
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2014-10
    Completion
    2015-08
    Enrolment
    800

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdverse Drug Events; Adverse Drug Reactions; Drug Interaction Potentiation; Drug Metabolism, Poor, CYP2D6-RELATED +9 more
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Drug-Drug Interaction of Clomipramine HCl and Sildenafil Citrate in Healthy Males

    NCT02028598 · start 2014-01

    Registered record
    Registry ID
    NCT02028598
    Conditions
    Healthy
    Interventions
    Treatment 1; Treatment 2; Treatment 3
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2014-01
    Completion
    2014-03
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionTreatment 1; Treatment 2; Treatment 3
    PhasePhase 1
    Registry statusCompleted

  • Supplemental Transcranial Magnetic Stimulation (TMS) vs. Standard Medication Monotherapy for Treating Major Depression: An Exploratory Field Study

    NCT01944657 · start 2013-09

    Registered record
    Registry ID
    NCT01944657
    Conditions
    1. Major Depressive Disorder
    Interventions
    Supplemental TMS; Standard Medication Monotherapy
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2013-09
    Completion
    2015-12
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    Condition1. Major Depressive Disorder
    InterventionSupplemental TMS; Standard Medication Monotherapy
    PhaseNot applicable
    Registry statusWithdrawn