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AMR Drug RepurposingSmart Screeningresearch prototype

Clomipramine Hydrochloride

FDA-approved product (capsule, oral), marketed as Anafranil, Clomipramine Hydrochloride.

Registered studies
33
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Clomipramine Hydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Depressive disorder
  • Major depressive disorder
  • Obsessive-compulsive disorder

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Non-selective monoamine reuptake inhibitors
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis and MRSA. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA43.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli37.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae18.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis67.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

33registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Clomipramine Hydrochloride in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-5.9 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-5.0 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-5.1 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-5.9 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Clomipramine Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Interpersonal Psychotherapy for Treatment Resistant Depression

    NCT01896349 · start 2013-04

    Registered record
    Registry ID
    NCT01896349
    Conditions
    Treatment Resistant Depression
    Interventions
    IPT+ antidepressant drugs; fluoxetine; sertraline; paroxetine; Citalopram; escitalopram; fluvoxamine; Venlafaxine; Duloxetine; Bupropion; Lithium; Risperidone; tranylcypromine; Imipramine; amitriptyline; Clomipramine; nortriptyline; trazodone; Mirtazapine; sulpiride
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2013-04
    Completion
    2014-11
    Enrolment
    74

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTreatment Resistant Depression
    InterventionIPT+ antidepressant drugs; fluoxetine; sertraline; paroxetine +16 more
    PhaseNot applicable
    Registry statusUnknown

  • Pharmaco(Epi)Genetic, Proteomic, and Microbiomic Study of Obsessive-Compulsive Disorder

    NCT02431845 · start 2013-01-01

    Registered record
    Registry ID
    NCT02431845
    Conditions
    Obsessive-Compulsive Disorder
    Interventions
    SSRIs
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2013-01-01
    Completion
    2030-12-31
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObsessive-Compulsive Disorder
    InterventionSSRIs
    PhaseNot applicable
    Registry statusRecruiting

  • Trial of PED-1 in Male Patients With Premature Ejaculation

    NCT01439984 · start 2011-09

    Registered record
    Registry ID
    NCT01439984
    Conditions
    Premature Ejaculation
    Interventions
    Clomipramine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2011-09
    Completion
    2012-06
    Enrolment
    159

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPremature Ejaculation
    InterventionClomipramine
    PhasePhase 3
    Registry statusCompleted

  • Phase 2 Trial of PED-1 and PED-2 in Male Patients With Premature Ejaculation

    NCT01203202 · start 2010-09

    Registered record
    Registry ID
    NCT01203202
    Conditions
    Premature Ejaculation
    Interventions
    Clomipramine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2010-09
    Completion
    2011-01
    Enrolment
    104

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPremature Ejaculation
    InterventionClomipramine
    PhasePhase 2
    Registry statusCompleted

  • Efficacy of Antidepressants in Chronic Back Pain

    NCT00964886 · start 2010-01

    Registered record
    Registry ID
    NCT00964886
    Conditions
    Back Pain
    Interventions
    cognitive behavioral therapy; desipramine hydrochloride; cognitive behavioral therapy; benztropine mesylate 0.125 mg daily; desipramine hydrochloride
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2010-01
    Completion
    2015-12
    Enrolment
    142

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBack Pain
    Interventioncognitive behavioral therapy; desipramine hydrochloride; cognitive behavioral therapy; benztropine mesylate 0.125 mg daily +1 more
    PhasePhase 2
    Registry statusCompleted

  • Continuation Electroconvulsive Therapy (C-ECT) for Relapse Prevention in Major Depression

    NCT01305707 · start 2009-07

    Registered record
    Registry ID
    NCT01305707
    Conditions
    Depression
    Interventions
    C-ECT; PHARMACOTHERAPY
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2009-07
    Completion
    2014-07
    Enrolment
    104

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDepression
    InterventionC-ECT; PHARMACOTHERAPY
    PhasePhase 4
    Registry statusTerminated

  • Assessment of Pituitary Adenylate Cyclase Activating Polypeptide-Brain Derived Neurotrophic Factor (PACAP-BDNF) Signaling System Involvement in Etiology and Treatment of Major Depression

    NCT00944996 · start 2009-06

    Registered record
    Registry ID
    NCT00944996
    Conditions
    Major Depression
    Interventions
    SSRI; SNRI; TCA
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-06
    Completion
    2012-07
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMajor Depression
    InterventionSSRI; SNRI; TCA
    PhaseNot applicable
    Registry statusCompleted

  • Predicting Medication Response in Obsessive Compulsive Disorder

    NCT01404871 · start 2009-04

    Registered record
    Registry ID
    NCT01404871
    Conditions
    Obsessive Compulsive Disorder
    Interventions
    clomipramine; escitalopram; duloxetine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-04
    Completion
    2011-12
    Enrolment
    26

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObsessive Compulsive Disorder
    Interventionclomipramine; escitalopram; duloxetine
    PhaseNot applicable
    Registry statusCompleted

  • Using Drug Augmentation to Treat Obsessive Compulsive Disorder Patients Who Did Not Respond to Previous Treatment

    NCT00466609 · start 2007-05

    Registered record
    Registry ID
    NCT00466609
    Conditions
    Obsessive Compulsive Disorder
    Interventions
    Clomipramine (fluoxetine plus clomipramine); Quetiapine (fluoxetine plus quetiapine); Placebo (fluoxetine plus placebo)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-05
    Completion
    2010-04
    Enrolment
    54

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObsessive Compulsive Disorder
    InterventionClomipramine (fluoxetine plus clomipramine); Quetiapine (fluoxetine plus quetiapine); Placebo (fluoxetine plus placebo)
    PhasePhase 4
    Registry statusCompleted

  • Quetiapine Augmentation Versus Clomipramine Augmentation of SSRI for Obsessive-compulsive Disorder Patients

    NCT00564564 · start 2006-01

    Registered record
    Registry ID
    NCT00564564
    Conditions
    Obsessive Compulsive Disorder
    Interventions
    Quetiapine; Clomipramine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-01
    Completion
    2007-12
    Enrolment
    21

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObsessive Compulsive Disorder
    InterventionQuetiapine; Clomipramine
    PhasePhase 4
    Registry statusCompleted

  • Treatment-Resistant Depression, Hippocampus Atrophy and Serotonin Genetic Polymorphism

    NCT00704860 · start 2005-02

    Registered record
    Registry ID
    NCT00704860
    Conditions
    Major Depression
    Interventions
    Open label pharmacotherapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2005-02
    Completion
    2010-12
    Enrolment
    27

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMajor Depression
    InterventionOpen label pharmacotherapy
    PhasePhase 4
    Registry statusCompleted

  • Treatment of Obsessive Compulsive Disorder in Children

    NCT00074815 · start 2003-09

    Registered record
    Registry ID
    NCT00074815
    Conditions
    Obsessive-Compulsive Disorder
    Interventions
    Serotonin reuptake inhibitors management; Cognitive behavioral therapy by a psychologist; Instructional cognitive behavioral therapy by a psychiatrist
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2003-09
    Completion
    2009-11
    Enrolment
    124

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObsessive-Compulsive Disorder
    InterventionSerotonin reuptake inhibitors management; Cognitive behavioral therapy by a psychologist; Instructional cognitive behavioral therapy by a psychiatrist
    PhasePhase 3
    Registry statusCompleted

  • Quetiapine Augmentation in Severe Obsessive Compulsive Disorder

    NCT00254735 · start 2002-04

    Registered record
    Registry ID
    NCT00254735
    Conditions
    Obsessive Compulsive Disorder
    Interventions
    quetiapine fumarate; SSRI/Clomipramine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2002-04
    Completion
    2006-03
    Enrolment
    44

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObsessive Compulsive Disorder
    Interventionquetiapine fumarate; SSRI/Clomipramine
    PhasePhase 3
    Registry statusCompleted

  • Phase II Randomized Study of Intravenous Versus Oral Clomipramine in Patients With Obsessive Compulsive Disorder

    NCT00004310 · start 1999-10

    Registered record
    Registry ID
    NCT00004310
    Conditions
    Obsessive-Compulsive Disorder
    Interventions
    Clomipramine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    1999-10
    Completion
    Not recorded
    Enrolment
    76

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObsessive-Compulsive Disorder
    InterventionClomipramine
    PhasePhase 2
    Registry statusUnknown

  • Effect of Antidepressants on Back Pain

    NCT00018200 · start 1999-04

    Registered record
    Registry ID
    NCT00018200
    Conditions
    Back Pain; Sciatica
    Interventions
    Desipramine; Fluoxetine; Benztropine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    1999-04
    Completion
    2004-03
    Enrolment
    130

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBack Pain; Sciatica
    InterventionDesipramine; Fluoxetine; Benztropine
    PhasePhase 2
    Registry statusCompleted