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AMR Drug RepurposingSmart Screeningresearch prototype

Flortaucipir F-18

FDA-approved product (solution, intravenous), marketed as Tauvid.

Registered studies
30
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Flortaucipir F-18
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Alzheimer disease
  • Cognitive impairment
  • Neurodegenerative disease

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Other central nervous system diagnostic radiopharmaceuticals
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis and MRSA. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA51.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli24.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae18.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis42.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

30registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Flortaucipir F-18 in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-8.2 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-8.0 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.4 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-8.9 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Flortaucipir F-18 with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • 18F-AV-1451 High Resolution Autopsy Study

    NCT02350634 · start 2016-11-26

    Registered record
    Registry ID
    NCT02350634
    Conditions
    Alzheimer's Disease
    Interventions
    Flortaucipir F18
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2016-11-26
    Completion
    2017-06-16
    Enrolment
    3

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlzheimer's Disease
    InterventionFlortaucipir F18
    PhasePhase 1
    Registry statusCompleted

  • Follow up 18F-AV-1451 Scan in Confirmatory Cohort Subjects From Study 18F-AV-1451-A05

    NCT02795780 · start 2016-08

    Registered record
    Registry ID
    NCT02795780
    Conditions
    Alzheimer's Disease
    Interventions
    Flortaucipir F18; PET Scan
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2016-08
    Completion
    2017-08-28
    Enrolment
    79

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlzheimer's Disease
    InterventionFlortaucipir F18; PET Scan
    PhasePhase 2
    Registry statusCompleted

  • 18F-AV-1451 Autopsy Study

    NCT02516046 · start 2015-09

    Registered record
    Registry ID
    NCT02516046
    Conditions
    Alzheimer's Disease
    Interventions
    Flortaucipir F18; PET Scan
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2015-09
    Completion
    2018-07-15
    Enrolment
    156

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlzheimer's Disease
    InterventionFlortaucipir F18; PET Scan
    PhasePhase 3
    Registry statusCompleted

  • Tau Imaging in Professional Fighters

    NCT02278354 · start 2015-02-18

    Registered record
    Registry ID
    NCT02278354
    Conditions
    Alzheimer's Disease
    Interventions
    Flortaucipir F18; Brain PET scan
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2015-02-18
    Completion
    2017-02-03
    Enrolment
    35

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlzheimer's Disease
    InterventionFlortaucipir F18; Brain PET scan
    PhasePhase 1
    Registry statusCompleted

  • Augmenting Flortaucipir Dosimetry Estimates

    NCT02336360 · start 2015-01

    Registered record
    Registry ID
    NCT02336360
    Conditions
    Alzheimer's Disease
    Interventions
    Flortaucipir F18
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2015-01
    Completion
    2015-06
    Enrolment
    6

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlzheimer's Disease
    InterventionFlortaucipir F18
    PhasePhase 1
    Registry statusCompleted

  • Clinical Evaluation of Flortaucipir F 18

    NCT02278367 · start 2014-12

    Registered record
    Registry ID
    NCT02278367
    Conditions
    Alzheimer's Disease; Traumatic Brain Injury; Depression
    Interventions
    Flortaucipir F18; Brain PET scan
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2014-12
    Completion
    2019-06-26
    Enrolment
    179

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlzheimer's Disease; Traumatic Brain Injury; Depression
    InterventionFlortaucipir F18; Brain PET scan
    PhasePhase 2
    Registry statusCompleted

  • F 18 T807 Tau PET Imaging of Alzheimer's Disease

    NCT02414347 · start 2014-10-23

    Registered record
    Registry ID
    NCT02414347
    Conditions
    Alzheimer Disease
    Interventions
    F 18 T807
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2014-10-23
    Completion
    2026-12
    Enrolment
    900

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlzheimer Disease
    InterventionF 18 T807
    PhaseNot recorded
    Registry statusRecruiting

  • Flortaucipir PET Imaging in the Preclinical, Prodromal and Dementia Phases of Alzheimer's Disease

    NCT04468347 · start 2014-10

    Registered record
    Registry ID
    NCT04468347
    Conditions
    Alzheimer Disease; Mild Cognitive Impairment
    Interventions
    Flortaucipir F18; Brain PET scan
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2014-10
    Completion
    2018-02
    Enrolment
    89

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlzheimer Disease; Mild Cognitive Impairment
    InterventionFlortaucipir F18; Brain PET scan
    PhasePhase 1
    Registry statusCompleted

  • Tau Imaging in Subjects With Progressive Supranuclear Palsy, Corticobasal Degeneration and Healthy Volunteers

    NCT02167594 · start 2014-08-12

    Registered record
    Registry ID
    NCT02167594
    Conditions
    Progressive Supranuclear Palsy; Corticobasal Degeneration
    Interventions
    Flortaucipir F18; Brain PET scan
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2014-08-12
    Completion
    2016-07-11
    Enrolment
    29

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProgressive Supranuclear Palsy; Corticobasal Degeneration
    InterventionFlortaucipir F18; Brain PET scan
    PhasePhase 1
    Registry statusCompleted

  • 18F-AV-1451 and Florbetapir F 18 PET (Positron Emission Tomography) Imaging in Subjects at Risk for Chronic Traumatic Encephalopathy

    NCT02079766 · start 2014-06

    Registered record
    Registry ID
    NCT02079766
    Conditions
    Chronic Traumatic Encephalopathy
    Interventions
    florbetapir F 18; Flortaucipir F18
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2014-06
    Completion
    2015-10
    Enrolment
    41

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Traumatic Encephalopathy
    Interventionflorbetapir F 18; Flortaucipir F18
    PhasePhase 2
    Registry statusCompleted

  • Imaging Characteristics of a Follow-up 18F-AV-1451 Scan

    NCT02051764 · start 2014-05

    Registered record
    Registry ID
    NCT02051764
    Conditions
    Alzheimer's Disease
    Interventions
    Flortaucipir F18; Florbetapir F 18; Brain PET Scan
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2014-05
    Completion
    2016-12
    Enrolment
    44

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlzheimer's Disease
    InterventionFlortaucipir F18; Florbetapir F 18; Brain PET Scan
    PhasePhase 2
    Registry statusTerminated

  • Analysis of 18F-AV-1451 PET Imaging in Cognitively Healthy, MCI, and AD Subjects

    NCT02016560 · start 2013-12

    Registered record
    Registry ID
    NCT02016560
    Conditions
    Alzheimer's Disease
    Interventions
    florbetapir F 18; Flortaucipir F18; Brain PET Scan
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2013-12
    Completion
    2017-07-28
    Enrolment
    383

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlzheimer's Disease
    Interventionflorbetapir F 18; Flortaucipir F18; Brain PET Scan
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • A Study of Flortaucipir PET in Healthy Volunteers and Cognitively Impaired Subjects

    NCT01992380 · start 2013-11-13

    Registered record
    Registry ID
    NCT01992380
    Conditions
    Alzheimer's Disease
    Interventions
    Flortaucipir F18; Brain PET scan
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2013-11-13
    Completion
    2014-05-30
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlzheimer's Disease
    InterventionFlortaucipir F18; Brain PET scan
    PhasePhase 1
    Registry statusCompleted

  • Exploratory Evaluation of Flortaucipir Injection in Healthy Volunteers and Cognitively Impaired Subjects

    NCT04474405 · start 2013-08-16

    Registered record
    Registry ID
    NCT04474405
    Conditions
    Alzheimer Disease
    Interventions
    Flortaucipir F18; Brain PET Scan; Whole body PET scan; Florbetapir F 18; Brain MRI
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2013-08-16
    Completion
    2013-12-09
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlzheimer Disease
    InterventionFlortaucipir F18; Brain PET Scan; Whole body PET scan; Florbetapir F 18 +1 more
    PhaseEarly phase 1
    Registry statusCompleted

  • Alzheimer's Disease Neuroimaging Initiative 2

    NCT01231971 · start 2011-02-14

    Registered record
    Registry ID
    NCT01231971
    Conditions
    Mild Cognitive Impairment (MCI); Alzheimer's Disease (AD); Significant Memory Concern (SMC); Early Mild Cognitive Impairment (EMCI); Late Mild Cognitive Impairment (LMCI)
    Interventions
    Florbetapir; Flortaucipir
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2011-02-14
    Completion
    2017-11-29
    Enrolment
    1,182

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMild Cognitive Impairment (MCI); Alzheimer's Disease (AD); Significant Memory Concern (SMC); Early Mild Cognitive Impairment (EMCI) +1 more
    InterventionFlorbetapir; Flortaucipir
    PhaseNot recorded
    Registry statusCompleted