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AMR Drug RepurposingSmart Screeningresearch prototype

Leuprolide Acetate

FDA-approved product (solution, subcutaneous), marketed as Eligard Kit, Fensolvi Kit, Leuprolide Acetate and 8 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Leuprolide Acetate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Central precocious puberty
  • Metastatic prostate cancer
  • Neoplasm
  • Precocious puberty
  • Prostate adenocarcinoma
  • Prostate cancer
  • Prostate carcinoma

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Gonadotropin releasing hormone analogues
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli, MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA59.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli59.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae31.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis60.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Leuprolide Acetate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Leuprolide Acetate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • A Study of Neoadjuvant TAK-700 and Leuprorelin Acetate Followed by Surgery Versus Surgery Alone

    NCT03211052 · start 2013-02-18

    Registered record
    Registry ID
    NCT03211052
    Conditions
    Prostate Cancer
    Interventions
    TAK-700 and LHRH agonist; prostatectomy
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2013-02-18
    Completion
    2015-06-02
    Enrolment
    16

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Cancer
    InterventionTAK-700 and LHRH agonist; prostatectomy
    PhasePhase 2
    Registry statusTerminated

  • Study of Dual Trigger Ovulation in Oocyte Donors

    NCT01443546 · start 2013-01

    Registered record
    Registry ID
    NCT01443546
    Conditions
    Infertility
    Interventions
    HCG; Lupron Trigger; Dual Trigger
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2013-01
    Completion
    2016-06
    Enrolment
    26

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility
    InterventionHCG; Lupron Trigger; Dual Trigger
    PhasePhase 4
    Registry statusTerminated

  • Degarelix in the Treatment of Endometriosis Recurrence

    NCT01712763 · start 2012-11

    Registered record
    Registry ID
    NCT01712763
    Conditions
    Endometriosis
    Interventions
    degarelix; Leuprolide Acetate 11.25 MG/ML (Enantone 11,25)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2012-11
    Completion
    2016-03
    Enrolment
    360

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEndometriosis
    Interventiondegarelix; Leuprolide Acetate 11.25 MG/ML (Enantone 11,25)
    PhasePhase 3
    Registry statusCompleted

  • Study of Comprehensive Diagnosis and Treatment for Children Precocious Puberty

    NCT02920515 · start 2012-09

    Registered record
    Registry ID
    NCT02920515
    Conditions
    Central Precocious Puberty
    Interventions
    Triptorlin or Leuprorelin; Zhibo dihuang pills; Dabu ying pills
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-09
    Completion
    2015-08
    Enrolment
    740

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCentral Precocious Puberty
    InterventionTriptorlin or Leuprorelin; Zhibo dihuang pills; Dabu ying pills
    PhasePhase 4
    Registry statusCompleted

  • The Clinical Trial to Evaluate the Efficacy and Safety of Luphere Depot Inj. 3.75mg(Leuprolide Acetate 3.75mg) in Patients With Precocious Puberty

    NCT01634321 · start 2011-07

    Registered record
    Registry ID
    NCT01634321
    Conditions
    Central Precocious Puberty
    Interventions
    Luphere depot 3.75mg(Leuprolide acetate 3.75mg)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-07
    Completion
    2012-08
    Enrolment
    63

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCentral Precocious Puberty
    InterventionLuphere depot 3.75mg(Leuprolide acetate 3.75mg)
    PhasePhase 4
    Registry statusCompleted

  • Effect of GTx-758 on Total and Free Testosterone Levels in Men With Prostate Cancer

    NCT01326312 · start 2011-06

    Registered record
    Registry ID
    NCT01326312
    Conditions
    Prostate Cancer
    Interventions
    GTx-758 1000mg; Lupron Depot; GTx-758 2000mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2011-06
    Completion
    2012-12
    Enrolment
    159

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Cancer
    InterventionGTx-758 1000mg; Lupron Depot; GTx-758 2000mg
    PhasePhase 2
    Registry statusTerminated

  • Efficacy and Safety Study of ELIGARD 22.5mg With Prostate Cancer

    NCT01511874 · start 2011-01

    Registered record
    Registry ID
    NCT01511874
    Conditions
    Prostate Cancer
    Interventions
    ELIGARD 22.5mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-01
    Completion
    2013-12
    Enrolment
    42

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Cancer
    InterventionELIGARD 22.5mg
    PhasePhase 4
    Registry statusCompleted

  • Randomized Crossover Trial to Assess the Tolerability of Gonadotropin Releasing Hormone (GnRH) Analogue Administration

    NCT01161563 · start 2010-07

    Registered record
    Registry ID
    NCT01161563
    Conditions
    Prostate Cancer
    Interventions
    Triptorelin pamoate; Leuprolide acetate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-07
    Completion
    2011-04
    Enrolment
    118

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Cancer
    InterventionTriptorelin pamoate; Leuprolide acetate
    PhasePhase 4
    Registry statusCompleted

  • Influence of Male Hormones on Regional Fat Metabolism

    NCT01160328 · start 2010-06

    Registered record
    Registry ID
    NCT01160328
    Conditions
    Obesity
    Interventions
    Leuprolide; Testosterone
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2010-06
    Completion
    2013-01
    Enrolment
    39

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObesity
    InterventionLeuprolide; Testosterone
    PhasePhase 1
    Registry statusCompleted

  • A Phase 2 Study to Evaluate Safety and Efficacy of Abiraterone Acetate in Male Participants With Prostate Cancer

    NCT00924469 · start 2009-11

    Registered record
    Registry ID
    NCT00924469
    Conditions
    Prostate Cancer
    Interventions
    Abiraterone; Leuprolide; Prednisone
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2009-11
    Completion
    2012-03
    Enrolment
    58

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Cancer
    InterventionAbiraterone; Leuprolide; Prednisone
    PhasePhase 2
    Registry statusCompleted

  • Neoadjuvant Dasatinib Plus LHRH Analogue Therapy in High-Risk Localized Prostate Cancer

    NCT00860158 · start 2009-03

    Registered record
    Registry ID
    NCT00860158
    Conditions
    Prostate Cancer
    Interventions
    Dasatinib; Leuprolide Acetate (LHRH Analogue); Radical Prostatectomy
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2009-03
    Completion
    2010-12
    Enrolment
    1

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Cancer
    InterventionDasatinib; Leuprolide Acetate (LHRH Analogue); Radical Prostatectomy
    PhasePhase 2
    Registry statusTerminated

  • Oral Microdose Lupron Versus Luteal Estradiol Trial in Poor Responder In Vitro Fertilization (IVF) Patients

    NCT00826839 · start 2009-01

    Registered record
    Registry ID
    NCT00826839
    Conditions
    Infertility
    Interventions
    Oral contraceptive pill and microdose lupron; E2 patch/antagonist
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2009-01
    Completion
    2012-01
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility
    InterventionOral contraceptive pill and microdose lupron; E2 patch/antagonist
    PhasePhase 4
    Registry statusWithdrawn

  • Androgen Deprivation Therapy and Vorinostat Followed by Radical Prostatectomy in Treating Patients With Localized Prostate Cancer

    NCT00589472 · start 2007-11

    Registered record
    Registry ID
    NCT00589472
    Conditions
    Prostate Adenocarcinoma; Stage I Prostate Cancer; Stage IIA Prostate Cancer; Stage IIB Prostate Cancer; Stage III Prostate Cancer
    Interventions
    Bicalutamide; Goserelin Acetate; Laboratory Biomarker Analysis; Leuprolide Acetate; Therapeutic Conventional Surgery; Vorinostat
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2007-11
    Completion
    2010-06
    Enrolment
    19

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Adenocarcinoma; Stage I Prostate Cancer; Stage IIA Prostate Cancer; Stage IIB Prostate Cancer +1 more
    InterventionBicalutamide; Goserelin Acetate; Laboratory Biomarker Analysis; Leuprolide Acetate +2 more
    PhasePhase 2
    Registry statusCompleted

  • A Novel Approach to Endometrial Preparation in Recipients of Donor Eggs

    NCT01424618 · start 2006-01

    Registered record
    Registry ID
    NCT01424618
    Conditions
    Implantation, Embryo
    Interventions
    Leuprolide; Ganirelix
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2006-01
    Completion
    Not recorded
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionImplantation, Embryo
    InterventionLeuprolide; Ganirelix
    PhaseNot applicable
    Registry statusUnknown

  • Oral Androgens in Man-3 (ORAL T-3) Pharmacokinetics of Oral Testosterone

    NCT00161421 · start 2005-03

    Registered record
    Registry ID
    NCT00161421
    Conditions
    Contraception; Hypogonadism
    Interventions
    Oral Testosterone; Leuprolide (Lupron); Dutasteride
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2005-03
    Completion
    2006-07
    Enrolment
    18

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionContraception; Hypogonadism
    InterventionOral Testosterone; Leuprolide (Lupron); Dutasteride
    PhasePhase 2
    Registry statusCompleted