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AMR Drug RepurposingSmart Screeningresearch prototype

Triamcinolone

FDA-approved product (tablet, oral), marketed as Aristocort, Kenacort, Triamcinolone.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Triamcinolone
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Airway obstruction
  • Eye inflammation
  • Hemorrhoid
  • Nasal congestion
  • Skin disease

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Corticosteroids for local oral treatment; Corticosteroids; Corticosteroids, moderately potent (group ii); Corticosteroids, moderately potent, other combinations; Glucocorticoids
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA49.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli30.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae30.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis26.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Triamcinolone in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.2 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-8.5 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.2 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.8 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Triamcinolone with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Comparison of Chitodex Gel Vs NexFoam on Post-operative Outcomes in the Treatment of Chronic Rhinosinusitis

    NCT05083741 · start 2021-12-27

    Registered record
    Registry ID
    NCT05083741
    Conditions
    Chronic Rhinosinusitis
    Interventions
    Chitogel; Nexfoam
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Terminated
    Start
    2021-12-27
    Completion
    2024-08-08
    Enrolment
    7

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Rhinosinusitis
    InterventionChitogel; Nexfoam
    PhaseNot recorded
    Registry statusTerminated

  • Cell Therapy With Cellistem-OA for Symptomatic Knee Osteoarthritis

    NCT04863183 · start 2021-06-01

    Registered record
    Registry ID
    NCT04863183
    Conditions
    Mesenchymal Stem Cells; Knee Osteoarthritis; Cell Therapy
    Interventions
    CELLISTEM-OA; Triamcinolone acetonide
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Unknown
    Start
    2021-06-01
    Completion
    2022-06-30
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMesenchymal Stem Cells; Knee Osteoarthritis; Cell Therapy
    InterventionCELLISTEM-OA; Triamcinolone acetonide
    PhasePhase 1 / Phase 2
    Registry statusUnknown

  • Anti-Viral Effects of Voclosporin in COVID-19 Positive Kidney Transplant Recipients

    NCT04701528 · start 2020-11-15

    Registered record
    Registry ID
    NCT04701528
    Conditions
    Covid19; Kidney Transplant Infection
    Interventions
    Voclosporin; Tacrolimus
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2020-11-15
    Completion
    2022-10-25
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCovid19; Kidney Transplant Infection
    InterventionVoclosporin; Tacrolimus
    PhasePhase 2
    Registry statusCompleted

  • Effect of Zilretta Injection

    NCT04261049 · start 2020-08-01

    Registered record
    Registry ID
    NCT04261049
    Conditions
    Osteoarthritis, Knee
    Interventions
    Triamcinolone Acetonide Extended-Release Injectable Suspension
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2020-08-01
    Completion
    2022-01-10
    Enrolment
    35

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis, Knee
    InterventionTriamcinolone Acetonide Extended-Release Injectable Suspension
    PhasePhase 1
    Registry statusCompleted

  • The Efficacy of Topical Sesame Oil Versus Topical Triamcinolone on Oral Lichen Planus and Salivary Level of Oxidative Stress Biomarker [MDA]

    NCT03738176 · start 2019-12-16

    Registered record
    Registry ID
    NCT03738176
    Conditions
    Oral Lichen Planus
    Interventions
    Sesame Oil; triamcinolone in orabase
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Unknown
    Start
    2019-12-16
    Completion
    2020-12-30
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOral Lichen Planus
    InterventionSesame Oil; triamcinolone in orabase
    PhaseEarly phase 1
    Registry statusUnknown

  • The Use of Suprachoroidal Triamcinolone Acetonide to Treat Macular Edema in Retinal Vein Occlusion

    NCT05038072 · start 2019-07-25

    Registered record
    Registry ID
    NCT05038072
    Conditions
    Macular Edema; Retinal Vein Occlusion
    Interventions
    suprachoroidal injection of Triamcinolone Acetonide.
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-07-25
    Completion
    2021-02-28
    Enrolment
    16

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMacular Edema; Retinal Vein Occlusion
    Interventionsuprachoroidal injection of Triamcinolone Acetonide.
    PhaseNot applicable
    Registry statusCompleted

  • Ultrasound-guided Intervention and Hand Tenosynovitis in Patients With Diabetes Mellitus

    NCT03789526 · start 2018-12-11

    Registered record
    Registry ID
    NCT03789526
    Conditions
    Ultrasound Guided Injection
    Interventions
    ultrasound guidance
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2018-12-11
    Completion
    2019-02-01
    Enrolment
    52

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUltrasound Guided Injection
    Interventionultrasound guidance
    PhaseNot applicable
    Registry statusCompleted

  • The Effect of Micro Fragmented Adipose Tissue (MFAT) on Knee Osteoarthritis

    NCT03467919 · start 2018-04-01

    Registered record
    Registry ID
    NCT03467919
    Conditions
    Osteoarthritis, Knee; Knee Pain
    Interventions
    Micro Fragmented Adipose Tissue; Corticosteroid injection
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2018-04-01
    Completion
    2024-10-29
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis, Knee; Knee Pain
    InterventionMicro Fragmented Adipose Tissue; Corticosteroid injection
    PhasePhase 3
    Registry statusCompleted

  • Kybella With Triamcinolone

    NCT03361176 · start 2018-03-26

    Registered record
    Registry ID
    NCT03361176
    Conditions
    Adiposity
    Interventions
    Injectable sodium deoxycholate; Injectable sodium deoxycholate with Triamcinolone acetate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2018-03-26
    Completion
    2018-12-18
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdiposity
    InterventionInjectable sodium deoxycholate; Injectable sodium deoxycholate with Triamcinolone acetate
    PhasePhase 4
    Registry statusCompleted

  • Asthma Research in Children and Adolescents

    NCT04480242 · start 2017-07-26

    Registered record
    Registry ID
    NCT04480242
    Conditions
    Persistent Asthma; Asthma in Children; Asthma Exacerbation
    Interventions
    Inhaled Corticosteroids (ICs); Fixed-Dose Combination of Inhaled Corticosteroids and Long- Acting Beta-agonist (ICs/LABA); Other treatments; Inhaler device; Regularly monitoring of the Inhalation technique through mobile app
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Active not recruiting
    Start
    2017-07-26
    Completion
    2030-12-31
    Enrolment
    525

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPersistent Asthma; Asthma in Children; Asthma Exacerbation
    InterventionInhaled Corticosteroids (ICs); Fixed-Dose Combination of Inhaled Corticosteroids and Long- Acting Beta-agonist (ICs/LABA); Other treatments; Inhaler device +1 more
    PhaseNot recorded
    Registry statusActive not recruiting

  • Standardized and Modified Corticosteroid Subacromial Injection for Shoulder Impingement Syndrome

    NCT03148353 · start 2017-05-30

    Registered record
    Registry ID
    NCT03148353
    Conditions
    Shoulder Impingement
    Interventions
    Subacromial injection
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2017-05-30
    Completion
    2018-10-01
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionShoulder Impingement
    InterventionSubacromial injection
    PhaseNot applicable
    Registry statusCompleted

  • Mixed Gel of Hydrocortisone and Aluminium Phosphate Preventing Endoscopic Submucosal Dissection Postoperative Stenosis for Patients With Large Esophageal Carcinoma

    NCT03165344 · start 2017-02-10

    Registered record
    Registry ID
    NCT03165344
    Conditions
    Esophageal Stenosis Acquired
    Interventions
    Hydrocortisone sodium succinate mixed with Aluminium Phosphate gel (route of administration); Triamcinolone Acetonide (route of administration); Prednisone (route of administration)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2017-02-10
    Completion
    2019-12-31
    Enrolment
    66

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEsophageal Stenosis Acquired
    InterventionHydrocortisone sodium succinate mixed with Aluminium Phosphate gel (route of administration); Triamcinolone Acetonide (route of administration); Prednisone (route of administration)
    PhaseNot applicable
    Registry statusCompleted

  • Topical Steroid Formulation and Wet Wraps

    NCT02680301 · start 2016-03

    Registered record
    Registry ID
    NCT02680301
    Conditions
    Dermatitis, Atopic
    Interventions
    0.1% triamcinolone CREAM; 0.1% triamcinolone OINTMENT
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2016-03
    Completion
    2018-06-01
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDermatitis, Atopic
    Intervention0.1% triamcinolone CREAM; 0.1% triamcinolone OINTMENT
    PhasePhase 4
    Registry statusCompleted

  • Comparison Between Injections of Steroids and Autologous Platelet Rich Plasma in the Oral Erosions of Pemphigus Vulgaris

    NCT02828163 · start 2016-01

    Registered record
    Registry ID
    NCT02828163
    Conditions
    Oral Pemphigus Vulgaris
    Interventions
    Autologous Platelet rich plasma; Triamcinolone Acetonide
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2016-01
    Completion
    2016-10
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOral Pemphigus Vulgaris
    InterventionAutologous Platelet rich plasma; Triamcinolone Acetonide
    PhasePhase 3
    Registry statusCompleted

  • Study to Characterize the PK and Local Extent and Duration of Exposure From FX006 in Patients With OA of the Knee

    NCT02637323 · start 2015-11

    Registered record
    Registry ID
    NCT02637323
    Conditions
    Osteoarthritis of the Knee
    Interventions
    FX006 32 mg; TCA IR 40
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2015-11
    Completion
    2016-09
    Enrolment
    81

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis of the Knee
    InterventionFX006 32 mg; TCA IR 40
    PhasePhase 2
    Registry statusCompleted