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AMR Drug RepurposingSmart Screeningresearch prototype

Sufentanil Citrate

FDA-approved product (injectable, injection), marketed as Dsuvia, Sufenta Preservative Free, Sufentanil Citrate.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Sufentanil Citrate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Pain

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Opioid anesthetics
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis and E. coli. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA38.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli46.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae17.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis46.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Sufentanil Citrate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Sufentanil Citrate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • The Effect of Perioperative Intravenous Lidocaine Infusion on Post-amputation Pain in Amputee Patients

    NCT07783867 · start 2026-10-01

    Registered record
    Registry ID
    NCT07783867
    Conditions
    Amputation
    Interventions
    Lidocaine Hydrochloride, Injectable; 0.9% normal saline
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2026-10-01
    Completion
    2029-12-30
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAmputation
    InterventionLidocaine Hydrochloride, Injectable; 0.9% normal saline
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Remimazolam for Postoperative Sleep in Elderly Patients

    NCT07740343 · start 2026-08-01

    Registered record
    Registry ID
    NCT07740343
    Conditions
    Postoperative Sleep
    Interventions
    Remimazolam; propofol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2026-08-01
    Completion
    2027-02-28
    Enrolment
    84

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Sleep
    InterventionRemimazolam; propofol
    PhaseNot applicable
    Registry statusRecruiting

  • Dexmedetomidine-esketamine and tDCS for Prevention of Neurocognitive Complications After Surgery

    NCT07576517 · start 2026-06

    Registered record
    Registry ID
    NCT07576517
    Conditions
    Older Patients; Surgery; Dexmedetomidine; Esketamine; Transcranial Direct Current Stimulation; Perioperative Neurocognitive Disorders
    Interventions
    Dex-Esk; Placebo; Active tDCS; Sham tDCS
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Not yet recruiting
    Start
    2026-06
    Completion
    2030-06
    Enrolment
    1,160

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOlder Patients; Surgery; Dexmedetomidine; Esketamine +2 more
    InterventionDex-Esk; Placebo; Active tDCS; Sham tDCS
    PhasePhase 4
    Registry statusNot yet recruiting

  • The Efficacy and Safety of Liposomal Bupivacaine in Relieving Postoperative Pain After Video-assisted Thoracoscopic Surgery

    NCT07432711 · start 2026-03-02

    Registered record
    Registry ID
    NCT07432711
    Conditions
    Video-assisted Thoracoscopic Surgery (VATS); Pain Management; Liposomal Bupivacaine; Local Injection
    Interventions
    Bupivacaine hydrochloride; Liposomal bupivacaine plus bupivacaine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2026-03-02
    Completion
    2027-06-30
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVideo-assisted Thoracoscopic Surgery (VATS); Pain Management; Liposomal Bupivacaine; Local Injection
    InterventionBupivacaine hydrochloride; Liposomal bupivacaine plus bupivacaine
    PhaseNot applicable
    Registry statusRecruiting

  • Effect of Tegileridine Versus Sufentanil as Analgesic Components on Opioid-Induced Cough During Anesthesia Induction

    NCT07323043 · start 2026-01-15

    Registered record
    Registry ID
    NCT07323043
    Conditions
    General Anesthetic Drug Adverse Reaction
    Interventions
    Tegilerdine; Sufentanil
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2026-01-15
    Completion
    2026-10-13
    Enrolment
    190

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGeneral Anesthetic Drug Adverse Reaction
    InterventionTegilerdine; Sufentanil
    PhaseNot applicable
    Registry statusRecruiting

  • Impact of Perioperative Dexmedetomidine and Esketamine on Postoperative Quality of Recovery

    NCT07308756 · start 2026-01-05

    Registered record
    Registry ID
    NCT07308756
    Conditions
    General Anesthesia; Surgery; Dexmedetomidine; Esketamine; Quality of Recovery
    Interventions
    Dexmedetomidine; Esketamine; Dexmedetomidine-esketamine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2026-01-05
    Completion
    2027-04
    Enrolment
    316

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGeneral Anesthesia; Surgery; Dexmedetomidine; Esketamine +1 more
    InterventionDexmedetomidine; Esketamine; Dexmedetomidine-esketamine; Placebo
    PhasePhase 4
    Registry statusRecruiting

  • Effects of Rectal Indomethacin Suppository on Postoperative CRBD in Patients Undergoing LRP

    NCT07607990 · start 2026-01-01

    Registered record
    Registry ID
    NCT07607990
    Conditions
    Prostate Cancer (Post Prostatectomy); Perioperative Anesthetic; Catheter-related Bladder Discomfort (CRBD)
    Interventions
    Indomethacin suppository
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2026-01-01
    Completion
    2026-12-31
    Enrolment
    130

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Cancer (Post Prostatectomy); Perioperative Anesthetic; Catheter-related Bladder Discomfort (CRBD)
    InterventionIndomethacin suppository
    PhaseNot applicable
    Registry statusRecruiting

  • Effects and Safety of Oliceridine in Anesthesia Induction:A Randomised Controlled Trial

    NCT07372209 · start 2025-10-01

    Registered record
    Registry ID
    NCT07372209
    Conditions
    Gynecological Laparoscopic Surgery; General Anesthetic; Intubation
    Interventions
    Oliceridine; Sufentanil
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2025-10-01
    Completion
    2025-12-31
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGynecological Laparoscopic Surgery; General Anesthetic; Intubation
    InterventionOliceridine; Sufentanil
    PhaseNot applicable
    Registry statusCompleted

  • Oliceridine on Postoperative Nausea and Vomiting in Gynecological Laparoscopic Surgery

    NCT07026162 · start 2025-07-21

    Registered record
    Registry ID
    NCT07026162
    Conditions
    Gynecologic Surgical Procedures; Postoperative Nausea and Vomiting (PONV); Laparoscopy
    Interventions
    Oliceridine; Sufentanil
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2025-07-21
    Completion
    2026-02-25
    Enrolment
    96

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGynecologic Surgical Procedures; Postoperative Nausea and Vomiting (PONV); Laparoscopy
    InterventionOliceridine; Sufentanil
    PhasePhase 4
    Registry statusCompleted

  • Comparison of the Analgesic Effect of Oliceridine Versus Morphine or Sufentanil for Postoperative Analgesia in Lumbar Surgeries: a Randomized Control Trial

    NCT06990893 · start 2025-06-01

    Registered record
    Registry ID
    NCT06990893
    Conditions
    Sufentanil; Morphine; Validity; Safety; Oliceridine
    Interventions
    Oliceridine; Morphine; Sufentanil
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2025-06-01
    Completion
    2026-10-01
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSufentanil; Morphine; Validity; Safety +1 more
    InterventionOliceridine; Morphine; Sufentanil
    PhaseNot applicable
    Registry statusRecruiting

  • Effect of Low-dose EsketaMine on dElirium in High-risk Elderly Patients uNdergoing elecTive Surgery (ELEMENT)

    NCT06817239 · start 2025-02-12

    Registered record
    Registry ID
    NCT06817239
    Conditions
    Delirium in Old Age; Delirium, Postoperative; Anesthesia; Cognitive Dysfunction; Pain, Postoperative; Esketamine; Non-cardiac Surgery
    Interventions
    Esketamine; Normal saline
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2025-02-12
    Completion
    2027-07
    Enrolment
    1,670

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDelirium in Old Age; Delirium, Postoperative; Anesthesia; Cognitive Dysfunction +3 more
    InterventionEsketamine; Normal saline
    PhaseNot applicable
    Registry statusRecruiting

  • Regional Anesthesia Techniques in Breast Surgery

    NCT06779656 · start 2025-02-01

    Registered record
    Registry ID
    NCT06779656
    Conditions
    Augmentation; Fibroadenoma; Mastectomy
    Interventions
    General Anesthesia (GA); Paravertebral Block (PVB); Rhomboid Intercostal and Subserratus Plane Block (RISS); Pectoral Nerves Block II (PECS II); Intercostal Nerve Block (INB); Serratus Anterior Plane Block (SAPB); Epidural Block
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2025-02-01
    Completion
    2025-05-10
    Enrolment
    180

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAugmentation; Fibroadenoma; Mastectomy
    InterventionGeneral Anesthesia (GA); Paravertebral Block (PVB); Rhomboid Intercostal and Subserratus Plane Block (RISS); Pectoral Nerves Block II (PECS II) +3 more
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Outcomes for Anesthesiologist-Led Care of Analgesic Protocol in Anorectal Surgery

    NCT06015165 · start 2024-09-10

    Registered record
    Registry ID
    NCT06015165
    Conditions
    Postoperative Pain
    Interventions
    Analgesia plan for Anes. Group; Analgesia plan for Surg. Group; Multi-modal analgesia during the surgery
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2024-09-10
    Completion
    2025-10-10
    Enrolment
    216

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Pain
    InterventionAnalgesia plan for Anes. Group; Analgesia plan for Surg. Group; Multi-modal analgesia during the surgery
    PhaseNot applicable
    Registry statusRecruiting

  • Effects of Esketamine on Recovery of Consciousness After Propofol Anesthesia

    NCT06430645 · start 2024-05-05

    Registered record
    Registry ID
    NCT06430645
    Conditions
    Post-anesthesia Recovery
    Interventions
    Esketamine; Esketamine; Saline
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2024-05-05
    Completion
    2024-12-31
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost-anesthesia Recovery
    InterventionEsketamine; Esketamine; Saline
    PhaseNot applicable
    Registry statusUnknown

  • Effect of the PIEB Versus CEI on the Quality of Postoperative Recovery in Patients Undergoing VATS Lobectomy

    NCT05930405 · start 2023-10-20

    Registered record
    Registry ID
    NCT05930405
    Conditions
    Video-assisted Thoracic Surgery
    Interventions
    programmed intermittent epidural bolus; continuous epidural infusion
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-10-20
    Completion
    2024-10-30
    Enrolment
    252

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVideo-assisted Thoracic Surgery
    Interventionprogrammed intermittent epidural bolus; continuous epidural infusion
    PhaseNot applicable
    Registry statusCompleted