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AMR Drug RepurposingSmart Screeningresearch prototype

Sufentanil Citrate

FDA-approved product (injectable, injection), marketed as Dsuvia, Sufenta Preservative Free, Sufentanil Citrate.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Sufentanil Citrate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Pain

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Opioid anesthetics
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis and E. coli. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA38.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli46.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae17.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis46.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Sufentanil Citrate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Sufentanil Citrate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Hybrid Closure of Congenital Heart Disease

    NCT02794584 · start 2011-01

    Registered record
    Registry ID
    NCT02794584
    Conditions
    Pediatric Ventricular Septal Defects
    Interventions
    sufentanil anesthesia; Hybrid closure; Control
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-01
    Completion
    2016-12
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPediatric Ventricular Septal Defects
    Interventionsufentanil anesthesia; Hybrid closure; Control
    PhaseNot applicable
    Registry statusCompleted

  • A Dosing and Efficacy Study of Intra-nasal Sufentanil for Moderate to Severe Pain

    NCT01012999 · start 2009-11

    Registered record
    Registry ID
    NCT01012999
    Conditions
    Pain; Opiate
    Interventions
    sufentanil
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Terminated
    Start
    2009-11
    Completion
    2011-03
    Enrolment
    16

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain; Opiate
    Interventionsufentanil
    PhasePhase 1 / Phase 2
    Registry statusTerminated

  • Surgical Pleth Index (SPI) Guided Analgesia During Sevoflurane Anesthesia

    NCT01525537 · start 2009-03

    Registered record
    Registry ID
    NCT01525537
    Conditions
    Balanced Anesthesia
    Interventions
    administration of sufentanil; sufentanil
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-03
    Completion
    2011-10
    Enrolment
    82

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBalanced Anesthesia
    Interventionadministration of sufentanil; sufentanil
    PhaseNot applicable
    Registry statusCompleted

  • Myocardial Injury in Remifentanil-based Versus Sevoflurane-sufentanil Balanced Regimens in OPCAB Surgery

    NCT02499445 · start 2007-11

    Registered record
    Registry ID
    NCT02499445
    Conditions
    Ischemic Heart Disease
    Interventions
    Remifentanil; sevoflurane 1; sevoflurane 2; propofol; sufentanil
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2007-11
    Completion
    2014-11
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIschemic Heart Disease
    InterventionRemifentanil; sevoflurane 1; sevoflurane 2; propofol +1 more
    PhaseNot applicable
    Registry statusCompleted

  • Effect of Epidural Anesthesia and Analgesia on Patients' Outcomes After Liver Resection

    NCT01617811 · start 2007-08

    Registered record
    Registry ID
    NCT01617811
    Conditions
    Hepatectomy
    Interventions
    epidural anesthesia and analgesia
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2007-08
    Completion
    2008-12
    Enrolment
    26

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHepatectomy
    Interventionepidural anesthesia and analgesia
    PhaseNot applicable
    Registry statusCompleted