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AMR Drug RepurposingSmart Screeningresearch prototype

Chlorhexidine Gluconate

FDA-approved product (solution, topical), marketed as Bioscrub, Brian Care, Chg Scrub and 17 more.

Registered studies
50+
Lab records
5
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Chlorhexidine Gluconate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Eye infection
  • Gingivitis
  • Infection
  • Periodontitis
  • Pharyngitis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Antiinfectives and antiseptics for local oral treatment; Antiinfectives; Biguanides and amidines; Medicated dressings with antiinfectives; Antiseptics
Anti-infective classification
Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC A01AB03; WHO ATC D08AC02; WHO ATC D08AC52; WHO ATC D09AA12; WHO ATC S01AX09; WHO ATC S02AA09; WHO ATC S03AA04

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against K. pneumoniae, MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA60.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli58.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae69.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis42.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 1 of 1 lab record
  • E. coli: measured active in 3 of 3 lab records
  • K. pneumoniae: measured active in 1 of 1 lab record
Open Chlorhexidine Gluconate in ChEMBL Registered studies below
Show the 5 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-8.0 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.3 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.4 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-8.1 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Chlorhexidine Gluconate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • A Comparative Study of the Antibacterial Effects of Two Preoperative Hair Removal Methods in Male Patients With Urethral Stricture

    NCT07508566 · start 2026-04-01

    Registered record
    Registry ID
    NCT07508566
    Conditions
    Urethral Stricture
    Interventions
    Wiping with wet wipes containing 2% chlorhexidine gluconate (CHG).
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2026-04-01
    Completion
    2026-08-31
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUrethral Stricture
    InterventionWiping with wet wipes containing 2% chlorhexidine gluconate (CHG).
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Chlorhexidine vs Essential Oil Mouthwash for Plaque Control

    NCT07822256 · start 2026-02-03

    Registered record
    Registry ID
    NCT07822256
    Conditions
    Gingivitis Infection; Dental Plaque
    Interventions
    Chlorhexidine Gluconate Mouthwash; Essential Oil mouthwash
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2026-02-03
    Completion
    2026-08-28
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGingivitis Infection; Dental Plaque
    InterventionChlorhexidine Gluconate Mouthwash; Essential Oil mouthwash
    PhaseNot applicable
    Registry statusCompleted

  • Homemade Herbal Mouthwash in Gingivitis. A Randomized Clinical Trial.

    NCT07401069 · start 2026-02-01

    Registered record
    Registry ID
    NCT07401069
    Conditions
    Gingivitis
    Interventions
    Chlorhexidine 0,12%; herbal Mouthwash
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Not yet recruiting
    Start
    2026-02-01
    Completion
    2026-07-30
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGingivitis
    InterventionChlorhexidine 0,12%; herbal Mouthwash
    PhasePhase 3
    Registry statusNot yet recruiting

  • Machine Learning Prediction of Possible Central Line Associated Blood Stream Infections and Rate of Reduction

    NCT07108660 · start 2025-07-01

    Registered record
    Registry ID
    NCT07108660
    Conditions
    Central Line Associated Blood Stream Infections (CLABSI)
    Interventions
    Infection Preventionist Led Best Practices Reminders
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2025-07-01
    Completion
    2027-12
    Enrolment
    17,800

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCentral Line Associated Blood Stream Infections (CLABSI)
    InterventionInfection Preventionist Led Best Practices Reminders
    PhaseNot applicable
    Registry statusRecruiting

  • Antimicrobial Photodynamic Therapy Or Lingual Scraper Associated With Periodontal Treatment In The Reduction Of Halitosis.

    NCT07433816 · start 2025-06-20

    Registered record
    Registry ID
    NCT07433816
    Conditions
    Halitosis; Halitoses; Fetor Oris; Oral Malodor
    Interventions
    Tongue scraper and oral rinse treatment; Tongue scraper and aPDT (photodynamic therapy); full mouth scaling
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2025-06-20
    Completion
    2025-12-30
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHalitosis; Halitoses; Fetor Oris; Oral Malodor
    InterventionTongue scraper and oral rinse treatment; Tongue scraper and aPDT (photodynamic therapy); full mouth scaling
    PhaseNot applicable
    Registry statusCompleted

  • Effects of Chlorhexidine Gluconate, Ozonated Water and Hypochlorous Acid Solutions Used in the Oral Care of Patients Supported by Mechanical Ventilation on the Integrity of the Oral Mucosa

    NCT06942026 · start 2025-04-27

    Registered record
    Registry ID
    NCT06942026
    Conditions
    Oral Mucosal Disorder
    Interventions
    Control 1
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Not yet recruiting
    Start
    2025-04-27
    Completion
    2025-09-30
    Enrolment
    63

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOral Mucosal Disorder
    InterventionControl 1
    PhasePhase 4
    Registry statusNot yet recruiting

  • A Prospective Cohort Study to Evaluate the Safety, Efficacy, and Usability of the EpiZact Device

    NCT06729255 · start 2025-03-15

    Registered record
    Registry ID
    NCT06729255
    Conditions
    Postdural Puncture Headache; Epidural Analgesia, Obstetric
    Interventions
    EpiZact-assisted epidural placement
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Not yet recruiting
    Start
    2025-03-15
    Completion
    2026-12-31
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostdural Puncture Headache; Epidural Analgesia, Obstetric
    InterventionEpiZact-assisted epidural placement
    PhasePhase 4
    Registry statusNot yet recruiting

  • IDEAL: Efficacy of Porcine Placental Extracellular Matrix Augmented Plus Standard of Care (SOC) Versus SOC Alone for the Management of Diabetic Foot Ulcers

    NCT06616844 · start 2025-02-12

    Registered record
    Registry ID
    NCT06616844
    Conditions
    Wound Heal; Ulcer
    Interventions
    InnovaMatrix® AC
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2025-02-12
    Completion
    2028-01
    Enrolment
    235

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionWound Heal; Ulcer
    InterventionInnovaMatrix® AC
    PhaseNot applicable
    Registry statusRecruiting

  • Central Venous Catheter vs Midline in Difficulty Access Patient - Pilot Trial

    NCT06719869 · start 2025-01-13

    Registered record
    Registry ID
    NCT06719869
    Conditions
    Difficult Intravenous Access
    Interventions
    Midline intravenous catheter; Central Venous Catheter (CVC):
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2025-01-13
    Completion
    2025-09-04
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDifficult Intravenous Access
    InterventionMidline intravenous catheter; Central Venous Catheter (CVC):
    PhaseNot applicable
    Registry statusCompleted

  • Single Lumen Midline Catheter vs Long Peripheral Intravenous Cather for Difficult Intravenous Access in the ED

    NCT06668766 · start 2025-01-01

    Registered record
    Registry ID
    NCT06668766
    Conditions
    Difficult Intravenous Access; Midline Catheter; Peripheral Intravenous Catheter; Emergency Department Patient
    Interventions
    10-cm Single Lumen Mildine; 4.78 cm Long Peripheral Intravenous Catheter
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2025-01-01
    Completion
    2026-03-03
    Enrolment
    270

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDifficult Intravenous Access; Midline Catheter; Peripheral Intravenous Catheter; Emergency Department Patient
    Intervention10-cm Single Lumen Mildine; 4.78 cm Long Peripheral Intravenous Catheter
    PhaseNot applicable
    Registry statusCompleted

  • Chlorhexidine Lavage for Recurrent Urinary Tract Infection

    NCT06598514 · start 2024-12-23

    Registered record
    Registry ID
    NCT06598514
    Conditions
    Urinary Tract Infections; Recurrent Urinary Tract Infection
    Interventions
    Chlorhexidine; Sterile Water
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Active not recruiting
    Start
    2024-12-23
    Completion
    2026-06
    Enrolment
    136

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUrinary Tract Infections; Recurrent Urinary Tract Infection
    InterventionChlorhexidine; Sterile Water
    PhasePhase 4
    Registry statusActive not recruiting

  • A Comparison of Chlorhexidine and Green Tea Mouthwash in Patients With Gingivitis and Their Salivary Neutrophil and TAC Levels

    NCT06875440 · start 2024-09-22

    Registered record
    Registry ID
    NCT06875440
    Conditions
    Periodontal Diseases
    Interventions
    CHX mouthwash
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Enrolling by invitation
    Start
    2024-09-22
    Completion
    2025-04-20
    Enrolment
    84

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeriodontal Diseases
    InterventionCHX mouthwash
    PhaseNot applicable
    Registry statusEnrolling by invitation

  • Effects of Dry Needling on Vertical Jump Performance

    NCT06184672 · start 2024-02-08

    Registered record
    Registry ID
    NCT06184672
    Conditions
    Sports Physical Therapy
    Interventions
    dry needling
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2024-02-08
    Completion
    2024-03-12
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSports Physical Therapy
    Interventiondry needling
    PhaseNot applicable
    Registry statusUnknown

  • Efficacy of Hypochlorous Acid as a Postoperative Wound Antiseptic

    NCT06760403 · start 2023-05-02

    Registered record
    Registry ID
    NCT06760403
    Conditions
    Wound Healing
    Interventions
    Hypochlorous acid
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-05-02
    Completion
    2023-12-01
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionWound Healing
    InterventionHypochlorous acid
    PhaseNot applicable
    Registry statusCompleted

  • Hepatic Venous Pressure Gradient and Elastography in Porto-sinusoidal Vascular Disorder

    NCT05719857 · start 2023-03

    Registered record
    Registry ID
    NCT05719857
    Conditions
    Portal Hypertension; Non-Cirrhotic Portal Hypertension; Non-Cirrhotic Portal Fibrosis; Regenerative Nodular Hyperplasia; Incomplete Septal Cirrhosis; Obliterative Portal Venopathy; Idiopathic Non-Cirrhotic Portal Hypertension; Hepatoportal Sclerosis; Idiopathic Portal Hypertension; Vascular Disorder of Liver
    Interventions
    Hepatic vein pressure gradient measurement; Ultrasound-guided percutaneous liver biopsy; Multiparametric Abdominal Magnetic Resonance with Elastography
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2023-03
    Completion
    2024-07
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPortal Hypertension; Non-Cirrhotic Portal Hypertension; Non-Cirrhotic Portal Fibrosis; Regenerative Nodular Hyperplasia +6 more
    InterventionHepatic vein pressure gradient measurement; Ultrasound-guided percutaneous liver biopsy; Multiparametric Abdominal Magnetic Resonance with Elastography
    PhaseNot applicable
    Registry statusUnknown