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AMR Drug RepurposingSmart Screeningresearch prototype

Chlorhexidine Gluconate

FDA-approved product (solution, topical), marketed as Bioscrub, Brian Care, Chg Scrub and 17 more.

Registered studies
50+
Lab records
5
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Chlorhexidine Gluconate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Eye infection
  • Gingivitis
  • Infection
  • Periodontitis
  • Pharyngitis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Antiinfectives and antiseptics for local oral treatment; Antiinfectives; Biguanides and amidines; Medicated dressings with antiinfectives; Antiseptics
Anti-infective classification
Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC A01AB03; WHO ATC D08AC02; WHO ATC D08AC52; WHO ATC D09AA12; WHO ATC S01AX09; WHO ATC S02AA09; WHO ATC S03AA04

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli, K. pneumoniae and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA60.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli58.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae69.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis42.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 1 of 1 lab record
  • E. coli: measured active in 3 of 3 lab records
  • K. pneumoniae: measured active in 1 of 1 lab record
Open Chlorhexidine Gluconate in ChEMBL Registered studies below
Show the 5 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-8.0 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.3 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.4 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-8.1 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Chlorhexidine Gluconate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Influence of Intra Canal Medications on Postoperative Flare-up in Endodontic Re-treatment Cases

    NCT03064191 · start 2017-09

    Registered record
    Registry ID
    NCT03064191
    Conditions
    Postoperative Pain; Pain, Dental
    Interventions
    calcium hydroxide chlorhexidine combination; calcium hydroxide intra-canal medicament
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2017-09
    Completion
    2018-04-13
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Pain; Pain, Dental
    Interventioncalcium hydroxide chlorhexidine combination; calcium hydroxide intra-canal medicament
    PhaseNot applicable
    Registry statusUnknown

  • Post Operative Pain and Level of Endotoxins With Calcium Hydroxide and Calcium Hydroxide Mixed With Chlorhexidine in Treating Necrotic Teeth

    NCT03009006 · start 2017-01-03

    Registered record
    Registry ID
    NCT03009006
    Conditions
    Necrotic Pulp
    Interventions
    Chlorhexidine 2% gel - Calcium Hydroxide Paste - Non-Setting; Calcium Hydroxide Paste - Non-Setting
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2017-01-03
    Completion
    2018-01
    Enrolment
    45

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNecrotic Pulp
    InterventionChlorhexidine 2% gel - Calcium Hydroxide Paste - Non-Setting; Calcium Hydroxide Paste - Non-Setting
    PhaseNot applicable
    Registry statusUnknown

  • Effectiveness of the Ozone Application in Two-Visit Indirect Pulp Therapy of Permanent Molars With Deep Carious Lesion

    NCT03693066 · start 2017-01

    Registered record
    Registry ID
    NCT03693066
    Conditions
    Ozone; Caries
    Interventions
    Ozone; chlorhexidine digluconate; Control
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2017-01
    Completion
    2018-01
    Enrolment
    105

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOzone; Caries
    InterventionOzone; chlorhexidine digluconate; Control
    PhaseNot applicable
    Registry statusCompleted

  • Evaluating Safety and Effectiveness of Octenidine Dihydrochloride

    NCT03140254 · start 2016-09

    Registered record
    Registry ID
    NCT03140254
    Conditions
    Preoperative Skin Preparation
    Interventions
    Chlorhexidine gluconate; N,N'-(1,10-decanediyldi-1(4H)-Pyridinyl-4-ylidene)-Bis-(1-octanamine) Dihydrochloride; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2016-09
    Completion
    2017-03-17
    Enrolment
    145

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPreoperative Skin Preparation
    InterventionChlorhexidine gluconate; N,N'-(1,10-decanediyldi-1(4H)-Pyridinyl-4-ylidene)-Bis-(1-octanamine) Dihydrochloride; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Use of 2% Chlorhexidine Cloths Reduce Surgical Site Infections

    NCT02385708 · start 2015-08

    Registered record
    Registry ID
    NCT02385708
    Conditions
    Surgical Site Infection
    Interventions
    2% Chlorohexidine Gluconate Standard of Care; 2% Chlorohexidine Gluconate Chin to Toe
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-08
    Completion
    2018-06-21
    Enrolment
    163

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgical Site Infection
    Intervention2% Chlorohexidine Gluconate Standard of Care; 2% Chlorohexidine Gluconate Chin to Toe
    PhaseNot applicable
    Registry statusCompleted

  • A Clinical Trial to Study the Effects of Two Home Made Mouthwashes in Patients With Gum Diseases

    NCT02546804 · start 2015-06

    Registered record
    Registry ID
    NCT02546804
    Conditions
    Gingivitis; Periodontitis
    Interventions
    HOT SALT WATER; POTASSIUM PERMANGANATE; CHLORHEXIDINE
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-06
    Completion
    2015-12
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGingivitis; Periodontitis
    InterventionHOT SALT WATER; POTASSIUM PERMANGANATE; CHLORHEXIDINE
    PhaseNot applicable
    Registry statusCompleted

  • Mouthwash With Chlorhexidine 0.12%/Ethyl Alcohol 7% Compared to Ethyl Alcohol 7%

    NCT02414581 · start 2015-04

    Registered record
    Registry ID
    NCT02414581
    Conditions
    Neutropenia
    Interventions
    chlorhexidine 0.12%/Ethyl alcohol 7%; Ethyl Alcohol 7%; Chlorhexidine 2%/Ethyl alcohol 7%
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2015-04
    Completion
    2016-09
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeutropenia
    Interventionchlorhexidine 0.12%/Ethyl alcohol 7%; Ethyl Alcohol 7%; Chlorhexidine 2%/Ethyl alcohol 7%
    PhasePhase 3
    Registry statusCompleted

  • Antimicrobial Agent for Reducing Bacteria in Aerosols and Oral Cavity

    NCT02319668 · start 2015-02-01

    Registered record
    Registry ID
    NCT02319668
    Conditions
    Dental Prophylaxis and Implant Surgery
    Interventions
    0.2% w/v Chlorhexidine digluconate; Sodium fluoride toothpaste (Aquafresh Mild & Minty)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-02-01
    Completion
    2016-02-29
    Enrolment
    38

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDental Prophylaxis and Implant Surgery
    Intervention0.2% w/v Chlorhexidine digluconate; Sodium fluoride toothpaste (Aquafresh Mild & Minty)
    PhasePhase 4
    Registry statusCompleted

  • HYPOCHLOROUS ACID SUBSTANTIVITY AS ANTIPLAQUE AGENT (HOCl-SAP)

    NCT03174756 · start 2015-01-15

    Registered record
    Registry ID
    NCT03174756
    Conditions
    Hypochlorous Acid; Mouthwashes
    Interventions
    Hypochlorous Acid; Chlorhexidine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2015-01-15
    Completion
    2016-11-30
    Enrolment
    75

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypochlorous Acid; Mouthwashes
    InterventionHypochlorous Acid; Chlorhexidine; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Preoperative Chlorhexidine Gluconate (CHG) Cloth on Healthy Subjects

    NCT02222896 · start 2014-08

    Registered record
    Registry ID
    NCT02222896
    Conditions
    Surgery
    Interventions
    Chlorhexidine Gluconate; Vehicle; DynaHex-2
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2014-08
    Completion
    2015-05
    Enrolment
    347

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgery
    InterventionChlorhexidine Gluconate; Vehicle; DynaHex-2
    PhasePhase 3
    Registry statusCompleted

  • Comparison of Resin Salve and Octenidine in Patients With Neuropathic Diabetic Foot Ulcers

    NCT02169167 · start 2014-06

    Registered record
    Registry ID
    NCT02169167
    Conditions
    Diabetes Mellitus; Diabetes Complications; Diabetic Neuropathies; Wound Infection
    Interventions
    Resin salve treatment; Octenidine treatment
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-06
    Completion
    2015-05
    Enrolment
    35

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetes Mellitus; Diabetes Complications; Diabetic Neuropathies; Wound Infection
    InterventionResin salve treatment; Octenidine treatment
    PhaseNot applicable
    Registry statusCompleted

  • Trial of 2% Chlorhexidine Bathing on Nosocomial Infections in the Surgical Intensive Care Unit

    NCT01640925 · start 2012-07

    Registered record
    Registry ID
    NCT01640925
    Conditions
    Cross Infection; Pneumonia, Ventilator-associated; Catheter-related Infections; Infection Due to Indwelling Urinary Catheter; Surgical Wound Infection
    Interventions
    Chlorhexidine gluconate; Standard bathing
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-07
    Completion
    2014-09
    Enrolment
    350

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCross Infection; Pneumonia, Ventilator-associated; Catheter-related Infections; Infection Due to Indwelling Urinary Catheter +1 more
    InterventionChlorhexidine gluconate; Standard bathing
    PhaseNot applicable
    Registry statusCompleted

  • Prospective, Randomized Study Evaluating The Efficacy of Chlorhexidine Gluconate Impregnated No-Rinse Cloths.

    NCT02469311 · start 2012-03

    Registered record
    Registry ID
    NCT02469311
    Conditions
    Osteoarthritis; Infection
    Interventions
    chlorhexidine impregnated cloths; Standard of care bathing with antibacterial soap and water
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2012-03
    Completion
    2014-04
    Enrolment
    539

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis; Infection
    Interventionchlorhexidine impregnated cloths; Standard of care bathing with antibacterial soap and water
    PhasePhase 2
    Registry statusTerminated

  • Post-Operative Colonization Rates of Femoral Nerve Catheters Treated With Chlorhexidine-Impregnated Patch

    NCT01411891 · start 2011-08

    Registered record
    Registry ID
    NCT01411891
    Conditions
    Catheter Infections; Spinal Catheter (Epidural) (Subdural); Complications, Infection or Inflammation
    Interventions
    Chlorhexidine impregnated patch (Biopatch)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-08
    Completion
    2012-04
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCatheter Infections; Spinal Catheter (Epidural) (Subdural); Complications, Infection or Inflammation
    InterventionChlorhexidine impregnated patch (Biopatch)
    PhasePhase 4
    Registry statusCompleted

  • Determination of a Threshold for Mouth Rinse Induced Discoloration of Teeth

    NCT01382914 · start 2011-04

    Registered record
    Registry ID
    NCT01382914
    Conditions
    Discoloration of Teeth
    Interventions
    chlorhexidine 0.12%
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-04
    Completion
    2011-05
    Enrolment
    16

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiscoloration of Teeth
    Interventionchlorhexidine 0.12%
    PhaseNot applicable
    Registry statusCompleted