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AMR Drug RepurposingSmart Screeningresearch prototype

Chlorhexidine Gluconate

FDA-approved product (solution, topical), marketed as Bioscrub, Brian Care, Chg Scrub and 17 more.

Registered studies
50+
Lab records
5
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Chlorhexidine Gluconate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Eye infection
  • Gingivitis
  • Infection
  • Periodontitis
  • Pharyngitis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Antiinfectives and antiseptics for local oral treatment; Antiinfectives; Biguanides and amidines; Medicated dressings with antiinfectives; Antiseptics
Anti-infective classification
Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC A01AB03; WHO ATC D08AC02; WHO ATC D08AC52; WHO ATC D09AA12; WHO ATC S01AX09; WHO ATC S02AA09; WHO ATC S03AA04

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli, K. pneumoniae and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA60.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli58.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae69.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis42.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 1 of 1 lab record
  • E. coli: measured active in 3 of 3 lab records
  • K. pneumoniae: measured active in 1 of 1 lab record
Open Chlorhexidine Gluconate in ChEMBL Registered studies below
Show the 5 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-8.0 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.3 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.4 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-8.1 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Chlorhexidine Gluconate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Ultrasound-assisted or Landmark-based Intrathecal Administration of Nusinersen in Adult Patients With Spinal Muscular Atrophy (The EchoSpin Study)

    NCT05644899 · start 2022-12-16

    Registered record
    Registry ID
    NCT05644899
    Conditions
    Anesthesia, Spinal; Spinal Puncture Complications; Spinal Muscular Atrophy; Ultrasonography
    Interventions
    Interlaminar ultrasound-assisted intrathecal administration of nusinersen; Landmark-based intrathecal administration of nusinersen
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2022-12-16
    Completion
    2023-01-10
    Enrolment
    51

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnesthesia, Spinal; Spinal Puncture Complications; Spinal Muscular Atrophy; Ultrasonography
    InterventionInterlaminar ultrasound-assisted intrathecal administration of nusinersen; Landmark-based intrathecal administration of nusinersen
    PhaseNot recorded
    Registry statusCompleted

  • Hyaluronic Gel vs Chlorhexidine in Periodontal Patients

    NCT05312606 · start 2022-04-04

    Registered record
    Registry ID
    NCT05312606
    Conditions
    Periodontal Diseases
    Interventions
    Aftoral Oral gel; Unidea Chlorhexidine digluconate mouthwash 0.20%
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-04-04
    Completion
    2022-11-05
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeriodontal Diseases
    InterventionAftoral Oral gel; Unidea Chlorhexidine digluconate mouthwash 0.20%
    PhaseNot applicable
    Registry statusCompleted

  • OZOCLO_MUCOSITIS: a New Protocol for Prevention of Oral Mucositis

    NCT05211622 · start 2022-03-10

    Registered record
    Registry ID
    NCT05211622
    Conditions
    Mucositis (MeSH Unique ID: D052016); Stomatitis (MeSH Unique ID: D013280)
    Interventions
    1. alpha acid lipoic - tables; 2. ozonated oil - mouthwash; 3. chlorhexidine 0,2% - mouthwash; 4. sodium bicarbonate 5% solution - mouthwash
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2022-03-10
    Completion
    2023-01-10
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMucositis (MeSH Unique ID: D052016); Stomatitis (MeSH Unique ID: D013280)
    Intervention1. alpha acid lipoic - tables; 2. ozonated oil - mouthwash; 3. chlorhexidine 0,2% - mouthwash; 4. sodium bicarbonate 5% solution - mouthwash
    PhasePhase 4
    Registry statusUnknown

  • Effects of Two Daily CHX Mouthrinses on Plaque, Gingivitis and Staining

    NCT07351370 · start 2022-01-15

    Registered record
    Registry ID
    NCT07351370
    Conditions
    Mouthwashes; Chlorhexidine; Dental Plaque; Gingival and Periodontal Disease; Randomized Controlled Trial
    Interventions
    chlorhexidine/ cetylpyridinium chloride/ hydrogen peroxide mouthwash; Chlorhexidine/ cetylpyridinium chloride; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2022-01-15
    Completion
    2022-07-20
    Enrolment
    81

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMouthwashes; Chlorhexidine; Dental Plaque; Gingival and Periodontal Disease +1 more
    Interventionchlorhexidine/ cetylpyridinium chloride/ hydrogen peroxide mouthwash; Chlorhexidine/ cetylpyridinium chloride; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Skip Prep of Vaginal Delivery to Prevent Puerperal / Perinatal Infection in Vaginal Delivery

    NCT05122169 · start 2021-12

    Registered record
    Registry ID
    NCT05122169
    Conditions
    Vaginal Delivery; Surgical Site Infection
    Interventions
    Povidone-Iodine; Chlorhexidine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2021-12
    Completion
    2026-05-31
    Enrolment
    4,140

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVaginal Delivery; Surgical Site Infection
    InterventionPovidone-Iodine; Chlorhexidine
    PhaseNot applicable
    Registry statusUnknown

  • Preterm Labor Prevention Using Vaginal Antiseptics Prior to 16 Weeks of Gestation

    NCT05944094 · start 2021-06-01

    Registered record
    Registry ID
    NCT05944094
    Conditions
    Preterm Birth
    Interventions
    Clorhexidine
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2021-06-01
    Completion
    2023-06-16
    Enrolment
    1,117

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPreterm Birth
    InterventionClorhexidine
    PhaseNot recorded
    Registry statusCompleted

  • Lasers in Peri-implantitis Treatment

    NCT05733234 · start 2021-05-20

    Registered record
    Registry ID
    NCT05733234
    Conditions
    Peri-Implantitis
    Interventions
    Laser ,Fotona, Light Walker AT, Ljubljana, Slovenia; Mechanical Treatment
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2021-05-20
    Completion
    2022-03-21
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeri-Implantitis
    InterventionLaser ,Fotona, Light Walker AT, Ljubljana, Slovenia; Mechanical Treatment
    PhaseNot applicable
    Registry statusCompleted

  • Tongue Dysbiosis Effects on Arterial Pressure of Periodontitis Patients

    NCT04027179 · start 2020-08

    Registered record
    Registry ID
    NCT04027179
    Conditions
    Periodontitis; Normal Blood Pressure
    Interventions
    0.12% chlorhexidine digluconate mouthwash; Periodontal instrumentation; Placebo mouthwash
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2020-08
    Completion
    2022-07
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeriodontitis; Normal Blood Pressure
    Intervention0.12% chlorhexidine digluconate mouthwash; Periodontal instrumentation; Placebo mouthwash
    PhasePhase 4
    Registry statusUnknown

  • Comparison Trial for Chloraprep Versus Aqueous Chlorhexidine (2%) for the Prevention of Catheter-related Bacteremia

    NCT03489512 · start 2019-10-01

    Registered record
    Registry ID
    NCT03489512
    Conditions
    Sepsis Affecting Skin; Central Venous Catheter Related Bacteremia
    Interventions
    A (Chloraprep); B (Clorhexidine 2%)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2019-10-01
    Completion
    2021-04-01
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSepsis Affecting Skin; Central Venous Catheter Related Bacteremia
    InterventionA (Chloraprep); B (Clorhexidine 2%)
    PhasePhase 4
    Registry statusWithdrawn

  • Influence of Implant Component Materials on Peri-implant Soft Tissue Horst Response.

    NCT05843526 · start 2019-05-01

    Registered record
    Registry ID
    NCT05843526
    Conditions
    Dental Implants; Soft Tissue Inflammation; Immunohistochemistry; Dental Implants, Single-Tooth; Histology; Dental Implantation
    Interventions
    Experimental healing abutment
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-05-01
    Completion
    2022-10-01
    Enrolment
    68

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDental Implants; Soft Tissue Inflammation; Immunohistochemistry; Dental Implants, Single-Tooth +2 more
    InterventionExperimental healing abutment
    PhaseNot applicable
    Registry statusCompleted

  • Effect of Natural Antibacterial Mouthwash on Taste, Salivary pH and Bacteria in High Caries Risk pt

    NCT03623048 · start 2019-03

    Registered record
    Registry ID
    NCT03623048
    Conditions
    Decay, Dental
    Interventions
    chlorhexidine; saline; Propolis extract; pomegranate extract
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2019-03
    Completion
    2019-04
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDecay, Dental
    Interventionchlorhexidine; saline; Propolis extract; pomegranate extract
    PhaseNot applicable
    Registry statusUnknown

  • Effectiveness of Propolis Mouthwash on Gingivitis

    NCT04032548 · start 2019-02-18

    Registered record
    Registry ID
    NCT04032548
    Conditions
    Gingivitis
    Interventions
    Placebo mouthwash; Propolis mouthwash; Chlorhexidine mouthwash
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-02-18
    Completion
    2019-06-05
    Enrolment
    45

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGingivitis
    InterventionPlacebo mouthwash; Propolis mouthwash; Chlorhexidine mouthwash
    PhaseNot applicable
    Registry statusCompleted

  • Urethral Sterilization With Chlorhexidine Digluconate to Facilitate Primary Repair & Same-Session Implantation

    NCT03614429 · start 2018-06-01

    Registered record
    Registry ID
    NCT03614429
    Conditions
    Penile Prosthesis; Complications
    Interventions
    Chlorhexidine gel will be prepared according to an international product Instillagel®
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2018-06-01
    Completion
    2018-12-01
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPenile Prosthesis; Complications
    InterventionChlorhexidine gel will be prepared according to an international product Instillagel®
    PhasePhase 2
    Registry statusUnknown

  • Floraseal Versus Iodine Impregnated Adhesive Drapes

    NCT03466489 · start 2018-01-01

    Registered record
    Registry ID
    NCT03466489
    Conditions
    Surgical Site Infection; Surgical Wound Infection
    Interventions
    Floraseal
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2018-01-01
    Completion
    2020-02-01
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgical Site Infection; Surgical Wound Infection
    InterventionFloraseal
    PhaseNot applicable
    Registry statusWithdrawn

  • Chitosan,Chitosan Nanoparticles,and Chlorhexidine Gluconate, as Intra Canal Medicaments in Primary Teeth

    NCT03588351 · start 2018-01-01

    Registered record
    Registry ID
    NCT03588351
    Conditions
    Necrotic Pulp
    Interventions
    chitosan nanoparticles gel; chitosan gel; chlorhexidine gluconate
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2018-01-01
    Completion
    2018-08-30
    Enrolment
    45

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNecrotic Pulp
    Interventionchitosan nanoparticles gel; chitosan gel; chlorhexidine gluconate
    PhaseNot applicable
    Registry statusUnknown