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AMR Drug RepurposingSmart Screeningresearch prototype

Ganirelix Acetate

FDA-approved product (injectable, injection), marketed as Fyremadel, Ganirelix Acetate.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Ganirelix Acetate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Female infertility
  • Positive regulation of ovulation
  • Reproductive Techniques, Assisted

Indications ChEMBL records as approved, from FDA and DailyMed labels.

WHO therapeutic group
Anti-gonadotropin-releasing hormones
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA69.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli55.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae30.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis61.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Ganirelix Acetate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Ganirelix Acetate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Single Injection of Ganirelix in Gonadotropin Intrauterine Insemination (IUI) Cycles

    NCT01286051 · start 2011-01

    Registered record
    Registry ID
    NCT01286051
    Conditions
    Compare Pregnancy Rates Between FSH Stimulation and FSH and; GnRH Antagonist
    Interventions
    Follistim administration; Follistim plus Ganirelix
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-01
    Completion
    2012-09
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCompare Pregnancy Rates Between FSH Stimulation and FSH and; GnRH Antagonist
    InterventionFollistim administration; Follistim plus Ganirelix
    PhaseNot applicable
    Registry statusCompleted

  • Ovarian Response Prediction in In Vitro Fertilization (IVF) Patients

    NCT01206803 · start 2010-09

    Registered record
    Registry ID
    NCT01206803
    Conditions
    Infertility, Subfertility
    Interventions
    Ovarian stimulation in a GnRH-antagonist protocol
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2010-09
    Completion
    2014-01
    Enrolment
    294

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility, Subfertility
    InterventionOvarian stimulation in a GnRH-antagonist protocol
    PhaseNot recorded
    Registry statusCompleted

  • A Comparative Study of Two Patterns of Controlled Ovarian Hyperstimulation in Mid Follicular Phase or Early Luteal Phase for Egg Donors

    NCT01385332 · start 2010-03

    Registered record
    Registry ID
    NCT01385332
    Conditions
    Stimulation in the Ovary
    Interventions
    Early luteal phase; Late follicular phase -COH-
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-03
    Completion
    2012-09
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStimulation in the Ovary
    InterventionEarly luteal phase; Late follicular phase -COH-
    PhaseNot applicable
    Registry statusCompleted

  • Short Versus Long Protocol for IVF and IVF+ICSI

    NCT00756028 · start 2009-01

    Registered record
    Registry ID
    NCT00756028
    Conditions
    Infertility; Ovarian Hyperstimulation Syndrome; Quality of Life; Live Birth
    Interventions
    Patients receiving short protocol IVF/ICSI-treatment.; Long protocol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-01
    Completion
    2015-12
    Enrolment
    1,099

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility; Ovarian Hyperstimulation Syndrome; Quality of Life; Live Birth
    InterventionPatients receiving short protocol IVF/ICSI-treatment.; Long protocol
    PhasePhase 4
    Registry statusCompleted

  • Oral Microdose Lupron Versus Luteal Estradiol Trial in Poor Responder In Vitro Fertilization (IVF) Patients

    NCT00826839 · start 2009-01

    Registered record
    Registry ID
    NCT00826839
    Conditions
    Infertility
    Interventions
    Oral contraceptive pill and microdose lupron; E2 patch/antagonist
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2009-01
    Completion
    2012-01
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility
    InterventionOral contraceptive pill and microdose lupron; E2 patch/antagonist
    PhasePhase 4
    Registry statusWithdrawn

  • MENOPUR® Versus FOLLISTIM®

    NCT00802360 · start 2008-12

    Registered record
    Registry ID
    NCT00802360
    Conditions
    Infertility
    Interventions
    Menotropin; Progestrone vaginal insert; follitropin beta; Progesterone in oil; Ganirelix
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-12
    Completion
    2010-01
    Enrolment
    173

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility
    InterventionMenotropin; Progestrone vaginal insert; follitropin beta; Progesterone in oil +1 more
    PhasePhase 4
    Registry statusCompleted

  • Antagonist/Letrozole in Poor Responders

    NCT00823004 · start 2008-06

    Registered record
    Registry ID
    NCT00823004
    Conditions
    Ovarian Stimulation
    Interventions
    letrozole; oral contraceptive (Marvelone); GnRH agonist (buserelin); recombinant FSH or hMG; ganirelix acetate
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2008-06
    Completion
    2009-10
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOvarian Stimulation
    Interventionletrozole; oral contraceptive (Marvelone); GnRH agonist (buserelin); recombinant FSH or hMG +1 more
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Compromised Microcirculation in Women With Polycystic Ovary Syndrome

    NCT00757185 · start 2008-02

    Registered record
    Registry ID
    NCT00757185
    Conditions
    Polycystic Ovary Syndrome
    Interventions
    ganirelix acetate; methyl testosterone
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2008-02
    Completion
    2012-12
    Enrolment
    28

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPolycystic Ovary Syndrome
    Interventionganirelix acetate; methyl testosterone
    PhaseEarly phase 1
    Registry statusCompleted

  • Sex Hormones and Atherosclerosis Prevention in Perimenopausal Women

    NCT00608062 · start 2007-03

    Registered record
    Registry ID
    NCT00608062
    Conditions
    Arterial Stiffening; Aging; Menopause
    Interventions
    GnRHant - Ganirelix acetate; Transdermal estradiol patch; Transdermal placebo patch
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2007-03
    Completion
    2012-10-25
    Enrolment
    155

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionArterial Stiffening; Aging; Menopause
    InterventionGnRHant - Ganirelix acetate; Transdermal estradiol patch; Transdermal placebo patch
    PhaseNot applicable
    Registry statusCompleted

  • To Investigate Efficacy and Safety of a Single Injection of Org 36286 for Ovarian Stimulation Using Daily Recombinant FSH as Reference (Ensure)(P05690/MK-8962-001)

    NCT00702845 · start 2006-12-28

    Registered record
    Registry ID
    NCT00702845
    Conditions
    Infertility
    Interventions
    corifollitropin alfa (Org 36286); recFSH (follitropin beta); gonadatropin releasing hormone (GnRH) antagonist (ganirelix); human chorion gonadatropin (hCG); progesterone; placebo-recFSH (follitropin alfa); placebo-corifollitropin alfa; open-label recFSH
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-12-28
    Completion
    2007-11-15
    Enrolment
    397

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility
    Interventioncorifollitropin alfa (Org 36286); recFSH (follitropin beta); gonadatropin releasing hormone (GnRH) antagonist (ganirelix); human chorion gonadatropin (hCG) +4 more
    PhasePhase 3
    Registry statusCompleted

  • Follow-up Protocol on the Outcome of Frozen-thawed Embryo Transfer Cycles From Clinical Trial P05690 (P05711)

    NCT00702546 · start 2006-12

    Registered record
    Registry ID
    NCT00702546
    Conditions
    In Vitro Fertilization
    Interventions
    corifollitropin alfa; recFSH (follitropin alfa); gonadatropin releasing hormone (GnRH) antagonist ganirelix; human chorion gonadatropin (hCG); progesterone; placebo-recFSH (follitropin alfa); placebo-corifollitropin alfa; open-label recFSH
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2006-12
    Completion
    2008-12
    Enrolment
    102

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIn Vitro Fertilization
    Interventioncorifollitropin alfa; recFSH (follitropin alfa); gonadatropin releasing hormone (GnRH) antagonist ganirelix; human chorion gonadatropin (hCG) +4 more
    PhaseNot recorded
    Registry statusCompleted

  • A Comparison of the Microdose Leuprolide Protocol vs. Luteal Phase Ganirelix Protocol in Women Who Are or Who Are Predicted to be Low Responders

    NCT00633555 · start 2006-07

    Registered record
    Registry ID
    NCT00633555
    Conditions
    Infertility
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2006-07
    Completion
    2010-09
    Enrolment
    54

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Follow-up Study of Frozen-thawed Embryo Transfer (FTET) Cycles After Cryopreservation of Embryos in Clinical Trial P05787 (P05716)

    NCT00702273 · start 2006-04-19

    Registered record
    Registry ID
    NCT00702273
    Conditions
    In Vitro Fertilization
    Interventions
    150 µg Corifollitropin Alfa; 200 IU RecFSH/Follitropin beta (Days 1 to 7); Placebo for Corifollitropin Alfa; Placebo for RecFSH/Follitropin beta; 200 IU RecFSH/Follitropin beta (Days 8 to hCG); Ganirelix; hCG; Progesterone
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2006-04-19
    Completion
    2009-05-31
    Enrolment
    344

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIn Vitro Fertilization
    Intervention150 µg Corifollitropin Alfa; 200 IU RecFSH/Follitropin beta (Days 1 to 7); Placebo for Corifollitropin Alfa; Placebo for RecFSH/Follitropin beta +4 more
    PhaseNot recorded
    Registry statusCompleted

  • Follicle-Stimulating Hormone (FSH) and the Onset of Puberty

    NCT00734279 · start 2006-03

    Registered record
    Registry ID
    NCT00734279
    Conditions
    Delayed Puberty; Precocious Puberty
    Interventions
    Leuprolide Acetate - Early Puberty Leuprolide Visit; Ganirelix - Early Puberty Ganirelix Visit; Ganirelix - Delayed Puberty Ganirelix Visit; Leuprolide Acetate- Delayed Puberty Leuprolide Visit
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2006-03
    Completion
    2010-12
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDelayed Puberty; Precocious Puberty
    InterventionLeuprolide Acetate - Early Puberty Leuprolide Visit; Ganirelix - Early Puberty Ganirelix Visit; Ganirelix - Delayed Puberty Ganirelix Visit; Leuprolide Acetate- Delayed Puberty Leuprolide Visit
    PhaseEarly phase 1
    Registry statusCompleted

  • Sex Hormones and Orthostatic Tolerance

    NCT01153581 · start 2006-02

    Registered record
    Registry ID
    NCT01153581
    Conditions
    Orthostatic Intolerance
    Interventions
    Ganirelix acetate; 17β-Oestradiol; Progesterone
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2006-02
    Completion
    2013-05
    Enrolment
    109

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOrthostatic Intolerance
    InterventionGanirelix acetate; 17β-Oestradiol; Progesterone
    PhasePhase 2
    Registry statusCompleted