Skip to content
AMR Drug RepurposingSmart Screeningresearch prototype

Cefotaxime Sodium

FDA-approved product (injectable, injection), marketed as Cefotaxime, Cefotaxime And Dextrose 2.4% In Plastic Container, Cefotaxime And Dextrose 3.9% In Plastic Container and 4 more.

Registered studies
28
Lab records
300
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Cefotaxime Sodium
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Gonorrhea
  • Infection
  • Pneumonia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Third-generation cephalosporins
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01DD01

Repurposing investigation

Cefotaxime Sodium is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA89.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli>99% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae34.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis51.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

28registered studies name this medicine, for any condition. See them below.

Experimental

  • MRSA: measured active in 11 of 16 lab records
  • E. coli: measured active in 37 of 37 lab records
  • K. pneumoniae: measured active in 118 of 247 lab records
Open Cefotaxime Sodium in ChEMBL Registered studies below
Show the latest 150 of 300 laboratory records, with sources

Loading records…

Every record is in ChEMBL, linked above. “Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.3 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.7 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.1 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Cefotaxime Sodium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Penile Fracture: A Comparison of Erectile Function After Immediate Repair Versus Delayed Repair

    NCT03449940 · start 2015-01

    Registered record
    Registry ID
    NCT03449940
    Conditions
    Erectile Dysfunction
    Interventions
    Immediate repair; Delayed repair; Lidocaine; Ceftriaxone; Diclofenac Sodium
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-01
    Completion
    2017-12
    Enrolment
    46

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionErectile Dysfunction
    InterventionImmediate repair; Delayed repair; Lidocaine; Ceftriaxone +1 more
    PhaseNot applicable
    Registry statusCompleted

  • Efficacy, Pharmacokinetics and Safety of Meropenem in Infants Below 90 Days With Clinical or Confirmed Late-onset Sepsis

    NCT01551394 · start 2012-09

    Registered record
    Registry ID
    NCT01551394
    Conditions
    Sepsis
    Interventions
    Meropenem; Ampicillin + gentamicin or cefotaxime + gentamicin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2012-09
    Completion
    2014-12
    Enrolment
    272

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSepsis
    InterventionMeropenem; Ampicillin + gentamicin or cefotaxime + gentamicin
    PhasePhase 3
    Registry statusCompleted

  • A Phase 3 Study Of Intravenous Metronidazole For Intrabdominal Infection

    NCT01473836 · start 2011-11

    Registered record
    Registry ID
    NCT01473836
    Conditions
    Intra-abdominal Infections
    Interventions
    Metronidazole; Ceftriaxone sodium
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2011-11
    Completion
    2012-10
    Enrolment
    38

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIntra-abdominal Infections
    InterventionMetronidazole; Ceftriaxone sodium
    PhasePhase 3
    Registry statusCompleted

  • Study on Cefotaxime and Sulbactam Sodium for Injection (2:1) for Treatment of Respiratory and Urinary Tract Infection

    NCT01426191 · start 2011-08

    Registered record
    Registry ID
    NCT01426191
    Conditions
    Respiratory Tract Infections; Urinary Tract Infections
    Interventions
    xinzhijun
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2011-08
    Completion
    2016-12
    Enrolment
    2,032

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRespiratory Tract Infections; Urinary Tract Infections
    Interventionxinzhijun
    PhaseNot recorded
    Registry statusCompleted

  • Efficacy and Safety of Ertapenem Sodium (MK-0826) Following Colorectal Surgery in Chinese Adults (MK-0826-056)

    NCT01254344 · start 2010-12

    Registered record
    Registry ID
    NCT01254344
    Conditions
    Infection; Surgical Site Infection
    Interventions
    ertapenem sodium; ceftriaxone sodium; placebo to metronidazole; metronidazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2010-12
    Completion
    2011-12
    Enrolment
    599

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfection; Surgical Site Infection
    Interventionertapenem sodium; ceftriaxone sodium; placebo to metronidazole; metronidazole
    PhasePhase 3
    Registry statusCompleted

  • Ceftriaxone in the Management of Bipolar Depression

    NCT00566111 · start 2007-09

    Registered record
    Registry ID
    NCT00566111
    Conditions
    Bipolar Depression
    Interventions
    ceftriaxone; Saline solution
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2007-09
    Completion
    2009-12
    Enrolment
    5

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBipolar Depression
    Interventionceftriaxone; Saline solution
    PhaseNot applicable
    Registry statusTerminated

  • Pharmacokinetic and Safety Study of HYLENEX Recombinant-Augmented Subcutaneous Ceftriaxone Administration

    NCT00493220 · start 2007-06

    Registered record
    Registry ID
    NCT00493220
    Conditions
    Healthy
    Interventions
    SC HYLENEX and Ceftriaxone; SC Placebo and Ceftriaxone; IV Ceftriaxone
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2007-06
    Completion
    2007-09
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionSC HYLENEX and Ceftriaxone; SC Placebo and Ceftriaxone; IV Ceftriaxone
    PhasePhase 1
    Registry statusCompleted

  • Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection (cIAI)

    NCT00230971 · start 2005-10

    Registered record
    Registry ID
    NCT00230971
    Conditions
    Appendicitis; Cholecystitis; Diverticulitis; Intra-Abdominal Abscess; Intra-Abdominal Infection; Peritonitis
    Interventions
    tigecycline; ceftriaxone plus metronidazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2005-10
    Completion
    2008-09
    Enrolment
    473

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAppendicitis; Cholecystitis; Diverticulitis; Intra-Abdominal Abscess +2 more
    Interventiontigecycline; ceftriaxone plus metronidazole
    PhasePhase 4
    Registry statusCompleted

  • Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection

    NCT00195351 · start 2005-09

    Registered record
    Registry ID
    NCT00195351
    Conditions
    Appendicitis; Cholecystitis; Cross Infection; Diverticulitis; Peritonitis
    Interventions
    tigecycline; ceftriaxone sodium + metronidazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2005-09
    Completion
    2008-02
    Enrolment
    467

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAppendicitis; Cholecystitis; Cross Infection; Diverticulitis +1 more
    Interventiontigecycline; ceftriaxone sodium + metronidazole
    PhasePhase 4
    Registry statusCompleted

  • Effect of, OAT3, on the Renal Secretion of Cefotaxime

    NCT00187655 · start 2004-01

    Registered record
    Registry ID
    NCT00187655
    Conditions
    Focus Groups
    Interventions
    Cefotaxime
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2004-01
    Completion
    2013-12
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFocus Groups
    InterventionCefotaxime
    PhasePhase 1
    Registry statusCompleted

  • VNP20009 in Treating Patients With Advanced or Metastatic Solid Tumors That Have Not Responded to Previous Therapy

    NCT00004216 · start 1999-08

    Registered record
    Registry ID
    NCT00004216
    Conditions
    Unspecified Adult Solid Tumor, Protocol Specific
    Interventions
    salmonella VNP20009; cefixime; ceftriaxone sodium; ciprofloxacin; trimethoprim-sulfamethoxazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    1999-08
    Completion
    2008-01
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUnspecified Adult Solid Tumor, Protocol Specific
    Interventionsalmonella VNP20009; cefixime; ceftriaxone sodium; ciprofloxacin +1 more
    PhasePhase 1
    Registry statusCompleted

  • A Pilot Study Evaluating Penicillin G and Ceftriaxone as Therapies for Presumed Neurosyphilis in HIV Seropositive Individuals

    NCT00000648

    Registered record
    Registry ID
    NCT00000648
    Conditions
    HIV Infections; Neurosyphilis
    Interventions
    Penicillin G potassium; Ceftriaxone sodium
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    Not recorded
    Completion
    1996-02
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections; Neurosyphilis
    InterventionPenicillin G potassium; Ceftriaxone sodium
    PhaseNot applicable
    Registry statusCompleted

  • Prospective Comparison of Ampicillin / Amoxicillin Versus Ceftriaxone for the Treatment of Salmonella Infections in AIDS Patients

    NCT00002052

    Registered record
    Registry ID
    NCT00002052
    Conditions
    HIV Infections; Salmonella Infections
    Interventions
    Ceftriaxone sodium; Ampicillin sodium; Amoxicillin trihydrate
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections; Salmonella Infections
    InterventionCeftriaxone sodium; Ampicillin sodium; Amoxicillin trihydrate
    PhaseNot applicable
    Registry statusCompleted