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AMR Drug RepurposingSmart Screeningresearch prototype

Sodium Tetradecyl Sulfate

FDA-approved product (injectable, injection), marketed as Sodium Tetradecyl Sulfate, Sotradecol.

Registered studies
18
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Sodium Tetradecyl Sulfate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Varicose veins

Indications ChEMBL records as approved, from FDA and DailyMed labels.

WHO therapeutic group
Sclerosing agents for local injection
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA30.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli26.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae15.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis55.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

18registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Sodium Tetradecyl Sulfate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-5.8 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-5.8 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-6.0 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.7 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Sodium Tetradecyl Sulfate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Endoscopic Shunts Embolization for Refractory Hepatic Encephalopathy

    NCT07553858 · start 2026-05-01

    Registered record
    Registry ID
    NCT07553858
    Conditions
    Hepatic Encephalopathy; Liver Cirrhosis; Portal Shunt Systemic
    Interventions
    Endoscopic ultrasound-guided transgastric embolization of the spontaneous portosystemic shunts; Interventional Radiology for shunt embolization/retrograde tranvenous obliteration
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2026-05-01
    Completion
    2028-11-01
    Enrolment
    34

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHepatic Encephalopathy; Liver Cirrhosis; Portal Shunt Systemic
    InterventionEndoscopic ultrasound-guided transgastric embolization of the spontaneous portosystemic shunts; Interventional Radiology for shunt embolization/retrograde tranvenous obliteration
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Study Comparing Glycerin With 1% Lidocaine and Epinephrine Versus Glycerin With 1% Lidocaine Without Epinephrine for the Sclerotherapy of Leg Telangiectasias

    NCT07342413 · start 2026-02-01

    Registered record
    Registry ID
    NCT07342413
    Conditions
    Leg Veins
    Interventions
    Right leg treated with Glycerin compounded with 1% Lidocaine and Epinephrine; Left leg treated with Glycerin compounded with 1% Lidocaine and Epinephrine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Not yet recruiting
    Start
    2026-02-01
    Completion
    2026-07-30
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLeg Veins
    InterventionRight leg treated with Glycerin compounded with 1% Lidocaine and Epinephrine; Left leg treated with Glycerin compounded with 1% Lidocaine and Epinephrine
    PhasePhase 4
    Registry statusNot yet recruiting

  • Treatment of Epidermoid Cysts

    NCT05597995 · start 2022-11-01

    Registered record
    Registry ID
    NCT05597995
    Conditions
    Epidermoid Cyst
    Interventions
    Sodium Tetradecyl Sulfate
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2022-11-01
    Completion
    2023-05-30
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEpidermoid Cyst
    InterventionSodium Tetradecyl Sulfate
    PhasePhase 2
    Registry statusUnknown

  • Endoscopic Ultrasound-guided Coil With Cyanoacrylate Injection Versus Balloon-Occluded Retrograde Transvenous Obliteration in Managing Patients With Gastric Varices

    NCT05500625 · start 2022-08-30

    Registered record
    Registry ID
    NCT05500625
    Conditions
    Gastric Varix
    Interventions
    Endoscopic ultrasound-guided coil embolization combined with endoscopic cyanoacrylate injection; Ballon-occluded retrograde transvenous obliteration
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2022-08-30
    Completion
    2025-01-30
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGastric Varix
    InterventionEndoscopic ultrasound-guided coil embolization combined with endoscopic cyanoacrylate injection; Ballon-occluded retrograde transvenous obliteration
    PhaseNot applicable
    Registry statusUnknown

  • Outcomes of Sclerotherapy of the Ulcer Bed Compared to a Combination of Ablation and Injections

    NCT05633277 · start 2020-09-30

    Registered record
    Registry ID
    NCT05633277
    Conditions
    Venous Reflux; Venous Insufficiency; Venous Ulcer; Venous Disease
    Interventions
    Polidocanol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2020-09-30
    Completion
    2024-03
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVenous Reflux; Venous Insufficiency; Venous Ulcer; Venous Disease
    InterventionPolidocanol
    PhaseNot applicable
    Registry statusUnknown

  • is Ultrasound-guided Foam Sclerotherapy a Cost-effective Alternate for Treatment of Varicose Veins?

    NCT04655417 · start 2020-02-21

    Registered record
    Registry ID
    NCT04655417
    Conditions
    Pain; Leg Edema; Cost Effectiveness; Cosmesis
    Interventions
    Sodium Tetradecyl Sulfate
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Unknown
    Start
    2020-02-21
    Completion
    2021-02-21
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain; Leg Edema; Cost Effectiveness; Cosmesis
    InterventionSodium Tetradecyl Sulfate
    PhaseEarly phase 1
    Registry statusUnknown

  • Low Concentrate Detergents Versus Hypertonic Glucose for the Treatment of Telangiectasia

    NCT04132323 · start 2019-10-25

    Registered record
    Registry ID
    NCT04132323
    Conditions
    Sclerotherapy
    Interventions
    Sclerotherapy
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-10-25
    Completion
    2022-03-15
    Enrolment
    172

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSclerotherapy
    InterventionSclerotherapy
    PhaseNot applicable
    Registry statusCompleted

  • Balloon-occluded Retrograde Transvenous Obliteration for Gastric Variceal Rebleeding

    NCT06106971 · start 2018-06-28

    Registered record
    Registry ID
    NCT06106971
    Conditions
    Gastric Varices Bleeding; Liver Decompensation
    Interventions
    Sodium tetradecyl sulfate; Cyanoacrylate
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2018-06-28
    Completion
    2025-06
    Enrolment
    68

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGastric Varices Bleeding; Liver Decompensation
    InterventionSodium tetradecyl sulfate; Cyanoacrylate
    PhasePhase 3
    Registry statusUnknown

  • A Study Evaluating ClariVein With a Sclerosing Agent for the Treatment of Venous Insufficiency

    NCT03311269 · start 2017-09-22

    Registered record
    Registry ID
    NCT03311269
    Conditions
    Venous Insufficiency
    Interventions
    ClariVein RES; Sodium Tetradecyl Sulfate 1% Injection; Sodium Tetradecyl Sulfate 3% Injection
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2017-09-22
    Completion
    2020-03-27
    Enrolment
    19

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVenous Insufficiency
    InterventionClariVein RES; Sodium Tetradecyl Sulfate 1% Injection; Sodium Tetradecyl Sulfate 3% Injection
    PhasePhase 2
    Registry statusTerminated

  • IVF Outcomes After Varicocele Repair

    NCT03090438 · start 2017-05

    Registered record
    Registry ID
    NCT03090438
    Conditions
    Infertility, Male; Varicocele; In Vitro Fertilization
    Interventions
    Varicocele embolization
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2017-05
    Completion
    2021-05
    Enrolment
    250

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility, Male; Varicocele; In Vitro Fertilization
    InterventionVaricocele embolization
    PhaseNot applicable
    Registry statusUnknown

  • Pilot RCT Evaluating a One Stop Vein Clinic

    NCT02557542 · start 2015-10

    Registered record
    Registry ID
    NCT02557542
    Conditions
    Varicose Veins
    Interventions
    One Stop Vein Clinic; Radiofrequency ablation; Endovenous laser ablation; Foam sclerotherapy (Polidocanol or Sodium Tetradecyl Sulphate)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2015-10
    Completion
    2021-03
    Enrolment
    3

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVaricose Veins
    InterventionOne Stop Vein Clinic; Radiofrequency ablation; Endovenous laser ablation; Foam sclerotherapy (Polidocanol or Sodium Tetradecyl Sulphate)
    PhaseNot applicable
    Registry statusTerminated

  • Laser Ablation Versus Mechanochemical Ablation Trial

    NCT02627846 · start 2015-06-01

    Registered record
    Registry ID
    NCT02627846
    Conditions
    Varicose Veins
    Interventions
    EVLA; ClariVein®; Lidocaine with 1:200,000 epinephrine solution; Lidocaine with 1:200,000 epinephrine solution; Sodium Bicarbonate; Sodium Tetradecyl Sulphate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-06-01
    Completion
    2023-09-04
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVaricose Veins
    InterventionEVLA; ClariVein®; Lidocaine with 1:200,000 epinephrine solution; Lidocaine with 1:200,000 epinephrine solution +2 more
    PhasePhase 4
    Registry statusCompleted

  • RCT Comparing Standard Cannula Delivered FS, UGFS and ClariVein® in the Management of SVI

    NCT02010437 · start 2014-01

    Registered record
    Registry ID
    NCT02010437
    Conditions
    Superficial Venous Insufficiency, Varicose Veins
    Interventions
    Sodium Tetradecyl Sulphate (STS)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2014-01
    Completion
    2015-04
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSuperficial Venous Insufficiency, Varicose Veins
    InterventionSodium Tetradecyl Sulphate (STS)
    PhasePhase 4
    Registry statusWithdrawn

  • Investigation Into the Pathophysiology and Treatment of Varicose Veins

    NCT06192472 · start 2013-04

    Registered record
    Registry ID
    NCT06192472
    Conditions
    Varicose Veins
    Interventions
    Chemical sclerotherapy; 1% Sodium Tetradecyl Sulphate; 3% Sodium Tetradecyl Sulphate; 0.5% Polidocanol; 3% Polidcanol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2013-04
    Completion
    2015-09
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVaricose Veins
    InterventionChemical sclerotherapy; 1% Sodium Tetradecyl Sulphate; 3% Sodium Tetradecyl Sulphate; 0.5% Polidocanol +1 more
    PhaseNot applicable
    Registry statusCompleted

  • Compare Two Different Sclerosing Agents in the Treatment of Venous Malformations

    NCT01347294 · start 2011-08

    Registered record
    Registry ID
    NCT01347294
    Conditions
    Venous Malformation
    Interventions
    Bleomycin; Fibrovein; Bleomycin + Fibrovein
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2011-08
    Completion
    2025-06-30
    Enrolment
    135

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVenous Malformation
    InterventionBleomycin; Fibrovein; Bleomycin + Fibrovein
    PhasePhase 4
    Registry statusUnknown