Tolvaptan
FDA-approved product (tablet, oral), marketed as Jynarque, Samsca, Tolvaptan.
- Registered studies
- 50+
- Lab records
- 0
- Pathogens at ≥40%
- 3 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLApproved for
- Autosomal dominant polycystic kidney disease
- Cardiovascular disease
- Congestive heart failure
- Heart failure
- Hyponatremia
- Inappropriate ADH syndrome
- Polycystic Kidney Disease
Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗
- WHO therapeutic group
- Vasopressin antagonists
- FDA pharmacologic class
- Vasopressin V2 Receptor Antagonist FDA label ↗
- Anti-infective classification
- Not classified as an anti-infective.
Repurposing investigation
This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis, MRSA and E. coli. It was surfaced computationally for further investigation; it is not an established treatment for these infections.
AI-predicted activity
AI prediction · nothing measured- MRSA60.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- E. coli44.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- K. pneumoniae19.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- M. tuberculosis70.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredAutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Tolvaptan with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- FurazolidoneExisting use: Other antiinfectives and antiseptics91.4% AI-predicted activityagainst M. tuberculosisLab records exist49 registered studies
- TriflupromazineExisting use: Psychosis90.6% AI-predicted activityagainst M. tuberculosisNo documented evidence found
- ValdecoxibExisting use: Dysmenorrhea, Osteoarthritis, Rheumatic disease and 1 more88.6% AI-predicted activityagainst M. tuberculosisLab records exist31 registered studies
- CelecoxibExisting use: Ankylosing spondylitis, Cancer, Colorectal neoplasm and 15 more87.6% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- Dorzolamide HydrochlorideExisting use: Glaucoma, Ocular hypertension, Open-angle glaucoma86.8% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- MethazolamideExisting use: Glaucoma, Open-angle glaucoma85.6% AI-predicted activityagainst M. tuberculosisLab records exist11 registered studies
- AcetazolamideExisting use: Altitude sickness, Angle-closure glaucoma, Congestive heart failure and 5 more85.2% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- Trifluoperazine HydrochlorideExisting use: Anxiety disorder, Mental or behavioural disorder, Psychosis and 1 more84.6% AI-predicted activityagainst M. tuberculosis1 registered study
- TriclosanExisting use: Phenol and derivatives, Medicated dressings with antiinfectives84.2% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- NitrofurazoneExisting use: Eye infection, Leishmaniasis, Trypanosomiasis84.0% AI-predicted activityagainst M. tuberculosis8 registered studies
- BrinzolamideExisting use: Glaucoma, Ocular hypertension, Open-angle glaucoma83.8% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- ZonisamideExisting use: Epilepsy, Focal-onset seizure, Partial epilepsy and 1 more82.8% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
A Dose-finding Study of OPC-41061 in Treatment of Cardiac Edema (Congestive Heart Failure)
NCT00234104 · start 2004-08
Registered record
- Registry ID
- NCT00234104
- Conditions
- Heart Failure, Congestive; Edema
- Interventions
- OPC-41061(Tolvaptan)
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- 2004-08
- Completion
- 2006-01
- Enrolment
- 122
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHeart Failure, Congestive; EdemaInterventionOPC-41061(Tolvaptan)PhasePhase 2Registry statusCompletedEVEREST: Efficacy of Vasopressin Antagonism in hEart failuRE: Outcome Study With Tolvaptan
NCT00071331 · start 2003-09
Registered record
- Registry ID
- NCT00071331
- Conditions
- Congestive Heart Failure
- Interventions
- Tolvaptan
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2003-09
- Completion
- 2006-07
- Enrolment
- 3,600
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionCongestive Heart FailureInterventionTolvaptanPhasePhase 3Registry statusCompleted"SALT Trial" Study of Ascending Levels of Tolvaptan in Hyponatremia
NCT00072683 · start 2003-04-01
Registered record
- Registry ID
- NCT00072683
- Conditions
- Hyponatremias; Water Intoxication; Inappropriate ADH Syndrome; Water-Electrolyte Imbalances
- Interventions
- tolvaptan; placebo matching tolvaptan
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2003-04-01
- Completion
- 2005-12-01
- Enrolment
- 205
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHyponatremias; Water Intoxication; Inappropriate ADH Syndrome; Water-Electrolyte ImbalancesInterventiontolvaptan; placebo matching tolvaptanPhasePhase 3Registry statusCompletedMulticenter, Randomized, Double-Blind, Placebo Controlled, Efficacy Study on the Effects of Tolvaptan on Left Ventricular Dilatation in Congestive Heart Failure Patients
NCT00043758 · start 2002-07
Registered record
- Registry ID
- NCT00043758
- Conditions
- Congestive Heart Failure
- Interventions
- Tolvaptan
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- 2002-07
- Completion
- 2004-07
- Enrolment
- 170
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionCongestive Heart FailureInterventionTolvaptanPhasePhase 2Registry statusCompletedAcute Heart Failure Patients With High Copeptin Treated With Tolvaptan Targets Increased AVP Activation for Treatment (ACTIVATE)
NCT01733134
Registered record
- Registry ID
- NCT01733134
- Conditions
- Acute Heart Failure
- Interventions
- Tolvaptan; placebo
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Withdrawn
- Start
- Not recorded
- Completion
- Not recorded
- Enrolment
- 0
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionAcute Heart FailureInterventionTolvaptan; placeboPhasePhase 3Registry statusWithdrawn