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AMR Drug RepurposingSmart Screeningresearch prototype

Brinzolamide

FDA-approved product (suspension/drops, ophthalmic), marketed as Azopt, Brinzolamide.

Registered studies
50+
Lab records
4
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Brinzolamide
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Glaucoma
  • Ocular hypertension
  • Open-angle glaucoma

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Carbonic anhydrase inhibitors
FDA pharmacologic class
Carbonic Anhydrase Inhibitor FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA47.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli46.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae36.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis83.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • M. tuberculosis: measured active in 4 of 4 lab records
Open Brinzolamide in ChEMBL Registered studies below
Show the 4 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.4 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.4 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-6.4 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.5 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Brinzolamide with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • AZARGA Transition Study in Taiwan for Patients With Uncontrolled Intraocular Pressure

    NCT01484951 · start 2011-05

    Registered record
    Registry ID
    NCT01484951
    Conditions
    Glaucoma
    Interventions
    Brinzolamide 1% and timolol 0.5% fixed combination eye drops
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-05
    Completion
    2012-03
    Enrolment
    74

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGlaucoma
    InterventionBrinzolamide 1% and timolol 0.5% fixed combination eye drops
    PhasePhase 4
    Registry statusCompleted

  • Efficacy and Safety Study of Brinzolamide 1%/Brimonidine 0.2% vs. Brinzolamide 1% and Brimonidine 0.2%

    NCT01297517 · start 2011-02

    Registered record
    Registry ID
    NCT01297517
    Conditions
    Open-Angle Glaucoma; Ocular Hypertension
    Interventions
    Brinzolamide 1%/brimonidine tartrate 0.2% ophthalmic suspension; Brinzolamide ophthalmic suspension, 1%; Brimonidine tartrate ophthalmic solution, 0.2%
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2011-02
    Completion
    2012-03
    Enrolment
    1,001

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOpen-Angle Glaucoma; Ocular Hypertension
    InterventionBrinzolamide 1%/brimonidine tartrate 0.2% ophthalmic suspension; Brinzolamide ophthalmic suspension, 1%; Brimonidine tartrate ophthalmic solution, 0.2%
    PhasePhase 3
    Registry statusCompleted

  • Fixed Combination Brinzolamide 1%/Timolol 0.5% Versus Brinzolamide 1% + Timolol 0.5% in Open-Angle Glaucoma or Ocular Hypertension

    NCT01357616 · start 2010-11

    Registered record
    Registry ID
    NCT01357616
    Conditions
    Open-Angle Glaucoma; Ocular Hypertension
    Interventions
    Brinzolamide 1% / Timolol 0.5% fixed combination ophthalmic suspension; Brinzolamide 1% ophthalmic suspension; Timolol 0.5% ophthalmic solution
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2010-11
    Completion
    2013-01
    Enrolment
    328

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOpen-Angle Glaucoma; Ocular Hypertension
    InterventionBrinzolamide 1% / Timolol 0.5% fixed combination ophthalmic suspension; Brinzolamide 1% ophthalmic suspension; Timolol 0.5% ophthalmic solution
    PhasePhase 3
    Registry statusCompleted

  • Patient Preference Comparison of AZARGA Versus COSOPT in Patients With Glaucoma

    NCT01471158 · start 2010-09

    Registered record
    Registry ID
    NCT01471158
    Conditions
    Glaucoma
    Interventions
    Brinzolamide/Timolol Maleate Fixed Combination (AZARGA); Dorzolamide/timolol Maleate Fixed Combination (COSOPT)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-09
    Completion
    2011-05
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGlaucoma
    InterventionBrinzolamide/Timolol Maleate Fixed Combination (AZARGA); Dorzolamide/timolol Maleate Fixed Combination (COSOPT)
    PhasePhase 4
    Registry statusCompleted

  • Comparison of the Efficacy of AZARGA® Versus COSOPT® in Patients With Open-Angled Glaucoma or Ocular Hypertension

    NCT01111890 · start 2010-04

    Registered record
    Registry ID
    NCT01111890
    Conditions
    Glaucoma; Ocular Hypertension
    Interventions
    Azarga (brinzolamide 1% / timolol 0.5%); Cosopt (dorzolamide 2% / timolol 0.5%)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-04
    Completion
    2011-07
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGlaucoma; Ocular Hypertension
    InterventionAzarga (brinzolamide 1% / timolol 0.5%); Cosopt (dorzolamide 2% / timolol 0.5%)
    PhasePhase 4
    Registry statusCompleted

  • ELAZOP Switching Study in Korea

    NCT01055366 · start 2010-03

    Registered record
    Registry ID
    NCT01055366
    Conditions
    Open Angle Glaucoma
    Interventions
    Elazop (Azarga)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-03
    Completion
    2011-12
    Enrolment
    96

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOpen Angle Glaucoma
    InterventionElazop (Azarga)
    PhasePhase 4
    Registry statusCompleted

  • Safety and Efficacy of Brinzolamide/Brimonidine Fixed Combination

    NCT00961649 · start 2009-10

    Registered record
    Registry ID
    NCT00961649
    Conditions
    Open-Angle Glaucoma; Ocular Hypertension
    Interventions
    Brinzolamide 1%/brimonidine tartrate 0.2% ophthalmic suspension; Brinzolamide ophthalmic suspension, 1%; Brimonidine tartrate ophthalmic solution, 0.2%; Vehicle
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2009-10
    Completion
    2010-02
    Enrolment
    195

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOpen-Angle Glaucoma; Ocular Hypertension
    InterventionBrinzolamide 1%/brimonidine tartrate 0.2% ophthalmic suspension; Brinzolamide ophthalmic suspension, 1%; Brimonidine tartrate ophthalmic solution, 0.2%; Vehicle
    PhasePhase 2
    Registry statusTerminated

  • Efficacy and Safety of Adding Azarga to Prostaglandin Monotherapy

    NCT00966576 · start 2009-07

    Registered record
    Registry ID
    NCT00966576
    Conditions
    Glaucoma
    Interventions
    Brinzolamide/Timolol Maleate Fixed Combination (AZARGA)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-07
    Completion
    2010-08
    Enrolment
    47

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGlaucoma
    InterventionBrinzolamide/Timolol Maleate Fixed Combination (AZARGA)
    PhasePhase 4
    Registry statusCompleted

  • Safety and Efficacy of Brinzolamide Dosed TID With Dorzolamide Dosed TID in Reducing Intraocular Pressure in Patients With Open Angle Glaucoma or Ocular Hypertension

    NCT00761995 · start 2009-02

    Registered record
    Registry ID
    NCT00761995
    Conditions
    Glaucoma; Ocular Hypertension
    Interventions
    Azopt; Cosopt
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-02
    Completion
    2010-07
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGlaucoma; Ocular Hypertension
    InterventionAzopt; Cosopt
    PhasePhase 4
    Registry statusCompleted

  • Travoprost/Brinzolamide Fixed Combination Versus Travatan and Versus AZOPT

    NCT00767494 · start 2008-10

    Registered record
    Registry ID
    NCT00767494
    Conditions
    Glaucoma; Ocular Hypertension
    Interventions
    Travoprost/Brinzolamide fixed combination; Azopt; Travatan
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2008-10
    Completion
    2009-02
    Enrolment
    17

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGlaucoma; Ocular Hypertension
    InterventionTravoprost/Brinzolamide fixed combination; Azopt; Travatan
    PhasePhase 3
    Registry statusTerminated

  • Argon Laser Peripheral Iridoplasty for Primary Angle Closure Glaucoma

    NCT00980473 · start 2007-09

    Registered record
    Registry ID
    NCT00980473
    Conditions
    Glaucoma
    Interventions
    Argon Laser Iridoplasty; Travatan/ Timolol/Azopt
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2007-09
    Completion
    Not recorded
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGlaucoma
    InterventionArgon Laser Iridoplasty; Travatan/ Timolol/Azopt
    PhasePhase 3
    Registry statusUnknown

  • IOP Lowering Efficacy of Travoprost/Brinzolamide Fixed Combination Ophthalmic Suspension in Patients With Open-Angle Glaucoma or Ocular Hypertension

    NCT00527501 · start 2007-08

    Registered record
    Registry ID
    NCT00527501
    Conditions
    Open-angle Glaucoma; Ocular Hypertension
    Interventions
    Travoprost/brinzolamide
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2007-08
    Completion
    2007-12
    Enrolment
    136

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOpen-angle Glaucoma; Ocular Hypertension
    InterventionTravoprost/brinzolamide
    PhasePhase 2
    Registry statusCompleted

  • IOP-Lowering Efficacy of Brinzolamide 1.0% Added to Travoprost 0.004%/Timolol 0.5% Fixed Combination as Adjunctive Therapy

    NCT00382226 · start 2006-09

    Registered record
    Registry ID
    NCT00382226
    Conditions
    Glaucoma
    Interventions
    Azopt
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-09
    Completion
    2007-08
    Enrolment
    195

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGlaucoma
    InterventionAzopt
    PhasePhase 4
    Registry statusCompleted

  • Brimonidine 0.1% Versus Brinzolamide 1% as Adjunctive Therapy to Latanoprost 0.005%

    NCT00440141 · start 2006-07

    Registered record
    Registry ID
    NCT00440141
    Conditions
    Glaucoma; Ocular Hypertension
    Interventions
    latanoprost 0.005% eye drops and brimonidine 0.1% eye drops; latanoprost 0.005% eye drops and brinzolamide 1.0% eye drops
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-07
    Completion
    2007-03
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGlaucoma; Ocular Hypertension
    Interventionlatanoprost 0.005% eye drops and brimonidine 0.1% eye drops; latanoprost 0.005% eye drops and brinzolamide 1.0% eye drops
    PhasePhase 4
    Registry statusCompleted

  • A Study of a Glaucoma Therapy to Treat Open-Angle Glaucoma or Ocular Hypertension

    NCT00326092 · start 2006-05

    Registered record
    Registry ID
    NCT00326092
    Conditions
    Open-angle Glaucoma; Ocular Hypertension
    Interventions
    Brinzolamide/Timolol
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2006-05
    Completion
    2006-08
    Enrolment
    88

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOpen-angle Glaucoma; Ocular Hypertension
    InterventionBrinzolamide/Timolol
    PhasePhase 2
    Registry statusCompleted