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AMR Drug RepurposingSmart Screeningresearch prototype

Ramipril

FDA-approved product (capsule, oral), marketed as Altace, Ramipril, Vostally.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Ramipril
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Acute myocardial infarction
  • Cardiovascular disease
  • Congestive heart failure
  • Coronary artery disease
  • Diabetes mellitus
  • Heart failure
  • Hypertension
  • Myocardial infarction
  • Stroke

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Ace inhibitors, plain
FDA pharmacologic class
Angiotensin Converting Enzyme Inhibitor FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA38.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli27.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae18.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis59.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Ramipril in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Ramipril with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Efficacy and Safety of Aliskiren/Ramipril/Amlodipine Compared With Ramipril/Amlodipine and Aliskiren/Amlodipine in Patients With Metabolic Syndrome

    NCT00542269 · start 2008-03

    Registered record
    Registry ID
    NCT00542269
    Conditions
    Hypertension With Metabolic Syndrome
    Interventions
    Amlodipine; Aliskiren; Ramipril
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2008-03
    Completion
    2009-07
    Enrolment
    178

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension With Metabolic Syndrome
    InterventionAmlodipine; Aliskiren; Ramipril
    PhasePhase 4
    Registry statusTerminated

  • Study Evaluating The Effect Of Ramipril On Urinary Protein Excretion In Renal Transplant Patients Converted To Sirolimus

    NCT00502242 · start 2007-12

    Registered record
    Registry ID
    NCT00502242
    Conditions
    Kidney Transplant
    Interventions
    ramipril; ramipril
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-12
    Completion
    2013-09
    Enrolment
    229

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKidney Transplant
    Interventionramipril; ramipril
    PhasePhase 4
    Registry statusCompleted

  • African American Study of Kidney Disease and Hypertension ABPM Pilot Study

    NCT00582777 · start 2007-11

    Registered record
    Registry ID
    NCT00582777
    Conditions
    Hypertensive Renal Disease
    Interventions
    USUAL - take your BP Meds as you usually do; HS DOSING; ADD On Dosing
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2007-11
    Completion
    2008-12
    Enrolment
    180

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertensive Renal Disease
    InterventionUSUAL - take your BP Meds as you usually do; HS DOSING; ADD On Dosing
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Left Atrial Remodelling in Hypertension: Effects of Ramipril or Irbesartan

    NCT00517322 · start 2007-08

    Registered record
    Registry ID
    NCT00517322
    Conditions
    Left Atrial Volume; Hypertensive Heart Disease; Antihypertensive Drugs; Diastolic Function; Renin Angiotensin System
    Interventions
    ramipril; irbesartan
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2007-08
    Completion
    2010-08
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLeft Atrial Volume; Hypertensive Heart Disease; Antihypertensive Drugs; Diastolic Function +1 more
    Interventionramipril; irbesartan
    PhasePhase 4
    Registry statusUnknown

  • Bioequivalence Study of Ramipril 10 mg Capsules Under Fasting Conditions

    NCT00879476 · start 2007-01

    Registered record
    Registry ID
    NCT00879476
    Conditions
    Healthy
    Interventions
    Ramipril 10mg capsules
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2007-01
    Completion
    2007-03
    Enrolment
    68

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionRamipril 10mg capsules
    PhaseNot applicable
    Registry statusCompleted

  • A Safety and Efficacy Trial of Aliskiren 150mg , 300 mg Compared to Ramipril 5mg, 10mg in the Elderly

    NCT00368277 · start 2006-09

    Registered record
    Registry ID
    NCT00368277
    Conditions
    Hypertension
    Interventions
    Aliskiren; Ramipril; Hydrochlorothiazide; Amlodipine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-09
    Completion
    2008-02
    Enrolment
    901

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionAliskiren; Ramipril; Hydrochlorothiazide; Amlodipine
    PhasePhase 3
    Registry statusCompleted

  • Effects of Sodium Intake on (PK/PD) Relationship of a Single Dose of a Renin Angiotensin System-Blocker

    NCT00310778 · start 2006-03

    Registered record
    Registry ID
    NCT00310778
    Conditions
    Healthy
    Interventions
    high sodium diet; low sodium diet; ramipril 10 mg; valsartan 160 mg; candesartan 8 mg; atenolol 50 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2006-03
    Completion
    2007-03
    Enrolment
    64

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    Interventionhigh sodium diet; low sodium diet; ramipril 10 mg; valsartan 160 mg +2 more
    PhasePhase 1
    Registry statusCompleted

  • A Clinical Study to Compare an Aliskiren Based Hypertensive Regimen With a Ramipril Based One Followed by a Randomized Withdrawal.

    NCT00219063 · start 2005-02

    Registered record
    Registry ID
    NCT00219063
    Conditions
    Hypertension
    Interventions
    aliskiren
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-02
    Completion
    2006-03
    Enrolment
    844

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    Interventionaliskiren
    PhasePhase 3
    Registry statusCompleted

  • Italian Study on the Cardiovascular Effects of Systolic Blood Pressure Control - CARDIOSIS Study

    NCT00421863 · start 2005-02

    Registered record
    Registry ID
    NCT00421863
    Conditions
    Hypertension
    Interventions
    Triatec 10 mg; Triatec HCT 5; Lasix 25; Micardis 80 mg; Micardis plus 80/12.5; Catapresan TTS 2; Norvasc 10 mg; Triatec 5 mg; Pluscor
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2005-02
    Completion
    2009-01
    Enrolment
    1,111

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionTriatec 10 mg; Triatec HCT 5; Lasix 25; Micardis 80 mg +5 more
    PhasePhase 4
    Registry statusCompleted

  • Bioequivalency Study of Ramipril 10 mg Capsules Under Fasting Conditions

    NCT00702091 · start 2005-01

    Registered record
    Registry ID
    NCT00702091
    Conditions
    Hypertension
    Interventions
    Ramipril
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2005-01
    Completion
    2005-01
    Enrolment
    39

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionRamipril
    PhaseNot applicable
    Registry statusCompleted

  • To Demonstrate the Relative Bioavailability Study of Ramipril 10 mg Capsules Under Fasting Conditions

    NCT00946465 · start 2004-10

    Registered record
    Registry ID
    NCT00946465
    Conditions
    Hypertension
    Interventions
    Ramipril 10 Capsule (Sandoz); Altace (Ramipril) 10 Capsule (Aventis Pharmaceutical)
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2004-10
    Completion
    2004-11
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionRamipril 10 Capsule (Sandoz); Altace (Ramipril) 10 Capsule (Aventis Pharmaceutical)
    PhasePhase 1
    Registry statusCompleted

  • To Demonstrate the Relative Bioavailability Study of Ramipril 10 mg Capsules Under Non-Fasting Conditions

    NCT00946621 · start 2004-10

    Registered record
    Registry ID
    NCT00946621
    Conditions
    Hypertension
    Interventions
    Ramipril 10 mg Capsule (Sandoz); Altace (Ramipril) 10 mg Capsule (Aventis Pharmaceutical)
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2004-10
    Completion
    2004-11
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionRamipril 10 mg Capsule (Sandoz); Altace (Ramipril) 10 mg Capsule (Aventis Pharmaceutical)
    PhasePhase 1
    Registry statusCompleted

  • Irbesartan Versus Placebo in Combination With Ramipril for Treatment of Albuminuria

    NCT00095290 · start 2004-09

    Registered record
    Registry ID
    NCT00095290
    Conditions
    Albuminuria
    Interventions
    Ramipril + Irbesartan; Ramipril + Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-09
    Completion
    2005-11
    Enrolment
    400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlbuminuria
    InterventionRamipril + Irbesartan; Ramipril + Placebo
    PhasePhase 4
    Registry statusCompleted

  • Ramipril 10 mg/Day Prevention

    NCT01053910 · start 2003-10

    Registered record
    Registry ID
    NCT01053910
    Conditions
    Atherosclerosis
    Interventions
    Ramipril
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2003-10
    Completion
    Not recorded
    Enrolment
    1,012

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtherosclerosis
    InterventionRamipril
    PhasePhase 4
    Registry statusCompleted

  • Safety and Effects of Ramipril Combined With Candesartan

    NCT00356395 · start 2003-08

    Registered record
    Registry ID
    NCT00356395
    Conditions
    Hypertension
    Interventions
    ramipril, candesartan
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2003-08
    Completion
    2006-03
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    Interventionramipril, candesartan
    PhasePhase 4
    Registry statusCompleted