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AMR Drug RepurposingSmart Screeningresearch prototype

Testosterone Cypionate

FDA-approved product (injectable, injection), marketed as Azmiro, Depo-Testosterone, Testosterone Cypionate.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Testosterone Cypionate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cancer
  • Hypogonadism
  • Hypogonadotropic hypogonadism
  • Klinefelter's syndrome
  • Neoplasm
  • Orchitis
  • Physiological sexual disorder
  • Sexual dysfunction

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
3-oxoandrosten (4) derivatives
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA56.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli32.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae26.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis24.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Testosterone Cypionate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-9.0 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-8.0 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-10.0 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-10.4 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Testosterone Cypionate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Difluoromethylornithine and High Dose Testosterone With Enzalutamide in Metastatic Castration-Resistant Prostate Cancer

    NCT06059118 · start 2023-10-04

    Registered record
    Registry ID
    NCT06059118
    Conditions
    Prostate Cancer
    Interventions
    DFMO; testosterone cypionate; Luteinizing hormone-releasing hormone (LHRH) analogue; Enzalutamide
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Recruiting
    Start
    2023-10-04
    Completion
    2029-11-30
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Cancer
    InterventionDFMO; testosterone cypionate; Luteinizing hormone-releasing hormone (LHRH) analogue; Enzalutamide
    PhasePhase 2
    Registry statusRecruiting

  • Hormone Secretion in Transgender Males

    NCT04321551 · start 2023-07-01

    Registered record
    Registry ID
    NCT04321551
    Conditions
    Transgender; Healthy
    Interventions
    Testosterone Cyp 200Mg/Ml Inj (in Oil); Letrozole
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2023-07-01
    Completion
    2028-12-31
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTransgender; Healthy
    InterventionTestosterone Cyp 200Mg/Ml Inj (in Oil); Letrozole
    PhasePhase 4
    Registry statusWithdrawn

  • Testosterone Replacement to Alleviate Pain in Postmenopausal Women (TRAPP Trial)

    NCT04895306 · start 2022-11-15

    Registered record
    Registry ID
    NCT04895306
    Conditions
    Pain; Opioid Use; Androgen Deficiency; Back Pain
    Interventions
    Testosterone Cypionate; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2022-11-15
    Completion
    2026-03-27
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain; Opioid Use; Androgen Deficiency; Back Pain
    InterventionTestosterone Cypionate; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Effect of Dose Fractionation of Testosterone Cypionate on Transgender Men with Erythrocytosis

    NCT05487794 · start 2022-09-01

    Registered record
    Registry ID
    NCT05487794
    Conditions
    Testosterone; Transsexualism; Hematologic Diseases
    Interventions
    Testosterone Cypionate 100 MG/ML
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-09-01
    Completion
    2024-12-17
    Enrolment
    46

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTestosterone; Transsexualism; Hematologic Diseases
    InterventionTestosterone Cypionate 100 MG/ML
    PhaseNot applicable
    Registry statusCompleted

  • Can Testosterone Accelerate Injury Recovery After Arthroscopic Rotator Cuff Repair

    NCT04345666 · start 2021-08

    Registered record
    Registry ID
    NCT04345666
    Conditions
    Rotator Cuff Tears
    Interventions
    Testosterone cypionate; Placebos
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Withdrawn
    Start
    2021-08
    Completion
    2023-01
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRotator Cuff Tears
    InterventionTestosterone cypionate; Placebos
    PhasePhase 2 / Phase 3
    Registry statusWithdrawn

  • Extreme Bipolar Androgen Therapy With Darolutamide and Testosterone Cypionate in Patients With Metastatic Castration-Resistant Prostate Cancer (ExBAT Trial)

    NCT04558866 · start 2021-06-09

    Registered record
    Registry ID
    NCT04558866
    Conditions
    Prostate Cancer
    Interventions
    Testosterone Cypionate; Darolutamide
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2021-06-09
    Completion
    2024-04-02
    Enrolment
    51

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Cancer
    InterventionTestosterone Cypionate; Darolutamide
    PhasePhase 2
    Registry statusCompleted

  • Locomotor Training With Testosterone to Promote Bone and Muscle Health After Spinal Cord Injury

    NCT04460872 · start 2021-01-31

    Registered record
    Registry ID
    NCT04460872
    Conditions
    Spinal Cord Injury; Spinal Cord Injuries; Trauma, Nervous System; Wounds and Injury; Central Nervous System Diseases; Spinal Cord Diseases; Gonadal Disorders; Endocrine System Diseases; Hypogonadism; Genital Diseases, Male; Spinal Cord Trauma; Injuries, Spinal Cord; Walking, Difficulty; Gait Disorders, Neurologic; Locomotion Disorder, Neurologic; Wounds and Injuries; Nervous System Diseases; Testosterone Deficiency; Androgen Deficiency; Hormone Deficiency
    Interventions
    Testosterone Enanthate; Locomotor Training
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Recruiting
    Start
    2021-01-31
    Completion
    2026-06-30
    Enrolment
    21

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSpinal Cord Injury; Spinal Cord Injuries; Trauma, Nervous System; Wounds and Injury +16 more
    InterventionTestosterone Enanthate; Locomotor Training
    PhasePhase 2
    Registry statusRecruiting

  • Perioperative Testosterone Replacement Therapy for the Improvement of Post-Operative Outcomes in Patients With Low Testosterone

    NCT04731376 · start 2021-01-25

    Registered record
    Registry ID
    NCT04731376
    Conditions
    Hypogonadism; Malignant Urinary System Neoplasm; Urinary System Disorder; Urinary System Neoplasm
    Interventions
    Best Practice; Quality-of-Life Assessment; Questionnaire Administration; Testosterone Cypionate
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Active not recruiting
    Start
    2021-01-25
    Completion
    2026-12-31
    Enrolment
    56

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypogonadism; Malignant Urinary System Neoplasm; Urinary System Disorder; Urinary System Neoplasm
    InterventionBest Practice; Quality-of-Life Assessment; Questionnaire Administration; Testosterone Cypionate
    PhasePhase 1
    Registry statusActive not recruiting

  • Effect of Transgender Therapy on Muscle, Fat and Tissue Receptors

    NCT04551144 · start 2020-10-06

    Registered record
    Registry ID
    NCT04551144
    Conditions
    Gender Incongruence; Transgenderism
    Interventions
    testosterone cypionate; Estradiol Valerate
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Terminated
    Start
    2020-10-06
    Completion
    2023-01-18
    Enrolment
    4

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGender Incongruence; Transgenderism
    Interventiontestosterone cypionate; Estradiol Valerate
    PhaseNot recorded
    Registry statusTerminated

  • Biomarker Analysis of Castration-resistant Prostate Cancer Undergoing Bipolar Androgen Therapy

    NCT04424654 · start 2020-09-22

    Registered record
    Registry ID
    NCT04424654
    Conditions
    Prostate Cancer
    Interventions
    Testosterone cypionate
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2020-09-22
    Completion
    2022-07-01
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Cancer
    InterventionTestosterone cypionate
    PhasePhase 2
    Registry statusCompleted

  • Sequential Testosterone and Enzalutamide Prevents Unfavorable Progression

    NCT04363164 · start 2020-08-19

    Registered record
    Registry ID
    NCT04363164
    Conditions
    Castration Resistant Metastatic Prostate Cancer
    Interventions
    Testosterone cypionate; Enzalutamide; Testosterone enanthate
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Recruiting
    Start
    2020-08-19
    Completion
    2028-07
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCastration Resistant Metastatic Prostate Cancer
    InterventionTestosterone cypionate; Enzalutamide; Testosterone enanthate
    PhasePhase 2
    Registry statusRecruiting

  • A Comparison of Side Effects in Hypogonadal Men Treated With Natesto Versus Testosterone Injections

    NCT04439799 · start 2020-08-07

    Registered record
    Registry ID
    NCT04439799
    Conditions
    Hypogonadism, Male
    Interventions
    Testosterone Cypionate 200 Mg/ML; Intranasal Testosterone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2020-08-07
    Completion
    2023-02-09
    Enrolment
    81

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypogonadism, Male
    InterventionTestosterone Cypionate 200 Mg/ML; Intranasal Testosterone
    PhasePhase 4
    Registry statusCompleted

  • Generation of Biological Samples Positive to Testosterone for Anti-doping Control

    NCT04207684 · start 2020-02-04

    Registered record
    Registry ID
    NCT04207684
    Conditions
    Healthy Volunteers
    Interventions
    Testosterone injection
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2020-02-04
    Completion
    2020-02-26
    Enrolment
    4

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Volunteers
    InterventionTestosterone injection
    PhasePhase 1
    Registry statusCompleted

  • Improving Quality of Life of Prostate Cancer Survivors With Androgen Deficiency

    NCT03716739 · start 2019-03-19

    Registered record
    Registry ID
    NCT03716739
    Conditions
    Prostate Cancer
    Interventions
    Testosterone Cypionate 100 MG/ML; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2019-03-19
    Completion
    2025-07-16
    Enrolment
    136

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Cancer
    InterventionTestosterone Cypionate 100 MG/ML; Placebo
    PhasePhase 2
    Registry statusCompleted

  • A Bioequivalence Study of Testosterone Cypionate in Hypogonadal Males

    NCT03792477 · start 2019-01-19

    Registered record
    Registry ID
    NCT03792477
    Conditions
    Hypogonadism
    Interventions
    Test formulation; Reference formulation
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2019-01-19
    Completion
    2020-04-02
    Enrolment
    74

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypogonadism
    InterventionTest formulation; Reference formulation
    PhasePhase 1
    Registry statusCompleted