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AMR Drug RepurposingSmart Screeningresearch prototype

Nifedipine

FDA-approved product (capsule, oral), marketed as Adalat, Adalat Cc, Afeditab Cr and 3 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Nifedipine
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cardiovascular disease
  • Coronary Vasospasm
  • Hypertension

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Dihydropyridine derivatives
FDA pharmacologic class
Dihydropyridine Calcium Channel Blocker FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA46.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli32.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae12.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis55.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Nifedipine in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-5.2 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.2 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-6.9 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.0 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Nifedipine with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Nifedipine Pharmacokinetics and Pharmacodynamics When Used as a Tocolytic in Acute Threatened Preterm Labour

    NCT02068404 · start 2014-04

    Registered record
    Registry ID
    NCT02068404
    Conditions
    Preterm Labor
    Interventions
    Nifedipine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2014-04
    Completion
    2016-01
    Enrolment
    75

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPreterm Labor
    InterventionNifedipine
    PhasePhase 4
    Registry statusUnknown

  • Transdermal Nitroglycerin and Nifedipine in Preterm Labor

    NCT02583633 · start 2013-10

    Registered record
    Registry ID
    NCT02583633
    Conditions
    Managing Preterm Labor
    Interventions
    Transdermal nitroglycerin; nifedipine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2013-10
    Completion
    2014-10
    Enrolment
    112

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionManaging Preterm Labor
    InterventionTransdermal nitroglycerin; nifedipine
    PhasePhase 4
    Registry statusCompleted

  • Maternal Serum Level of ACTH as a Predictive Marker of Preterm Labor in Patients With Threatened Preterm Labor

    NCT01773135 · start 2013-01

    Registered record
    Registry ID
    NCT01773135
    Conditions
    Threatened Preterm Labor
    Interventions
    collection of blood sample and tocolysis adminstration
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2013-01
    Completion
    2014-01
    Enrolment
    262

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionThreatened Preterm Labor
    Interventioncollection of blood sample and tocolysis adminstration
    PhaseNot recorded
    Registry statusCompleted

  • Diastolic Heart Failure Management by Nifedipine

    NCT01157481 · start 2010-07

    Registered record
    Registry ID
    NCT01157481
    Conditions
    Diastolic Heart Failure
    Interventions
    Conventional therapy plus nifedipine; Conventional therapy
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2010-07
    Completion
    2016-12
    Enrolment
    226

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiastolic Heart Failure
    InterventionConventional therapy plus nifedipine; Conventional therapy
    PhaseNot applicable
    Registry statusUnknown

  • Sevoflurane Versus Intravenous Anaesthetic Agents in Morbid Obese Patients

    NCT01279499 · start 2010-04

    Registered record
    Registry ID
    NCT01279499
    Conditions
    Morbid Obesity
    Interventions
    Sevoflurane; Sevoflurane; Propofol- Remifentanyl; Propofol, Remifentanyl
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Unknown
    Start
    2010-04
    Completion
    2011-07
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMorbid Obesity
    InterventionSevoflurane; Sevoflurane; Propofol- Remifentanyl; Propofol, Remifentanyl
    PhasePhase 2 / Phase 3
    Registry statusUnknown

  • FOCUS (Nifedipine GITS's Effect on Central Pressure Assessed by Applanation Tonometry)

    NCT01071122 · start 2010-01

    Registered record
    Registry ID
    NCT01071122
    Conditions
    Hypertension
    Interventions
    Nifedipine (Adalat, BAYA1040) and Valsartan; Nifedipine (Adalat, BAYA1040); Valsartan
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-01
    Completion
    2012-02
    Enrolment
    365

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionNifedipine (Adalat, BAYA1040) and Valsartan; Nifedipine (Adalat, BAYA1040); Valsartan
    PhasePhase 4
    Registry statusCompleted

  • Amlodipine Prevents Morning Blood Pressure Surge Study

    NCT01030081 · start 2009-10

    Registered record
    Registry ID
    NCT01030081
    Conditions
    Hypertension
    Interventions
    Amlodipine (Norvasc®); Nifedipine GITS (Adalat® XL 30
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-10
    Completion
    2013-03
    Enrolment
    510

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionAmlodipine (Norvasc®); Nifedipine GITS (Adalat® XL 30
    PhasePhase 4
    Registry statusCompleted

  • The Effect of LipoCol Forte® Capsules on the Pharmacokinetics of Nifedipine After Administering Single-dose Combination to Healthy Subjects

    NCT01346657 · start 2009-07

    Registered record
    Registry ID
    NCT01346657
    Conditions
    Healthy Volunteers
    Interventions
    Nifidipine & LipoCol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-07
    Completion
    2009-07
    Enrolment
    14

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Volunteers
    InterventionNifidipine & LipoCol
    PhasePhase 4
    Registry statusCompleted

  • Drug Discrimination in Methadone-Maintained Humans Study 2

    NCT00733239 · start 2008-08

    Registered record
    Registry ID
    NCT00733239
    Conditions
    Opioid Dependence
    Interventions
    2-4 of the drugs listed below
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2008-08
    Completion
    2010-10
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOpioid Dependence
    Intervention2-4 of the drugs listed below
    PhasePhase 1
    Registry statusCompleted

  • Efficacy and Safety of Stent Implantation in Symptomatic Extra- and Intracranial Artery Stenosis

    NCT00691314 · start 2008-06

    Registered record
    Registry ID
    NCT00691314
    Conditions
    Stroke; Transient Ischemic Attack; Atherosclerosis; Stenosis; Stents
    Interventions
    Stent implantation (Wingspan, Coroflex, and TiTAN2); Standard medical treatment
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2008-06
    Completion
    2010-12
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStroke; Transient Ischemic Attack; Atherosclerosis; Stenosis +1 more
    InterventionStent implantation (Wingspan, Coroflex, and TiTAN2); Standard medical treatment
    PhaseNot applicable
    Registry statusCompleted

  • Indomethacin Versus Nifedipine for Preterm Labor Tocolysis

    NCT00486824 · start 2007-04

    Registered record
    Registry ID
    NCT00486824
    Conditions
    Obstetric Labor, Premature
    Interventions
    Indomethacin; Nifedipine
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2007-04
    Completion
    2012-12-08
    Enrolment
    29

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObstetric Labor, Premature
    InterventionIndomethacin; Nifedipine
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Efficacy Study of Topical Application of Nifedipine Cream to Treat Vulvar Vestibulitis

    NCT00496184 · start 2006-04

    Registered record
    Registry ID
    NCT00496184
    Conditions
    Vulvar Diseases; Vulvar Pain; Vestibulitis; Vestibulodynia; Vulvodynia
    Interventions
    Nifedipine cream topical application
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-04
    Completion
    2008-05
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVulvar Diseases; Vulvar Pain; Vestibulitis; Vestibulodynia +1 more
    InterventionNifedipine cream topical application
    PhasePhase 3
    Registry statusCompleted

  • The Effects of Cilnidipine on Metabolic Syndrome Improvement

    NCT00325936 · start 2005-07

    Registered record
    Registry ID
    NCT00325936
    Conditions
    Hypertension; Metabolic Syndrome X
    Interventions
    Cilnidipine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2005-07
    Completion
    2007-06
    Enrolment
    186

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension; Metabolic Syndrome X
    InterventionCilnidipine
    PhasePhase 4
    Registry statusCompleted

  • A Relative Bioavailability Study of 60 mg Nifedipine ER Tablets Under Non-fasting Conditions

    NCT00864617 · start 2005-05

    Registered record
    Registry ID
    NCT00864617
    Conditions
    Healthy
    Interventions
    Nifedipine Extended Release tablets 60 mg, single dose; ADALAT® CC Extended Release Tablets 60 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2005-05
    Completion
    2005-05
    Enrolment
    84

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionNifedipine Extended Release tablets 60 mg, single dose; ADALAT® CC Extended Release Tablets 60 mg
    PhasePhase 1
    Registry statusCompleted

  • Losartan Therapy in Pulmonary Hypertension

    NCT00519870 · start 2005-01

    Registered record
    Registry ID
    NCT00519870
    Conditions
    Pulmonary Hypertension
    Interventions
    nifedipine, losartan; losartan; Nifedipine, losartan
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-01
    Completion
    2005-07
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Hypertension
    Interventionnifedipine, losartan; losartan; Nifedipine, losartan
    PhasePhase 3
    Registry statusCompleted