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AMR Drug RepurposingSmart Screeningresearch prototype

Clavulanate Potassium

FDA-approved product (tablet, oral).

Registered studies
50+
Lab records
28
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Clavulanate Potassium
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Infection
  • Infectious otitis media
  • Otitis media
  • Pneumonia
  • Respiratory tract infectious disorder
  • Sinusitis
  • Soft Tissue Infections
  • Urinary tract infection

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Combinations of penicillins, incl. beta-lactamase inhibitors
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01CR02

Repurposing investigation

Clavulanate Potassium is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA4.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli74.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae73.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis39.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 1 of 8 lab records
  • E. coli: measured active in 9 of 16 lab records
  • K. pneumoniae: measured active in 4 of 4 lab records
Open Clavulanate Potassium in ChEMBL Registered studies below
Show the 28 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-5.6 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.5 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-5.7 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-5.3 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Clavulanate Potassium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Preschool Wheeze: Inflammation/Infection Guided Management

    NCT02517099 · start 2015-06-05

    Registered record
    Registry ID
    NCT02517099
    Conditions
    Asthma
    Interventions
    Beclometasone; Co-amoxiclav; Azithromycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2015-06-05
    Completion
    2018-08-17
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAsthma
    InterventionBeclometasone; Co-amoxiclav; Azithromycin
    PhasePhase 2
    Registry statusCompleted

  • Effect of Vitamin D on Drug Resistant Helicobacter Pylori (HP) Eradication Study

    NCT03142620 · start 2015-03

    Registered record
    Registry ID
    NCT03142620
    Conditions
    H. Pylori Infection
    Interventions
    Esomeprazole; Amoxicillin-Potassium Clavulanate Combination; Clarithromycin; Vitamin D3
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2015-03
    Completion
    2017-12
    Enrolment
    96

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionH. Pylori Infection
    InterventionEsomeprazole; Amoxicillin-Potassium Clavulanate Combination; Clarithromycin; Vitamin D3
    PhasePhase 3
    Registry statusUnknown

  • Trial on the Ideal Duration of Oral Antibiotics in Children With Pneumonia

    NCT02258763 · start 2014-11

    Registered record
    Registry ID
    NCT02258763
    Conditions
    Pneumonia
    Interventions
    Amoxicillin-Potassium Clavulanate Combination; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2014-11
    Completion
    2018-10
    Enrolment
    19

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia
    InterventionAmoxicillin-Potassium Clavulanate Combination; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Phase 2 Trial to Evaluate the Early Bactericidal Activity, Safety and Tolerability of Meropenem Plus Amoxycillin/CA and Faropenem Plus Amoxycillin/CA in Adult Patients With Newly Diagnosed Pulmonary Tuberculosis

    NCT02349841 · start 2014-09

    Registered record
    Registry ID
    NCT02349841
    Conditions
    Pulmonary Tuberculosis
    Interventions
    Meropenem; Faropenem; Amoxycillin/clavulanic acid; Rifafour e275
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2014-09
    Completion
    2014-12
    Enrolment
    46

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Tuberculosis
    InterventionMeropenem; Faropenem; Amoxycillin/clavulanic acid; Rifafour e275
    PhasePhase 2
    Registry statusCompleted

  • Levofloxacin in Bacterial Rhinosinussitis

    NCT02712502 · start 2014-09

    Registered record
    Registry ID
    NCT02712502
    Conditions
    Rhinosinusitis
    Interventions
    Levofloxacin; Amoxicillin-Potassium Clavulanate Combination
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2014-09
    Completion
    2014-12
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRhinosinusitis
    InterventionLevofloxacin; Amoxicillin-Potassium Clavulanate Combination
    PhaseNot recorded
    Registry statusCompleted

  • Phase I Study of Safety and Immunogenicity of ADU-623

    NCT01967758 · start 2014-01-08

    Registered record
    Registry ID
    NCT01967758
    Conditions
    Astrocytic Tumors; Glioblastoma Multiforme; Anaplastic Astrocytoma; Brain Tumor
    Interventions
    Cohort 1; Cohort 2; Cohort 3; Antibiotics
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2014-01-08
    Completion
    2018-08-15
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAstrocytic Tumors; Glioblastoma Multiforme; Anaplastic Astrocytoma; Brain Tumor
    InterventionCohort 1; Cohort 2; Cohort 3; Antibiotics
    PhasePhase 1
    Registry statusCompleted

  • A New Antibiotic Prophylaxis Regimen to Prevent Bacteremia Following Dental Procedures

    NCT02115776 · start 2014-01

    Registered record
    Registry ID
    NCT02115776
    Conditions
    Bacteremia
    Interventions
    Amoxicillin-Potassium Clavulanate; Amoxicillin; Chlorhexidine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-01
    Completion
    2015-05
    Enrolment
    266

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacteremia
    InterventionAmoxicillin-Potassium Clavulanate; Amoxicillin; Chlorhexidine
    PhaseNot applicable
    Registry statusCompleted

  • Duration of Antibiotic Therapy as Part of Maximal Medical Therapy for Chronic Rhinosinusitis

    NCT01825408 · start 2013-02

    Registered record
    Registry ID
    NCT01825408
    Conditions
    Sinusitis
    Interventions
    Doxycycline; Azithromycin; Augmentin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2013-02
    Completion
    2014-06
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSinusitis
    InterventionDoxycycline; Azithromycin; Augmentin
    PhasePhase 4
    Registry statusCompleted

  • Prophylactic Antibiotics After Functional Endoscopic Sinus Surgery: a Randomized, Double-blind Placebo Controlled Trial

    NCT01919411 · start 2013-02

    Registered record
    Registry ID
    NCT01919411
    Conditions
    Sinusitis
    Interventions
    Amoxicillin-Potassium Clavulanate; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2013-02
    Completion
    2018-09
    Enrolment
    134

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSinusitis
    InterventionAmoxicillin-Potassium Clavulanate; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Initial Antibiotics and Delayed Appendectomy for Acute Appendicitis

    NCT01697059 · start 2012-09

    Registered record
    Registry ID
    NCT01697059
    Conditions
    Acute Appendicitis
    Interventions
    Piperacillin + Amoxicillin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-09
    Completion
    2015-05
    Enrolment
    73

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Appendicitis
    InterventionPiperacillin + Amoxicillin
    PhaseNot applicable
    Registry statusCompleted

  • Efficacy of Short-Course Antimicrobial Treatment for Children With Acute Otitis Media and Impact on Resistance

    NCT01511107 · start 2012-01

    Registered record
    Registry ID
    NCT01511107
    Conditions
    Acute Otitis Media
    Interventions
    Amoxicillin-Clavulanate, 10 days; Amoxicillin-Clavulanate, 5 days
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2012-01
    Completion
    2015-10
    Enrolment
    520

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Otitis Media
    InterventionAmoxicillin-Clavulanate, 10 days; Amoxicillin-Clavulanate, 5 days
    PhasePhase 2
    Registry statusTerminated

  • A Safety and Tolerability Study of Doripenem Compared With Cefepime in Hospitalized Children With Bacterial Pneumonia

    NCT01110421 · start 2010-12

    Registered record
    Registry ID
    NCT01110421
    Conditions
    Pneumonia, Bacterial; Community-Acquired Infections; Nosocomial Infection; Pneumonia, Ventilator-Associated
    Interventions
    Cefepime placebo; Cefepime; Doripenem; Doripenem placebo; Amoxicillin/clavulanate potassium
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2010-12
    Completion
    2012-03
    Enrolment
    7

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia, Bacterial; Community-Acquired Infections; Nosocomial Infection; Pneumonia, Ventilator-Associated
    InterventionCefepime placebo; Cefepime; Doripenem; Doripenem placebo +1 more
    PhasePhase 3
    Registry statusTerminated

  • Short (5 Days) Versus Long (14 Days) Duration of Antimicrobial Therapy for Acute Bacterial Sinusitis in Children

    NCT01166945 · start 2010-11

    Registered record
    Registry ID
    NCT01166945
    Conditions
    Sinusitis
    Interventions
    Amoxicillin-Potassium Clavulanate Combination; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-11
    Completion
    2016-02
    Enrolment
    98

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSinusitis
    InterventionAmoxicillin-Potassium Clavulanate Combination; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • Monotherapy Versus Bitherapy in Non-severe Hospitalized Community-acquired Pneumonia

    NCT00818610 · start 2009-01

    Registered record
    Registry ID
    NCT00818610
    Conditions
    Community-acquired Pneumonia
    Interventions
    Beta lactam (amoxicillin / clav. acid OR cefuroxime); Beta-lactam (amoxicillin / clav. acid OR cefuroxime) AND macrolide (clarithromycin)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-01
    Completion
    2013-04
    Enrolment
    601

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCommunity-acquired Pneumonia
    InterventionBeta lactam (amoxicillin / clav. acid OR cefuroxime); Beta-lactam (amoxicillin / clav. acid OR cefuroxime) AND macrolide (clarithromycin)
    PhasePhase 4
    Registry statusCompleted

  • Zmax Compared to Augmentin in Sinusitis

    NCT00367120 · start 2006-06

    Registered record
    Registry ID
    NCT00367120
    Conditions
    Sinusitis
    Interventions
    Azithromycin Extended Release; Amoxicillin/Clavulanate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-06
    Completion
    2007-02
    Enrolment
    762

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSinusitis
    InterventionAzithromycin Extended Release; Amoxicillin/Clavulanate
    PhasePhase 4
    Registry statusCompleted