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AMR Drug RepurposingSmart Screeningresearch prototype

Clavulanate Potassium

FDA-approved product (tablet, oral).

Registered studies
50+
Lab records
28
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Clavulanate Potassium
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Infection
  • Infectious otitis media
  • Otitis media
  • Pneumonia
  • Respiratory tract infectious disorder
  • Sinusitis
  • Soft Tissue Infections
  • Urinary tract infection

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Combinations of penicillins, incl. beta-lactamase inhibitors
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01CR02

Repurposing investigation

Clavulanate Potassium is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA4.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli74.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae73.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis39.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 1 of 8 lab records
  • E. coli: measured active in 9 of 16 lab records
  • K. pneumoniae: measured active in 4 of 4 lab records
Open Clavulanate Potassium in ChEMBL Registered studies below
Show the 28 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-5.6 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.5 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-5.7 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-5.3 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Clavulanate Potassium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Azithromycin+Amoxicillin/Clavulanate vs Amoxicillin/Clavulanate in COVID19 Patients With Pneumonia in Non-intensive Unit

    NCT04363060 · start 2020-04-30

    Registered record
    Registry ID
    NCT04363060
    Conditions
    COVID-19 Pneumonia
    Interventions
    Azithromycin with amoxicillin/clavulanate; amoxicillin/clavulanate
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2020-04-30
    Completion
    2020-07-30
    Enrolment
    104

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCOVID-19 Pneumonia
    InterventionAzithromycin with amoxicillin/clavulanate; amoxicillin/clavulanate
    PhasePhase 3
    Registry statusUnknown

  • Bacteriological Study of Acute Follicular Tonsillitis

    NCT04321733 · start 2020-04

    Registered record
    Registry ID
    NCT04321733
    Conditions
    Acute Follicular Tonsillitis
    Interventions
    Amoxicillin Clavulanate
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2020-04
    Completion
    2021-10
    Enrolment
    66

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Follicular Tonsillitis
    InterventionAmoxicillin Clavulanate
    PhaseNot recorded
    Registry statusUnknown

  • 2-day Prophylactic Antibiotic is Effective in Transoral Endoscopic Thyroidectomy

    NCT04268407 · start 2020-02-26

    Registered record
    Registry ID
    NCT04268407
    Conditions
    Thyroid Nodule
    Interventions
    Amoxicillin Clavulanate
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2020-02-26
    Completion
    2021-12-31
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionThyroid Nodule
    InterventionAmoxicillin Clavulanate
    PhaseNot applicable
    Registry statusCompleted

  • A Study to Compare Different Antibiotics and Different Modes of Fluid Treatment for Children With Severe Pneumonia

    NCT04041791 · start 2019-08-19

    Registered record
    Registry ID
    NCT04041791
    Conditions
    Pneumonia
    Interventions
    Benzyl penicillin; Gentamicin Sulfate; Ceftriaxone; Amoxicillin Clavulanate; Intravenous fluid; Nasogastric feeds; Ampicillin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2019-08-19
    Completion
    2024-04-05
    Enrolment
    4,392

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia
    InterventionBenzyl penicillin; Gentamicin Sulfate; Ceftriaxone; Amoxicillin Clavulanate +3 more
    PhasePhase 3
    Registry statusCompleted

  • Pharmacokinetics and Pleural Fluid Penetration of Amoxicillin and Clavulanic Acid in Patients With Pleural Infections

    NCT04350502 · start 2019-07-18

    Registered record
    Registry ID
    NCT04350502
    Conditions
    Pleural Infection; Empyema; Community-acquired Pneumonia; Pharmacokinetic; Amoxicillin
    Interventions
    chest tube drainage; antibiotic concentration in pleural fluid; Amoxicillin + clavulanic acid
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-07-18
    Completion
    2025-12-01
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPleural Infection; Empyema; Community-acquired Pneumonia; Pharmacokinetic +1 more
    Interventionchest tube drainage; antibiotic concentration in pleural fluid; Amoxicillin + clavulanic acid
    PhaseNot applicable
    Registry statusCompleted

  • Topical Arnica and Mucopolysaccharide Polysulfate on Postoperative Pain, Edema and Trismus

    NCT04534426 · start 2018-12-01

    Registered record
    Registry ID
    NCT04534426
    Conditions
    Impacted Third Molar Tooth
    Interventions
    : Arnica montana; Mucopolysaccharide polysulfate; Control group
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2018-12-01
    Completion
    2020-01-30
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionImpacted Third Molar Tooth
    Intervention: Arnica montana; Mucopolysaccharide polysulfate; Control group
    PhasePhase 4
    Registry statusCompleted

  • Sulopenem Versus Ertapenem for Complicated Intra-abdominal Infection (cIAI)

    NCT03358576 · start 2018-09-18

    Registered record
    Registry ID
    NCT03358576
    Conditions
    Intra Abdominal Infections
    Interventions
    Ertapenem; Sulopenem-Etzadroxil/Probenecid; Ciprofloxacin; Metronidazole; Amoxicillin-Clavulanate; Sulopenem
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2018-09-18
    Completion
    2019-10-02
    Enrolment
    674

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIntra Abdominal Infections
    InterventionErtapenem; Sulopenem-Etzadroxil/Probenecid; Ciprofloxacin; Metronidazole +2 more
    PhasePhase 3
    Registry statusCompleted

  • Comparing Efficacy of Postoperative Oral Antibiotic Use in Trans-Oral Thyroidectomy

    NCT03295955 · start 2017-09-04

    Registered record
    Registry ID
    NCT03295955
    Conditions
    Surgical Wound Infection; Thyroid Nodule
    Interventions
    Amoxicillin Clavulanate
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2017-09-04
    Completion
    2018-12-03
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgical Wound Infection; Thyroid Nodule
    InterventionAmoxicillin Clavulanate
    PhaseNot applicable
    Registry statusUnknown

  • An Oral Amoxicillin-Clavulanate Regimen to Prevent Bacteremia Following Dental Procedures

    NCT02783404 · start 2017-02-27

    Registered record
    Registry ID
    NCT02783404
    Conditions
    Bacteraemia; Endocarditis
    Interventions
    Amoxicillin; Amoxicillin-Potassium Clavulanate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2017-02-27
    Completion
    2022-05-17
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacteraemia; Endocarditis
    InterventionAmoxicillin; Amoxicillin-Potassium Clavulanate
    PhasePhase 4
    Registry statusTerminated

  • Early Stoppage Versus Continuation of Antimicrobial Therapy in Low Risk Pediatric Cancer Patients With Febrile Neutropenia, Before Recovery of Counts: -DALFEN Study

    NCT03003273 · start 2017-01

    Registered record
    Registry ID
    NCT03003273
    Conditions
    Neutropenia, Febrile; Pediatric Cancer
    Interventions
    stoppage of antibiotics; amoxycillin/clavulanic acid; levofloxacin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2017-01
    Completion
    2018-12
    Enrolment
    142

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeutropenia, Febrile; Pediatric Cancer
    Interventionstoppage of antibiotics; amoxycillin/clavulanic acid; levofloxacin
    PhasePhase 3
    Registry statusTerminated

  • Helicobacter Pylori Eradication Study

    NCT03130452 · start 2016-12-17

    Registered record
    Registry ID
    NCT03130452
    Conditions
    Helicobacter Pylori Infection
    Interventions
    Lansoprazole 30mg; Amoxicillin 1.0g Tab; Clarithromycin 500mg; Metronidazole 500 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2016-12-17
    Completion
    2019-05-31
    Enrolment
    423

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHelicobacter Pylori Infection
    InterventionLansoprazole 30mg; Amoxicillin 1.0g Tab; Clarithromycin 500mg; Metronidazole 500 mg
    PhasePhase 4
    Registry statusCompleted

  • Initial Non-operative Treatment Strategy Versus Appendectomy Treatment Strategy for Simple Appendicitis in Children

    NCT02848820 · start 2016-12

    Registered record
    Registry ID
    NCT02848820
    Conditions
    Appendicitis
    Interventions
    Augmentin + Gentamicin; Appendectomy
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2016-12
    Completion
    2024-12
    Enrolment
    302

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAppendicitis
    InterventionAugmentin + Gentamicin; Appendectomy
    PhasePhase 4
    Registry statusUnknown

  • Safety and Efficacy of Solithromycin in Adolescents and Children With Community-Acquired Bacterial Pneumonia

    NCT02605122 · start 2016-04

    Registered record
    Registry ID
    NCT02605122
    Conditions
    Community-acquired Bacterial Pneumonia
    Interventions
    Solithromycin; Standard of Care
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Terminated
    Start
    2016-04
    Completion
    2018-03-21
    Enrolment
    97

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCommunity-acquired Bacterial Pneumonia
    InterventionSolithromycin; Standard of Care
    PhasePhase 2 / Phase 3
    Registry statusTerminated

  • Pharmacokinetic Study of the Association of Amoxicillin / Clavulanic Acid to Obese Adults

    NCT02571959 · start 2015-07-24

    Registered record
    Registry ID
    NCT02571959
    Conditions
    Obesity
    Interventions
    amoxicillin and clavulanic acid; amoxicillin and clavulanic acid
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2015-07-24
    Completion
    2017-06-16
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObesity
    Interventionamoxicillin and clavulanic acid; amoxicillin and clavulanic acid
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Efficacy of Antibiotic Therapy in Severe Alcoholic Hepatitis Treated With Prednisolone

    NCT02281929 · start 2015-06-13

    Registered record
    Registry ID
    NCT02281929
    Conditions
    Alcoholic Hepatitis; Alcoholic Liver Disease
    Interventions
    Amoxicillin; Placebo; Prednisolone
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2015-06-13
    Completion
    2019-11-19
    Enrolment
    297

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlcoholic Hepatitis; Alcoholic Liver Disease
    InterventionAmoxicillin; Placebo; Prednisolone
    PhasePhase 3
    Registry statusCompleted