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AMR Drug RepurposingSmart Screeningresearch prototype

Trimethoprim

FDA-approved product (tablet, oral), marketed as Proloprim, Trimethoprim, Trimpex and 2 more.

Registered studies
50+
Lab records
56
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Trimethoprim
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Infection
  • Otitis media
  • Pneumocystosis
  • Urinary tract infection

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Trimethoprim and derivatives
FDA pharmacologic class
Dihydrofolate Reductase Inhibitor Antibacterial FDA label ↗
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01EA01; FDA class Dihydrofolate Reductase Inhibitor Antibacterial

Repurposing investigation

Trimethoprim is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA79.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli>99% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae76.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis9.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 7 of 8 lab records
  • E. coli: measured active in 32 of 33 lab records
  • K. pneumoniae: measured active in 7 of 12 lab records
  • M. tuberculosis: measured active in 0 of 3 lab records
Open Trimethoprim in ChEMBL Registered studies below
Show the 56 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.4 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.4 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-6.1 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.2 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Trimethoprim with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Dropless Pars Plana Vitrectomy Study

    NCT05331664 · start 2022-07-25

    Registered record
    Registry ID
    NCT05331664
    Conditions
    Rhegmatogenous Retinal Detachment
    Interventions
    Pars plana vitrectomy; Triamcinolone Acetonide 40mg/mL; Moxifloxacin 0.5% or Polymyxin/Trimethoprim if patient is allergic to moxifloxacin; Prednisolone 1%; Atropine 1%
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2022-07-25
    Completion
    2026-08-30
    Enrolment
    168

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRhegmatogenous Retinal Detachment
    InterventionPars plana vitrectomy; Triamcinolone Acetonide 40mg/mL; Moxifloxacin 0.5% or Polymyxin/Trimethoprim if patient is allergic to moxifloxacin; Prednisolone 1% +1 more
    PhasePhase 4
    Registry statusCompleted

  • Evaluating a Dropless Postoperative Regimen After Cataract Surgery in a Vulnerable, County-hospital Population

    NCT05157113 · start 2022-05-31

    Registered record
    Registry ID
    NCT05157113
    Conditions
    Cataract; Surgery; Compliance, Patient; Compliance, Medication; Satisfaction, Patient
    Interventions
    Dropless Regimen; Standard Regimen
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2022-05-31
    Completion
    2026-06-01
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCataract; Surgery; Compliance, Patient; Compliance, Medication +1 more
    InterventionDropless Regimen; Standard Regimen
    PhasePhase 4
    Registry statusRecruiting

  • Efficacy and Safety of Hemoperfusion With Polymyxin B in Septic Shock Associated With Severe Endotoxemia in Cardiac Surgery Patients (РМХ vs SS)

    NCT04920565 · start 2021-11-01

    Registered record
    Registry ID
    NCT04920565
    Conditions
    Multiple Organ Dysfunction With Severe Endotoxemia
    Interventions
    hemoperfusion with polymyxin B
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2021-11-01
    Completion
    2025-12
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMultiple Organ Dysfunction With Severe Endotoxemia
    Interventionhemoperfusion with polymyxin B
    PhaseNot applicable
    Registry statusRecruiting

  • Study of the Safety, Tolerability, and PK of MRX-8 Administered Intravenously to HVs in SAD and MAD Cohorts

    NCT04649541 · start 2020-11-29

    Registered record
    Registry ID
    NCT04649541
    Conditions
    Safety
    Interventions
    MRX-8; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2020-11-29
    Completion
    2021-12-01
    Enrolment
    69

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSafety
    InterventionMRX-8; Placebo
    PhasePhase 1
    Registry statusCompleted

  • Pharmacokinetics of Polymyxin B in Adult Patients With Cystic Fibrosis

    NCT04335370 · start 2019-01-09

    Registered record
    Registry ID
    NCT04335370
    Conditions
    Cystic Fibrosis; Polymyxin B
    Interventions
    Blood Draw
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2019-01-09
    Completion
    2021-07-01
    Enrolment
    9

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCystic Fibrosis; Polymyxin B
    InterventionBlood Draw
    PhaseNot recorded
    Registry statusCompleted

  • Tacrolimus for Malar Edema

    NCT03715387 · start 2018-10-10

    Registered record
    Registry ID
    NCT03715387
    Conditions
    Edema Face
    Interventions
    Tacrolimus Topical 0.1% Topical Ointment; Polysporin Ointment
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Unknown
    Start
    2018-10-10
    Completion
    2019-07-01
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEdema Face
    InterventionTacrolimus Topical 0.1% Topical Ointment; Polysporin Ointment
    PhasePhase 2 / Phase 3
    Registry statusUnknown

  • Efficacy Analysis of Tigecycline-based Therapy and Polymyxin B-based Therapy in ICU Infection

    NCT04970537 · start 2017-07-23

    Registered record
    Registry ID
    NCT04970537
    Conditions
    Tigecycline; Polymyxin B; Intensive Care Unit
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2017-07-23
    Completion
    2021-07-31
    Enrolment
    800

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTigecycline; Polymyxin B; Intensive Care Unit
    InterventionNot recorded
    PhaseNot recorded
    Registry statusUnknown

  • Polymyxin B Monotherapy vs Combination Therapy in Critically Ill Patients With Multi-drug Resistant Pathogens

    NCT03159078 · start 2017-05-25

    Registered record
    Registry ID
    NCT03159078
    Conditions
    Trauma; Resistant Infection; Critical Illness
    Interventions
    Polymyxin B
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2017-05-25
    Completion
    2019-12-01
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTrauma; Resistant Infection; Critical Illness
    InterventionPolymyxin B
    PhasePhase 3
    Registry statusUnknown

  • Safety and Efficacy of Heparin Dosing Score Protocol for Polymyxin-B Hemoperfusion

    NCT03177330 · start 2017-05-15

    Registered record
    Registry ID
    NCT03177330
    Conditions
    Septic Shock; Polymyxin B Hemoperfusion
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2017-05-15
    Completion
    2017-07
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSeptic Shock; Polymyxin B Hemoperfusion
    InterventionNot recorded
    PhaseNot recorded
    Registry statusUnknown

  • Effect of Different Colistin Doses on Clinical Outcome of Pediatric Cancer Patients With Gram Negative Infections

    NCT03397914 · start 2017-01

    Registered record
    Registry ID
    NCT03397914
    Conditions
    Gram-Negative Bacterial Infections; Pediatric Cancer; Colistin; Colistin Adverse Reaction; MIC
    Interventions
    Colistimethate Sodium
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2017-01
    Completion
    2019-03
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGram-Negative Bacterial Infections; Pediatric Cancer; Colistin; Colistin Adverse Reaction +1 more
    InterventionColistimethate Sodium
    PhasePhase 4
    Registry statusCompleted

  • Efficacy of Polymyxin B Hemoperfusion on Severe Sepsis Secondary to Pneumonia or Urinary Tract Infection

    NCT02871024 · start 2016-08

    Registered record
    Registry ID
    NCT02871024
    Conditions
    Sepsis
    Interventions
    Toraymyxin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2016-08
    Completion
    2019-03-26
    Enrolment
    1

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSepsis
    InterventionToraymyxin
    PhaseNot applicable
    Registry statusTerminated

  • A Study to Evaluate the Safety and Immunogenicity of Monovalent OPV2 in Children Aged 1 to 5 Years in Lithuania

    NCT02582255 · start 2015-11

    Registered record
    Registry ID
    NCT02582255
    Conditions
    Poliomyelitis
    Interventions
    Sabin mOPV2
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-11
    Completion
    2016-12-22
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPoliomyelitis
    InterventionSabin mOPV2
    PhasePhase 4
    Registry statusCompleted

  • Assessment of the Efficacy of POLYGYNAX® in the Empirical Treatment of Infectious Vaginitis

    NCT02515656 · start 2015-09

    Registered record
    Registry ID
    NCT02515656
    Conditions
    Vaginitis
    Interventions
    POLYGYNAX®; GYNODAKTARIN®; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2015-09
    Completion
    2016-08
    Enrolment
    661

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVaginitis
    InterventionPOLYGYNAX®; GYNODAKTARIN®; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Heparin for the Treatment of Burn Wound Pain

    NCT02497326 · start 2015-04

    Registered record
    Registry ID
    NCT02497326
    Conditions
    Second Degree Burns
    Interventions
    Polyfax & Lignocain gel or silvazine cream; Topical Heparin; Tramadol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2015-04
    Completion
    2015-12
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSecond Degree Burns
    InterventionPolyfax & Lignocain gel or silvazine cream; Topical Heparin; Tramadol
    PhaseNot applicable
    Registry statusUnknown

  • Trial to Test if Antibiotic Ointments & Cream Will Sting After Application on a Minor Wound After Tape Stripping Injury

    NCT02320695 · start 2015-03

    Registered record
    Registry ID
    NCT02320695
    Conditions
    Sting
    Interventions
    Saline; Isopropyl Alcohol; Pain Relieving Cream; Antibiotic/Pain Relieving Ointment; Original Ointment; Pain Relief Ointment
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-03
    Completion
    2015-03
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSting
    InterventionSaline; Isopropyl Alcohol; Pain Relieving Cream; Antibiotic/Pain Relieving Ointment +2 more
    PhaseNot applicable
    Registry statusCompleted