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AMR Drug RepurposingSmart Screeningresearch prototype

Prazosin Hydrochloride

FDA-approved product (capsule, oral), marketed as Minipress, Minipress Xl, Prazosin Hydrochloride.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Prazosin Hydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Diabetes mellitus
  • Hypertension

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Alpha-adrenoreceptor antagonists
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli, MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA54.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli56.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae33.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis57.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Prazosin Hydrochloride in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.0 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-5.9 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.7 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.5 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Prazosin Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Complementary Combination Therapy for Cocaine Dependence

    NCT02538744 · start 2015-08

    Registered record
    Registry ID
    NCT02538744
    Conditions
    Cocaine Dependence
    Interventions
    Doxazosin; Modafinil; cocaine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2015-08
    Completion
    2018-08-21
    Enrolment
    45

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCocaine Dependence
    InterventionDoxazosin; Modafinil; cocaine; Placebo
    PhasePhase 1
    Registry statusCompleted

  • Effectiveness of Prazosin on the Urinary Sodium Excretion Response to Mental Stress

    NCT02431936 · start 2015-04

    Registered record
    Registry ID
    NCT02431936
    Conditions
    Hypertension; Stress, Psychological; Blood Pressure
    Interventions
    Prazosin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2015-04
    Completion
    2019-04-16
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension; Stress, Psychological; Blood Pressure
    InterventionPrazosin; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Prazosin and Naltrexone (PaN) Study for Veterans With Alcohol Use Disorders

    NCT02322047 · start 2015-03-03

    Registered record
    Registry ID
    NCT02322047
    Conditions
    Alcohol Use Disorder; Posttraumatic Stress Disorder (PTSD)
    Interventions
    Prazosin; Naltrexone; Placebo (Prazosin); Placebo (Naltrexone)
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2015-03-03
    Completion
    2018-10-10
    Enrolment
    31

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlcohol Use Disorder; Posttraumatic Stress Disorder (PTSD)
    InterventionPrazosin; Naltrexone; Placebo (Prazosin); Placebo (Naltrexone)
    PhasePhase 2
    Registry statusCompleted

  • Prazosin Augmentation of Outpatient Treatment of Alcohol Use Disorders in Active Duty Soldiers With and Without PTSD

    NCT02226367 · start 2015-01

    Registered record
    Registry ID
    NCT02226367
    Conditions
    Alcohol Use Disorders; Stress Disorders, Posttraumatic; Combat Disorders
    Interventions
    prazosin hydrochloride; placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-01
    Completion
    2018-10-20
    Enrolment
    158

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlcohol Use Disorders; Stress Disorders, Posttraumatic; Combat Disorders
    Interventionprazosin hydrochloride; placebo
    PhaseNot applicable
    Registry statusCompleted

  • Varenicline + Prazosin for Heavy Drinking Smokers

    NCT02193256 · start 2014-07

    Registered record
    Registry ID
    NCT02193256
    Conditions
    Cigarette Smoking; Alcohol Use Disorders
    Interventions
    Varenicline; Prazosin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2014-07
    Completion
    2015-06
    Enrolment
    5

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCigarette Smoking; Alcohol Use Disorders
    InterventionVarenicline; Prazosin; Placebo
    PhaseEarly phase 1
    Registry statusCompleted

  • Reducing Suicidal Ideation Through Treatment of Nightmares-Post Traumatic Stress Disorder (PTSD)

    NCT02199652 · start 2014-03

    Registered record
    Registry ID
    NCT02199652
    Conditions
    Post Traumatic Stress Disorder; Suicidal Ideation; Nightmares
    Interventions
    Prazosin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2014-03
    Completion
    2017-12-01
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost Traumatic Stress Disorder; Suicidal Ideation; Nightmares
    InterventionPrazosin; Placebo
    PhasePhase 4
    Registry statusCompleted

  • The Effects of Prazosin on Dopamine in Healthy Humans: A PET Pilot Study

    NCT01999530 · start 2013-11

    Registered record
    Registry ID
    NCT01999530
    Conditions
    Healthy
    Interventions
    Prazosin Hydrochloride
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2013-11
    Completion
    2016-08
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionPrazosin Hydrochloride
    PhasePhase 1
    Registry statusCompleted

  • Neural Mechanisms of Change During the Treatment of Alcohol Use Disorders With Prazosin

    NCT01916941 · start 2013-09

    Registered record
    Registry ID
    NCT01916941
    Conditions
    Alcohol Use Disorder
    Interventions
    Prazosin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2013-09
    Completion
    2017-09
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlcohol Use Disorder
    InterventionPrazosin; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • The Changes of Urine Growth Factors Level

    NCT06282731 · start 2013-05-31

    Registered record
    Registry ID
    NCT06282731
    Conditions
    Benign Prostatic Hyperplasia
    Interventions
    Silodosin
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2013-05-31
    Completion
    2017-04-27
    Enrolment
    74

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBenign Prostatic Hyperplasia
    InterventionSilodosin
    PhaseEarly phase 1
    Registry statusCompleted

  • Prazosin for Smoking Cessation

    NCT01642433 · start 2012-07

    Registered record
    Registry ID
    NCT01642433
    Conditions
    Nicotine Dependence
    Interventions
    Placebo; Prazosin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2012-07
    Completion
    2013-09
    Enrolment
    1

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNicotine Dependence
    InterventionPlacebo; Prazosin
    PhasePhase 2
    Registry statusTerminated

  • Two Stepped Care Models for Posttraumatic Stress Disorder (PTSD) Among Cambodian Refugees With PTSD

    NCT01542372 · start 2012-04

    Registered record
    Registry ID
    NCT01542372
    Conditions
    Posttraumatic Stress Disorder (PTSD)
    Interventions
    Medication augmentation; CBT
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2012-04
    Completion
    2014-03
    Enrolment
    114

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPosttraumatic Stress Disorder (PTSD)
    InterventionMedication augmentation; CBT
    PhasePhase 4
    Registry statusTerminated

  • DOXAZOSIN FOR PTSD

    NCT02308202 · start 2012-01

    Registered record
    Registry ID
    NCT02308202
    Conditions
    PTSD
    Interventions
    doxazosin; Perindopril; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2012-01
    Completion
    2014-06-30
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPTSD
    Interventiondoxazosin; Perindopril; Placebo
    PhasePhase 1
    Registry statusCompleted

  • Doxazosin an a1 Antagonist for Alcohol Dependence

    NCT01437046 · start 2011-11-01

    Registered record
    Registry ID
    NCT01437046
    Conditions
    Alcohol Dependence; Anxiety
    Interventions
    Doxazosin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2011-11-01
    Completion
    2015-03-01
    Enrolment
    41

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlcohol Dependence; Anxiety
    InterventionDoxazosin; Placebo
    PhaseEarly phase 1
    Registry statusCompleted

  • Orthostatic Hypotension Treatment on Rehab Unit

    NCT01030874 · start 2011-10

    Registered record
    Registry ID
    NCT01030874
    Conditions
    Orthostatic Hypotension; Falls
    Interventions
    Medication review; Nutrition/Salt intake; Education; Exercise; Drug Recommendations
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-10
    Completion
    2016-05
    Enrolment
    356

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOrthostatic Hypotension; Falls
    InterventionMedication review; Nutrition/Salt intake; Education; Exercise +1 more
    PhaseNot applicable
    Registry statusCompleted

  • Doxazosin and Ramipril in Hypertension

    NCT02901977 · start 2011-03

    Registered record
    Registry ID
    NCT02901977
    Conditions
    Hypertension
    Interventions
    Ramipril; Doxazosin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-03
    Completion
    2015-04
    Enrolment
    71

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionRamipril; Doxazosin
    PhasePhase 4
    Registry statusCompleted