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AMR Drug RepurposingSmart Screeningresearch prototype

Butorphanol Tartrate

FDA-approved product (injectable, injection), marketed as Butorphanol Tartrate, Butorphanol Tartrate Preservative Free, Stadol and 1 more.

Registered studies
24
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Butorphanol Tartrate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Drug dependence
  • Pain

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Morphinan derivatives
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA52.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli41.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae34.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis45.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

24registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Butorphanol Tartrate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.7 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.1 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.7 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.6 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Butorphanol Tartrate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Butorphanol Mitigate Emergence Agitation in Patients Undergoing Functional Endoscopic Sinus Surgery

    NCT03398759 · start 2018-02-01

    Registered record
    Registry ID
    NCT03398759
    Conditions
    Agitation
    Interventions
    Butorphanol; Placebos
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2018-02-01
    Completion
    2020-12-31
    Enrolment
    700

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAgitation
    InterventionButorphanol; Placebos
    PhaseNot applicable
    Registry statusUnknown

  • Using Preoperative Anxiety Score to Determine the Total Dose of Butorphanol for Sedation

    NCT03810391 · start 2017-12-01

    Registered record
    Registry ID
    NCT03810391
    Conditions
    Preoperative Anxiety Score; Total Dose of Butorphanol
    Interventions
    Butorphanol; physiological saline
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2017-12-01
    Completion
    2018-12-31
    Enrolment
    126

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPreoperative Anxiety Score; Total Dose of Butorphanol
    InterventionButorphanol; physiological saline
    PhasePhase 2
    Registry statusCompleted

  • Intravenous Dexmedetomidine for Cesarean Section

    NCT03065530 · start 2017-02-07

    Registered record
    Registry ID
    NCT03065530
    Conditions
    Breast Feeding; Analgesia Obstetrical; Postoperative Pain
    Interventions
    Normal Saline; Dexmedetomidine 0.03ug/kg/h; Dexmedetomidine 0.05ug/kg/h; Dexmedetomidine 0.08ug/kg/h
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2017-02-07
    Completion
    2017-10-05
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBreast Feeding; Analgesia Obstetrical; Postoperative Pain
    InterventionNormal Saline; Dexmedetomidine 0.03ug/kg/h; Dexmedetomidine 0.05ug/kg/h; Dexmedetomidine 0.08ug/kg/h
    PhasePhase 4
    Registry statusCompleted

  • Effect of Butorphanol Combined With Flurbiprofen Axetil on Preventing Hyperalgesia Induced by Remifentanil in Patients

    NCT02043366 · start 2014-02

    Registered record
    Registry ID
    NCT02043366
    Conditions
    Pain; Anesthesia
    Interventions
    Normal Saline; Butorphanol; Flurbiprofen axetil; Remifentanil; Sufentanil
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2014-02
    Completion
    2015-08
    Enrolment
    180

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain; Anesthesia
    InterventionNormal Saline; Butorphanol; Flurbiprofen axetil; Remifentanil +1 more
    PhaseNot applicable
    Registry statusCompleted

  • Comparing Sedara to Butorphanol in Early Labor

    NCT01636999 · start 2012-09

    Registered record
    Registry ID
    NCT01636999
    Conditions
    Labor Pain
    Interventions
    50% Nitrous Oxide/50% Oxygen
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2012-09
    Completion
    2014-09
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLabor Pain
    Intervention50% Nitrous Oxide/50% Oxygen
    PhaseNot applicable
    Registry statusWithdrawn

  • Propofol-butorphanol Anesthesia During Uterine Curettage

    NCT00795314 · start 2008-11

    Registered record
    Registry ID
    NCT00795314
    Conditions
    Abortion; Curettage
    Interventions
    Fentanyl Citrate; Butorphanol Tartrate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-11
    Completion
    2009-07
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbortion; Curettage
    InterventionFentanyl Citrate; Butorphanol Tartrate
    PhasePhase 4
    Registry statusCompleted

  • Comparison of Analgesic Efficacy of Fentanyl, Sufentanil and Butorphanol After Remifentanil Anesthesia

    NCT00738192 · start 2008-07

    Registered record
    Registry ID
    NCT00738192
    Conditions
    Postoperative Pain
    Interventions
    Fentanyl citrate; Sufentanil citrate; Butorphanol tartrate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-07
    Completion
    2009-03
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Pain
    InterventionFentanyl citrate; Sufentanil citrate; Butorphanol tartrate
    PhasePhase 4
    Registry statusCompleted

  • Comparison of Pain Therapeutic Effects After Benign Mastectomy

    NCT00519246 · start 2007-02

    Registered record
    Registry ID
    NCT00519246
    Conditions
    Pain, Postoperative; Mastectomy
    Interventions
    Saline; Opioid; Opioid; NSAID; NSAID; Opioid; Opioid
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-02
    Completion
    2007-12
    Enrolment
    2,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain, Postoperative; Mastectomy
    InterventionSaline; Opioid; Opioid; NSAID +3 more
    PhasePhase 4
    Registry statusCompleted

  • Comparison of Butorphanol and Tramadol Associated Patient-Controlled Analgesia (PCA) After Hysterectomy

    NCT00510666 · start 2007-01

    Registered record
    Registry ID
    NCT00510666
    Conditions
    Postoperative Pain; Hysterectomy
    Interventions
    Saline; Butorphanol tartrate; Tramadol Hydrochloride; Saline
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-01
    Completion
    2007-05
    Enrolment
    841

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Pain; Hysterectomy
    InterventionSaline; Butorphanol tartrate; Tramadol Hydrochloride; Saline
    PhasePhase 4
    Registry statusCompleted