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AMR Drug RepurposingSmart Screeningresearch prototype

Methylprednisolone Sodium Succinate

FDA-approved product (injectable, injection), marketed as A-Methapred, Methylprednisolone, Methylprednisolone Sodium Succinate and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Methylprednisolone Sodium Succinate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Acne
  • Anemia
  • Asthma
  • Atopic eczema
  • Bursitis
  • Crohn's disease
  • Dermatitis
  • Endocrine system disease
  • Frozen shoulder
  • Inflammation
  • Juvenile idiopathic arthritis
  • Leukemia
  • Lymphoma
  • Multiple sclerosis
  • Osteoarthritis
  • Pneumonia
  • and 6 more

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Corticosteroids, weak (group i); Corticosteroids, combinations for treatment of acne; Glucocorticoids; Corticosteroids for systemic use, combinations
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis and MRSA. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA52.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli30.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae28.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis40.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Methylprednisolone Sodium Succinate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Methylprednisolone Sodium Succinate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Fluoroscopy Guided Lumbar Facet Joint Injection Versus Ultrasound Guided Injection in Patients With Low Back Pain Due to Facet Syndrome

    NCT03770585 · start 2015-09-30

    Registered record
    Registry ID
    NCT03770585
    Conditions
    Facet Syndrome of Lumbar Spine
    Interventions
    Fluoroscopy guided Facet joint injection; Ultrsound guided Facet joint injection
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-09-30
    Completion
    2018-07-30
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFacet Syndrome of Lumbar Spine
    InterventionFluoroscopy guided Facet joint injection; Ultrsound guided Facet joint injection
    PhaseNot applicable
    Registry statusCompleted

  • 3-month Screening Biopsy to Optimize the Immunosuppression in Renal Transplantation

    NCT02444429 · start 2015-09-02

    Registered record
    Registry ID
    NCT02444429
    Conditions
    Renal Transplantation
    Interventions
    Corticosteroid boluses Methylprednisolone; No therapeutic modification; Stop maintenance corticotherapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2015-09-02
    Completion
    2024-06-21
    Enrolment
    346

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRenal Transplantation
    InterventionCorticosteroid boluses Methylprednisolone; No therapeutic modification; Stop maintenance corticotherapy
    PhasePhase 3
    Registry statusCompleted

  • Stem Cell Transplantation for Stiff Person Syndrome (SPS)

    NCT02282514 · start 2014-10

    Registered record
    Registry ID
    NCT02282514
    Conditions
    Stiff-Person Syndrome
    Interventions
    Autologous Hematopoietic Stem Cells; Cyclophosphamide; Mesna; rATG; Methylprednisolone; G-CSF; Rituxan
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Terminated
    Start
    2014-10
    Completion
    2019-08-30
    Enrolment
    23

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStiff-Person Syndrome
    InterventionAutologous Hematopoietic Stem Cells; Cyclophosphamide; Mesna; rATG +3 more
    PhasePhase 1 / Phase 2
    Registry statusTerminated

  • Effect of Local Intraoperative Steroid on Dysphagia After ACDF

    NCT03311425 · start 2014-08-01

    Registered record
    Registry ID
    NCT03311425
    Conditions
    Dysphagia
    Interventions
    Methylprednisolone; Dexamethasone
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2014-08-01
    Completion
    2019-07-20
    Enrolment
    140

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDysphagia
    InterventionMethylprednisolone; Dexamethasone
    PhasePhase 3
    Registry statusCompleted

  • Outcomes of Steroid and Oxygen Therapy Versus Placebo Therapy in Non-arteritic Anterior Ischemic Optic Neuropathy

    NCT02439866 · start 2014-02

    Registered record
    Registry ID
    NCT02439866
    Conditions
    NAION( Non-arteritic Anterior Ischemic Optic Neuropathy)
    Interventions
    placebo; Intravenous methylprednisolone; normobaric oxygen with face mask
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2014-02
    Completion
    Not recorded
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNAION( Non-arteritic Anterior Ischemic Optic Neuropathy)
    Interventionplacebo; Intravenous methylprednisolone; normobaric oxygen with face mask
    PhasePhase 3
    Registry statusUnknown

  • Arthralgia of the Temporomandibular Joint. Pain Relief Following One Intra-articular Injection of Methylprednisolone

    NCT01995019 · start 2013-12-10

    Registered record
    Registry ID
    NCT01995019
    Conditions
    Arthralgia; TMJ
    Interventions
    Methylprednisolone; Physiologic saline
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2013-12-10
    Completion
    2017-03-15
    Enrolment
    56

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionArthralgia; TMJ
    InterventionMethylprednisolone; Physiologic saline
    PhasePhase 4
    Registry statusCompleted

  • Role of CVVH in Patients With Acute Paraquat Poisoning

    NCT01709604 · start 2012-10

    Registered record
    Registry ID
    NCT01709604
    Conditions
    Poisoning by Paraquat With Undetermined Intent
    Interventions
    CVVH; Standardized therapy regimens
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2012-10
    Completion
    2016-06
    Enrolment
    110

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPoisoning by Paraquat With Undetermined Intent
    InterventionCVVH; Standardized therapy regimens
    PhaseNot recorded
    Registry statusCompleted

  • Treatment of Post-surgical Cystoid Macular Edema With Topical Steroids Trial (TEMPEST-1)

    NCT01769352 · start 2012-08

    Registered record
    Registry ID
    NCT01769352
    Conditions
    Post-surgical Cystoid Macular Edema (PSCME)
    Interventions
    PredA + Kelac
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2012-08
    Completion
    2016-04
    Enrolment
    42

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost-surgical Cystoid Macular Edema (PSCME)
    InterventionPredA + Kelac
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Methylprednisolone Replacement for Dexamethasone-induced Hiccup

    NCT01277731 · start 2010-07

    Registered record
    Registry ID
    NCT01277731
    Conditions
    Dexamethasone; Hiccup
    Interventions
    Methylprednisolone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2010-07
    Completion
    2011-12
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDexamethasone; Hiccup
    InterventionMethylprednisolone
    PhaseNot applicable
    Registry statusWithdrawn

  • Administration of Methylprednisolone for Prevention of Ovarian Hyper Stimulation Syndrome

    NCT01014104 · start 2009-10

    Registered record
    Registry ID
    NCT01014104
    Conditions
    Ovarian Hyperstimulation Syndrome
    Interventions
    Methylprednisolone; Control
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2009-10
    Completion
    2010-12
    Enrolment
    218

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOvarian Hyperstimulation Syndrome
    InterventionMethylprednisolone; Control
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Safety and Efficacy Study of Allogenic Mesenchymal Stem Cells to Treat Extensive Chronic Graft Versus Host Disease

    NCT00972660 · start 2009-09

    Registered record
    Registry ID
    NCT00972660
    Conditions
    Graft Versus Host Disease
    Interventions
    Mesenchymal stem cell (MSC); Prednisone and cyclosporine or primary therapies
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2009-09
    Completion
    2017-12
    Enrolment
    52

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGraft Versus Host Disease
    InterventionMesenchymal stem cell (MSC); Prednisone and cyclosporine or primary therapies
    PhasePhase 2
    Registry statusUnknown

  • Randomized Trial for Mixed Acute Rejection

    NCT00771875 · start 2008-09

    Registered record
    Registry ID
    NCT00771875
    Conditions
    Graft Rejection
    Interventions
    Rabbit Antithymocyte Globulin (RATG); Rituximab; Bortezomib; Acetaminophen; Antihistamine; Methylprednisolone
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2008-09
    Completion
    2013-03
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGraft Rejection
    InterventionRabbit Antithymocyte Globulin (RATG); Rituximab; Bortezomib; Acetaminophen +2 more
    PhasePhase 2
    Registry statusCompleted

  • Haploidentical Transplant With NK Cell Infusion for Pediatric Acute Leukemia and Solid Tumors

    NCT00582816 · start 2008-08

    Registered record
    Registry ID
    NCT00582816
    Conditions
    Leukemia; Solid Tumors
    Interventions
    Clinimacs Cell Separation System; conditioning chemotherapy; DLI
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Terminated
    Start
    2008-08
    Completion
    2015-08
    Enrolment
    9

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLeukemia; Solid Tumors
    InterventionClinimacs Cell Separation System; conditioning chemotherapy; DLI
    PhasePhase 1 / Phase 2
    Registry statusTerminated

  • A Study to Compare the Efficacy and Safety of FK506MR vs Prograf® in Patients Undergoing Kidney Transplantation

    NCT00481819 · start 2007-07

    Registered record
    Registry ID
    NCT00481819
    Conditions
    Kidney Transplantation
    Interventions
    FK506MR; Prograf; Mycophenolate Mofetil; Methylprednisolone; Prednisolone
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-07
    Completion
    2009-03
    Enrolment
    240

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKidney Transplantation
    InterventionFK506MR; Prograf; Mycophenolate Mofetil; Methylprednisolone +1 more
    PhasePhase 3
    Registry statusCompleted

  • Systemic Methylprednisolone in Chronic Rhinosinusitis

    NCT01205984 · start 2007-07

    Registered record
    Registry ID
    NCT01205984
    Conditions
    Chronic Rhinosinusitis; Children
    Interventions
    methylprednisolone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-07
    Completion
    2010-04
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Rhinosinusitis; Children
    Interventionmethylprednisolone
    PhasePhase 4
    Registry statusCompleted