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AMR Drug RepurposingSmart Screeningresearch prototype

Piperacillin Sodium

FDA-approved product (injectable, injection), marketed as Piperacillin, Pipracil.

Registered studies
50+
Lab records
245
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Piperacillin Sodium
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Appendicitis
  • Bacterial disease
  • Cellulitis
  • Diabetic foot
  • Endometritis
  • Pelvic Inflammatory Disease
  • Peritonitis
  • Pneumonia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Penicillins with extended spectrum
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01CA12

Repurposing investigation

Piperacillin Sodium is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA92.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli16.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae28.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis42.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 6 of 12 lab records
  • E. coli: measured active in 10 of 42 lab records
  • K. pneumoniae: measured active in 30 of 191 lab records
Open Piperacillin Sodium in ChEMBL Registered studies below
Show the latest 150 of 245 laboratory records, with sources

Loading records…

Every record is in ChEMBL, linked above. “Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.0 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.3 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.2 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.2 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Piperacillin Sodium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • EC-MOTION : ExtraCorporeal Membrane Oxygenation and Therapeutic Drug Monitoring of Drugs of infectION

    NCT02917486 · start 2016-01

    Registered record
    Registry ID
    NCT02917486
    Conditions
    Infection
    Interventions
    blood sample
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2016-01
    Completion
    2019-07
    Enrolment
    44

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfection
    Interventionblood sample
    PhaseNot recorded
    Registry statusCompleted

  • Piperacillin PK Analysis in Severe Sepsis Patients

    NCT02569086 · start 2015-11-01

    Registered record
    Registry ID
    NCT02569086
    Conditions
    Sepsis; Severe Sepsis
    Interventions
    Blood draw
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2015-11-01
    Completion
    2016-06-30
    Enrolment
    22

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSepsis; Severe Sepsis
    InterventionBlood draw
    PhaseNot recorded
    Registry statusCompleted

  • Bioelectrical Impedance Analysis as a Bedside Tool to Estimate Volume of Distribution of Hydrophilic Antimicrobials in Critically Ill Patients

    NCT03410771 · start 2015-10-01

    Registered record
    Registry ID
    NCT03410771
    Conditions
    Electric Impedance; Pharmacokinetics; Capillary Leak Syndrome
    Interventions
    Monitor antibiotic exposure (PK profile); Bioelectrical impedance analysis to measure body composition
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2015-10-01
    Completion
    2016-06-01
    Enrolment
    68

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionElectric Impedance; Pharmacokinetics; Capillary Leak Syndrome
    InterventionMonitor antibiotic exposure (PK profile); Bioelectrical impedance analysis to measure body composition
    PhaseNot recorded
    Registry statusCompleted

  • Trial of Meropenem Versus Piperacillin-Tazobactam on Mortality and Clinial Response

    NCT02437045 · start 2015-04

    Registered record
    Registry ID
    NCT02437045
    Conditions
    Bloodstream Infections
    Interventions
    Meropenem; Piperacillin-tazobactam combination product
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-04
    Completion
    2020-12-31
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBloodstream Infections
    InterventionMeropenem; Piperacillin-tazobactam combination product
    PhasePhase 4
    Registry statusCompleted

  • Piperacillin/Tazobactam for Empirical Therapy of Febrile Neutropenia

    NCT01714570 · start 2012-11

    Registered record
    Registry ID
    NCT01714570
    Conditions
    Febrile; Neutropenia; Hematopoietic Stem Cell Transplantation
    Interventions
    Piperacillin-tazobactam combination product; Imipenem
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-11
    Completion
    2014-04
    Enrolment
    123

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFebrile; Neutropenia; Hematopoietic Stem Cell Transplantation
    InterventionPiperacillin-tazobactam combination product; Imipenem
    PhaseNot applicable
    Registry statusCompleted

  • Initial Antibiotics and Delayed Appendectomy for Acute Appendicitis

    NCT01697059 · start 2012-09

    Registered record
    Registry ID
    NCT01697059
    Conditions
    Acute Appendicitis
    Interventions
    Piperacillin + Amoxicillin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-09
    Completion
    2015-05
    Enrolment
    73

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Appendicitis
    InterventionPiperacillin + Amoxicillin
    PhaseNot applicable
    Registry statusCompleted

  • Pharmacokinetic of Doripenem and Piperacillin/Tazobactam in More Than 120 kg Critically Ill Patients

    NCT01517815 · start 2012-02

    Registered record
    Registry ID
    NCT01517815
    Conditions
    Septic Shock
    Interventions
    Doripenem or Piperacillin/Tazobactam; Doripenem or Piperacillin/Tazobactam
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-02
    Completion
    2013-06
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSeptic Shock
    InterventionDoripenem or Piperacillin/Tazobactam; Doripenem or Piperacillin/Tazobactam
    PhaseNot applicable
    Registry statusCompleted

  • Piperacillin Sodium and Sulbactam Sodium for Injection (2:1) for Treatment of Respiratory and Urinary Tract Infection

    NCT01897831 · start 2011-08

    Registered record
    Registry ID
    NCT01897831
    Conditions
    Respiratory Tract Infections; Urinary Tract Infections
    Interventions
    xin te mie
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2011-08
    Completion
    2015-11
    Enrolment
    2,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRespiratory Tract Infections; Urinary Tract Infections
    Interventionxin te mie
    PhasePhase 4
    Registry statusUnknown

  • Antimicrobial Prophylaxis in Thyroid and Parathyroid Surgery

    NCT01805856 · start 2010-11

    Registered record
    Registry ID
    NCT01805856
    Conditions
    Thyroid Disease; Parathyroid Disease
    Interventions
    PIPC piperacillin sodium; CEZ, cefazolin sodium
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-11
    Completion
    2012-05
    Enrolment
    2,164

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionThyroid Disease; Parathyroid Disease
    InterventionPIPC piperacillin sodium; CEZ, cefazolin sodium
    PhaseNot applicable
    Registry statusCompleted

  • Role of Antibiotics in Preventing Infection in Babies Born Through Meconium Stained Liquor

    NCT01290003 · start 2010-06

    Registered record
    Registry ID
    NCT01290003
    Conditions
    Neonatal Sepsis
    Interventions
    Piperacillin-Tazobactam and Amikacin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-06
    Completion
    2011-01
    Enrolment
    250

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeonatal Sepsis
    InterventionPiperacillin-Tazobactam and Amikacin
    PhaseNot applicable
    Registry statusCompleted

  • Piperacllin Versus Placebo in Patients Undergoing Surgery for Acute Cholecystitis

    NCT02619149 · start 2009-03

    Registered record
    Registry ID
    NCT02619149
    Conditions
    Cholecystitis, Acute
    Interventions
    Piperacillin-tazobactam combination product; Saline solution
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2009-03
    Completion
    2018-01
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCholecystitis, Acute
    InterventionPiperacillin-tazobactam combination product; Saline solution
    PhasePhase 3
    Registry statusCompleted

  • Standard Vs Adjusted Dosing of Piperacillin/Tazobactam in Acute Renal Failure and Septic Shock

    NCT00816790 · start 2009-01

    Registered record
    Registry ID
    NCT00816790
    Conditions
    Septic Shock; Acute Renal Failure
    Interventions
    Piperacillin/Tazobactam; Piperacillin/Tazobactam
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2009-01
    Completion
    2011-06
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSeptic Shock; Acute Renal Failure
    InterventionPiperacillin/Tazobactam; Piperacillin/Tazobactam
    PhasePhase 4
    Registry statusTerminated

  • Risk Factors for Piperacillin/Tazobactam Resistance in Extended-Spectrum Beta-Lactamase (ESBL) Producing Organisms

    NCT00573521 · start 2007-11

    Registered record
    Registry ID
    NCT00573521
    Conditions
    Enterobacteriaceae Infections
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2007-11
    Completion
    2017-06
    Enrolment
    450

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEnterobacteriaceae Infections
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Effects of Therapy With Sulfamylon® 5% Topical Solution Compared to a Historical Control Group

    NCT00634166 · start 2007-09

    Registered record
    Registry ID
    NCT00634166
    Conditions
    Burns
    Interventions
    Sulfamylon® For 5 % Topical Solution; Topical Antimicrobial/Antifungal Medications
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2007-09
    Completion
    2014-04
    Enrolment
    220

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBurns
    InterventionSulfamylon® For 5 % Topical Solution; Topical Antimicrobial/Antifungal Medications
    PhasePhase 4
    Registry statusTerminated

  • Tazocin Intervention Study

    NCT00478855 · start 2006-09

    Registered record
    Registry ID
    NCT00478855
    Conditions
    Bacterial Infections
    Interventions
    Tazocin (Piperacillin/Tazobactem)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-09
    Completion
    2007-06
    Enrolment
    500

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacterial Infections
    InterventionTazocin (Piperacillin/Tazobactem)
    PhasePhase 4
    Registry statusCompleted