Plazomicin Sulfate
FDA-approved product (solution, intravenous), marketed as Zemdri.
- Registered studies
- 0
- Lab records
- 11
- Pathogens at ≥40%
- 4 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLApproved for
- Bacterial disease
- Pyelonephritis
- Urinary tract infection
Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗
- WHO therapeutic group
- Other aminoglycosides
- Anti-infective classification
- Classified as an existing antimicrobial.WHO ATC J01GB14
Repurposing investigation
Plazomicin Sulfate is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.
AI-predicted activity
AI prediction · nothing measured- MRSA58.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- E. coli57.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- K. pneumoniae90.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
- M. tuberculosis47.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
No evidence found
The registry was searched and no registered study names this medicine.
Experimental
- K. pneumoniae: measured active in 11 of 11 lab records
Show the 11 laboratory records, with sources
Loading records…
“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.
Docking
Computational · nothing measuredDihydrofolate reductase ↗ (E. coli)
Not yet docked: queued in the docking rundetails
KPC-2 carbapenemase ↗ (K. pneumoniae)
Not yet docked: queued in the docking rundetails
Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)
Not yet docked: queued in the docking rundetails
Dihydrofolate reductase ↗ (MRSA)
Not yet docked: queued in the docking rundetails
AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Plazomicin Sulfate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- TicagrelorExisting use: Acute coronary syndrome, Acute myocardial infarction, Coronary artery disease and 6 more62.4% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Quinapril HydrochlorideExisting use: Cardiovascular disease, Diabetes mellitus, Heart failure and 3 more62.3% AI-predicted activityagainst M. tuberculosis33 registered studies
- BelzutifanExisting use: Clear cell renal carcinoma, Hemangioblastoma, Neoplasm and 4 more62.2% AI-predicted activityagainst M. tuberculosis45 registered studies
- ChlorprothixeneExisting use: Psychosis62.2% AI-predicted activityagainst M. tuberculosis4 registered studies
- CrizotinibExisting use: Cancer, Neoplasm, Non-small cell lung carcinoma62.2% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Pacritinib CitrateExisting use: Neoplasm, Polycythemia vera, Primary myelofibrosis62.2% AI-predicted activityagainst M. tuberculosis2 registered studies
- PralatrexateExisting use: Cancer, Mature T-cell and NK-cell non-Hodgkin lymphoma, Neoplasm and 2 more62.1% AI-predicted activityagainst M. tuberculosis44 registered studies
- Methdilazine HydrochlorideExisting use: Allergic disease62.0% AI-predicted activityagainst M. tuberculosisNo documented evidence found
- SirolimusExisting use: Adenoma sebaceum, Angiofibroma, Cancer and 5 more62.0% AI-predicted activityagainst M. tuberculosis50+ registered studies
- AdagrasibExisting use: Neoplasm, Non-small cell lung carcinoma61.9% AI-predicted activityagainst M. tuberculosis40 registered studies
- TrandolaprilExisting use: Cardiovascular disease, Heart failure, Hypertension and 2 more61.9% AI-predicted activityagainst M. tuberculosis29 registered studies
- Almotriptan MalateExisting use: Migraine disorder61.8% AI-predicted activityagainst M. tuberculosis16 registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
No evidence found: the registry was searched and no registered study names this medicine.