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AMR Drug RepurposingSmart Screeningresearch prototype

Amiodarone Hydrochloride

FDA-approved product (tablet, oral), marketed as Amiodarone Hydrochloride, Cordarone, Nexterone and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Amiodarone Hydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cardiac arrhythmia
  • Ventricular arrhythmia
  • Ventricular fibrillation
  • Ventricular tachycardia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Antiarrhythmics, class iii
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA43.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli33.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae21.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis56.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Amiodarone Hydrochloride in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Amiodarone Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Catheter Ablation Versus Anti-arrhythmic Drugs for Ventricular Tachycardia

    NCT05524077 · start 2020-07-08

    Registered record
    Registry ID
    NCT05524077
    Conditions
    Heart Disease Structural Disorder; Ventricular Tachycardia; Cardiomyopathy, Dilated; Sarcoidosis; Cardiomyopathy, Hypertrophic; Cardiomyopathy Ischemic; Cardiomyopathy, Familial; Arrhythmogenic Right Ventricular Cardiomyopathy 1; Arrhythmogenic Left Ventricular Cardiomyopathy
    Interventions
    Ablation; Anti-arrhythmic Drugs (AADs)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Active not recruiting
    Start
    2020-07-08
    Completion
    2026-06-30
    Enrolment
    162

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHeart Disease Structural Disorder; Ventricular Tachycardia; Cardiomyopathy, Dilated; Sarcoidosis +5 more
    InterventionAblation; Anti-arrhythmic Drugs (AADs)
    PhaseNot applicable
    Registry statusActive not recruiting

  • Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

    NCT04278404 · start 2020-03-05

    Registered record
    Registry ID
    NCT04278404
    Conditions
    Coronavirus Infection (COVID-19); Pulmonary Arterial Hypertension; Urinary Tract Infections in Children; Hypertension; Pain; Hyperphosphatemia; Primary Hyperaldosteronism; Edema; Hypokalemia; Heart Failure; Hemophilia; Menorrhagia; Insomnia; Pneumonia; Skin Infection; Arrythmia; Asthma in Children; Bronchopulmonary Dysplasia; Adrenal Insufficiency; Fibrinolysis; Hemorrhage; Attention Deficit Hyperactivity Disorder; Multisystem Inflammatory Syndrome in Children (MIS-C); Kawasaki Disease; Coagulation Disorder; Down Syndrome
    Interventions
    The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2020-03-05
    Completion
    2026-12
    Enrolment
    5,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCoronavirus Infection (COVID-19); Pulmonary Arterial Hypertension; Urinary Tract Infections in Children; Hypertension +22 more
    InterventionThe POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
    PhaseNot recorded
    Registry statusRecruiting

  • Comparison of Two Strategies for the Management of Atrial Fibrillation After Cardiac Surgery

    NCT04223739 · start 2019-12-13

    Registered record
    Registry ID
    NCT04223739
    Conditions
    Atrial Fibrillation; Cardiac Surgery
    Interventions
    Landiolol; Amiodarone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2019-12-13
    Completion
    2022-06-01
    Enrolment
    380

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation; Cardiac Surgery
    InterventionLandiolol; Amiodarone
    PhasePhase 4
    Registry statusUnknown

  • Percutaneous Left Stellate Ganglion Block In Out-of-hospital Cardiac Arrest Due to Refractory VEntricular Arrhythmias (LIVE Study)

    NCT04168970 · start 2019-06-12

    Registered record
    Registry ID
    NCT04168970
    Conditions
    Out-Of-Hospital Cardiac Arrest; Ventricular Fibrillation Sustained; Shockable Rhythm; Medical Etiology; Refractory Ventricular Arrhythmias
    Interventions
    PSGB
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2019-06-12
    Completion
    2026-05-31
    Enrolment
    62

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOut-Of-Hospital Cardiac Arrest; Ventricular Fibrillation Sustained; Shockable Rhythm; Medical Etiology +1 more
    InterventionPSGB
    PhaseNot recorded
    Registry statusCompleted

  • Sympathetic Denervation by Video-assisted Thoracoscopy in Control of Cardiac Arrhythmias in Patients With Chagas Disease

    NCT04239144 · start 2018-11-09

    Registered record
    Registry ID
    NCT04239144
    Conditions
    Chagas Cardiomyopathy; Ventricular Arrythmia
    Interventions
    Bilateral sympathectomy; Catheter ablation
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2018-11-09
    Completion
    2025-12-12
    Enrolment
    45

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChagas Cardiomyopathy; Ventricular Arrythmia
    InterventionBilateral sympathectomy; Catheter ablation
    PhaseNot applicable
    Registry statusCompleted

  • Propafenone Versus Amiodarone in Septic Shock

    NCT03029169 · start 2017-10-23

    Registered record
    Registry ID
    NCT03029169
    Conditions
    Supraventricular Arrhythmia; Septic Shock
    Interventions
    Propafenone i.v.; Amiodarone i.v.
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2017-10-23
    Completion
    2022-08-01
    Enrolment
    210

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSupraventricular Arrhythmia; Septic Shock
    InterventionPropafenone i.v.; Amiodarone i.v.
    PhasePhase 4
    Registry statusCompleted

  • Intraoperative Amiodarone to Prevent Atrial Fibrillation in Lung Transplant Patients

    NCT03221764 · start 2017-10-19

    Registered record
    Registry ID
    NCT03221764
    Conditions
    Atrial Fibrillation; Lung Transplant; Complications
    Interventions
    Amiodarone with CoSeal; CO2 driver
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2017-10-19
    Completion
    2019-04-01
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation; Lung Transplant; Complications
    InterventionAmiodarone with CoSeal; CO2 driver
    PhasePhase 2
    Registry statusCompleted

  • Use of Amiodarone in Atrial Fibrillation Associated With Severe Sepsis or Septic Shock

    NCT02668432 · start 2016-05

    Registered record
    Registry ID
    NCT02668432
    Conditions
    New Onset Atrial Fibrillation; Severe Sepsis; Septic Shock
    Interventions
    Amiodarone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2016-05
    Completion
    2018-09-20
    Enrolment
    9

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNew Onset Atrial Fibrillation; Severe Sepsis; Septic Shock
    InterventionAmiodarone
    PhasePhase 4
    Registry statusTerminated

  • Treatment of Postoperative Atrial Fibrillation - Comparison of Amiodarone and Placebo.

    NCT02715687 · start 2016-03

    Registered record
    Registry ID
    NCT02715687
    Conditions
    Atrial Fibrillation
    Interventions
    Amiodarone; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2016-03
    Completion
    2018-12
    Enrolment
    400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation
    InterventionAmiodarone; Placebo
    PhasePhase 3
    Registry statusUnknown

  • Study of Statin for Reduction of Postoperative Paroxysmal Atrial Fibrillation

    NCT02502110 · start 2015-08

    Registered record
    Registry ID
    NCT02502110
    Conditions
    Paroxysmal Atrial Fibrillation
    Interventions
    rosuvastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2015-08
    Completion
    2019-06
    Enrolment
    346

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionParoxysmal Atrial Fibrillation
    Interventionrosuvastatin
    PhasePhase 4
    Registry statusUnknown

  • Compare the Renal Protective Effects of Febuxostat and Benzbromarone

    NCT02338323 · start 2015-01

    Registered record
    Registry ID
    NCT02338323
    Conditions
    Chronic Kidney Disease; Hyperuricemia; Abnormal Renal Function
    Interventions
    Febuxostat; Benzbromarone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-01
    Completion
    2018-12
    Enrolment
    160

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Kidney Disease; Hyperuricemia; Abnormal Renal Function
    InterventionFebuxostat; Benzbromarone
    PhaseNot applicable
    Registry statusCompleted

  • Rate Control Versus Rhythm Control For Postoperative Atrial Fibrillation

    NCT02132767 · start 2014-05

    Registered record
    Registry ID
    NCT02132767
    Conditions
    Postoperative Atrial Fibrillation
    Interventions
    Amiodarone; DC-cardioversion; Rate Control
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2014-05
    Completion
    2015-09
    Enrolment
    523

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Atrial Fibrillation
    InterventionAmiodarone; DC-cardioversion; Rate Control
    PhasePhase 3
    Registry statusCompleted

  • Effectiveness Study of Atrial Fibrillation

    NCT01856075 · start 2012-10

    Registered record
    Registry ID
    NCT01856075
    Conditions
    Atrial Fibrillation
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2012-10
    Completion
    2015-08
    Enrolment
    1,015

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • A Study Comparing Vernakalant Therapy to Amiodarone Therapy in Acute Management of Recent Onset Atrial Fibrillation (AF) (MK-6621-055)

    NCT01627106 · start 2012-09

    Registered record
    Registry ID
    NCT01627106
    Conditions
    Atrial Fibrillation
    Interventions
    Vernakalant; Amiodarone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2012-09
    Completion
    2016-03
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation
    InterventionVernakalant; Amiodarone
    PhasePhase 4
    Registry statusWithdrawn

  • Amiodarone, Lidocaine or Neither for Out-Of-Hospital Cardiac Arrest Due to Ventricular Fibrillation or Tachycardia

    NCT01401647 · start 2012-05

    Registered record
    Registry ID
    NCT01401647
    Conditions
    Cardiac Arrest
    Interventions
    amiodarone; Lidocaine; Normal saline
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2012-05
    Completion
    2016-01
    Enrolment
    3,024

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCardiac Arrest
    Interventionamiodarone; Lidocaine; Normal saline
    PhasePhase 3
    Registry statusCompleted