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AMR Drug RepurposingSmart Screeningresearch prototype

Amiodarone Hydrochloride

FDA-approved product (tablet, oral), marketed as Amiodarone Hydrochloride, Cordarone, Nexterone and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Amiodarone Hydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cardiac arrhythmia
  • Ventricular arrhythmia
  • Ventricular fibrillation
  • Ventricular tachycardia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Antiarrhythmics, class iii
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA43.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli33.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae21.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis56.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Amiodarone Hydrochloride in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Amiodarone Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Combined Amiodarone and Electrical Cardioversion for Postoperative Atrial Fibrillation After Cardiac Surgery

    NCT01558128 · start 2012-03

    Registered record
    Registry ID
    NCT01558128
    Conditions
    Cardiac Disease
    Interventions
    Amiodarone; Cardioversion
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2012-03
    Completion
    2013-03
    Enrolment
    1

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCardiac Disease
    InterventionAmiodarone; Cardioversion
    PhaseNot applicable
    Registry statusTerminated

  • Epigallocatechingallate (EGCG) in Cardiac AL Amyloidosis

    NCT01511263 · start 2012-01

    Registered record
    Registry ID
    NCT01511263
    Conditions
    Primary Amyloidosis of Light Chain Type
    Interventions
    Diuretics (plus antiarrhythmic drugs, i.e. amiodarone, in case of complex ventricular arrhithmias); Diuretics (plus antiarrhythmic drugs, i.e. amiodarone, in case of complex ventricular arrhythmias) plus EGCG
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2012-01
    Completion
    2016-07
    Enrolment
    86

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPrimary Amyloidosis of Light Chain Type
    InterventionDiuretics (plus antiarrhythmic drugs, i.e. amiodarone, in case of complex ventricular arrhithmias); Diuretics (plus antiarrhythmic drugs, i.e. amiodarone, in case of complex ventricular arrhythmias) plus EGCG
    PhasePhase 2
    Registry statusTerminated

  • Dronaderone to Prevent Recurrent Implantable Cardioverter Defibrillator (ICD) Shocks

    NCT01430806 · start 2011-10

    Registered record
    Registry ID
    NCT01430806
    Conditions
    ICD; ICD SHOCKS; DRONEDARONE
    Interventions
    Dronedarone arm; Dronedarone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2011-10
    Completion
    2015-12
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionICD; ICD SHOCKS; DRONEDARONE
    InterventionDronedarone arm; Dronedarone
    PhaseNot applicable
    Registry statusUnknown

  • Early Treatment of Atrial Fibrillation for Stroke Prevention Trial

    NCT01288352 · start 2011-07-01

    Registered record
    Registry ID
    NCT01288352
    Conditions
    Atrial Fibrillation; Stroke
    Interventions
    early standardised rhythm control
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-07-01
    Completion
    2020-05-31
    Enrolment
    2,789

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation; Stroke
    Interventionearly standardised rhythm control
    PhasePhase 4
    Registry statusCompleted

  • Pulmonary Vein Ablation Versus Amiodarone in the Elderly

    NCT01276093 · start 2011-07

    Registered record
    Registry ID
    NCT01276093
    Conditions
    Atrial Fibrillation
    Interventions
    PVI ablation; Amiodarone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2011-07
    Completion
    2016-03
    Enrolment
    59

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation
    InterventionPVI ablation; Amiodarone
    PhaseNot applicable
    Registry statusTerminated

  • Necessity of Anti-Arrhythmic Medication After Surgical Ablation for Atrial Fibrillation

    NCT01416935 · start 2011-01-01

    Registered record
    Registry ID
    NCT01416935
    Conditions
    Atrial Fibrillation
    Interventions
    No Amiodarone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2011-01-01
    Completion
    2016-07
    Enrolment
    186

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation
    InterventionNo Amiodarone
    PhaseNot applicable
    Registry statusTerminated

  • Pharmacokinetics and Optimal Timing of Dronedarone Initiation Following Long-term Amiodarone in Patients With Paroxysmal or Persistent Atrial Fibrillation

    NCT01199081 · start 2010-10

    Registered record
    Registry ID
    NCT01199081
    Conditions
    Atrial Fibrillation
    Interventions
    Dronedarone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-10
    Completion
    2012-04
    Enrolment
    154

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation
    InterventionDronedarone
    PhasePhase 4
    Registry statusCompleted

  • Evaluate the Pharmacokinetics and Safety of MK-4448 in Participants With Nonvalvular Atrial Fibrillation or Atrial Flutter

    NCT01229254 · start 2010-09

    Registered record
    Registry ID
    NCT01229254
    Conditions
    Atrial Fibrillation; Atrial Flutter
    Interventions
    Amiodarone; Betrixaban 60 mg; Betrixaban 90 mg; Betrixaban 30 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2010-09
    Completion
    2011-04
    Enrolment
    189

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation; Atrial Flutter
    InterventionAmiodarone; Betrixaban 60 mg; Betrixaban 90 mg; Betrixaban 30 mg
    PhasePhase 2
    Registry statusCompleted

  • Catheter Ablation Versus Amiodarone for Shock Prophylaxis in Defibrillator Patients With Ventricular Tachycardia

    NCT01097330 · start 2010-08

    Registered record
    Registry ID
    NCT01097330
    Conditions
    Defibrillators, Implantable; Tachycardia, Ventricular
    Interventions
    Ablation; Amiodarone
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2010-08
    Completion
    2012-03
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDefibrillators, Implantable; Tachycardia, Ventricular
    InterventionAblation; Amiodarone
    PhasePhase 3
    Registry statusTerminated

  • Amiodarone Prophylaxis for Atrial Fibrillation in Patients Undergoing Surgery for Lung Cancer

    NCT00724581 · start 2008-08

    Registered record
    Registry ID
    NCT00724581
    Conditions
    Atrial Fibrillation
    Interventions
    Amiodarone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2008-08
    Completion
    2009-12
    Enrolment
    275

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation
    InterventionAmiodarone
    PhasePhase 4
    Registry statusUnknown

  • Prevention of Postoperative Atrial Fibrillation

    NCT01742039 · start 2008-07

    Registered record
    Registry ID
    NCT01742039
    Conditions
    Postoperative Atrial Fibrillation
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2008-07
    Completion
    2011-06
    Enrolment
    160

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Atrial Fibrillation
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Efficiency of Radiofrequency Ablation for Surgical Treatment of Chronic Atrial Fibrillation With Rheumatic Valve Disease

    NCT01013688 · start 2008-03

    Registered record
    Registry ID
    NCT01013688
    Conditions
    Rheumatic Valve Disease; Atrial Fibrillation
    Interventions
    Cardioblate® Surgical Ablation System
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2008-03
    Completion
    2010-05
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRheumatic Valve Disease; Atrial Fibrillation
    InterventionCardioblate® Surgical Ablation System
    PhasePhase 3
    Registry statusUnknown

  • Ablation vs Drug Therapy for Atrial Fibrillation - Pilot Trial

    NCT00578617 · start 2006-09

    Registered record
    Registry ID
    NCT00578617
    Conditions
    Atrial Fibrillation; Arrhythmia
    Interventions
    Rate Control; Ablation Therapy; Rate Control; Rate control; Rate control; Rate control; Rate Control; Rate Control; Rate Control; Rhythm Control; Rhythm control; Rhythm control; Rhythm control; Rhythm control; Rhythm control
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2006-09
    Completion
    2010-06
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation; Arrhythmia
    InterventionRate Control; Ablation Therapy; Rate Control; Rate control +11 more
    PhaseNot applicable
    Registry statusCompleted

  • n-3 Polyunsaturated Fatty Acids (PUFAs) in the Prevention of Atrial Fibrillation

    NCT01198275 · start 2006-01

    Registered record
    Registry ID
    NCT01198275
    Conditions
    Atrial Fibrillation
    Interventions
    n-3 PUFAs; Placebo; RASS inhibitors and/or RAS blockers; Amiodarone
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-01
    Completion
    2008-05
    Enrolment
    199

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation
    Interventionn-3 PUFAs; Placebo; RASS inhibitors and/or RAS blockers; Amiodarone
    PhasePhase 3
    Registry statusCompleted

  • Prevention of Atrial Fibrillation Following Noncardiac Thoracic Surgery

    NCT00127712 · start 2004-09

    Registered record
    Registry ID
    NCT00127712
    Conditions
    Atrial Fibrillation
    Interventions
    Amiodarone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-09
    Completion
    2008-02
    Enrolment
    130

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation
    InterventionAmiodarone
    PhasePhase 4
    Registry statusCompleted