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AMR Drug RepurposingSmart Screeningresearch prototype

Doxycycline

FDA-approved product (for suspension, oral), marketed as Doxychel, Doxycycline, Monodox and 15 more.

Registered studies
50+
Lab records
7
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Doxycycline
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Acne
  • Anthrax infection
  • Bacterial disease
  • Brucellosis
  • Gonorrhea
  • Infection
  • Malaria
  • Ornithosis
  • Periodontitis
  • Pneumonia
  • Rosacea
  • Spotted fever
  • Tularemia
  • Typhus
  • Vibrio infectious disease

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Antiinfectives and antiseptics for local oral treatment; Tetracyclines
FDA pharmacologic class
Tetracycline-class Drug FDA label ↗
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01AA02; FDA class Tetracycline-class Drug

Repurposing investigation

Doxycycline is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA80.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli88.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae64.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis62.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 1 of 1 lab record
  • E. coli: measured active in 4 of 6 lab records
Open Doxycycline in ChEMBL Registered studies below
Show the 7 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.9 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.8 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.5 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.3 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Doxycycline with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Effects of Low-Dose Doxycycline on Oral Bone Loss

    NCT00066027 · start 2002-06-01

    Registered record
    Registry ID
    NCT00066027
    Conditions
    Periodontitis
    Interventions
    20 mg doxycycline hyclate; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2002-06-01
    Completion
    2005-10-01
    Enrolment
    128

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeriodontitis
    Intervention20 mg doxycycline hyclate; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Risk of Acute Liver Injury in Users of Antimicrobials

    NCT01434173 · start 2001-07

    Registered record
    Registry ID
    NCT01434173
    Conditions
    Drug-Induced Liver Injury
    Interventions
    Moxifloxacin (Avelox, BAY12-8039); Amoxicillin, Amoxicillin plus clavulanic acid, Cefuroxime, Clarithromycin, Doxycycline, Levofloxacin, Telithromycin
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2001-07
    Completion
    2009-03
    Enrolment
    1,299,056

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDrug-Induced Liver Injury
    InterventionMoxifloxacin (Avelox, BAY12-8039); Amoxicillin, Amoxicillin plus clavulanic acid, Cefuroxime, Clarithromycin, Doxycycline, Levofloxacin, Telithromycin
    PhaseNot recorded
    Registry statusCompleted

  • Azithromycin/Bicillin Syphilis

    NCT00031499 · start 2000-06

    Registered record
    Registry ID
    NCT00031499
    Conditions
    Syphilis
    Interventions
    Azithromycin; Benzathine Penicillin; Doxycycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2000-06
    Completion
    2009-03
    Enrolment
    593

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSyphilis
    InterventionAzithromycin; Benzathine Penicillin; Doxycycline
    PhasePhase 3
    Registry statusCompleted

  • Randomized Controlled Trial of Doxycycline to Prevent Acquisition of Mycoplasma Pneumoniae in an Outbreak Setting

    NCT00207584 · start 1994-01

    Registered record
    Registry ID
    NCT00207584
    Conditions
    Mycoplasma Pneumoniae
    Interventions
    Doxycycline treatment
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    1994-01
    Completion
    1994-04
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMycoplasma Pneumoniae
    InterventionDoxycycline treatment
    PhaseNot applicable
    Registry statusCompleted

  • Trial of the Use of Doxycycline After Rotator Cuff Repair

    NCT02388477

    Registered record
    Registry ID
    NCT02388477
    Conditions
    Rotator Cuff Injury
    Interventions
    Doxycycline; sugar pill
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRotator Cuff Injury
    InterventionDoxycycline; sugar pill
    PhaseNot applicable
    Registry statusWithdrawn