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AMR Drug RepurposingSmart Screeningresearch prototype

Doxycycline

FDA-approved product (for suspension, oral), marketed as Doxychel, Doxycycline, Monodox and 15 more.

Registered studies
50+
Lab records
7
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Doxycycline
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Acne
  • Anthrax infection
  • Bacterial disease
  • Brucellosis
  • Gonorrhea
  • Infection
  • Malaria
  • Ornithosis
  • Periodontitis
  • Pneumonia
  • Rosacea
  • Spotted fever
  • Tularemia
  • Typhus
  • Vibrio infectious disease

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Antiinfectives and antiseptics for local oral treatment; Tetracyclines
FDA pharmacologic class
Tetracycline-class Drug FDA label ↗
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01AA02; FDA class Tetracycline-class Drug

Repurposing investigation

Doxycycline is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA80.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli88.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae64.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis62.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 1 of 1 lab record
  • E. coli: measured active in 4 of 6 lab records
Open Doxycycline in ChEMBL Registered studies below
Show the 7 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.9 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.8 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.5 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.3 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Doxycycline with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Use of a Novel Diet (UC DIET) for Treatment of Mild to Moderate Active Pediatric Ulcerative Colitis

    NCT02345733 · start 2015-09-01

    Registered record
    Registry ID
    NCT02345733
    Conditions
    Ulcerative Colitis (UC)
    Interventions
    Ulcerative Colitis Diet; Antibiotic cocktail
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-09-01
    Completion
    2021-10-29
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUlcerative Colitis (UC)
    InterventionUlcerative Colitis Diet; Antibiotic cocktail
    PhasePhase 4
    Registry statusCompleted

  • A Two Week Nitazoxanidebased Quadruple Regimen

    NCT02621359 · start 2015-01

    Registered record
    Registry ID
    NCT02621359
    Conditions
    Dyspepsia
    Interventions
    Nitazoxanide; Levofloxacin; Doxycyclin; Omeprazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2015-01
    Completion
    2022-12
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDyspepsia
    InterventionNitazoxanide; Levofloxacin; Doxycyclin; Omeprazole
    PhasePhase 3
    Registry statusUnknown

  • The Effect of Nebulization of Alkaline Solution on Treating XDRAB Pneumonia With C/S Plus Minocycline

    NCT02060149 · start 2014-03

    Registered record
    Registry ID
    NCT02060149
    Conditions
    Pneumonia
    Interventions
    C/S plus minocycline.; nebulization with pH 7.4 solution; nebulization with pH 7.8 solution; No nebulization
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Unknown
    Start
    2014-03
    Completion
    2015-04
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia
    InterventionC/S plus minocycline.; nebulization with pH 7.4 solution; nebulization with pH 7.8 solution; No nebulization
    PhasePhase 1 / Phase 2
    Registry statusUnknown

  • Aczone 5% Gel as Maintenance Treatment of Acne Vulgaris Following Completion of Oral Doxycycline and Aczone 5% Gel

    NCT01885910 · start 2013-07

    Registered record
    Registry ID
    NCT01885910
    Conditions
    Acne Vulgaris
    Interventions
    Doxycycline 100mg; Aczone 5% gel
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2013-07
    Completion
    2014-07
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcne Vulgaris
    InterventionDoxycycline 100mg; Aczone 5% gel
    PhasePhase 4
    Registry statusCompleted

  • Efficacy of Subantimicrobial Dose Doxycycline for Moderate to Severe and Active Graves' Orbitopathy

    NCT01727973 · start 2012-10

    Registered record
    Registry ID
    NCT01727973
    Conditions
    Graves Ophthalmopathy; Graves Disease; Eye Diseases; Thyroid Diseases; Endocrine System Diseases; Eye Diseases, Hereditary; Hyperthyroidism; Autoimmune Diseases; Immune System Diseases
    Interventions
    Doxycycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2012-10
    Completion
    2013-11
    Enrolment
    14

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGraves Ophthalmopathy; Graves Disease; Eye Diseases; Thyroid Diseases +5 more
    InterventionDoxycycline
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Efficacy of Doxycycline Prophylaxis to Reduce Syphilis in High-Risk, HIV-Positive MSM

    NCT02257658 · start 2011-09

    Registered record
    Registry ID
    NCT02257658
    Conditions
    Syphilis
    Interventions
    Doxycycyline; Incentive
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-09
    Completion
    2013-01
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSyphilis
    InterventionDoxycycyline; Incentive
    PhaseNot applicable
    Registry statusCompleted

  • Efficacy of Dead Sea Peloid Gel in Chronic Endometritis

    NCT02680275 · start 2011-07

    Registered record
    Registry ID
    NCT02680275
    Conditions
    Chronic Endometritis
    Interventions
    Dead Sea Peloid Gel
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-07
    Completion
    2013-06
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Endometritis
    InterventionDead Sea Peloid Gel
    PhaseNot applicable
    Registry statusCompleted

  • Doxycycline Versus Standard Care to Prevent Seroma Formation

    NCT01188954 · start 2010-01

    Registered record
    Registry ID
    NCT01188954
    Conditions
    Seroma
    Interventions
    doxycycline; No intervention
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2010-01
    Completion
    2012-11
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSeroma
    Interventiondoxycycline; No intervention
    PhaseNot applicable
    Registry statusWithdrawn

  • Treatment Failure of Chlamydial Infection in Males and Females in Youth Correctional Facilities

    NCT00980148 · start 2009-12-02

    Registered record
    Registry ID
    NCT00980148
    Conditions
    Chlamydial Infection
    Interventions
    Azithromycin; Doxycycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2009-12-02
    Completion
    2014-05-27
    Enrolment
    567

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChlamydial Infection
    InterventionAzithromycin; Doxycycline
    PhasePhase 3
    Registry statusCompleted

  • Doxycycline and Airway Inflammation in Chronic Obstructive Pulmonary Disease (COPD)

    NCT00857038 · start 2009-04

    Registered record
    Registry ID
    NCT00857038
    Conditions
    Chronic Obstructive Pulmonary Disease; Inflammation; Pulmonary Emphysema
    Interventions
    Doxycycline; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2009-04
    Completion
    2010-01
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Obstructive Pulmonary Disease; Inflammation; Pulmonary Emphysema
    InterventionDoxycycline; Placebo
    PhasePhase 4
    Registry statusUnknown

  • Doxycycline in Treatment of Bleeding With Depot Medroxyprogesterone Acetate (DMPA)

    NCT01254799 · start 2008-01

    Registered record
    Registry ID
    NCT01254799
    Conditions
    Uterine Hemorrhage
    Interventions
    Doxycycline; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-01
    Completion
    2011-01
    Enrolment
    68

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUterine Hemorrhage
    InterventionDoxycycline; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Mycoplasma Genitalium Antibiotic Susceptibility and Treatment (MEGA)

    NCT00358462 · start 2007-01

    Registered record
    Registry ID
    NCT00358462
    Conditions
    Urethritis
    Interventions
    Azithromycin; Doxycycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-01
    Completion
    2011-11
    Enrolment
    606

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUrethritis
    InterventionAzithromycin; Doxycycline
    PhasePhase 3
    Registry statusCompleted

  • Microorganism in Overactive Bladder Patients

    NCT00883818 · start 2007-01

    Registered record
    Registry ID
    NCT00883818
    Conditions
    Overactive Bladder
    Interventions
    azithromycin, doxycycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-01
    Completion
    2007-12
    Enrolment
    84

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOveractive Bladder
    Interventionazithromycin, doxycycline
    PhasePhase 4
    Registry statusCompleted

  • Comparison of Doxycycline and Cefuroxime Axetil in Erythema Migrans

    NCT03584919 · start 2006-06-01

    Registered record
    Registry ID
    NCT03584919
    Conditions
    Erythema Chronicum Migrans
    Interventions
    doxycycline; Cefuroxime Axetil 500Mg Tab; control subjects
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2006-06-01
    Completion
    2007-09-30
    Enrolment
    509

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionErythema Chronicum Migrans
    Interventiondoxycycline; Cefuroxime Axetil 500Mg Tab; control subjects
    PhaseNot applicable
    Registry statusCompleted

  • Tetracycline-Derivatives for Treatment of Cerebral Arteriovenous Malformations and Aneurysms

    NCT00243893 · start 2004-07

    Registered record
    Registry ID
    NCT00243893
    Conditions
    Aneurysms; Arteriovenous Malformations
    Interventions
    minocycline; doxycycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2004-07
    Completion
    2008-10
    Enrolment
    26

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAneurysms; Arteriovenous Malformations
    Interventionminocycline; doxycycline
    PhasePhase 1
    Registry statusCompleted