Skip to content
AMR Drug RepurposingSmart Screeningresearch prototype

Doxycycline

FDA-approved product (for suspension, oral), marketed as Doxychel, Doxycycline, Monodox and 15 more.

Registered studies
50+
Lab records
7
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Doxycycline
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Acne
  • Anthrax infection
  • Bacterial disease
  • Brucellosis
  • Gonorrhea
  • Infection
  • Malaria
  • Ornithosis
  • Periodontitis
  • Pneumonia
  • Rosacea
  • Spotted fever
  • Tularemia
  • Typhus
  • Vibrio infectious disease

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Antiinfectives and antiseptics for local oral treatment; Tetracyclines
FDA pharmacologic class
Tetracycline-class Drug FDA label ↗
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01AA02; FDA class Tetracycline-class Drug

Repurposing investigation

Doxycycline is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA80.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli88.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae64.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis62.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 1 of 1 lab record
  • E. coli: measured active in 4 of 6 lab records
Open Doxycycline in ChEMBL Registered studies below
Show the 7 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.9 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.8 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.5 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.3 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Doxycycline with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Subantimicrobial Doxycycline in Acne

    NCT05399290 · start 2020-11-19

    Registered record
    Registry ID
    NCT05399290
    Conditions
    Acne Vulgaris; Pediatrics
    Interventions
    Doxycycline Hyclate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2020-11-19
    Completion
    2021-11-08
    Enrolment
    22

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcne Vulgaris; Pediatrics
    InterventionDoxycycline Hyclate
    PhasePhase 4
    Registry statusCompleted

  • Comparison Of Doxycycline And Common Salt For Treatment Of Umbilical Granuloma: A Randomised Control Trial

    NCT05545462 · start 2020-10-01

    Registered record
    Registry ID
    NCT05545462
    Conditions
    Umbilical Granuloma
    Interventions
    Doxycyclin; COMMON SALT
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2020-10-01
    Completion
    2021-09-30
    Enrolment
    196

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUmbilical Granuloma
    InterventionDoxycyclin; COMMON SALT
    PhaseNot applicable
    Registry statusCompleted

  • RepurpoSing Old Drugs TO SuppRess a Modern Threat: COVID-19 STORM

    NCT04433078 · start 2020-06-22

    Registered record
    Registry ID
    NCT04433078
    Conditions
    Cytokine Storm; SARS-CoV-2
    Interventions
    Doxycycline; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Withdrawn
    Start
    2020-06-22
    Completion
    2021-04-13
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCytokine Storm; SARS-CoV-2
    InterventionDoxycycline; Placebo
    PhasePhase 2
    Registry statusWithdrawn

  • Re-evaluation of Some Old Rheumatoid Arthritis Therapy: A Randomized Controlled Trial

    NCT03194204 · start 2019-10-01

    Registered record
    Registry ID
    NCT03194204
    Conditions
    Rheumatoid Arthritis
    Interventions
    Doxycycline Tablets
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-10-01
    Completion
    2020-02-20
    Enrolment
    160

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRheumatoid Arthritis
    InterventionDoxycycline Tablets
    PhaseNot applicable
    Registry statusCompleted

  • Effect of Doxycycline on Cardiac Remodelling in STEMI Patients

    NCT03960411 · start 2019-05-25

    Registered record
    Registry ID
    NCT03960411
    Conditions
    ST Elevation Myocardial Infarction; Anterior Wall Myocardial Infarction; Heart Failure; Remodeling, Ventricular
    Interventions
    Doxycycline 100Mg Capsule; Placebo oral capsule
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2019-05-25
    Completion
    2019-11
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionST Elevation Myocardial Infarction; Anterior Wall Myocardial Infarction; Heart Failure; Remodeling, Ventricular
    InterventionDoxycycline 100Mg Capsule; Placebo oral capsule
    PhasePhase 3
    Registry statusUnknown

  • A Trial of Doxycycline vs. Standard Supportive Therapy in Newly-diagnosed Cardiac AL Amyloidosis Patients Undergoing Bortezomib-based Therapy

    NCT03474458 · start 2019-02-11

    Registered record
    Registry ID
    NCT03474458
    Conditions
    Cardiac AL Amyloidosis
    Interventions
    Doxycycline; Standard of care therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Terminated
    Start
    2019-02-11
    Completion
    2022-05-30
    Enrolment
    19

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCardiac AL Amyloidosis
    InterventionDoxycycline; Standard of care therapy
    PhasePhase 2 / Phase 3
    Registry statusTerminated

  • A 24 Month Study, to Compare the Efficacy of Doxycycline vs. Placebo for Improving Filarial Lymphedema in Mali

    NCT02927496 · start 2018-06-19

    Registered record
    Registry ID
    NCT02927496
    Conditions
    Lymphedema; Lymphatic Filariasis; Filariasis
    Interventions
    Doxycycline; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2018-06-19
    Completion
    2020-12-19
    Enrolment
    220

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLymphedema; Lymphatic Filariasis; Filariasis
    InterventionDoxycycline; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Tenofovir/Emtricitabine With Doxycycline for Combination HIV and Syphilis Pre-exposure Prophylaxis in HIV-negative MSM

    NCT02844634 · start 2018-05-15

    Registered record
    Registry ID
    NCT02844634
    Conditions
    HIV; Syphilis
    Interventions
    Doxycycline 100mg PO daily x 12 months; Tenofovir/emtricitabine 200/300mg PO daily; Doxycycline 100mg PO daily x 6 months
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2018-05-15
    Completion
    2022-09-07
    Enrolment
    52

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV; Syphilis
    InterventionDoxycycline 100mg PO daily x 12 months; Tenofovir/emtricitabine 200/300mg PO daily; Doxycycline 100mg PO daily x 6 months
    PhasePhase 4
    Registry statusCompleted

  • Anti-chlamydophila Antibiotic Combination Therapy in the Treatment of Patients With Coronary Heart Disease

    NCT03618108 · start 2018-04-04

    Registered record
    Registry ID
    NCT03618108
    Conditions
    Coronary Heart Disease; Chlamydophila Pneumoniae Infections
    Interventions
    Doxycycline Capsule; Azithromycin Capsule; Rifabutin Oral Capsule; Placebo oral capsule; Placebo Oral Tablet; Placebo oral capsule
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2018-04-04
    Completion
    2020-11-30
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCoronary Heart Disease; Chlamydophila Pneumoniae Infections
    InterventionDoxycycline Capsule; Azithromycin Capsule; Rifabutin Oral Capsule; Placebo oral capsule +2 more
    PhasePhase 2
    Registry statusTerminated

  • S. Aureus Decolonization in HPN Patients.

    NCT03173053 · start 2018-02-08

    Registered record
    Registry ID
    NCT03173053
    Conditions
    Staphylococcus Aureus; Motility Disorder
    Interventions
    Doxycycline; Trimethoprim; Sulfamethoxazole/trimethoprim; Clindamycin; Clarithromycin; Ciprofloxacin; Fusidic Acid; Rifampin; Chlorhexidine; Mupirocin; Betadine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2018-02-08
    Completion
    2021-10-14
    Enrolment
    63

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus; Motility Disorder
    InterventionDoxycycline; Trimethoprim; Sulfamethoxazole/trimethoprim; Clindamycin +7 more
    PhaseNot applicable
    Registry statusTerminated

  • A Controlled Study to Assess the Efficacy, Safety and Tolerability of Oral DFD-29 Extended Release Capsules

    NCT03340961 · start 2017-10-01

    Registered record
    Registry ID
    NCT03340961
    Conditions
    Rosacea
    Interventions
    DFD-29 Extended Release Capsules (40 mg); DFD-29 Extended Release Capsules (20 mg); Oraycea® (doxycycline) Capsules; Placebo Capsules
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2017-10-01
    Completion
    2019-03-31
    Enrolment
    205

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRosacea
    InterventionDFD-29 Extended Release Capsules (40 mg); DFD-29 Extended Release Capsules (20 mg); Oraycea® (doxycycline) Capsules; Placebo Capsules
    PhasePhase 2
    Registry statusCompleted

  • Treatment Modalities of Oral Lichen Planus

    NCT03237533 · start 2017-06-01

    Registered record
    Registry ID
    NCT03237533
    Conditions
    Oral Lichen Planus
    Interventions
    Dexamethasone
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Unknown
    Start
    2017-06-01
    Completion
    2017-12-31
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOral Lichen Planus
    InterventionDexamethasone
    PhaseEarly phase 1
    Registry statusUnknown

  • Metformin Hydrochloride and Doxycycline in Treating Patients With Head and Neck Squamous Cell Carcinoma

    NCT03076281 · start 2017-04-03

    Registered record
    Registry ID
    NCT03076281
    Conditions
    Larynx; LIP; Oral Cavity; Pharynx
    Interventions
    Metformin Hydrochloride; Doxycycline; Metformin +Doxycycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2017-04-03
    Completion
    2018-12-03
    Enrolment
    7

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLarynx; LIP; Oral Cavity; Pharynx
    InterventionMetformin Hydrochloride; Doxycycline; Metformin +Doxycycline
    PhasePhase 2
    Registry statusTerminated

  • Trial of Antimicrobials Versus Placebo in Addition to Fecal Transplant Therapy in Ulcerative Colitis

    NCT02606032 · start 2016-05

    Registered record
    Registry ID
    NCT02606032
    Conditions
    Ulcerative Colitis
    Interventions
    Metronidazole; Doxycycline; Terbinafine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2016-05
    Completion
    2021-01-27
    Enrolment
    75

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUlcerative Colitis
    InterventionMetronidazole; Doxycycline; Terbinafine; Placebo
    PhasePhase 2
    Registry statusCompleted

  • A Trial of Doxycycline in Renal Disease

    NCT02753426 · start 2016-04

    Registered record
    Registry ID
    NCT02753426
    Conditions
    Chronic Kidney Disease; Cardiorenal Syndrome
    Interventions
    Doxycycline; Placebo (for Doxycycline)
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2016-04
    Completion
    2018-01
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Kidney Disease; Cardiorenal Syndrome
    InterventionDoxycycline; Placebo (for Doxycycline)
    PhasePhase 1
    Registry statusCompleted