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AMR Drug RepurposingSmart Screeningresearch prototype

Chlorothiazide

FDA-approved product (suspension, oral), marketed as Chlorothiazide, Diuril, Chlorothiazide Sodium.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Chlorothiazide
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cardiovascular disease
  • Chronic kidney disease
  • Congestive heart failure
  • Edema
  • Glomerulonephritis
  • Heart failure
  • Hypertension
  • Nephrotic syndrome
  • Preeclampsia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Thiazides, plain; Thiazides, combinations with psycholeptics and/or analgesics
FDA pharmacologic class
Thiazide Diuretic FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA37.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli33.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae12.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis68.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Chlorothiazide in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.0 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-8.1 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-6.0 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.4 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Chlorothiazide with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Fasting Study of Olmesartan Medoxomil and Hydrochlorothiazide Tablets 40 mg/25 mg and Benicar HCT® Tablets 40 mg/25 mg

    NCT01020214 · start 2006-11

    Registered record
    Registry ID
    NCT01020214
    Conditions
    Healthy
    Interventions
    Olmesartan Medoxomil and Hydrochlorothiazide Tablets 40 mg/25 mg; Benicar HCT® Tablets 40 mg/25 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2006-11
    Completion
    2006-11
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionOlmesartan Medoxomil and Hydrochlorothiazide Tablets 40 mg/25 mg; Benicar HCT® Tablets 40 mg/25 mg
    PhasePhase 1
    Registry statusCompleted

  • A Safety and Efficacy Trial of Aliskiren 150mg , 300 mg Compared to Ramipril 5mg, 10mg in the Elderly

    NCT00368277 · start 2006-09

    Registered record
    Registry ID
    NCT00368277
    Conditions
    Hypertension
    Interventions
    Aliskiren; Ramipril; Hydrochlorothiazide; Amlodipine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-09
    Completion
    2008-02
    Enrolment
    901

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionAliskiren; Ramipril; Hydrochlorothiazide; Amlodipine
    PhasePhase 3
    Registry statusCompleted

  • Glycemic And Blood Pressure Control In Type 2 Diabetes, In A Primary Care Unit: A Staged Management Strategy

    NCT00935805 · start 2006-07

    Registered record
    Registry ID
    NCT00935805
    Conditions
    Diabetes Mellitus; Arterial Hypertension
    Interventions
    Metformin; Glybenclamide; NPH insulin; Hydrochlorothiazide; Propranolol; Captopril; Amlodipine
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2006-07
    Completion
    2012-07
    Enrolment
    124

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetes Mellitus; Arterial Hypertension
    InterventionMetformin; Glybenclamide; NPH insulin; Hydrochlorothiazide +3 more
    PhaseNot recorded
    Registry statusUnknown

  • Trial of Telmisartan 80 mg/HCTZ 12.5 mg and Telmisartan 40 mg/HCTZ 12.5 mg in Patients With Hypertension

    NCT00326768 · start 2006-05

    Registered record
    Registry ID
    NCT00326768
    Conditions
    Hypertension
    Interventions
    Telmisartan 40 mg/HCTZ 12.5 mg; Telmisartan 40 mg; Telmisartan 80 mg/HCTZ 12.5 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-05
    Completion
    2007-08
    Enrolment
    184

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionTelmisartan 40 mg/HCTZ 12.5 mg; Telmisartan 40 mg; Telmisartan 80 mg/HCTZ 12.5 mg
    PhasePhase 3
    Registry statusCompleted

  • Bioequivalence Study of Hydrochlorothiazide 50mg Tablets Under Fasting Conditions

    NCT00776646 · start 2006-05

    Registered record
    Registry ID
    NCT00776646
    Conditions
    Healthy
    Interventions
    hydrochlorothiazide 50 mg tablet
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2006-05
    Completion
    2006-08
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    Interventionhydrochlorothiazide 50 mg tablet
    PhaseNot applicable
    Registry statusCompleted

  • Olmesartan and an add-on Treatment in Patients With Mild to Moderate Hypertension

    NCT00311155 · start 2006-03

    Registered record
    Registry ID
    NCT00311155
    Conditions
    Essential Hypertension
    Interventions
    olmesartan medoxomil + hydrochlorothiazide, if necessary + amlodipine, if necessary
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-03
    Completion
    2008-04
    Enrolment
    694

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEssential Hypertension
    Interventionolmesartan medoxomil + hydrochlorothiazide, if necessary + amlodipine, if necessary
    PhasePhase 4
    Registry statusCompleted

  • A Study to Evaluate the Combination of Valsartan and Amlodipine in Hypertensive Patients Not Controlled on Monotherapy

    NCT00327145 · start 2006-03

    Registered record
    Registry ID
    NCT00327145
    Conditions
    Hypertension
    Interventions
    valsartan; hydrochlorothiazide; amlodipine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-03
    Completion
    2007-01
    Enrolment
    894

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    Interventionvalsartan; hydrochlorothiazide; amlodipine
    PhasePhase 3
    Registry statusCompleted

  • Renin Profiling in Selection of Initial Antihypertensive Drug

    NCT00834600 · start 2005-12

    Registered record
    Registry ID
    NCT00834600
    Conditions
    Hypertension
    Interventions
    olmesartan, hydrochlorothiazide, amlodipine; hydrochlorothiazide (HCTZ) or olmesartan
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2005-12
    Completion
    2011-10
    Enrolment
    185

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    Interventionolmesartan, hydrochlorothiazide, amlodipine; hydrochlorothiazide (HCTZ) or olmesartan
    PhaseNot applicable
    Registry statusCompleted

  • Valsartan/Hydrochlorothiazide Combination in the Treatment of Severe Hypertension

    NCT00273299 · start 2005-11

    Registered record
    Registry ID
    NCT00273299
    Conditions
    Hypertension
    Interventions
    valsartan plus hydrochlorothiazide
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-11
    Completion
    2006-07
    Enrolment
    607

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    Interventionvalsartan plus hydrochlorothiazide
    PhasePhase 3
    Registry statusCompleted

  • PHARES Study: Management of Resistant Hypertension

    NCT00224549 · start 2005-04

    Registered record
    Registry ID
    NCT00224549
    Conditions
    Hypertension
    Interventions
    irbesartan, amlodipine and hydrochlorothiazide
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2005-04
    Completion
    2009-08
    Enrolment
    180

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    Interventionirbesartan, amlodipine and hydrochlorothiazide
    PhasePhase 4
    Registry statusCompleted

  • Antiproteinuric Effect of Valsartan and Lisinopril

    NCT00171574 · start 2004-11

    Registered record
    Registry ID
    NCT00171574
    Conditions
    Hypertension; Diabetic Nephropathy
    Interventions
    Valsartan; Valsartan plus HCTZ; Lisinopril
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-11
    Completion
    2006-07
    Enrolment
    124

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension; Diabetic Nephropathy
    InterventionValsartan; Valsartan plus HCTZ; Lisinopril
    PhasePhase 4
    Registry statusCompleted

  • An Examination of the Safety and Blood Pressure Lowering Effect of Increasing Doses of Benicar® and Benicar® HCT in Patients With Hypertension

    NCT00185068 · start 2004-03

    Registered record
    Registry ID
    NCT00185068
    Conditions
    Hypertension
    Interventions
    Olmesartan medoxomil; Olmesartan medoxomil/hydrochlorothiazide; Hydrochlorothiazide
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-03
    Completion
    2004-10
    Enrolment
    110

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionOlmesartan medoxomil; Olmesartan medoxomil/hydrochlorothiazide; Hydrochlorothiazide
    PhasePhase 4
    Registry statusCompleted

  • Losartan Potassium/Hydrochlorothiazide 100/25 mg Tablets in Healthy Subjects Under Fasting Conditions

    NCT01149486 · start 2004-01

    Registered record
    Registry ID
    NCT01149486
    Conditions
    Healthy
    Interventions
    Losartan potassium/Hydrochlorothiazide; Hyzaar®
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2004-01
    Completion
    2004-02
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionLosartan potassium/Hydrochlorothiazide; Hyzaar®
    PhasePhase 1
    Registry statusCompleted

  • Factorial Study of Metoprolol Succinate TOPROL-XL (324A)

    NCT00642096 · start 2003-06

    Registered record
    Registry ID
    NCT00642096
    Conditions
    High Blood Pressure (Hypertension).
    Interventions
    Metoprolol Succinate; Hydrochlorothiazide
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2003-06
    Completion
    2004-07
    Enrolment
    1,900

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHigh Blood Pressure (Hypertension).
    InterventionMetoprolol Succinate; Hydrochlorothiazide
    PhasePhase 3
    Registry statusCompleted

  • Bioequivalence Study of Fosinopril Sodium/ Hydrochlorothiazide 20/ 12.5 mg Tablets Under Fasting Conditions

    NCT00777972 · start 2003-03

    Registered record
    Registry ID
    NCT00777972
    Conditions
    Healthy
    Interventions
    Fosinopril sodium and hydrochlorothiazide 20-12.5 mg tablets
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2003-03
    Completion
    2003-04
    Enrolment
    34

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionFosinopril sodium and hydrochlorothiazide 20-12.5 mg tablets
    PhaseNot applicable
    Registry statusCompleted