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AMR Drug RepurposingSmart Screeningresearch prototype

Cefuroxime Sodium

FDA-approved product (injectable, injection), marketed as Cefuroxime And Dextrose In Duplex Container, Cefuroxime Sodium, Cefuroxime Sodium In Plastic Container and 4 more.

Registered studies
50+
Lab records
17
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Cefuroxime Sodium
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Eye infection
  • Infection
  • Pneumonia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Second-generation cephalosporins; Antibiotics
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01DC02; WHO ATC S01AA27

Repurposing investigation

Cefuroxime Sodium is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA94.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli77.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae20.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis46.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 6 of 6 lab records
  • E. coli: measured active in 2 of 2 lab records
  • K. pneumoniae: measured active in 1 of 9 lab records
Open Cefuroxime Sodium in ChEMBL Registered studies below
Show the 17 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.5 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.6 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.2 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.0 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Cefuroxime Sodium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Antibiotic Prophylaxis for Transrectal Prostate Biopsy

    NCT01659866 · start 2012-08

    Registered record
    Registry ID
    NCT01659866
    Conditions
    Infection
    Interventions
    Ciprofloxacin; trimethoprim-sulfamethoxazole; cefuroxime; ceftriaxone; gentamicin; amikacin; aztreonam; imipenem; ceftriaxone; gentamicin; amikacin; aztreonam; imipenem
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-08
    Completion
    2016-08
    Enrolment
    563

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfection
    InterventionCiprofloxacin; trimethoprim-sulfamethoxazole; cefuroxime; ceftriaxone +9 more
    PhasePhase 4
    Registry statusCompleted

  • Pharmacokinetics of Small Spectrum Beta-lactam Antibiotics (Amoxicillin/Clavulanic Acid and Cefuroxime) in Patients on Intensive Care Units

    NCT01581047 · start 2012-03-15

    Registered record
    Registry ID
    NCT01581047
    Conditions
    Infection
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2012-03-15
    Completion
    2014-05-07
    Enrolment
    37

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfection
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Examination of the Efficacy of Preventive Antibiotic Treatment During the Puerperium Among Pregnant Women With Recurrent Urinary Tract Infections

    NCT01507974 · start 2012-01-16

    Registered record
    Registry ID
    NCT01507974
    Conditions
    Pregnancy Complications
    Interventions
    Preventive antibiotic treatment- NITROFURANTOIN; Preventive antibiotic treatment- CEPHALEXIN; PREVENTIVE TREATMENT- AMOXICILLIN; PREVENTIVE TREATMENT- AMOXICILLIN AND CLAVULANATE POTASSIUM; PREVENTIVE TREATMENT- CEFUROXIME; PREVENTIVE TREATMENT SULFAMETHOXAZOLE AND TRIMETHOPRIM
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-01-16
    Completion
    2015-01-01
    Enrolment
    220

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPregnancy Complications
    InterventionPreventive antibiotic treatment- NITROFURANTOIN; Preventive antibiotic treatment- CEPHALEXIN; PREVENTIVE TREATMENT- AMOXICILLIN; PREVENTIVE TREATMENT- AMOXICILLIN AND CLAVULANATE POTASSIUM +2 more
    PhaseNot applicable
    Registry statusCompleted

  • Laparoscopic Management of Periappendicular Abscess

    NCT01283815 · start 2011-01

    Registered record
    Registry ID
    NCT01283815
    Conditions
    Appendicitis; Abdominal Abscess
    Interventions
    Laparoscopic appendectomy; Conservative management with percutaneous drainage
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2011-01
    Completion
    2014-08
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAppendicitis; Abdominal Abscess
    InterventionLaparoscopic appendectomy; Conservative management with percutaneous drainage
    PhasePhase 2
    Registry statusCompleted

  • Tailored Antibiotics Prophylaxis for Percutaneous Endoscopic Gastrostomy

    NCT01237730 · start 2010-07

    Registered record
    Registry ID
    NCT01237730
    Conditions
    The Patients Who Receive Percutaneous Endoscopic Gastrostomy; Peristomal Wound Infection After the Operation of PEG; Prophylactic Antibiotics Before PEG
    Interventions
    cefuroxime; Tailored antibiotic
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2010-07
    Completion
    2011-08
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionThe Patients Who Receive Percutaneous Endoscopic Gastrostomy; Peristomal Wound Infection After the Operation of PEG; Prophylactic Antibiotics Before PEG
    Interventioncefuroxime; Tailored antibiotic
    PhaseNot applicable
    Registry statusUnknown

  • Monotherapy Versus Bitherapy in Non-severe Hospitalized Community-acquired Pneumonia

    NCT00818610 · start 2009-01

    Registered record
    Registry ID
    NCT00818610
    Conditions
    Community-acquired Pneumonia
    Interventions
    Beta lactam (amoxicillin / clav. acid OR cefuroxime); Beta-lactam (amoxicillin / clav. acid OR cefuroxime) AND macrolide (clarithromycin)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-01
    Completion
    2013-04
    Enrolment
    601

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCommunity-acquired Pneumonia
    InterventionBeta lactam (amoxicillin / clav. acid OR cefuroxime); Beta-lactam (amoxicillin / clav. acid OR cefuroxime) AND macrolide (clarithromycin)
    PhasePhase 4
    Registry statusCompleted

  • The Effect of Intracameral Cefuroxime on Post-op Fibrin in Pediatric Cataract Surgery

    NCT00730938 · start 2008-02

    Registered record
    Registry ID
    NCT00730938
    Conditions
    Cataract; Endophthalmitis
    Interventions
    cefuroxime; Saline placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2008-02
    Completion
    2008-08
    Enrolment
    45

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCataract; Endophthalmitis
    Interventioncefuroxime; Saline placebo
    PhaseNot applicable
    Registry statusCompleted

  • Orally Administered Trimethoprim-sulfamethoxazole and Metronidazole as Prophylaxis of Infection Following Elective Colorectal Surgery

    NCT00613769 · start 2007-09

    Registered record
    Registry ID
    NCT00613769
    Conditions
    Infection Prophylaxis in Colo Rectal Surgery
    Interventions
    trimethoprim-sulfamethoxazole + metronidazole; cefuroxime and metronidazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-09
    Completion
    2012-05
    Enrolment
    1,073

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfection Prophylaxis in Colo Rectal Surgery
    Interventiontrimethoprim-sulfamethoxazole + metronidazole; cefuroxime and metronidazole
    PhasePhase 4
    Registry statusCompleted

  • Antibiotics in Free Flaps Reconstructions

    NCT02436083 · start 2007-07

    Registered record
    Registry ID
    NCT02436083
    Conditions
    Postoperative Infection
    Interventions
    antibiotic (use of penicilline, unacid, cefuroxime)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-07
    Completion
    2014-12
    Enrolment
    350

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Infection
    Interventionantibiotic (use of penicilline, unacid, cefuroxime)
    PhasePhase 4
    Registry statusCompleted

  • Comparison of Doxycycline and Cefuroxime Axetil in Erythema Migrans

    NCT03584919 · start 2006-06-01

    Registered record
    Registry ID
    NCT03584919
    Conditions
    Erythema Chronicum Migrans
    Interventions
    doxycycline; Cefuroxime Axetil 500Mg Tab; control subjects
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2006-06-01
    Completion
    2007-09-30
    Enrolment
    509

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionErythema Chronicum Migrans
    Interventiondoxycycline; Cefuroxime Axetil 500Mg Tab; control subjects
    PhaseNot applicable
    Registry statusCompleted

  • Inflammatory Responses in Solitary and Multiple Erythema Migrans

    NCT03980015 · start 2006-06-01

    Registered record
    Registry ID
    NCT03980015
    Conditions
    Erythema Migrans
    Interventions
    antibiotic treatment
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2006-06-01
    Completion
    2019-05-31
    Enrolment
    134

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionErythema Migrans
    Interventionantibiotic treatment
    PhaseNot recorded
    Registry statusCompleted

  • Comparison of Doxycycline and Cefuroxime Axetil for Treatment of Erythema Migrans: Clinical and Microbiological Outcome

    NCT01518192 · start 2006-06

    Registered record
    Registry ID
    NCT01518192
    Conditions
    Erythema Migrans; Post-Lyme Disease Symptoms
    Interventions
    doxycycline; cefuroxime axetil
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-06
    Completion
    2009-01
    Enrolment
    544

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionErythema Migrans; Post-Lyme Disease Symptoms
    Interventiondoxycycline; cefuroxime axetil
    PhasePhase 4
    Registry statusCompleted

  • Do Corticosteroid Injections During Total Knee Replacement Improve Early Clinical Results?

    NCT00492973 · start 2006-03

    Registered record
    Registry ID
    NCT00492973
    Conditions
    Osteoarthritis; Post-traumatic; Arthrosis
    Interventions
    methylprednisolone acetate; active comparator
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2006-03
    Completion
    2008-02
    Enrolment
    101

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis; Post-traumatic; Arthrosis
    Interventionmethylprednisolone acetate; active comparator
    PhaseNot applicable
    Registry statusCompleted

  • Ampicillin/Sulbactam Versus Cefuroxime as Antimicrobial Prophylaxis for Cesarean Section

    NCT01138852 · start 2004-07

    Registered record
    Registry ID
    NCT01138852
    Conditions
    Surgical Site Infections
    Interventions
    Ampicillin-sulbactam; Cefuroxime
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-07
    Completion
    2008-12
    Enrolment
    176

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgical Site Infections
    InterventionAmpicillin-sulbactam; Cefuroxime
    PhasePhase 4
    Registry statusCompleted

  • PERSPECTIVE: Telithromycin - Acute Exacerbation of Chronic Bronchitis

    NCT00132938 · start 2004-01

    Registered record
    Registry ID
    NCT00132938
    Conditions
    Chronic Bronchitis
    Interventions
    telithromycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-01
    Completion
    2006-05
    Enrolment
    5,660

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Bronchitis
    Interventiontelithromycin
    PhasePhase 4
    Registry statusCompleted