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AMR Drug RepurposingSmart Screeningresearch prototype

Cefuroxime Sodium

FDA-approved product (injectable, injection), marketed as Cefuroxime And Dextrose In Duplex Container, Cefuroxime Sodium, Cefuroxime Sodium In Plastic Container and 4 more.

Registered studies
50+
Lab records
17
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Cefuroxime Sodium
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Eye infection
  • Infection
  • Pneumonia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Second-generation cephalosporins; Antibiotics
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01DC02; WHO ATC S01AA27

Repurposing investigation

Cefuroxime Sodium is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA94.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli77.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae20.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis46.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 6 of 6 lab records
  • E. coli: measured active in 2 of 2 lab records
  • K. pneumoniae: measured active in 1 of 9 lab records
Open Cefuroxime Sodium in ChEMBL Registered studies below
Show the 17 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.5 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.6 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.2 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.0 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Cefuroxime Sodium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • APLAUD Trial (Antibiotics vs PLacebo for Acute Uncomplicated Diverticulitis)

    NCT07492134 · start 2026-07-07

    Registered record
    Registry ID
    NCT07492134
    Conditions
    Acute Uncomplicated Diverticulitis
    Interventions
    Amoxicillin-Clavulanate 875 Mg-125 Mg Oral Tablet; Placebo; Metronidazole; Cefuroxime
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Recruiting
    Start
    2026-07-07
    Completion
    2028-10-01
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Uncomplicated Diverticulitis
    InterventionAmoxicillin-Clavulanate 875 Mg-125 Mg Oral Tablet; Placebo; Metronidazole; Cefuroxime
    PhasePhase 2
    Registry statusRecruiting

  • Prophylactic Antibiotics in Preventing Surgical Site Infection After Hepatobiliary Surgery in High-Resistant Settings

    NCT07620223 · start 2026-05-24

    Registered record
    Registry ID
    NCT07620223
    Conditions
    Hepatobiliary Surgery; Prophylactic Antibiotics
    Interventions
    Piperacillin-tazobactam
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2026-05-24
    Completion
    2029-01-31
    Enrolment
    378

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHepatobiliary Surgery; Prophylactic Antibiotics
    InterventionPiperacillin-tazobactam
    PhaseNot applicable
    Registry statusRecruiting

  • Efficacy and Safety of Sanyong Jiedu Granules in Treating Lumps-Type Non-Lactational Mastiti

    NCT07512648 · start 2026-03-20

    Registered record
    Registry ID
    NCT07512648
    Conditions
    Plasmacytic Mastitis; Granulomatous Lobular Mastitis
    Interventions
    Sanyong Jiedu Granules; Standard Medication
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Not yet recruiting
    Start
    2026-03-20
    Completion
    2028-07-31
    Enrolment
    210

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPlasmacytic Mastitis; Granulomatous Lobular Mastitis
    InterventionSanyong Jiedu Granules; Standard Medication
    PhaseNot applicable
    Registry statusNot yet recruiting

  • Effects of Red and Infrared Photobiomodulation in Rhinoplasty at a Single Centre

    NCT07033039 · start 2026-01-30

    Registered record
    Registry ID
    NCT07033039
    Conditions
    Rhinoplasty; Edema
    Interventions
    Photobiomodulation; Simulation of Photobiomodulation; Standard treatment protocol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2026-01-30
    Completion
    2030-11-30
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRhinoplasty; Edema
    InterventionPhotobiomodulation; Simulation of Photobiomodulation; Standard treatment protocol
    PhaseNot applicable
    Registry statusRecruiting

  • Pivmecillinam as Oral Step-Down Treatment for Escherichia Coli Febrile Urinary Tract Infection Versus Standard of Care

    NCT07236944 · start 2025-12

    Registered record
    Registry ID
    NCT07236944
    Conditions
    Febrile Urinary Tract Infection
    Interventions
    Pivmecillinam; Standard of Care (Investigator Choice)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2025-12
    Completion
    2029-03
    Enrolment
    560

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFebrile Urinary Tract Infection
    InterventionPivmecillinam; Standard of Care (Investigator Choice)
    PhasePhase 4
    Registry statusRecruiting

  • Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing

    NCT06406114 · start 2025-05-05

    Registered record
    Registry ID
    NCT06406114
    Conditions
    Drug Allergy; Cephalosporin Allergy; Drug Hypersensitivity; Antibiotic Allergy; Beta Lactam Adverse Reaction; Drug-Induced Anaphylaxis; Cephalosporin Reaction
    Interventions
    Beta-lactam antibiotic (cefazolin, cefuroxime, cefotaxime, ceftazidime, ceftriaxone, cefepime, pre-pen, penicillin G, ampicillin, and histamine) double-blind skin testing; Culprit cephalosporin (cefazolin, ceftazidime, ceftriaxone, cefepime, cephalexin, cefaclor, cefadroxil, cefuroxime, cefpodoxime, cefdinir, or cefixime) double-blind placebo-controlled drug challenge; Similar cephalosporin (cefepime, ceftriaxone, cefaclor, cephalexin, cefixime, or cefdinir) antibiotic double-blind placebo-controlled drug challenge; Dissimilar cephalosporin (ceftriaxone or cefazolin) antibiotic double-blind placebo-controlled drug challenge; Amoxicillin double-blind placebo-controlled drug challenge
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Recruiting
    Start
    2025-05-05
    Completion
    2028-12-31
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDrug Allergy; Cephalosporin Allergy; Drug Hypersensitivity; Antibiotic Allergy +3 more
    InterventionBeta-lactam antibiotic (cefazolin, cefuroxime, cefotaxime, ceftazidime, ceftriaxone, cefepime, pre-pen, penicillin G, ampicillin, and histamine) double-blind skin testing; Culprit cephalosporin (cefazolin, ceftazidime, ceftriaxone, cefepime, cephalexin, cefaclor, cefadroxil, cefuroxime, cefpodoxime, cefdinir, or cefixime) double-blind placebo-controlled drug challenge; Similar cephalosporin (cefepime, ceftriaxone, cefaclor, cephalexin, cefixime, or cefdinir) antibiotic double-blind placebo-controlled drug challenge; Dissimilar cephalosporin (ceftriaxone or cefazolin) antibiotic double-blind placebo-controlled drug challenge +1 more
    PhasePhase 2
    Registry statusRecruiting

  • Clinical Trial Testing Whether Targeted Antibiotic Prophylaxis Can Reduce Infections After Cystectomy Compared to Empiric Prophylaxis

    NCT06709196 · start 2025-01-07

    Registered record
    Registry ID
    NCT06709196
    Conditions
    Cystectomy; Bladder Cancer Requiring Cystectomy; Postoperative Infections; Antibiotic Prophylaxis; Ileal Conduit
    Interventions
    Pivmecillinam; Pivmecillinam; Amoxicillin clavulanic acid; Amoxicillin; Cefuroxime; Ciprofloxacin; Linezolid; Nitrofurantoin; Trimethoprim; Sulfamethoxazole trimethoprim; Fluconazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2025-01-07
    Completion
    2027-01
    Enrolment
    248

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCystectomy; Bladder Cancer Requiring Cystectomy; Postoperative Infections; Antibiotic Prophylaxis +1 more
    InterventionPivmecillinam; Pivmecillinam; Amoxicillin clavulanic acid; Amoxicillin +7 more
    PhasePhase 4
    Registry statusRecruiting

  • Compound Phellodendron Decoction May Promote Wound Healing After Anal Fistulotomy

    NCT06663527 · start 2024-10-26

    Registered record
    Registry ID
    NCT06663527
    Conditions
    Fistula in Ano
    Interventions
    Fumigating-washing Therapy With CPD; fumigating-washing therapy with a placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2024-10-26
    Completion
    2025-02-01
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFistula in Ano
    InterventionFumigating-washing Therapy With CPD; fumigating-washing therapy with a placebo
    PhaseNot applicable
    Registry statusCompleted

  • Clinical Trial Comparing Oral Versus Intravenous Cefuroxime in Pregnant Women with Pyelonephritis

    NCT06527560 · start 2024-09-09

    Registered record
    Registry ID
    NCT06527560
    Conditions
    Pyelonephritis in Pregnancy
    Interventions
    Cefuroxime; Cefuroxime Axetil
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2024-09-09
    Completion
    2027-12-31
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPyelonephritis in Pregnancy
    InterventionCefuroxime; Cefuroxime Axetil
    PhasePhase 4
    Registry statusRecruiting

  • Colo-Pro_2: Bolus-continuous Infusion Cefuroxime Prophylaxis for the Prevention of Infections After Colorectal Surgery

    NCT05609240 · start 2023-05-10

    Registered record
    Registry ID
    NCT05609240
    Conditions
    Antibiotic Prophylaxis; Colorectal Surgery
    Interventions
    Cefuroxime
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2023-05-10
    Completion
    2025-05-01
    Enrolment
    180

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAntibiotic Prophylaxis; Colorectal Surgery
    InterventionCefuroxime
    PhasePhase 2
    Registry statusUnknown

  • Standard Versus Prolonged Antibiotic Prophylaxis After Pancreatoduodenectomy (SPARROW)

    NCT05784311 · start 2023-03-06

    Registered record
    Registry ID
    NCT05784311
    Conditions
    Pancreatic Cancer
    Interventions
    Cefuroxime; Metronidazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2023-03-06
    Completion
    2026-01
    Enrolment
    344

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPancreatic Cancer
    InterventionCefuroxime; Metronidazole
    PhasePhase 4
    Registry statusRecruiting

  • Medicine-induced Cardiac Hemodialysis on COVID-19

    NCT05711810 · start 2023-01-02

    Registered record
    Registry ID
    NCT05711810
    Conditions
    Severe Acute Respiratory Syndrome-related Coronavirus; Renal Dialysis; Vaccines; Myocarditis Allergic; Infection Viral
    Interventions
    Nifedipine 30 MG; Kangzhu BPCB0A-3A; Low Mobility; Enalapril Maleate 10Mg Tab; Lansoprazole 30Mg Ec Cap; Metoprolol Succinate; Coenzyme Q10; d-alpha tocopherol acetate; Omega-3; Duloxetine Hydrochloride 20 MG Oral Capsule, Delayed Release; Superoxide Dismutase
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2023-01-02
    Completion
    2023-01-12
    Enrolment
    1

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSevere Acute Respiratory Syndrome-related Coronavirus; Renal Dialysis; Vaccines; Myocarditis Allergic +1 more
    InterventionNifedipine 30 MG; Kangzhu BPCB0A-3A; Low Mobility; Enalapril Maleate 10Mg Tab +7 more
    PhasePhase 4
    Registry statusCompleted

  • Does Additional Use of Preoperative Azithromycin Decrease Posthysterectomy Infections

    NCT05337566 · start 2022-09-05

    Registered record
    Registry ID
    NCT05337566
    Conditions
    Infection Post Op; Hysterectomy; Antibiotics; Prophylactic
    Interventions
    Azithromycin Pill + Cefuroxime; Placebo + Cefuroxime
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2022-09-05
    Completion
    2030-12
    Enrolment
    2,278

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfection Post Op; Hysterectomy; Antibiotics; Prophylactic
    InterventionAzithromycin Pill + Cefuroxime; Placebo + Cefuroxime
    PhaseNot applicable
    Registry statusRecruiting

  • Preoperative Oral Antibiotics With vs Without Mechanical Bowel Preparation to Reduce Surgical Site Infections Following Colonic Resection: an International Randomized Controlled Trial.

    NCT04161599 · start 2022-03-01

    Registered record
    Registry ID
    NCT04161599
    Conditions
    Wounds and Injuries; Surgery--Complications
    Interventions
    Cefuroxime (750mg) I.V; Colonic Surgery; Cefuroxime 750mg oral; Metronidazole 250 MG Oral Tablet [Flagyl]; Metronidazole 1 g Intravenous; Cefuroxime 1,5 g Intravenous; Sodium picosulfate, light magnesium oxide, anhydrous citric acid 10 mg/3.5 g/10.97 g Oral
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2022-03-01
    Completion
    2024-07
    Enrolment
    968

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionWounds and Injuries; Surgery--Complications
    InterventionCefuroxime (750mg) I.V; Colonic Surgery; Cefuroxime 750mg oral; Metronidazole 250 MG Oral Tablet [Flagyl] +3 more
    PhasePhase 4
    Registry statusUnknown

  • Cefuroxime vs Ceftriaxone for SSI Prevention in Neurosurgery

    NCT05398081 · start 2021-12-01

    Registered record
    Registry ID
    NCT05398081
    Conditions
    Surgical Site Infection; Antibiotics Prophylaxis
    Interventions
    Cefuroxime (Zinnat®); Ceftriaxone (Rocephin®)
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2021-12-01
    Completion
    2022-03-05
    Enrolment
    96

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSurgical Site Infection; Antibiotics Prophylaxis
    InterventionCefuroxime (Zinnat®); Ceftriaxone (Rocephin®)
    PhasePhase 2
    Registry statusCompleted