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AMR Drug RepurposingSmart Screeningresearch prototype

Penicillin G Sodium

FDA-approved product (injectable, injection), marketed as Bicillin, Bicillin L-A, Permapen and 14 more.

Registered studies
50+
Lab records
18
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Penicillin G Sodium
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Eye infection
  • Infection

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Beta-lactamase sensitive penicillins; Antibiotics
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01CE01; WHO ATC J01CE08; WHO ATC J01CE09; WHO ATC S01AA14

Repurposing investigation

Penicillin G Sodium is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA76.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli52.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae5.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis27.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 6 of 10 lab records
  • E. coli: measured active in 2 of 4 lab records
  • K. pneumoniae: measured active in 0 of 4 lab records
Open Penicillin G Sodium in ChEMBL Registered studies below
Show the 18 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.2 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-8.3 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

-7.8 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Penicillin G Sodium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Trial of Meropenem Versus Piperacillin-Tazobactam on Mortality and Clinial Response

    NCT02437045 · start 2015-04

    Registered record
    Registry ID
    NCT02437045
    Conditions
    Bloodstream Infections
    Interventions
    Meropenem; Piperacillin-tazobactam combination product
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-04
    Completion
    2020-12-31
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBloodstream Infections
    InterventionMeropenem; Piperacillin-tazobactam combination product
    PhasePhase 4
    Registry statusCompleted

  • Phase 2 Trial to Evaluate the Early Bactericidal Activity, Safety and Tolerability of Meropenem Plus Amoxycillin/CA and Faropenem Plus Amoxycillin/CA in Adult Patients With Newly Diagnosed Pulmonary Tuberculosis

    NCT02349841 · start 2014-09

    Registered record
    Registry ID
    NCT02349841
    Conditions
    Pulmonary Tuberculosis
    Interventions
    Meropenem; Faropenem; Amoxycillin/clavulanic acid; Rifafour e275
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2014-09
    Completion
    2014-12
    Enrolment
    46

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Tuberculosis
    InterventionMeropenem; Faropenem; Amoxycillin/clavulanic acid; Rifafour e275
    PhasePhase 2
    Registry statusCompleted

  • Study of Levofloxacin-based Concomitant Therapy for H. Pylori Eradication in Diabetic Patients

    NCT02466919 · start 2014-05

    Registered record
    Registry ID
    NCT02466919
    Conditions
    Helicobacter Pylori Infection
    Interventions
    Pantoprazole; Amoxicillin; Metronidazole; Levofloxacin; Clarithromycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2014-05
    Completion
    2016-09
    Enrolment
    114

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHelicobacter Pylori Infection
    InterventionPantoprazole; Amoxicillin; Metronidazole; Levofloxacin +1 more
    PhasePhase 4
    Registry statusCompleted

  • A Randomized, Open-label Study on Helicobacter Pylori Eradication With Standard Triple Regimen Plus Acetazolamide

    NCT02090738 · start 2014-03

    Registered record
    Registry ID
    NCT02090738
    Conditions
    H. Pylori Infection
    Interventions
    Acetazolamide group; Standard regimen group
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Withdrawn
    Start
    2014-03
    Completion
    Not recorded
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionH. Pylori Infection
    InterventionAcetazolamide group; Standard regimen group
    PhasePhase 2
    Registry statusWithdrawn

  • Phase I Study of Safety and Immunogenicity of ADU-623

    NCT01967758 · start 2014-01-08

    Registered record
    Registry ID
    NCT01967758
    Conditions
    Astrocytic Tumors; Glioblastoma Multiforme; Anaplastic Astrocytoma; Brain Tumor
    Interventions
    Cohort 1; Cohort 2; Cohort 3; Antibiotics
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2014-01-08
    Completion
    2018-08-15
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAstrocytic Tumors; Glioblastoma Multiforme; Anaplastic Astrocytoma; Brain Tumor
    InterventionCohort 1; Cohort 2; Cohort 3; Antibiotics
    PhasePhase 1
    Registry statusCompleted

  • Piperacillin/Tazobactam for Empirical Therapy of Febrile Neutropenia

    NCT01714570 · start 2012-11

    Registered record
    Registry ID
    NCT01714570
    Conditions
    Febrile; Neutropenia; Hematopoietic Stem Cell Transplantation
    Interventions
    Piperacillin-tazobactam combination product; Imipenem
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-11
    Completion
    2014-04
    Enrolment
    123

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFebrile; Neutropenia; Hematopoietic Stem Cell Transplantation
    InterventionPiperacillin-tazobactam combination product; Imipenem
    PhaseNot applicable
    Registry statusCompleted

  • Use of Probiotic Lactobacilli for the Treatment of Lactational Mastitis

    NCT00716183 · start 2008-07

    Registered record
    Registry ID
    NCT00716183
    Conditions
    Mastitis
    Interventions
    Lactobacillus salivarius HN6; Lactobacillus reuteri CR20; Lactobacillus fermentum LC40; Beta-lactam antibiotic
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2008-07
    Completion
    2009-05
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMastitis
    InterventionLactobacillus salivarius HN6; Lactobacillus reuteri CR20; Lactobacillus fermentum LC40; Beta-lactam antibiotic
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Antibiotic Prophylaxis in the Prevention of Surgical Site Infections After Selected Urgent Abdominal Surgical Procedures

    NCT01524081 · start 2008-07

    Registered record
    Registry ID
    NCT01524081
    Conditions
    Acute Appendicitis; Perforated Gastroduodenal Ulcer; Small Bowel Obstruction
    Interventions
    Metronidazole, Cefuroxime; Amoxicillin (+ clavulanic acid) and Fluconazole; Placebo; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-07
    Completion
    2011-11
    Enrolment
    187

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Appendicitis; Perforated Gastroduodenal Ulcer; Small Bowel Obstruction
    InterventionMetronidazole, Cefuroxime; Amoxicillin (+ clavulanic acid) and Fluconazole; Placebo; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Special Drug Use Investigation for CLAVAMOX® (Amoxicillin/Clavulanate) Pediatrics Dry Syrup (Every Indication Excluded Otitis Media)

    NCT01406275 · start 2008-01

    Registered record
    Registry ID
    NCT01406275
    Conditions
    Otitis Maedia
    Interventions
    Amoxicillin and clavulanate
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2008-01
    Completion
    2008-12
    Enrolment
    363

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOtitis Maedia
    InterventionAmoxicillin and clavulanate
    PhaseNot recorded
    Registry statusCompleted

  • Bicillin L-A vs Placebo for the Treatment of Chronic, Plaque-Type Psoriasis Unresponsive to Topical Medications

    NCT00427609 · start 2007-01

    Registered record
    Registry ID
    NCT00427609
    Conditions
    Psoriasis
    Interventions
    Bicillin L-A
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2007-01
    Completion
    2009-11
    Enrolment
    5

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPsoriasis
    InterventionBicillin L-A
    PhasePhase 2
    Registry statusTerminated

  • Interactions Between Cranberry Juice and Antibiotics Used to Treat Urinary Tract Infections

    NCT00084201 · start 2006-07

    Registered record
    Registry ID
    NCT00084201
    Conditions
    Urinary Tract Infections
    Interventions
    Cranberry juice; Amoxicillin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2006-07
    Completion
    2007-06
    Enrolment
    18

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUrinary Tract Infections
    InterventionCranberry juice; Amoxicillin
    PhaseNot applicable
    Registry statusCompleted

  • Zmax Compared to Augmentin in Sinusitis

    NCT00367120 · start 2006-06

    Registered record
    Registry ID
    NCT00367120
    Conditions
    Sinusitis
    Interventions
    Azithromycin Extended Release; Amoxicillin/Clavulanate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-06
    Completion
    2007-02
    Enrolment
    762

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSinusitis
    InterventionAzithromycin Extended Release; Amoxicillin/Clavulanate
    PhasePhase 4
    Registry statusCompleted

  • Amoxicillin and Metronidazole in Association With Non-surgical Therapy in Aggressive Periodontitis Treatment

    NCT03933501 · start 2006-01-01

    Registered record
    Registry ID
    NCT03933501
    Conditions
    Generalized Aggressive Periodontitis
    Interventions
    amoxicillin and metronidazole; Placebos
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-01-01
    Completion
    2018-12-01
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGeneralized Aggressive Periodontitis
    Interventionamoxicillin and metronidazole; Placebos
    PhasePhase 4
    Registry statusCompleted

  • Guidelines for Acute Sinusitis

    NCT00132275 · start 2003-11

    Registered record
    Registry ID
    NCT00132275
    Conditions
    Sinusitis
    Interventions
    Amoxicillin potassium clavulanate
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2003-11
    Completion
    2006-08
    Enrolment
    240

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSinusitis
    InterventionAmoxicillin potassium clavulanate
    PhaseNot applicable
    Registry statusCompleted

  • Effect of Three Periodontal Therapies in Current Smokers and Non-Smokers

    NCT00066066 · start 2003-07

    Registered record
    Registry ID
    NCT00066066
    Conditions
    Periodontitis; Periodontal Diseases
    Interventions
    Scaling and root planing; Metronidazole; Amoxicillin; Doxycycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2003-07
    Completion
    2009-07
    Enrolment
    146

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeriodontitis; Periodontal Diseases
    InterventionScaling and root planing; Metronidazole; Amoxicillin; Doxycycline
    PhasePhase 2
    Registry statusCompleted