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AMR Drug RepurposingSmart Screeningresearch prototype

Sulfamethoxazole

FDA-approved product (tablet, oral), marketed as Gantanol, Gantanol-Ds, Sulfamethoxazole and 1 more.

Registered studies
50+
Lab records
17
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Sulfamethoxazole
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Infection
  • Pneumocystosis
  • Urinary tract infection

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Intermediate-acting sulfonamides
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01EC01

Repurposing investigation

Sulfamethoxazole is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA30.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli22.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae5.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis65.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • K. pneumoniae: measured active in 0 of 17 lab records
Open Sulfamethoxazole in ChEMBL Registered studies below
Show the 17 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.3 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.7 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.3 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.6 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Sulfamethoxazole with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Bacteriophage Therapy for Mycobacterium Abscessus Pulmonary Infection

    NCT07228702 · start 2026-01-11

    Registered record
    Registry ID
    NCT07228702
    Conditions
    Non-Tuberculous Mycobacterial (NTM) Pneumonia; Mycobacterium Abscessus Infection
    Interventions
    Mycobacteriophage Muddy_HRMN0052; Amikacin Injection; Clofazimine; Bedaquiline (B); Linezolid (LZD); Sulfamethoxazole/Trimethoprim; Imipenem + Cilastatin; Ceftaroline fosamil; Omadacycline Oral Tablet
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Enrolling by invitation
    Start
    2026-01-11
    Completion
    2027-10
    Enrolment
    1

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNon-Tuberculous Mycobacterial (NTM) Pneumonia; Mycobacterium Abscessus Infection
    InterventionMycobacteriophage Muddy_HRMN0052; Amikacin Injection; Clofazimine; Bedaquiline (B) +5 more
    PhasePhase 1
    Registry statusEnrolling by invitation

  • Drug-induced Crystalluria in Sulfamethoxazole, High Dose Ciprofloxacin and High Dose Amoxicillin

    NCT07772752 · start 2025-12-08

    Registered record
    Registry ID
    NCT07772752
    Conditions
    Drug-induced Crystalline Nephropathy; Drug-induced Crystalluria; Infections Treated With Sulfamethoxazole, High Dose Ciprofloxacin or High Dose iv Amoxicillin
    Interventions
    Crystalluria examination
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2025-12-08
    Completion
    2026-12-31
    Enrolment
    290

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDrug-induced Crystalline Nephropathy; Drug-induced Crystalluria; Infections Treated With Sulfamethoxazole, High Dose Ciprofloxacin or High Dose iv Amoxicillin
    InterventionCrystalluria examination
    PhaseNot applicable
    Registry statusRecruiting

  • Low Dose Trimethoprim-Sulfamethoxazole for the Treatment of Pneumocystis Jirovecii Pneumonia

    NCT04851015 · start 2025-11-28

    Registered record
    Registry ID
    NCT04851015
    Conditions
    Pneumocystis; Pneumocystis Pneumonia; Pneumocystis Jirovecii Infection; Pneumocystis Infections; Pneumocystis Carinii Infection; Pneumocystosis; Pneumonia (Etiology); Pneumocystis Carinii; Infection, Resulting From HIV Disease; Pneumocystosis Associated With AIDS
    Interventions
    trimethoprim-sulfamethoxazole; trimethoprim-sulfamethoxazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Recruiting
    Start
    2025-11-28
    Completion
    2030-12-31
    Enrolment
    416

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumocystis; Pneumocystis Pneumonia; Pneumocystis Jirovecii Infection; Pneumocystis Infections +6 more
    Interventiontrimethoprim-sulfamethoxazole; trimethoprim-sulfamethoxazole
    PhasePhase 3
    Registry statusRecruiting

  • Trimethoprim-sulfamethoxazole vs. Clindamycin for the Treatment of Children With Invasive MRSA Infections

    NCT06982105 · start 2025-05-20

    Registered record
    Registry ID
    NCT06982105
    Conditions
    Methicillin Resistant Staphylococcus Aureus; Osteomyelitis Acute; Septic Arthritis; Orbital Cellulitis; Facial Cellulitis; Mastoiditis; Cervical Adenitis; Retropharyngeal Abscess; Peritonsillar Abscess
    Interventions
    Trimethoprim Sulfamethoxazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2025-05-20
    Completion
    2027-06
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin Resistant Staphylococcus Aureus; Osteomyelitis Acute; Septic Arthritis; Orbital Cellulitis +5 more
    InterventionTrimethoprim Sulfamethoxazole
    PhasePhase 4
    Registry statusRecruiting

  • Nasal Iodine Swab Versus Oral Antibiotic to Prevent Surgical Site Infection After Undergoing Mohs Micrographic Surgery

    NCT06207786 · start 2024-09-01

    Registered record
    Registry ID
    NCT06207786
    Conditions
    Skin Cancer; Skin Cancer Face; Malignant Cutaneous Adnexal Neoplasm
    Interventions
    Povidone-Iodine Swabs; Staphylococcus nasal swab; Antibiotic
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2024-09-01
    Completion
    2030-05
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSkin Cancer; Skin Cancer Face; Malignant Cutaneous Adnexal Neoplasm
    InterventionPovidone-Iodine Swabs; Staphylococcus nasal swab; Antibiotic
    PhaseNot applicable
    Registry statusWithdrawn

  • Early Intravenous to Oral Antibiotic Switch in Uncomplicated Staphylococcus Aureus Bacteraemia

    NCT06336824 · start 2024-06-28

    Registered record
    Registry ID
    NCT06336824
    Conditions
    Staphylococcus Aureus Bacteremia
    Interventions
    Tab. Trimethoprim-sulfamethoxazole, Tab. Clindamycin, Tab. Cephalexin, or Tab. Linezolid; IV Cloxacillin, IV Cefazolin, IV Vancomycin, or IV Ceftaroline
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2024-06-28
    Completion
    2025-06
    Enrolment
    290

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus Bacteremia
    InterventionTab. Trimethoprim-sulfamethoxazole, Tab. Clindamycin, Tab. Cephalexin, or Tab. Linezolid; IV Cloxacillin, IV Cefazolin, IV Vancomycin, or IV Ceftaroline
    PhasePhase 3
    Registry statusUnknown

  • Efficacy of Cotrimoxazole as a De-escalation Treatment of Ventilator-Associated Pneumonia in Intensive Care Unit

    NCT05696093 · start 2023-10-19

    Registered record
    Registry ID
    NCT05696093
    Conditions
    Ventilator Associated Pneumonia
    Interventions
    cotrimoxazole; standard antibiotic therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Recruiting
    Start
    2023-10-19
    Completion
    2026-12-31
    Enrolment
    628

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVentilator Associated Pneumonia
    Interventioncotrimoxazole; standard antibiotic therapy
    PhasePhase 3
    Registry statusRecruiting

  • Comparing Oral Versus Parenteral Antimicrobial Therapy

    NCT05977868 · start 2023-08-04

    Registered record
    Registry ID
    NCT05977868
    Conditions
    Endovascular Infection; Bone and Joint Infection; Skin and Soft Tissue Infection; Pulmonary Infection; Gastrointestinal Infection; Genitourinary Infection
    Interventions
    Amoxicillin, amoxicillin-clavulanate, cefadroxil, cefpodoxime, cefalexin, ciprofloxacin, delafloxacin, doxycycline, levofloxacin, linezolid; Ampicillin, ampicillin-sulbactam, cefazolin, cefepime, ceftaroline, ceftazidime, ceftazidime-avibactam, dalbavancin, daptomycin, ertapenem
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2023-08-04
    Completion
    2025-02-14
    Enrolment
    94

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEndovascular Infection; Bone and Joint Infection; Skin and Soft Tissue Infection; Pulmonary Infection +2 more
    InterventionAmoxicillin, amoxicillin-clavulanate, cefadroxil, cefpodoxime, cefalexin, ciprofloxacin, delafloxacin, doxycycline, levofloxacin, linezolid; Ampicillin, ampicillin-sulbactam, cefazolin, cefepime, ceftaroline, ceftazidime, ceftazidime-avibactam, dalbavancin, daptomycin, ertapenem
    PhasePhase 4
    Registry statusTerminated

  • Randomized Trial of Culture Directed Versus Empiric Antibiotics for Urinary Tract Infections in Older Women

    NCT05726318 · start 2023-02-17

    Registered record
    Registry ID
    NCT05726318
    Conditions
    UTI
    Interventions
    Antibiotics
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2023-02-17
    Completion
    2024-08-02
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUTI
    InterventionAntibiotics
    PhasePhase 4
    Registry statusCompleted

  • Study of Rituximab Monotherapy on Children With New-onset Nephrotic Syndrome: A Randomized Controlled Trial

    NCT05734794 · start 2023-02-09

    Registered record
    Registry ID
    NCT05734794
    Conditions
    Nephrotic Syndrome in Children; Rituximab
    Interventions
    Rituximab; Steroid
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2023-02-09
    Completion
    2026-07-30
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNephrotic Syndrome in Children; Rituximab
    InterventionRituximab; Steroid
    PhasePhase 3
    Registry statusUnknown

  • Studying the Distribution of Accessory Gene Regulator (Agr) Quorum Sensing System and the Prevalence of Linezolid and Mupirocin Resistance in Biofilm Producer/Non Producer Staphylococcus Aureus in Sohag University Hospitals

    NCT06291181 · start 2023-01-01

    Registered record
    Registry ID
    NCT06291181
    Conditions
    Staphylococcus Aureus
    Interventions
    antibiotic sensitivity test
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-01-01
    Completion
    2023-06-30
    Enrolment
    265

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus
    Interventionantibiotic sensitivity test
    PhaseNot applicable
    Registry statusCompleted

  • Absorption of Antibiotics With High Oral Bioavailability in Short-bowel Syndrome

    NCT05302531 · start 2022-12-09

    Registered record
    Registry ID
    NCT05302531
    Conditions
    Short Bowel Syndrome; Infection, Bacterial
    Interventions
    Amoxicillin; Levofloxacin; Ofloxacin; Sulfamethoxazole trimethoprim
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Unknown
    Start
    2022-12-09
    Completion
    2025-02
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionShort Bowel Syndrome; Infection, Bacterial
    InterventionAmoxicillin; Levofloxacin; Ofloxacin; Sulfamethoxazole trimethoprim
    PhasePhase 1
    Registry statusUnknown

  • Collaborative Urological Prosthetics Investigation Directive Research Group

    NCT05100654 · start 2022-04-22

    Registered record
    Registry ID
    NCT05100654
    Conditions
    Erectile Dysfunction; Penile Prosthesis Infection
    Interventions
    Doxycycline; Ciprofloxacin; Augmentin; Bactrim
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Active not recruiting
    Start
    2022-04-22
    Completion
    2028-01-01
    Enrolment
    800

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionErectile Dysfunction; Penile Prosthesis Infection
    InterventionDoxycycline; Ciprofloxacin; Augmentin; Bactrim
    PhaseEarly phase 1
    Registry statusActive not recruiting

  • Role of Co-trimoxazole in Severe COVID-19 Patients

    NCT04470531 · start 2020-07-12

    Registered record
    Registry ID
    NCT04470531
    Conditions
    Covid19; Severe COVID-19 Patients
    Interventions
    oral co-trimoxazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2020-07-12
    Completion
    2021-01-30
    Enrolment
    94

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCovid19; Severe COVID-19 Patients
    Interventionoral co-trimoxazole
    PhasePhase 2
    Registry statusUnknown

  • Fluoroquinolone Associated Disability

    NCT03535558 · start 2018-05-17

    Registered record
    Registry ID
    NCT03535558
    Conditions
    Bronchitis; Sinusitis; Urinary Tract Infections
    Interventions
    Fluoroquinolone (FQ); Azithromycin (AZ); Sulfamethoxazole/Trimethoprim (ST) Fixed Dose Combination
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2018-05-17
    Completion
    2018-12-31
    Enrolment
    239,306

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBronchitis; Sinusitis; Urinary Tract Infections
    InterventionFluoroquinolone (FQ); Azithromycin (AZ); Sulfamethoxazole/Trimethoprim (ST) Fixed Dose Combination
    PhaseNot recorded
    Registry statusCompleted